Latest & greatest articles for acetaminophen

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Top results for acetaminophen

61. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. (PubMed)

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. Acetaminophen is a common therapy for fever in patients in the intensive care unit (ICU) who have probable infection, but its effects are unknown.We randomly assigned 700 ICU patients with fever (body temperature, ≥38°C) and known or suspected infection to receive either 1 g of intravenous acetaminophen or placebo every 6 hours until ICU discharge, resolution of fever, cessation of antimicrobial therapy, or death (...) . The primary outcome was ICU-free days (days alive and free from the need for intensive care) from randomization to day 28.The number of ICU-free days to day 28 did not differ significantly between the acetaminophen group and the placebo group: 23 days (interquartile range, 13 to 25) among patients assigned to acetaminophen and 22 days (interquartile range, 12 to 25) among patients assigned to placebo (Hodges-Lehmann estimate of absolute difference, 0 days; 96.2% confidence interval [CI], 0 to 1; P=0.07

2015 NEJM

62. N-Acetylcysteine for Acute Acetaminophen Overdose in the Pre-Hospital Setting

N-Acetylcysteine for Acute Acetaminophen Overdose in the Pre-Hospital Setting Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should (...) study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions. TITLE: N-Acetylcysteine for Acute Acetaminophen Overdose

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

63. Paracetamol (acetaminophen) for prevention or treatment of pain in newborns. (PubMed)

Paracetamol (acetaminophen) for prevention or treatment of pain in newborns. Newborn infants have the ability to experience pain. Newborns treated in neonatal intensive care units are exposed to numerous painful procedures. Healthy newborns are exposed to pain if the birth process consists of assisted vaginal birth by vacuum extraction or by forceps and during blood sampling for newborn screening tests.Primary objectiveTo determine the efficacy and safety of paracetamol for the prevention

2015 Cochrane

64. Systematic review with meta analysis: In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective

Systematic review with meta analysis: In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content (...) are here In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective Article Text Therapeutics/Prevention Systematic review with meta analysis In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective Bryan M Saltzman , Kirk A Campbell Statistics from Altmetric.com

2015 Evidence-Based Medicine (Requires free registration)

65. Pre-emptive Oral Non-Steroidal Anti-Inflammatory Drugs or Acetaminophen for Knee Arthroscopy: A Rapid Review

Pre-emptive Oral Non-Steroidal Anti-Inflammatory Drugs or Acetaminophen for Knee Arthroscopy: A Rapid Review Pre-emptive oral non-steroidal anti-inflammatory drugs or acetaminophen for knee arthroscopy: a rapid review Pre-emptive oral non-steroidal anti-inflammatory drugs or acetaminophen for knee arthroscopy: a rapid review Health Quality Ontario Citation Health Quality Ontario. Pre-emptive oral non-steroidal anti-inflammatory drugs or acetaminophen for knee arthroscopy: a rapid review (...) . Toronto: Health Quality Ontario (HQO). Rapid Review. 2014 Authors' conclusions Based on 2 RCTs, both with limitations due to risk of bias, there were inconsistent results regarding the effectiveness of pre-emptive oral celecoxib, a selective COX-2 inhibitor NSAID, for post-operative pain control in patients undergoing knee arthroscopy. No evidence was identified that evaluated the oral pre-emptive use of acetaminophen or conventional NSAIDs for post-operative pain control in patients undergoing knee

2014 Health Technology Assessment (HTA) Database.

66. Codeine, alone and with paracetamol (acetaminophen), for cancer pain. (PubMed)

Codeine, alone and with paracetamol (acetaminophen), for cancer pain. Pain is very common in patients with cancer. Opioid analgesics, including codeine, play a significant role in major guidelines on the management of cancer pain, particularly for mild to moderate pain. Codeine is widely available and inexpensive, which may make it a good choice, especially in low-resource settings. Its use is controversial, in part because codeine is not effective in a minority of patients who cannot convert

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2014 Cochrane

67. Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone

Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all (...) * Associated Topics Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone Ferne Kraglund DDS . Overview Systematic Review Conclusion Current evidence suggests that a combination of acetaminophen, also known as paracetamol, and a nonsteroidal anti-inflammatory drug (NSAID) may offer superior analgesia than does either drug alone. Critical Summary Assessment The authors of this high-quality review of 21 double-masked randomized controlled

2014 ADA Center for Evidence-Based Dentistry

68. Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone

Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all (...) * Associated Topics Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone Ferne Kraglund DDS . Overview Systematic Review Conclusion Current evidence suggests that a combination of acetaminophen, also known as paracetamol, and a nonsteroidal anti-inflammatory drug (NSAID) may offer superior analgesia than does either drug alone. Critical Summary Assessment The authors of this high-quality review of 21 double-masked randomized controlled

2014 ADA Center for Evidence-Based Dentistry

69. Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone

Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all (...) * Associated Topics Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone Ferne Kraglund DDS . Overview Systematic Review Conclusion Current evidence suggests that a combination of acetaminophen, also known as paracetamol, and a nonsteroidal anti-inflammatory drug (NSAID) may offer superior analgesia than does either drug alone. Critical Summary Assessment The authors of this high-quality review of 21 double-masked randomized controlled

2014 ADA Center for Evidence-Based Dentistry

70. For Post-Dental Extraction Pain, Co-therapy with Acetaminophen and Ibuprofen is More Effective in Pain Management than Acetaminophen or Ibuprofen Alone

For Post-Dental Extraction Pain, Co-therapy with Acetaminophen and Ibuprofen is More Effective in Pain Management than Acetaminophen or Ibuprofen Alone UTCAT2734, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title For Post-Dental Extraction Pain, Co-therapy with Acetaminophen and Ibuprofen is More Effective in Pain Management than Acetaminophen or Ibuprofen Alone Clinical Question In patients following a dental extraction (...) is the post-operative administration of combined acetaminophen and ibuprofen better than therapy with acetaminophen or ibuprofen alone for pain management? Clinical Bottom Line The post-operative use combined acetaminophen and ibuprofen provides superior pain relief compared to acetaminophen or ibuprofen alone. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Bailey/2013 Patient Group 2,241 patients ages 16-65

2014 UTHSCSA Dental School CAT Library

71. Tramadol/Acetaminophen Tablets Provide Rapid, Effective, and Dose-Dependent Analgesia Following Dental Surgery

Tramadol/Acetaminophen Tablets Provide Rapid, Effective, and Dose-Dependent Analgesia Following Dental Surgery UTCAT2725, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Tramadol/Acetaminophen Tablets Provide Rapid, Effective, and Dose-Dependent Analgesia Following Dental Surgery Clinical Question Following dental surgery, does Tramadol provide adequate analgesia when compared to hydrocodone/APAP or codeine/APAP (...) combination drug preparations? Clinical Bottom Line Tramadol/Acetaminophen 75/650mg tablets provide effective, rapid ( Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Jung/2004 128 healthy adults undergoing extraction of > or = 1 impacted 3rd molars Randomized Controlled Trial Key results Tr/APAP 75/650mg and Co/APAP/Ibuprofen 20/500/400mg mean total pain relief and the sum of pain intensity difference were

2014 UTHSCSA Dental School CAT Library

72. Pre-emptive Oral Non-Steroidal Anti-Inflammatory Drugs or Acetaminophen for Knee Arthroscopy

Pre-emptive Oral Non-Steroidal Anti-Inflammatory Drugs or Acetaminophen for Knee Arthroscopy Pre-emptive Oral Non-Steroidal Anti-Inflammatory Drugs or Acetaminophen for Knee Arthroscopy: A Rapid Review. August 2014; pp. 1–18 Pre-emptive Oral Non-Steroidal Anti- Inflammatory Drugs or Acetaminophen for Knee Arthroscopy: A Rapid Review Health Quality Ontario August 2014 Evidence Development and Standards Branch at Health Quality Ontario Pre-emptive Oral Non-Steroidal Anti-Inflammatory Drugs (...) or Acetaminophen for Knee Arthroscopy: A Rapid Review. August 2014; pp. 1–18 2 Suggested Citation This report should be cited as follows: Health Quality Ontario. Pre-emptive oral non-steroidal anti-inflammatory drugs or acetaminophen for knee arthroscopy: a rapid review. Toronto: Health Quality Ontario; 2014 August. 18 p. Available from: http://www.hqontario.ca/evidence/evidence-process/episodes-of-care#knee-arthroscopy. Permission Requests All inquiries regarding permission to reproduce any content in Health

2014 Health Quality Ontario

73. Intravenous acetaminophen for acute postoperative pain in adults

Intravenous acetaminophen for acute postoperative pain in adults Intravenous acetaminophen for acute postoperative pain in adults Intravenous acetaminophen for acute postoperative pain in adults Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Intravenous acetaminophen for acute postoperative pain in adults. Lansdale: HAYES, Inc.. Healthcare Technology Brief (...) the medications acetaminophen, opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), selective inhibitors of cyclo-oxygenase-2, ketamine, aspirin, and nonpharmacologic therapies. Opioids have side effects that can be dose limiting such as nausea, vomiting, constipation, decreased gastrointestinal motility, urinary retention, sedation, confusion, and respiratory depression. NSAIDs are contraindicated in patients with renal impairment and may cause bleeding, platelet dysfunction, renal toxicity

2014 Health Technology Assessment (HTA) Database.

74. Acetaminophen (paracetamol) for the common cold in adults. (PubMed)

Acetaminophen (paracetamol) for the common cold in adults. Acetaminophen is frequently prescribed for treating patients with the common cold, but there is little evidence as to whether it is effective.To determine the efficacy and safety of acetaminophen in the treatment of the common cold in adults.We searched CENTRAL 2013, Issue 1, Ovid MEDLINE (1950 to January week 5, 2013), EMBASE (1980 to February 2013), CINAHL (1982 to February 2013) and LILACS (1985 to February 2013).We included (...) randomised controlled trials (RCTs) comparing acetaminophen to placebo or no treatment in adults with the common cold. Studies were included if the trials used acetaminophen as one ingredient of a combination therapy. We excluded studies in which the participants had complications. Primary outcomes included subjective symptom score and duration of common cold symptoms. Secondary outcomes were overall well being, adverse events and financial costs.Two review authors independently screened studies

2013 Cochrane

75. Intravenous or rectal acetaminophen for post-operative pain

Intravenous or rectal acetaminophen for post-operative pain Intravenous or rectal acetaminophen for post-operative pain Intravenous or rectal acetaminophen for post-operative pain Mitchell MD, Umscheid CA Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mitchell MD, Umscheid CA. Intravenous or rectal acetaminophen for post-operative pain (...) . Philadelphia: Center for Evidence-based Practice (CEP). 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Humans; Pain, Postoperative Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence Center for Evidence-based Practice, University of Pennsylvania Health System, 3535 Market St. Suite 50, Philadelphia PA 19104

2013 Health Technology Assessment (HTA) Database.

76. King`s College Hospital Criteria for non-acetaminophen induced acute liver failure in an international cohort of children (PubMed)

King`s College Hospital Criteria for non-acetaminophen induced acute liver failure in an international cohort of children To validate King's College Hospital criteria (KCHC) in children with non-acetaminophen induced pediatric acute liver failure (PALF) and to determine whether re-optimizing the KCHC would improve predictive accuracy.We used the PALF study group database. Primary outcomes were survival without liver transplantation vs death at 21 days following enrollment. Classification

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2013 EvidenceUpdates

77. Intravenous acetaminophen reduces postoperative nausea and vomiting: a systematic review and meta-analysis (PubMed)

Intravenous acetaminophen reduces postoperative nausea and vomiting: a systematic review and meta-analysis Opioids are a key risk factor for postoperative nausea and vomiting (PONV). As intravenous (i.v.) acetaminophen reduces postoperative pain and opioid requirements, one would expect i.v. acetaminophen to be associated with a lower incidence of opioid-induced side effects, including PONV. We conducted a systematic search using Medline and Cochrane databases supplemented with hand search (...) of abstract proceedings to identify randomized-controlled trials of i.v. acetaminophen. Inclusion criteria were (a) randomized for i.v. acetaminophen vs a placebo control, (b) general anesthesia, and (c) reported or obtainable PONV outcomes. Primary outcome was postoperative nausea and secondary outcome was postoperative vomiting. We included 30 studies with 2364 patients (1223 in the acetaminophen group, 1141 in the placebo group). The relative risk (95% confidence interval) was 0.73 (0.60-0.88

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2013 EvidenceUpdates

78. For Patients With Dental Pain, Combination Therapy With Ibuprofen And Acetaminophen Is More Effective In Producing Analgesia Than Monotherapy With Ibuprofen Alone

For Patients With Dental Pain, Combination Therapy With Ibuprofen And Acetaminophen Is More Effective In Producing Analgesia Than Monotherapy With Ibuprofen Alone UTCAT2379, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title For Patients With Dental Pain, Combination Therapy With Ibuprofen And Acetaminophen Is More Effective In Producing Analgesia Than Monotherapy With Ibuprofen Alone Clinical Question In patients (...) with inflammatory pain, does the combination of ibuprofen and acetaminophen compared to ibuprofen alone produce greater analgesia? Clinical Bottom Line Combination therapy with ibuprofen and acetaminophen produces greater analgesia than ibuprofen alone in patients with inflammatory pain. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Daniels/2011 678 patients at least 16 years old with at least 3 impacted 3rd

2013 UTHSCSA Dental School CAT Library

79. Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. (PubMed)

Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period. Perineal pain is a common but poorly studied adverse outcome following childbirth. Pain may result from perineal trauma due to bruising, spontaneous tears, surgical incisions (episiotomies), or in association with operative births (ventouse or forceps assisted births).To determine the efficacy of a single administration of paracetamol (acetaminophen) systemic drugs used in the relief of acute (...) postpartum perineal painWe updated the search of the Cochrane Pregnancy and Childbirth Group's Trials Register on 6 November 2012.Randomised controlled trials (RCTs) assessing paracetamol (acetaminophen) in a single dose compared with placebo for women with early postpartum perineal pain. We excluded quasi-RCTs and cross-over studies.Two review authors assessed each paper for inclusion and extracted data. One review author reviewed the decisions and confirmed calculations for pain relief scores.We did

2013 Cochrane

80. Is Intravenous Acetylcysteine More Effective Than Oral Administration For the Prevention of Hepatotoxicity in Acetaminophen Overdose?

Is Intravenous Acetylcysteine More Effective Than Oral Administration For the Prevention of Hepatotoxicity in Acetaminophen Overdose? Systematic Review Snapshot TAKE-HOME MESSAGE Rates of hepatotoxicity from acetaminophen appear to be similar whether acetylcysteine is administered orally or intravenously. Is Intravenous Acetylcysteine More Effective Than Oral Administration for the Prevention of Hepatotoxicity in Acetaminophen Overdose? EBEM Commentators Evan Schwarz, MD Brian Cohn, MD (...) ’ com- prehensive search. Of 334 articles selected for abstraction, 16 articles with 5,164 acetaminophen overdose patients were included in the primary meta-analysis. The overall rate of hepatotoxicity was 12.9% (95% con- ?dence interval 9.6% to 17.2%); the proportion for patients treated with intravenousacetylcysteinewassimilar to that in orally treated patients. The authors did not include an assessment of the methodological quality of the included studies, nor didtheyprovide any assessment

2013 Annals of Emergency Medicine Systematic Review Snapshots