Latest & greatest articles for acetaminophen

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Top results for acetaminophen

101. Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis

Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis Etminan M, Sadatsafavi M, Jafari S, Doyle-Waters M, Aminzadeh K, FitzGerald JM CRD summary The authors concluded that there was an increased risk of asthma in adults and children who used (...) acetaminophen. Further research was needed. In light of unclear quality of the included studies and limited study information, the authors' conclusions should be treated with caution. Authors' objectives To determine the association between acetaminophen use and asthma or wheezing in children and adults and to assess the effect of prenatal acetaminophen use on the risk of asthma in young children. Searching MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), DARE, American College

2009 DARE.

102. Codeine-acetaminophen versus nonsteroidal anti-inflammatory drugs in the treatment of post-abdominal surgery pain: a systematic review of randomized trials

Codeine-acetaminophen versus nonsteroidal anti-inflammatory drugs in the treatment of post-abdominal surgery pain: a systematic review of randomized trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

103. Effectiveness of oral vs rectal acetaminophen: a meta-analysis (PubMed)

Effectiveness of oral vs rectal acetaminophen: a meta-analysis To determine, on the basis of published studies, the efficacy of rectal vs oral acetaminophen as treatment of fever and pain.MEDLINE, PubMed, and the Cochrane database as well as major pharmacologic textbooks and the references of all included studies were searched for studies comparing oral and rectal administration of acetaminophen.Randomized and quasi-randomized controlled studies comparing rectal and oral administration (...) of acetaminophen were included. Reviews, letters, and studies that compared combined treatments or additional drugs were excluded. Main Exposure Oral vs rectal acetaminophen.Standardized measures of temperature and pain reduction.For temperature reduction, 4 studies met the inclusion criteria. The decline in temperature 1 hour after administration of acetaminophen was no different between rectal and oral administration (weighted mean difference [WMD], -0.14 degrees C; 95% confidence interval [CI], -0.36

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2008 EvidenceUpdates

104. Single dose oral paracetamol (acetaminophen) for postoperative pain in adults. (PubMed)

Single dose oral paracetamol (acetaminophen) for postoperative pain in adults. This is an updated version of the original Cochrane review published in Issue 1, 2004 - this original review had been split from a previous title on 'Single dose paracetamol (acetaminophen) with and without codeine for postoperative pain'. The last version of this review concluded that paracetamol is an effective analgesic for postoperative pain, but additional trials have since been published. This review sought

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2008 Cochrane

105. Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal pain in children

Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal pain in children Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal pain in children | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal pain in children Article Text Therapeutics Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal

2008 Evidence-Based Medicine (Requires free registration)

106. Acetaminophen use during pregnancy: effects on risk for congenital abnormalities (PubMed)

Acetaminophen use during pregnancy: effects on risk for congenital abnormalities We evaluated if acetaminophen, one of the most frequently used drugs among pregnant women is associated with an increased prevalence of congenital abnormalities.We selected 88,142 pregnant women and their liveborn singletons from the Danish National Birth Cohort who had information on acetaminophen use during the first trimester of pregnancy. We used the National Hospital Registry to identify 3784 (4.3%) children (...) from the cohort diagnosed with 5847 congenital abnormalities.Children exposed to acetaminophen during the first trimester of pregnancy (n = 26,424) did not have an increased prevalence of congenital abnormalities (hazard ratio = 1.01, 0.93-1.08) compared with nonexposed children (n = 61,718). No association was found between congenital abnormalities and duration of use during the first trimester. Increased prevalence was not observed for specific abnormalities, except for "medial cysts, fistula

2008 EvidenceUpdates

107. Effectiveness of oral vs rectal acetaminophen: a meta-analysis

Effectiveness of oral vs rectal acetaminophen: a meta-analysis Effectiveness of oral vs rectal acetaminophen: a meta-analysis Effectiveness of oral vs rectal acetaminophen: a meta-analysis Goldstein L H, Berlin M, Berkovitch M, Kozer E CRD summary The authors concluded that oral and rectal acetaminophen had comparable effects on temperature reduction. Given the unclear quality of the included trials and the small numbers of participants included for analysis, the reliability of the authors (...) ' conclusions is unclear. Authors' objectives To compare the effectiveness of oral versus rectal acetaminophen as a treatment for fever and pain. Searching PubMed (1950 to October 2007) and the Cochrane Database of Systematic Reviews (2007) were searched for articles published in any language with an English abstract. Search terms were reported. References of major pharmacological textbooks, relevant reviews and the included studies were handsearched. Study selection Randomised (RCT) or quasi-randomised

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2008 DARE.

108. A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery (PubMed)

A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery Narcotics are used extensively in outpatient general surgery but are often poorly tolerated with variable efficacy. Acetaminophen combined with NSAIDs is a possible alternative. The objective of this study was to compare the efficacy of acetaminophen, codeine, and caffeine (Tylenol No. 3) with acetaminophen and ibuprofen for management of pain (...) after outpatient general surgery procedures.A double-blind randomized controlled trial was performed in patients undergoing outpatient inguinal/umbilical/ventral hernia repair or laparoscopic cholecystectomy. Patients were randomized to receive acetaminophen plus codeine plus caffeine (Tylenol No. 3) or acetaminophen plus ibuprofen (AcIBU) 4 times daily for 7 days or until pain-free. Pain intensity, measured four times daily by visual analogue scale, was the primary outcome. Secondary end points

2008 EvidenceUpdates

109. Tramadol hydrochloride /acetaminophen

Tramadol hydrochloride /acetaminophen Common Drug Review CEDAC Meeting – April 18, 2007 Page 1 of 2 Notice of CEDAC Final Recommendation – May 17, 2007 CEDAC FINAL RECOMMENDATION and REASONS for RECOMMENDATION TRAMADOL HYDROCHLORIDE/ACETAMINOPHEN (Tramacet ™ – Janssen-Ortho Inc.) Description: Tramacet ™ is a fixed dose combination of tramadol hydrochloride, a synthetic opioid analgesic, and acetaminophen. It is approved for the short term (five days or less) management of acute pain. Dosage (...) Forms: Tablets contain 37.5 mg of tramadol hydrochloride and 325 mg of acetaminophen. The recommended dose of Tramacet ™ is one to two tablets every four to six hours, as needed, for pain relief, to a maximum of eight tablets per day. Recommendation: The Canadian Expert Drug Advisory Committee (CEDAC) recommends that Tramacet ™ not be listed. Reasons for the Recommendation: 1. There is insufficient evidence that Tramacet ™ provides a therapeutic advantage over less expensive analgesics

2007 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

110. Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization

Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization Manley J, Taddio A CRD summary This review investigated use of acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunisation. The authors concluded (...) that acetaminophen and ibuprofen may prevent adverse events in young infants receiving diphtheria-tetanus toxoids-whole pertussis vaccine. No benefits were demonstrated for the diphtheria-tetanusoxides acellular pertussis vaccine. The conclusions may not be reliable due to methodological limitations. Authors' objectives To evaluate prophylactic use of acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunisation. Searching MEDLINE (1966 to February 2007), PubMed (1966

2007 DARE.

111. Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin plus paracetamol but had fewer adverse effects in acute gout-like arthritis

Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin plus paracetamol but had fewer adverse effects in acute gout-like arthritis Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin plus paracetamol but had fewer adverse effects in acute gout-like arthritis | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time (...) . To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin

2007 Evidence-Based Medicine (Requires free registration)

112. Interventions for paracetamol (acetaminophen) overdose. (PubMed)

Interventions for paracetamol (acetaminophen) overdose. Poisoning with paracetamol (acetaminophen) is a common cause of hepatotoxicity in the Western World. Inhibition of absorption, removal from the vascular system, antidotes, and liver transplantation are interventions for paracetamol poisoning.To assess the benefits and harms of interventions for paracetamol overdose.We identified trials through electronic databases, manual searches of bibliographies and journals, authors of trials

2006 Cochrane

113. Acetaminophen for osteoarthritis. (PubMed)

Acetaminophen for osteoarthritis. Osteoarthritis (OA) is the most common form of arthritis. Published guidelines and expert opinion are divided over the relative role of acetaminophen (also called paracetamol or Tylenol) and non-steroidal anti-inflammatory drugs (NSAIDs) as first-line pharmacologic therapy. The comparative safety of acetaminophen and NSAIDs is also important to consider. This update to the original 2003 review includes nine additional RCTs.To assess the efficacy and safety (...) of acetaminophen versus placebo and versus NSAIDs (ibuprofen, diclofenac, arthrotec, celecoxib, naproxen, rofecoxib) for treating OA.We searched MEDLINE (up to July 2005), EMBASE (2002-July 2005), Cochrane Central Register of Controlled Trials (CENTRAL), ACP Journal Club, DARE, Cochrane Database of Systematic Reviews (all from 1994 to July 2005). Reference lists of identified RCTs and pertinent review articles were also hand searched.Published randomized controlled trials (RCTs) evaluating the efficacy

2006 Cochrane

114. Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management.

Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund You are here Guidelines and Measures

2006 American Association of Poison Control Centers

115. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. (PubMed)

Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. During a clinical trial of a novel hydrocodone/acetaminophen combination, a high incidence of serum alanine aminotransferase (ALT) elevations was observed.To characterize the incidence and magnitude of ALT elevations in healthy participants receiving 4 g of acetaminophen daily, either alone or in combination with selected opioids, as compared with participants treated (...) with placebo.A randomized, single-blind, placebo-controlled, 5-treatment, parallel-group, inpatient, diet-controlled (meals provided), longitudinal study of 145 healthy adults in 2 US inpatient clinical pharmacology units.Each participant received either placebo (n = 39), 1 of 3 acetaminophen/opioid combinations (n = 80), or acetaminophen alone (n = 26). Each active treatment included 4 g of acetaminophen daily, the maximum recommended daily dosage. The intended treatment duration was 14 days. Main Outcomes

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2006 JAMA

116. Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials

Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

117. Costs and effectiveness of rofecoxib, celecoxib, and acetaminophen for preventing pain after ambulatory otolaryngologic surgery

Costs and effectiveness of rofecoxib, celecoxib, and acetaminophen for preventing pain after ambulatory otolaryngologic surgery Costs and effectiveness of rofecoxib, celecoxib, and acetaminophen for preventing pain after ambulatory otolaryngologic surgery Costs and effectiveness of rofecoxib, celecoxib, and acetaminophen for preventing pain after ambulatory otolaryngologic surgery Watcha M F, Issioui T, Klein K W, White P F Record Status This is a critical abstract of an economic evaluation (...) that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Three oral analgesic regimens for preventing pain after ambulatory surgery were examined. The regimens were acetaminophen (2 g), celecoxib (200 mg) and rofecoxib (50 mg). The drugs were administered 15 to 45 minutes before entering the operating room. Type

2003 NHS Economic Evaluation Database.

118. Interventions for paracetamol (acetaminophen) overdoses. (PubMed)

Interventions for paracetamol (acetaminophen) overdoses. Self-poisoning with paracetamol (acetaminophen) is a common cause of hepatotoxicity in the Western World. Interventions for paracetamol poisoning encompass inhibition of absorption, removal from the vascular system, antidotes, and liver transplantation.The objective was to assess the beneficial and harmful effects of interventions or combination of interventions for paracetamol overdose.The Cochrane Hepato-Biliary Group Controlled Trials

2002 Cochrane

119. Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial. (PubMed)

Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial. Osteoarthritis (OA) is often treated with nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, or specific inhibitors of cyclooxygenase 2 (COX-2).To assess the relative therapeutic efficacy of rofecoxib, celecoxib, and acetaminophen in adults with OA.Randomized, parallel-group, double-blind trial, conducted from June 1999 to February 2000, in 29 clinical centers in the United (...) States.Three hundred eighty-two patients aged at least 40 years who had OA of the knee that was previously treated with NSAIDs or acetaminophen.Patients were randomly assigned to receive rofecoxib, 12.5 mg/d (n = 96); rofecoxib, 25 mg/d (n = 95); celecoxib, 200 mg/d (n = 97); or acetaminophen, 4000 mg/d (n = 94) for 6 weeks.Assessments over days 1 to 6 and over 6 weeks included pain on walking, night pain, pain at rest, and morning stiffness as measured on a Western Ontario McMaster Universities

2002 JAMA

120. Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery

Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery Issioui T, Klein K W, White P F, Watcha M F, Skrivanek G D, Jones S B, Hu J, Marple B F, Ing C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each (...) abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Selective non-steroidal anti-inflammatory drugs (NSAIDs) given alone, or in combination, prior to outpatient otolaryngologic surgery were considered. The NSAIDs studied were rofecoxib (a cyclooxygenase-2 inhibitor; 50 mg) and acetaminophen (2 mg). Type of intervention Secondary prevention and treatment

2002 NHS Economic Evaluation Database.