Latest & greatest articles for acne

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acne or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on acne and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Acne treatment and clinical papers

Acne is a common skin condition characterised by whiteheads (or blackheads), pimples and oily skin. It can lead to possible scarring. It is typically caused when hair follicles become inflamed and the sebaceous glands in the skin are overactive. The over production of sebum and a combination of dead skin cells and dirt can clog follicles and pores causing a break out. Acne can affect any age group but it’s more common in adolescents.

There are many ways to treat acne depending on the severity of the case. Treatments include a range of medications such as topical retinoids, antibiotics and in severe cases isotretinoin is prescribed. Research is ongoing to determine the side effects and harms caused by these drugs. Clinical trials and studies are vital to assess treatment.

The Trip Database has an extensive collection of articles on acne ranging from clinical trials, systematic reviews, clinical guidelines and case reports. These can be found via searching the site.

Top results for acne

41. Is less more with isotretinoin and acne?

Is less more with isotretinoin and acne? Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,000 family physicians, family medicine residents and medical students in Alberta. Established over fifty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca March 14, 2016 Is less more (...) with isotretinoin and acne? Clinical Question: What is the efficacy and tolerability of low-dose compared to conventional dose isotretinoin in the treatment of acne? Bottom-line: Small randomized controlled trials (RCTs) and observational studies demonstrate low-dose (~20mg/day) isotretinoin improves acne similar to conventional dosing. Low-dose may reduce common side effects (chapped lips, dry skin, epistaxis) by 16-35% but may be associated with increased relapse rates, particularly with severe acne

2016 Tools for Practice

42. Acne clinical guideline

Acne clinical guideline Guidelines of care for the management of acne vulgaris - Journal of the American Academy of Dermatology Email/Username: Password: Remember me Search JAAD & JAAD Case Reports Search Terms Search within Search Access provided by Volume 74, Issue 5, Pages 945–973.e33 Guidelines of care for the management of acne vulgaris Work Group:, x Andrea L. Zaenglein Affiliations Penn State Hershey Medical Center, Hershey, Pennsylvania , MD (Co-Chair) a , x Arun L. Pathy Affiliations (...) translations or adaptations of the article | Fig 1 Treatment algorithm for the management of acne vulgaris in adolescents and young adults. The double asterisks (∗∗) indicate that the drug may be prescribed as a fixed combination product or as separate component. BP , Benzoyl peroxide. Hide Pane Expand all Collapse all Article Outline Acne is one of the most common disorders treated by dermatologists and other health care providers. While it most often affects adolescents, it is not uncommon in adults

2016 American Academy of Dermatology

43. Management of acne

Management of acne Guidelines CMAJ ©2015 8872147 Canada Inc. or its licensors CMAJ 1 CME A cne is one of the most burdensome dis­ eases globally. 1,2 Its prevalence among those aged 12 to 24 years is estimated to be 85%, although it can persist beyond young adulthood despite treatment. 3–5 Acne can adversely affect quality of life 6–13 and may lead to emotional distress and physical scarring. 14,15 The clinical presentation of acne (Figure 1) varies from primarily comedonal to mixed comedonal (...) and inflammatory acne. 16 Since the last Canadian acne guideline was published in 2000, 17 evidence for multiple addi­ tional treatments has been published. Thus, there was an unmet need for an updated, systematic­ ally developed, evidence­ based Canadian acne clinical practice guideline. This guideline pro­ vides recommendations adapted to the Canadian health care system to assist Canadian health care providers in the diagnosis of acne vulgaris, including investigations where appropriate; it also provides

2015 CPG Infobase

44. Complementary therapies for acne: do they hit the spot?

Complementary therapies for acne: do they hit the spot? Complementary therapies for acne: do they hit the spot? - Evidently Cochrane Search and hit Go By February 6, 2015 // What a misery acne can be and few teens escape it completely. It can last well into adulthood too. There are many treatments available, both over-the-counter and on prescription. Many people look to alternatives to medical treatment, such as herbal preparations and changes to their diet. Are they any good? A team from set (...) out to find out. Their brought together the best available evidence from randomised controlled trials on complementary therapies for acne. There are 35 trials (over 3000 people) looking at herbal medicine, acupuncture, wet cupping, diet, purified bee venom, and tea tree oil. Here’s what they found: Low- versus high-glycaemic load diets were compared. There was no clear evidence of a difference between groups in the number of non-inflammatory lesions after 12 weeks (2 studies combined). The low

2015 Evidently Cochrane

45. Complementary therapies for acne vulgaris. (Full text)

Complementary therapies for acne vulgaris. Acne is a chronic skin disease characterised by inflamed spots and blackheads on the face, neck, back, and chest. Cysts and scarring can also occur, especially in more severe disease. People with acne often turn to complementary and alternative medicine (CAM), such as herbal medicine, acupuncture, and dietary modifications, because of their concerns about the adverse effects of conventional medicines. However, evidence for CAM therapies has not been (...) systematically assessed.To assess the effects and safety of any complementary therapies in people with acne vulgaris.We searched the following databases from inception up to 22 January 2014: the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL; 2014,Issue 1), MEDLINE (from 1946), Embase (from 1974), PsycINFO (from 1806), AMED (from 1985), CINAHL (from 1981), Scopus (from 1966), and a number of other databases listed in the Methods section of the review

2015 Cochrane PubMed

46. The Effects of a Low Glycemic Load Diet on Acne Vulgaris in Adolescents and Young Adults

The Effects of a Low Glycemic Load Diet on Acne Vulgaris in Adolescents and Young Adults "The Effects of a Low Glycemic Load Diet on Acne Vulgaris in Adolescent" by Andrew White < > > > > > Title Author Date of Graduation Summer 8-8-2015 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Mark Pedemonte, MD Second Advisor Annjanette Sommers, PA-C, MS Rights . Abstract Background: Acne vulgaris is a common disease amongst adolescents in Western (...) societies. It is an interesting problem because, while it is very common among this particular population, it is very rare in non-Westernized societies. This observation has lead to recent exploration of what factors in Western society may, at least in part, be responsible for this. Recently there have been several epidemiological studies linking certain foods to acne. Of the foods showing a positive correlation, high glycemic load foods have been the most extensively studied. There have been a number

2015 Pacific University EBM Capstone Project

47. Antihistamine: A Useful Medication with Minimal Adverse Drug Reactions to Improve Acne Symptoms and Reduce Sebum Production

Antihistamine: A Useful Medication with Minimal Adverse Drug Reactions to Improve Acne Symptoms and Reduce Sebum Production "Antihistamine: A Useful Medication with Minimal Adverse Drug Reactions" by Lorraine Wang < > > > > > Title Author Date of Graduation Summer 8-8-2015 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor David Keene PA-C Rights . Abstract Background: Acne vulgaris is a common skin disease that affects not only teenagers (...) but also the general population. Although acne is not physically disabling, its psychological impact can be striking, contributing to low self-esteem, depression, and anxiety. As a result, there is a significant demand for effective acne therapies. Antihistamine is a widely used medication to treat several allergic skin conditions and yet it also has been found to decrease complications of acne and improve acne symptoms. For the severe cystic acne vulgaris, oral retinoids such as isotretinoin

2015 Pacific University EBM Capstone Project

48. Clinical and sebumetric evaluation of topical emulsions in the treatment of acne vulgaris. (Full text)

Clinical and sebumetric evaluation of topical emulsions in the treatment of acne vulgaris. Numerous plant products described in the scientific literature show distinct activities on the skin, such as moisturizing, antioxidant, sunscreen, anti-acne and depigmentation.The main objective of this study was to compare the effectiveness of emulsion formulations containing plant extracts (Hippophae rhamnoides and Cassia fistula) and placebo (without plant extracts) on acne patients.A single-blind (...) , randomized, placebo-controlled, split-face study was designed. Two groups of 25 patients each (aged 18-37 years) with grade I and grade II acne vulgaris received active formulations on the left side of their cheeks and placebo on the right side of their cheeks twice daily for 12 weeks. Prior to the study, signed consent was obtained from each patient. The anti-bacterial activity of the extracts and formulations was tested in vitro. The skin sebum contents of patients were evaluated by the sebumeter(®

2014 Postepy dermatologii i alergologii PubMed

49. Acne vulgaris

Acne vulgaris Acne vulgaris - NICE CKS Clinical Knowledge Summaries Share Acne vulgaris: Summary Acne vulgaris is a chronic inflammatory skin condition affecting mainly the face, back and chest - it is characterised by blockage and inflammation of the pilosebaceous unit (the hair follicle, hair shaft and sebaceous gland). It presents with lesions which can be non-inflammatory (comedones), inflammatory (papules, pustules and nodules) or a mixture of both. Up to 95% of adolescents in Western (...) industrialized countries are affected by acne to some extent — 20 to 35% develop moderate or severe acne. Complications of acne include skin changes such as scarring, post-inflammatory hyperpigmentation or depigmentation and psychosocial problems such as depression and anxiety. All people with acne should be advised: To avoid over cleaning the skin (which may cause dryness and irritation) - acne is not caused by poor hygiene. To use non-comedogenic make-up, cleansers and/or emollients with a pH close

2014 NICE Clinical Knowledge Summaries

50. Methyl aminolevulinate (Visonac) photodynamic therapy for acne vulgaris

Methyl aminolevulinate (Visonac) photodynamic therapy for acne vulgaris Methyl aminolevulinate (Visonac) photodynamic therapy for acne vulgaris Methyl aminolevulinate (Visonac) photodynamic therapy for acne vulgaris NIHR HSC Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSC. Methyl aminolevulinate (Visonac) photodynamic therapy (...) for acne vulgaris. Birmingham: NIHR Horizon Scanning Centre (NIHR HSC). Horizon Scanning Review. 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Acne Vulgaris; Aminolevulinic Acids; Photochemotherapy Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence The NIHR Horizon Scanning Centre, Department of Public Health, Epidemiology, and Biostatistics, School of Health&Population

2013 Health Technology Assessment (HTA) Database.

51. Acne vulgaris. (PubMed)

Acne vulgaris. Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinisation, inflammation, and bacterial colonisation of hair follicles on the face, neck, chest, and back by Propionibacterium acnes. Although early colonisation with P acnes and family history might have important roles in the disease, exactly what triggers acne and how treatment affects the course of the disease remain unclear. Other factors (...) such as diet have been implicated, but not proven. Facial scarring due to acne affects up to 20% of teenagers. Acne can persist into adulthood, with detrimental effects on self-esteem. There is no ideal treatment for acne, although a suitable regimen for reducing lesions can be found for most patients. Good quality evidence on comparative effectiveness of common topical and systemic acne therapies is scarce. Topical therapies including benzoyl peroxide, retinoids, and antibiotics when used in combination

2011 Lancet

52. Advice on the safe introduction and continued use of isotretinoin in acne in the UK

Advice on the safe introduction and continued use of isotretinoin in acne in the UK GUIDELINES BJD British Journal of Dermatology Advice on the safe introduction and continued use of isotretinoin in acne in the U.K. 2010 M.J.D. Good?eld, N.H. Cox,* A. Bowser, J.C. McMillan, L.G. Millard,§ N.B. Simpson– and A.D. Ormerod** Department of Dermatology, Leeds General In?rmary, Leeds LS1 3EX, U.K. *Department of Dermatology, Cumberland In?rmary, Carlisle CA2 7HY, U.K. Independent Acne Patient Advisor (...) words adverse effects, depression, isotretinoin, pregnancy prevention plan, safe use, teratogen Con?icts of interest M.J.D.G. (Chair) has received no direct or indirect sponsorship from either of the companies that supply isotretinoin. The Department in which he works has received both speci?c and nonspeci?c sponsorship for research from Roche in the past. The late N.H.C. received sponsorship from Roche to attend nontargeted educational meetings. A.B. is Chief Executive of the Acne Support Group

2010 British Association of Dermatologists

53. Acne best practice management

Acne best practice management RACGP - Acne – best practice management Search the RACGP website Latest issue December 2017 Vol 46(12) 881-960 Articles in the December issue discuss various health issues affecting school-aged children, including acne, eczema and growth disorders. Australian Family Physician Joint pain September 2010 / / / / Clinical Acne Best practice management Pages 656-660 David Cook George Krassas Tom Huang Background Acne vulgaris can have a substantial impact on a patient’s (...) quality of life; there can be significant psychosocial consequences and it can leave permanent physical scarring. Early and effective acne treatment is important. Objective/s To describe the outcome of an accredited clinical audit investigating general practitioner management of acne vulgaris and to provide an outline of current ‘best practice’ acne management. Discussion The audit was conducted over two cycles with GPs receiving educational material between cycles. Eighty-five GPs contributed data

2010 The Royal Australian College of General Practitioners

54. Acne best practice management

Acne best practice management 656 Reprinted from Aust RAli An F Amily Physici An Vol. 39, n o. 9, se Ptembe R 2010 David Cook George Krassas Tom Huang Acne Best practice management Background Acne vulgaris can have a substantial impact on a patient’s quality of life; there can be significant psychosocial consequences and it can leave permanent physical scarring. Early and effective acne treatment is important. Objective To describe the outcome of an accredited clinical audit investigating (...) general practitioner management of acne vulgaris and to provide an outline of current ‘best practice’ acne management. Discussion The audit was conducted over two cycles with GPs receiving educational material between cycles. Eighty-five GPs contributed data on 1638 patients. General practitioner management of acne was assessed against a set of preset standards and some acne treatment was found to be inconsistent with best practice, particularly for patients with moderate and moderate to severe acne

2010 The Royal Australian College of General Practitioners

55. Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne

Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

56. The use of salicylic acid in a new delivery system as a co-adjuvant topical treatment for acne vulgaris. (Full text)

The use of salicylic acid in a new delivery system as a co-adjuvant topical treatment for acne vulgaris. Topical preparations in the form of creams or ointments are the usual treatment for acne. These agents do not seem to penetrate the skin barrier deeply enough to produce the desired effect.We conducted a randomized, double-blinded, prospective study to evaluate the effectiveness of salicylic acid in a new delivery system, the Crown Carrier System (CCS, Trivitaderm LLC, Asheville, NC (...) ) for the treatment of acne.Thirty-seven patients with homogenous backgrounds were randomly divided into 3 groups. Group A was treated with salicylic acid in CCS, Group B was treated with CCS without salicylic acid, and Group C received salicylic acid alone. Patients were evaluated at 2 weeks and 8 weeks post-treatment.Twenty-five patients completed the evaluation. Most patients in Group A presented with no changes in the number of acne lesions but with significant improvement of inflammatory signs. Their overall

2009 Aesthetic surgery journal PubMed

57. Laser and other light therapies for the treatment of acne vulgaris: systematic review

Laser and other light therapies for the treatment of acne vulgaris: systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

58. Detecting implausible social network effects in acne, height, and headaches: longitudinal analysis. (Full text)

Detecting implausible social network effects in acne, height, and headaches: longitudinal analysis. To investigate whether "network effects" can be detected for health outcomes that are unlikely to be subject to network phenomena.Statistical analysis common in network studies, such as logistic regression analysis, controlled for own and friend's lagged health status. Analyses controlled for environmental confounders.Subsamples of the National Longitudinal Study of Adolescent Health (Add Health (...) ).4300 to 5400 male and female adolescents who nominated a friend in the dataset and who were both longitudinally surveyed. Measurements Health outcomes, including headache severity, acne severity, and height self reported by respondents in 1994-5, 1995-6, and 2000-1.Significant network effects were observed in the acquisition of acne, headaches, and height. A friend's acne problems increased an individual's odds of acne problems (odds ratio 1.62, 95% confidence interval 0.91 to 2.89). The likelihood

2008 BMJ PubMed

59. An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate to severe acne vulgaris: Assessment of efficacy and safety in 2813 patients (PubMed)

An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate to severe acne vulgaris: Assessment of efficacy and safety in 2813 patients We sought to evaluate efficacy, safety, and tolerability of a combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% (clindamycin-BPO 2.5%) aqueous gel in moderate to severe acne vulgaris.A total of 2813 patients, aged 12 years or older, were randomized to receive clindamycin-BPO (...) 2.5%, individual active ingredients, or vehicle in two identical, double-blind, controlled 12-week, 4-arm studies evaluating safety and efficacy (inflammatory and noninflammatory lesion counts) using Evaluator Global Severity Score and subject self-assessment.Clindamycin-BPO 2.5% demonstrated statistical superiority to individual active ingredients and vehicle in reducing both inflammatory and noninflammatory lesions and acne severity. Visibly greater improvement was observed by patients

2008 EvidenceUpdates

60. Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris

Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris Haedersdal M, Togsverd-Bo K, Wulf H C CRD summary This review investigated the efficacy and safety of optical treatments for acne vulgaris. The authors concluded that the treatments (...) had short-term efficacy. Photodynamic therapy had the most consistent outcomes. Poor reporting of the review process and limitations in the included studies precluded a thorough evaluation of the reliability of the authors' conclusions. Authors' objectives To assess the efficacy and adverse effects of optical treatments of acne vulgaris. Searching PubMed and The Cochrane Library were searched in March 2007 for relevant studies in the English language. Search terms were reported. Reference lists

2008 DARE.