Latest & greatest articles for acne

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acne or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on acne and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Acne treatment and clinical papers

Acne is a common skin condition characterised by whiteheads (or blackheads), pimples and oily skin. It can lead to possible scarring. It is typically caused when hair follicles become inflamed and the sebaceous glands in the skin are overactive. The over production of sebum and a combination of dead skin cells and dirt can clog follicles and pores causing a break out. Acne can affect any age group but it’s more common in adolescents.

There are many ways to treat acne depending on the severity of the case. Treatments include a range of medications such as topical retinoids, antibiotics and in severe cases isotretinoin is prescribed. Research is ongoing to determine the side effects and harms caused by these drugs. Clinical trials and studies are vital to assess treatment.

The Trip Database has an extensive collection of articles on acne ranging from clinical trials, systematic reviews, clinical guidelines and case reports. These can be found via searching the site.

Top results for acne

61. Acne.

Acne. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund You are here Guidelines and Measures Funding for the National Guideline Clearinghouse (NGC) has ended. Learn more about

2007 Finnish Medical Society Duodecim

62. Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study. (PubMed)

Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study. BACKGROUND: A fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for the once-daily treatment of acne. OBJECTIVE: To evaluate the efficacy and safety of adapalene 0.1% -BPO 2.5% fixed combination gel (adapalene-BPO) for the treatment of acne. METHODS: A total of 517 subjects were randomized (...) tolerability profile for adapalene-BPO were similar to adapalene monotherapy. LIMITATIONS: These data were generated in a controlled trial. Results obtained in clinical practice could differ. CONCLUSIONS: The fixed-dose combination of adapalene and BPO provides significantly greater efficacy for the treatment of acne vulgaris as early as week 1 relative to monotherapies, with a comparable safety profile to adapalene.

2007 EvidenceUpdates

63. Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome. (PubMed)

Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome. Insulin-sensitizing drugs (ISDs) have recently been advocated as possibly a safer and more effective long-term treatment than the oral contraceptive pill (OCP) in women with polycystic ovary syndrome (PCOS). It is important to directly compare the efficacy and safety of ISDs versus OCPs in the long-term (...) of difference in effect between metformin and the OCP on hirsutism and acne. There was either insufficient or no data on the relative efficacy of metformin or the OCP (alone or in combination) for preventing the development of diabetes, cardiovascular disease, or endometrial cancer. Metformin was less effective than the OCP in improving menstrual pattern (Peto odds ratio (OR) 0.08, 95% CI 0.01 to 0.45). Metformin resulted in a higher incidence of gastrointestinal (Peto OR 7.75, 95% CI 1.32 to 45.71

2007 Cochrane

64. Combined oral contraceptive pills for treatment of acne. (PubMed)

Combined oral contraceptive pills for treatment of acne. Acne is a common skin disorder among women. Although no uniform approach to the management of acne exists, combination oral contraceptives (COCs), which contain an estrogen and a progestin, often are prescribed for women.To determine the effectiveness of combined oral contraceptives (COCs) for the treatment of facial acne compared to placebo or other active therapies.We searched the computerized databases of the Cochrane Central Register (...) of Controlled Trials (CENTRAL), MEDLINE, EMBASE, POPLINE, Biological Abstracts and LILACS for randomized controlled trials of COCs and acne. We wrote to authors of identified trials to seek any unpublished or published trials that we might have missed.All randomized controlled trials reported in any language that compared the effectiveness of a COC containing an estrogen and a progestin to placebo or another active therapy for acne in women were eligible.We extracted data on total and specific (i.e., open

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2007 Cochrane

65. Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context

Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context Magin P J, Adams J, Pond C D, Smith W CRD summary This review examined topical and oral complementary and alternative treatments for acne. The authors concluded that the evidence base was limited (...) ; this reflects the poor quality of most of the included studies. The review methodology was poorly reported and the reliability of the review's conclusions is therefore unclear. Authors' objectives To examine the efficacy of different methods of complementary and alternative medicine (CAM) in the treatment of acne. Searching MEDLINE, EMBASE, AMED, DARE and the Cochrane Library were searched using the reported search terms. The dates of the search were not reported. The reference lists of identified articles

2006 DARE.

66. Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne

Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Ozolins M, Eady E A, Avery A, Cunliffe W J, O'Neill C, Simpson N (...) B, et al Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Ozolins M, Eady E A, Avery A, Cunliffe W J, O'Neill C, Simpson N B, et al. Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne. Health Technology Assessment 2005; 9(1): 1-212 Authors

2005 Health Technology Assessment (HTA) Database.

67. Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review

Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

68. A systematic review of the evidence for 'myths and misconceptions' in acne management: diet, face-washing and sunlight

A systematic review of the evidence for 'myths and misconceptions' in acne management: diet, face-washing and sunlight Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

69. Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne

Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you

2005 NIHR HTA programme

70. Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial. (PubMed)

Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial. We investigated the efficacy and cost-effectiveness of five antimicrobial regimens for mild to moderate facial acne and whether propionibacterial antibiotic resistance affects treatment response.In this randomised, observer-masked trial, 649 community participants were allocated one of five antibacterial regimens. Primary outcomes were

2004 Lancet

71. Treatment of acne vulgaris. (PubMed)

Treatment of acne vulgaris. Management of acne vulgaris by nondermatologists is increasing. Current understanding of the different presentations of acne allows for individualized treatments and improved outcomes.To review the best evidence available for individualized treatment of acne.Search of MEDLINE, EMBASE, and the Cochrane database to search for all English-language articles on acne treatment from 1966 to 2004.Well-designed randomized controlled trials, meta-analyses, and other systematic (...) reviews are the focus of this article.Acne literature is characterized by a lack of standardization with respect to outcome measures and methods used to grade disease severity.Main outcome measures of 29 randomized double-blind trials that were evaluated included reductions in inflammatory, noninflammatory, and total acne lesion counts. Topical retinoids reduce the number of comedones and inflammatory lesions in the range of 40% to 70%. These agents are the mainstay of therapy in patients

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2004 JAMA

72. Treatment of acne vulgaris with a pulsed dye laser: a randomized controlled trial. (PubMed)

Treatment of acne vulgaris with a pulsed dye laser: a randomized controlled trial. The high prevalence of acne vulgaris and its significant morbidity underscore the need for convenient, low-risk, and efficacious therapy. Treatment with various lasers has been reported to improve acne.To evaluate the clinical efficacy of pulsed dye laser therapy in the treatment of acne.Randomized, single-blind, controlled, split-face clinical trial of a volunteer sample of 40 patients aged 13 years or older (...) with facial acne conducted at an academic referral center from August 2002 to September 2003.One or 2 nonpurpuric pulsed dye laser treatments to half of the face (fluence of 3 J/cm2), serial blinded clinical assessments (lesion counts), and grading of acne severity using standardized bilateral serial photographs.Comparison of the changes in lesion counts from baseline to 12 weeks between treated and untreated sides of the face and changes in photographic evidence of acne severity as graded by a panel

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2004 JAMA

73. Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial

Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2004 NHS Economic Evaluation Database.

74. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. (PubMed)

Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. Hirsutism is the presence of excessive hair growth in women and is an important cosmetic condition often resulting in severe distress. Hirsutism is most often caused by increased production of male sex hormones also known as androgens. It is also affected by increased sensitivity to androgens in the hair follicles, and the secretory glands around the hair follicles, called sebaceous glands. Spironolactone (...) is an antiandrogen and aldosterone antagonist used to treat hirsutism.The objective of this review was to investigate the effectiveness of spironolactone and/or in combination with steroids (oral contraceptive pill included) in reducing excess hair growth and/or acne in women.We searched the Cochrane Menstrual Disorders and Subfertility Group trials register (searched 12 June 2003). The Cochrane Menstrual Disorders and Subfertility Group register is based on regular searches of MEDLINE, EMBASE, CINAHL, PsycINFO

2003 Cochrane

75. Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. (PubMed)

Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. Low-fluence (low irradiation energy density) pulsed-dye lasers (PDLs) have been used for atrophic acne scarring, and anecdotal experience suggests that long-term improvements in inflammatory acne can be seen after one PDL treatment. Our aim was to compare the efficacy and tolerability of such PDL treatment with sham treatment in patients with facial inflammatory acne in a double-blind, randomised controlled (...) trial.We recruited 41 adults with mild-to-moderate facial inflammatory acne. We randomly assigned patients to PDL (n=31) or sham treatment (n=10). Treatment was given at baseline and patients were seen after 2, 4, 8, and 12 weeks. Assessors and participants were unaware of treatment allocations. Primary outcome measures were acne severity after 12 weeks and adverse events at any time. Secondary measures were change in lesion counts after 12 weeks and change in acne severity with time. Analysis

2003 Lancet

76. High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study. (PubMed)

High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study. Administration of 13-cis retinoic acid (isotretinoin) for acne is occasionally accompanied by hyperlipidemia. It is not known why some persons develop this side effect.To determine whether isotretinoin triggers a familial susceptibility to hyperlipidemia and the metabolic syndrome.Cross-sectional comparison.University hospital (...) in Lausanne, Switzerland.102 persons in whom triglyceride levels increased at least 1.0 mmol/L (> or =89 mg/dL) (hyperresponders) and 100 persons in whom triglyceride levels changed 0.1 mmol/L (< or =9 mg/dL) or less (nonresponders) during isotretinoin therapy for acne. Parents of 71 hyperresponders and 60 nonresponders were also evaluated.Waist-to-hip ratio; fasting glucose, insulin, and lipid levels; and apoE genotype.Hyperresponders and nonresponders had similar pretreatment body weight and plasma

2002 Annals of Internal Medicine

77. Management of acne

Management of acne Management of acne Management of acne Lehmann H P, Andrews J S, Robinson K A, Holloway V L, Goodman S N Authors' objectives To provide a comprehensive review on the management of acne. Searching The search utilised several electronic databases from inception to 1999, including the CENTRAL Register in the Cochrane Library, MEDLINE, OLDMEDLINE (from 1960 to 1965), EMBASE, CINAHL and PsycINFO amongst others. Details of the searches were given in the report. In addition (...) of first-, second- and third-line treatments for acne were eligible for inclusion in the review. The included studies were of 140 different treatments, which were classified as: cleansers, keratolytics, topical antibacterials, keratolytic/topical antibacterial combinations, topical retinoids, topical antibacterial/retinoid combinations, oral antibacterials, oral antibacterial/keratolytics, oral antibacterial/topical retinoids, oral retinoids, anti-androgens and other. All individual treatments

2001 DARE.

78. Management of acne

Management of acne Management of acne Management of acne Agency for Healthcare Research and Quality Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Agency for Healthcare Research and Quality. Management of acne. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Report/Technology Assessment No. 17. 2001 Authors (...) ' objectives Acne is a common condition, particularly in adolescents and young adults, with potentially significant physical and psychological morbidity from scarring and from adverse effects of treatment, as well as significant economic burdens. The purpose of this review was to provide a comprehensive review of the literature on acne management. Authors' conclusions Despite the large number of English-language controlled trials regarding acne therapy, their methodological limitations prevent our ability

2001 Health Technology Assessment (HTA) Database.

79. Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data

Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Lawrenson R A, Seaman H E, Sundstrom A, Williams T J, Farmer R D Authors' objectives To identify (...) in the review Patients with acne. Patients taking minocycline for reasons other than acne were excluded, as were those for whom there were no details of their age and gender. The age of participants ranged from 14 to 73 years, with the majority of cases in their teens or early 20s. Outcomes assessed in the review Liver damage. Studies reporting findings of laboratory investigations indicating liver dysfunction, or where a specific reference was made by the authors to liver dysfunction, were included. How

2000 DARE.

80. The cost-effectiveness of isotretinoin in the treatment of acne. Part 3: A cost-minimisation pharmaco-economic model

The cost-effectiveness of isotretinoin in the treatment of acne. Part 3: A cost-minimisation pharmaco-economic model The cost-effectiveness of isotretinoin in the treatment of acne. Part 3: A cost-minimisation pharmaco-economic model The cost-effectiveness of isotretinoin in the treatment of acne. Part 3: A cost-minimisation pharmaco-economic model Wessels F, Anderson A N, Kropman K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS (...) EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Systemic isotretinoin at a daily dose of 1mg/kg (cumulative dose of 120 mg/kg) in the treatment of patients with a diagnosis of moderate to severe acne. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Patients with a diagnosis of moderate

1999 NHS Economic Evaluation Database.