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Latest & greatest articles for adverse events
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Adverse drug event-related emergency department visits associated with complex chronic conditions Outpatient adverse drug events (ADEs) can result in serious outcomes requiring emergency department (ED) visits and hospitalizations. The incidence and severity of ADEs in children with complex chronic conditions (CCCs), who often take multiple medications, is unknown. We sought to describe the characteristics of ADE-related ED visits, including association with CCC status; determine the implicated
Coding of adverseevents of suicidality in clinical study reports of duloxetine for the treatment of major depressive disorder: descriptive study. To assess the effects of coding and coding conventions on summaries and tabulations of adverseevents data on suicidality within clinical study reports.Systematic electronic search for adverseevents of suicidality in tables, narratives, and listings of adverseevents in individual patients within clinical study reports. Where possible, for each (...) event we extracted the original term reported by the investigator, the term as coded by the medical coding dictionary, medical coding dictionary used, and the patient's trial identification number. Using the patient's trial identification number, we attempted to reconcile data on the same event between the different formats for presenting data on adverseevents within the clinical study report.9 randomised placebo controlled trials of duloxetine for major depressive disorder submitted
Developing a risk model for in-hospital adverseevents following implantable cardioverter-defibrillator implantation: a report from the NCDR (National Cardiovascular Data Registry) To better inform patients and physicians of the expected risk of adverseevents and to assist hospitals' efforts to improve the outcomes of patients undergoing implantable cardioverter-defibrillator (ICD) implantation, we developed and validated a risk model using data from the NCDR (National Cardiovascular Data (...) Registry) ICD Registry.ICD prolong life in selected patients, but ICD implantation carries the risk of periprocedural complications.We analyzed data from 240,632 ICD implantation procedures between April 1, 2010, and December 31, 2011 in the registry. The study group was divided into a derivation (70%) and a validation (30%) cohort. Multivariable logistic regression was used to identify factors associated with in-hospital adverseevents (complications or mortality). A parsimonious risk score
Risk of Thiazide-Induced Metabolic AdverseEvents in Older Adults To evaluate the risk and predictors of thiazide-induced adverseevents (AEs) in multimorbid older adults in real-world clinical settings.Observational cohort study.National Veterans Affairs data from 2007 to 2008.Veterans aged 65 and older newly prescribed a thiazide (N = 1,060) compared with propensity-matched nonusers of antihypertensive medications (N = 1,060).The primary outcome was a composite of metabolic AEs defined
Safe Administration of Systemic Cancer Therapy Part 2: Administration of Chemotherapy and Management of Preventable AdverseEvents Safe Administration of Systemic Cancer Therapy Part 2: Administration of Systemic Treatment and Management of Preventable AdverseEvents | Cancer Care Ontario Google Tag Manager You are using an outdated browser. We suggest you update your browser for a better experience. for update. Browse Guidelines Browse Pathway Maps Sort by You are here Safe Administration (...) of Systemic Cancer Therapy Part 2: Administration of Systemic Treatment and Management of Preventable AdverseEvents Guideline Objective To provide guidance on processes, technologies and devices for the prevention and control of adverse effects that can happen during or following the administration of systemic treatment to adult cancer patients. Patient Population Adult patients who are going to receive chemotherapy treatment or are already receiving chemotherapy treatment for cancer. Intended Guideline
Quality of reporting in systematic reviews of adverseevents: systematic review. To examine the quality of reporting of harms in systematic reviews, and to determine the need for a reporting guideline specific for reviews of harms.Systematic review.Cochrane Database of Systematic Reviews (CDSR) and Database of Abstracts of Reviews of Effects (DARE).Databases were searched for systematic reviews having an adverseevent as the main outcome, published from January 2008 to April 2011. Adverse (...) events included an adverse reaction, harms, or complications associated with any healthcare intervention. Articles with a primary aim to investigate the complete safety profile of an intervention were also included. We developed a list of 37 items to measure the quality of reporting on harms in each review; data were collected as dichotomous outcomes ("yes" or "no" for each item).Of 4644 reviews identified, 309 were systematic reviews or meta-analyses primarily assessing harms (13 from CDSR; 296 from
Is Ambulatory Laparoscopic Roux-En-Y Gastric Bypass Associated With Higher AdverseEvents? To determine the impact of length of stay upon 30-day outcomes.It has been recommended the goal length of stay (LOS) after laparoscopic Roux-en-Y gastric bypass (LRYGB) should be 1 day to improve resource utilization. This study's aim was to assess LRYGB outcomes by LOS.Data were obtained from the BOLD (Bariatric Outcomes Longitudinal Database) for 51,788 laparoscopic gastric bypass (LRYGB) procedures
Rates of medical errors and preventable adverseevents among hospitalized children following implementation of a resident handoff bundle. Handoff miscommunications are a leading cause of medical errors. Studies comprehensively assessing handoff improvement programs are lacking.To determine whether introduction of a multifaceted handoff program was associated with reduced rates of medical errors and preventable adverseevents, fewer omissions of key data in written handoffs, improved verbal (...) handoff tool linked to the electronic medical record was introduced.The primary outcomes were the rates of medical errors and preventable adverseevents measured by daily systematic surveillance. The secondary outcomes were omissions in the printed handoff document and resident time-motion activity.Medical errors decreased from 33.8 per 100 admissions (95% CI, 27.3-40.3) to 18.3 per 100 admissions (95% CI, 14.7-21.9; P < .001), and preventable adverseevents decreased from 3.3 per 100 admissions (95
Neurological adverseevents of new generation sodium blocker antiepileptic drugs. Meta-analysis of randomized, double-blinded studies with eslicarbazepine acetate, lacosamide and oxcarbazepine Neurological adverseevents of new generation sodium blocker antiepileptic drugs. Meta-analysis of randomized, double-blinded studies with eslicarbazepine acetate, lacosamide and oxcarbazepine Neurological adverseevents of new generation sodium blocker antiepileptic drugs. Meta-analysis of randomized (...) , double-blinded studies with eslicarbazepine acetate, lacosamide and oxcarbazepine Zaccara G, Giovannelli F, Maratea D, Fadda V, Verrotti A CRD summary The authors concluded that antiepileptic drugs may cause neurological adverseevents in patients with drug resistant epilepsy, which can limit their use and impair treatment success; higher doses of oxcarbazepine were associated with more frequent adverseevents. The evidence had several limitations and the findings were not weighed against drug
Autoimmune, neurological, and venous thromboembolic adverseevents after immunisation of adolescent girls with quadrivalent human papillomavirus vaccine in Denmark and Sweden: cohort study. To assess the risk of serious adverseevents after vaccination of adolescent girls with quadrivalent human papillomavirus (qHPV) vaccine.Register based cohort study.Denmark and Sweden, October 2006 to December 2010.997,585 girls aged 10-17, among whom 296,826 received a total of 696,420 qHPV vaccine (...) . The rate ratios for five neurological events were not significantly increased and there were inverse associations with epilepsy (rate ratio 0.66, 95% confidence interval 0.54 to 0.80) and paralysis (0.56, 0.35 to 0.90). There was no association between exposure to qHPV vaccine and venous thromboembolism (0.86, 0.55 to 1.36).This large cohort study found no evidence supporting associations between exposure to qHPV vaccine and autoimmune, neurological, and venous thromboembolic adverseevents. Although
Risk of major adverse cardiac events following noncardiac surgery in patients with coronary stents. Guidelines recommend delaying noncardiac surgery in patients after coronary stent procedures for 1 year after drug-eluting stents (DES) and for 6 weeks after bare metal stents (BMS). The evidence underlying these recommendations is limited and conflicting.To determine risk factors for adverse cardiac events in patients undergoing noncardiac surgery following coronary stent implantation.A national (...) , retrospective cohort study of 41,989 Veterans Affairs (VA) and non-VA operations occurring in the 24 months after a coronary stent implantation between 2000 and 2010. Nonlinear generalized additive models examined the association between timing of surgery and stent type with major adverse cardiac events (MACE) adjusting for patient, surgery, and cardiac risk factors. A nested case-control study assessed the association between perioperative antiplatelet cessation and MACE.A composite 30-day MACE rate of all
Surgical adverseevents: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Severe adverseevents during antiviral therapy in hepatitis C virus cirrhotic patients: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Interventions to decrease the risk of adverse cardiac events for post-surgery or chemotherapy patients taking serotonin (5-HT3) receptor antagonists: protocol for a systematic review and network meta-analysis. Patients undergoing surgery or chemotherapy often experience nausea and vomiting. To increase their quality of life and treatment satisfaction, antiemetic medication, such as serotonin receptor antagonists, is often prescribed for patients experiencing these symptoms. However, early (...) warning signs suggest that serotonin receptor antagonists can cause harm, including arrhythmia. Our objective is to identify the most effective interventions that mitigate the risk of adverse cardiac events associated with serotonin receptor antagonists in patients undergoing surgery and chemotherapy through a systematic review and network meta-analysis.We will search electronic databases (for example, MEDLINE, Embase) from inception onwards, as well as dissertations and governmental reports
Aliskiren increased adverseevents in patients with diabetes and kidney disease who were receiving ACE inhibitors or ARBs. 23552833 2013 05 13 2013 04 04 1539-3704 158 6 2013 Mar 19 Annals of internal medicine Ann. Intern. Med. ACP Journal Club. Aliskiren increased adverseevents in patients with diabetes and kidney disease who were receiving ACE inhibitors or ARBs. JC7 10.7326/0003-4819-158-6-201303190-02007 de Leeuw Peter W PW Maastricht University Medical Centre and Cardiovascular Research
Meta-analysis of randomized trials of angioedema as an adverseevent of renin-angiotensin system inhibitors Meta-analysis of randomized trials of angioedema as an adverseevent of renin-angiotensin system inhibitors Meta-analysis of randomized trials of angioedema as an adverseevent of renin-angiotensin system inhibitors Makani H, Messerli FH, Romero J, Wever-Pinzon O, Korniyenko A, Sevilla Berrios R, Bangalore S CRD summary This review found that the risk of angio-oedema with angiotensin (...) trials of angioedema as an adverseevent of renin-angiotensin system inhibitors. American Journal of Cardiology 2012; 110(3): 383-391 PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Angioedema /chemically induced; Angiotensins /antagonists & Female; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Renin /antagonists & Renin-Angiotensin System /drug effects; inhibitors; inhibitors AccessionNumber 12012036646 Date bibliographic record published 18
Early Aquatic Physical Therapy Improves Function and Does Not Increase Risk of Wound-Related AdverseEvents for Adults After Orthopedic Surgery: A Systematic Review and Meta-Analysis To investigate whether early postoperative aquatic physical therapy is a low-risk and effective form of physical therapy to improve functional outcomes after orthopedic surgery.Databases MEDLINE, CINAHL, AMED, Embase, and PEDro were searched from the earliest date available until October 2011. Additional trials (...) were identified by searching reference lists and citation tracking.Controlled trials evaluating the effects of aquatic physical therapy on adverseevents for adults <3 months after orthopedic surgery. Two reviewers independently applied inclusion and exclusion criteria, and any disagreements were discussed until consensus could be reached. Searching identified 5069 potentially relevant articles, of which 8 controlled trials with 287 participants met inclusion criteria.A predefined data extraction
Adverseevents associated with EUS and EUS with FNA GUIDELINE Adverseevents associated with EUS and EUS with FNA This is one of a series of statements discussing the use of GI endoscopy in common clinical situations. The Stan- dards of Practice Committee of the American Society for Gastrointestinal Endoscopy prepared this text. In prepar- ing this document, a search of the medical literature was performed by using PubMed. Additional references were obtained from the bibliographies (...) nodes, often in close proximity to large vascular structures. EUS uses dedicated echoendoscopes that have unique optical and mechanical properties be- yond the addition of a US transducer. The incidence and types of adverseevents associated with EUS differ from those seen with other endoscopic procedures and are attributable to the use of FNA. This guideline focuses on the adverseevents speci?cally associated with EUS and EUS-FNA. Adverseevents associated with sedation and standard endoscopic