Latest & greatest articles for antibiotics

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This page lists the very latest high quality evidence on antibiotics and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Antibiotics

Antibiotics also referred to as antibacterial are a type of medicine that prevents the growth of bacteria. As such they are used to treat infections caused by bacteria. They kill or prevents bacteria from spreading.

Antibiotics are vital in modern day medicine; they are among the most frequently prescribed drug. There are over a 100 types of antibiotics, the main types and most commonly prescribed are penicillin, cephalosporin, macrolides, fluoroquinolone and tetracycline. They tend to be classified by mechanism of action. So, those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Antibiotics such as macrolides, lincosamides and tetracyclines inhibit protein synthesis.

Antibiotics can all be defined by their specificity. “Narrow-spectrum” antibiotics target specific types of bacteria, for instance gram-negative (-ve) or gram-positive (+ve), whereas broad-spectrum antibiotics affect a wide range of bacteria.

Antibiotics are increasingly suffering from antibiotic resistance caused by bacterial mutations meaning the bacteria evolves to not be sensitive to the specific antibiotics being used.

Clinical trials are important to the development and understanding of antibiotics and their side effects. Although they are deemed safe, over use of the drug can kill good bacteria and lead to antibiotic resistance. This halts the ability of bacteria and microorganisms to resist the effects of the antibiotic. Clinical trials and research allow scientists and medical professionals to study the effects and develop new antibiotics.

Trip has extensive coverage of the evidence base on antibiotics allowing users to easily find trusted answers. Coverage include guidelines, systematic reviews, controlled trials and evidence-based synopses.

Top results for antibiotics

81. The use of postoperative antibiotics following endoscopic sinus surgery for chronic rhinosinusitis: a systematic review

The use of postoperative antibiotics following endoscopic sinus surgery for chronic rhinosinusitis: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

82. What symptoms and clinical markers are associated poor prognosis, such as prolonged symptoms, re-consultation, antibiotic prescription, hospitalisation, and death in children with a suspected RTI in the home and presenting to primary care?

What symptoms and clinical markers are associated poor prognosis, such as prolonged symptoms, re-consultation, antibiotic prescription, hospitalisation, and death in children with a suspected RTI in the home and presenting to primary care? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission

2019 PROSPERO

83. The efficacy of Carbapenems versus new antibiotics for treatments of adult patients with complicated urinary tract infections: a systematic review and meta-analysis

The efficacy of Carbapenems versus new antibiotics for treatments of adult patients with complicated urinary tract infections: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

84. Short- versus standard-course antibiotic therapy in acute exacerbations of chronic obstructive pulmonary disease: a systematic review and meta-analysis of RCTs

Short- versus standard-course antibiotic therapy in acute exacerbations of chronic obstructive pulmonary disease: a systematic review and meta-analysis of RCTs Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

85. Prophylactic antibiotics for mastectomy with immediate breast reconstruction: a meta-analysis

Prophylactic antibiotics for mastectomy with immediate breast reconstruction: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

86. The effect of prophylactic antibiotics for preterm premature rupture of membranes on perinatal outcomes: a network meta-analysis

The effect of prophylactic antibiotics for preterm premature rupture of membranes on perinatal outcomes: a network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

87. The association between early life antibiotics and the presence of gastrointestinal disorders during childhood: a systematic review

The association between early life antibiotics and the presence of gastrointestinal disorders during childhood: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2019 PROSPERO

88. Short-course versus prolonged-course antibiotic therapy for sepsis in adults: systematic review and meta-analysis

Short-course versus prolonged-course antibiotic therapy for sepsis in adults: systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2019 PROSPERO

89. Systematic review on the amount of inappropriate use of antibiotics in primary care and the determinants which influence inappropriate use

Systematic review on the amount of inappropriate use of antibiotics in primary care and the determinants which influence inappropriate use Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO

90. Systematic review of the survey tools for determining the levels of knowledge and awareness of antibiotics and antimicrobial resistance (AMR) among general population

Systematic review of the survey tools for determining the levels of knowledge and awareness of antibiotics and antimicrobial resistance (AMR) among general population Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

91. Systematic review and meta-analysis of strategies for minimising unnecessary exposure to early life antibiotics in neonates

Systematic review and meta-analysis of strategies for minimising unnecessary exposure to early life antibiotics in neonates Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

92. The use of antibiotics under homeopathic treatment - a systematic review

The use of antibiotics under homeopathic treatment - a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2019 PROSPERO

93. Subcutaneous antibiotic: a systematic review

Subcutaneous antibiotic: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2019 PROSPERO

94. Effects of timing of adjunctive systemic antibiotics on the clinical outcome of periodontal therapy: a systematic review

Effects of timing of adjunctive systemic antibiotics on the clinical outcome of periodontal therapy: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

95. Examination of antibiotic administration period guided by procalcitonin in sepsis or septic shock: systematic review and meta-analysis

Examination of antibiotic administration period guided by procalcitonin in sepsis or septic shock: systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO

96. Prophylactic antibiotic prescriptions in oral implant surgery. Systematic review and meta-analysis

Prophylactic antibiotic prescriptions in oral implant surgery. Systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

97. Prevalence of antibiotic-resistance in Helicobacter pylori (H. pylori) in Vietnam: a systematic review and meta-analysis

Prevalence of antibiotic-resistance in Helicobacter pylori (H. pylori) in Vietnam: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

98. Impact of antibiotic combination therapy for the treatment of infections due to carbapenem-resistant Gram-negative bacteria: a systematic review and meta-analysis of in vivo and in vitro studies.

Impact of antibiotic combination therapy for the treatment of infections due to carbapenem-resistant Gram-negative bacteria: a systematic review and meta-analysis of in vivo and in vitro studies. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2019 PROSPERO

99. Serum procalcitonin for the prediction of bacterial exacerbation and guidance of antibiotic administration in severe COPD exacerbations: a systematic review and meta-analysis

Serum procalcitonin for the prediction of bacterial exacerbation and guidance of antibiotic administration in severe COPD exacerbations: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

100. Comparative efficacy of long-term antibiotic treatments in the primary prophylaxis of spontaneous bacterial peritonitis: a network meta-analysis

Comparative efficacy of long-term antibiotic treatments in the primary prophylaxis of spontaneous bacterial peritonitis: a network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO