Latest & greatest articles for antibiotics

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This page lists the very latest high quality evidence on antibiotics and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Antibiotics

Antibiotics also referred to as antibacterial are a type of medicine that prevents the growth of bacteria. As such they are used to treat infections caused by bacteria. They kill or prevents bacteria from spreading.

Antibiotics are vital in modern day medicine; they are among the most frequently prescribed drug. There are over a 100 types of antibiotics, the main types and most commonly prescribed are penicillin, cephalosporin, macrolides, fluoroquinolone and tetracycline. They tend to be classified by mechanism of action. So, those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Antibiotics such as macrolides, lincosamides and tetracyclines inhibit protein synthesis.

Antibiotics can all be defined by their specificity. “Narrow-spectrum” antibiotics target specific types of bacteria, for instance gram-negative (-ve) or gram-positive (+ve), whereas broad-spectrum antibiotics affect a wide range of bacteria.

Antibiotics are increasingly suffering from antibiotic resistance caused by bacterial mutations meaning the bacteria evolves to not be sensitive to the specific antibiotics being used.

Clinical trials are important to the development and understanding of antibiotics and their side effects. Although they are deemed safe, over use of the drug can kill good bacteria and lead to antibiotic resistance. This halts the ability of bacteria and microorganisms to resist the effects of the antibiotic. Clinical trials and research allow scientists and medical professionals to study the effects and develop new antibiotics.

Trip has extensive coverage of the evidence base on antibiotics allowing users to easily find trusted answers. Coverage include guidelines, systematic reviews, controlled trials and evidence-based synopses.

Top results for antibiotics

121. A systematic review comparing the efficacy and safety for different routes of antibiotic administration (partial oral therapy vs intravenous therapy) in the treatment of infective endocarditis

A systematic review comparing the efficacy and safety for different routes of antibiotic administration (partial oral therapy vs intravenous therapy) in the treatment of infective endocarditis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2019 PROSPERO

122. Antibiotic regimens for neonatal sepsis. A protocol for a systematic review with meta-analysis and trial sequential analysis

Antibiotic regimens for neonatal sepsis. A protocol for a systematic review with meta-analysis and trial sequential analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

123. An evaluation of daptomycin alone and in combination with ß-lactam antibiotics against resistant phenotypes of gram-positive cocci

An evaluation of daptomycin alone and in combination with ß-lactam antibiotics against resistant phenotypes of gram-positive cocci Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2019 PROSPERO

124. Prevention of early-onset Group B streptococcal sepsis in infants, using universal screening versus risk-based protocols for antibiotic prophylaxis: a systematic review and meta-analysis

Prevention of early-onset Group B streptococcal sepsis in infants, using universal screening versus risk-based protocols for antibiotic prophylaxis: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility

2019 PROSPERO

125. Healthcare-associated infections (HAI) and prescribing of antibiotics in hospital inpatients in the Caribbean Community (CARICOM) states: a mixed methods systematic review

Healthcare-associated infections (HAI) and prescribing of antibiotics in hospital inpatients in the Caribbean Community (CARICOM) states: a mixed methods systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

126. Harmful outcomes due to reported patient antibiotic allergy labels

Harmful outcomes due to reported patient antibiotic allergy labels Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g

2019 PROSPERO

127. Fuke Qianjin combined with antibiotics in treatment of acute pelvic inflammatory disease (PID): a systematic review

Fuke Qianjin combined with antibiotics in treatment of acute pelvic inflammatory disease (PID): a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2019 PROSPERO

128. Oral antibiotic therapy for infective endocarditis: a systematic review

Oral antibiotic therapy for infective endocarditis: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2019 PROSPERO

129. Antibiotic treatments for shigellosis in children: a systematic review and network meta-analysis

Antibiotic treatments for shigellosis in children: a systematic review and network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

130. Do long-term antibiotics for acne lead to problematic infections or antimicrobial resistance?

Do long-term antibiotics for acne lead to problematic infections or antimicrobial resistance? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

131. To determine the safety and effectiveness of long-term inhaled antibiotics in the treatment of adult patients with non-cystic fibrosis bronchiectasis (NCFBE) and chronic Pseudomonas aeruginosa infection.

To determine the safety and effectiveness of long-term inhaled antibiotics in the treatment of adult patients with non-cystic fibrosis bronchiectasis (NCFBE) and chronic Pseudomonas aeruginosa infection. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2019 PROSPERO

132. Prevalence of time-related bias in pharmacoepidemiology studies on the use of anti-emetics, antifungal, and antibiotic medications during pregnancy: a systematic review

Prevalence of time-related bias in pharmacoepidemiology studies on the use of anti-emetics, antifungal, and antibiotic medications during pregnancy: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

133. Perioperative antibiotics for preventing post-surgical site infections in solid organ transplant recipients [Cochrane protocol]

Perioperative antibiotics for preventing post-surgical site infections in solid organ transplant recipients [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

134. Effect of intravenous injection with different antibiotic prophylaxis against the intracranial infection after craniotomy: a bayesian network meta-analysis

Effect of intravenous injection with different antibiotic prophylaxis against the intracranial infection after craniotomy: a bayesian network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

135. Mathematical modeling of antibiotic-resistant organisms (ARO) transmission in health-care facilities: a systematic review of methods and parameters

Mathematical modeling of antibiotic-resistant organisms (ARO) transmission in health-care facilities: a systematic review of methods and parameters Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

136. The use of antibiotics in implant therapy. Systematic review and meta-analysis

The use of antibiotics in implant therapy. Systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

137. Strategies to reduce antibiotic use in women with uncomplicated urinary tract infection in primary care - an individual patient data meta-analysis

Strategies to reduce antibiotic use in women with uncomplicated urinary tract infection in primary care - an individual patient data meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

138. Fluoroquinolone antibiotic-induced joint and cartilage damage in children: a meta-analysis

Fluoroquinolone antibiotic-induced joint and cartilage damage in children: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

139. The clinical effect and reproductive outcomes of antibiotic treatment for chronic endometritis: a systematic review and meta-analysis

The clinical effect and reproductive outcomes of antibiotic treatment for chronic endometritis: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2019 PROSPERO

140. The efficacy of antibiotic prophylaxis to prevent spontaneous bacterial peritonitis

The efficacy of antibiotic prophylaxis to prevent spontaneous bacterial peritonitis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO