Latest & greatest articles for bronchiolitis

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Bronchiolitis

Bronchiolitis is mainly caused by the respiratory syncytial virus (RSV). The virus travels down to the bronchioles in the lungs causing them to become inflamed making it difficult to breath.

Almost every child will be infected with RSV by the time they reach two years. Adults can also contract the virus, typically during winter months.

In mild cases bronchiolitis will clear up without treatment. The virus that causes bronchiolitis travels through tiny droplets of liquid and can be passed through the air or contracted by touching infected surfaces.

Symptoms include: Sore throat, dry cough, blocked nose and aches and pains throughout the body.

Although there is no cure for chronic bronchiolitis research and clinical studies on bronchiolitis suggest that some lifestyle changes can ease symptoms: avoid smoking, eat a healthy diet and maintain regular exercise. In extreme cases steroids can be prescribed to help minimise inflammation.

Read more on medications used to treat bronchiolitis and the causes of the virus.

Top results for bronchiolitis

21. Bronchiolitis

Bronchiolitis Bronchiolitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Bronchiolitis Last reviewed: February 2019 Last updated: January 2019 Summary Leading cause of hospital admission in infants under 1 year of age. Respiratory syncytial virus (RSV) is the most common cause. Most cases are mild and self-limiting, and supportive care is the only indicated therapy. Cough may persist for weeks, after 10 to 14 days (...) of acute illness. Some patients may go on to develop recurrent wheeze. Definition Viral bronchiolitis is an acute viral infection of the lower respiratory tract. Although it can affect individuals of any age, the term is most often used to refer to infection in infancy. It is characterised by epithelial cell destruction, cellular oedema, and airway obstruction by inflammatory debris and mucus. The clinical manifestations include cough, wheeze, and laboured breathing. Respiratory syncytial virus (RSV

2018 BMJ Best Practice

22. Nebulised hypertonic saline solution for acute bronchiolitis in infants. (PubMed)

Nebulised hypertonic saline solution for acute bronchiolitis in infants. Airway oedema (swelling) and mucus plugging are the principal pathological features in infants with acute viral bronchiolitis. Nebulised hypertonic saline solution (≥ 3%) may reduce these pathological changes and decrease airway obstruction. This is an update of a review first published in 2008, and previously updated in 2010 and 2013.To assess the effects of nebulised hypertonic (≥ 3%) saline solution in infants (...) hypertonic saline alone or in conjunction with bronchodilators as an active intervention and nebulised 0.9% saline, or standard treatment as a comparator in children under 24 months with acute bronchiolitis. The primary outcome for inpatient trials was length of hospital stay, and the primary outcome for outpatients or emergency department trials was rate of hospitalisation.Two review authors independently performed study selection, data extraction, and assessment of risk of bias in included studies. We

2017 Cochrane

23. International Variation in Asthma and Bronchiolitis Guidelines

International Variation in Asthma and Bronchiolitis Guidelines Guideline recommendations for the same clinical condition may vary. The purpose of this study was to determine the degree of agreement among comparable asthma and bronchiolitis treatment recommendations from guidelines.National and international guidelines were searched by using guideline databases (eg, National Guidelines Clearinghouse: December 16-17, 2014, and January 9, 2015). Guideline recommendations were categorized as (1 (...) ) recommend, (2) optionally recommend, (3) abstain from recommending, (4) recommend against a treatment, and (5) not addressed by the guideline. The degree of agreement between recommendations was evaluated by using an unweighted and weighted κ score. Pairwise comparisons of the guidelines were evaluated similarly.There were 7 guidelines for asthma and 4 guidelines for bronchiolitis. For asthma, there were 166 recommendation topics, with 69 recommendation topics given in ≥2 guidelines. For bronchiolitis

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2017 EvidenceUpdates

24. Are leukotriene inhibitors useful for bronchiolitis?

Are leukotriene inhibitors useful for bronchiolitis? Bronchiolitis is a prevalent disease in children under two years of age, which carries significant morbidity and mortality. However, there is controversy regarding the optimal therapeutic management. Leukotriene inhibitors have been proposed as an alternative, although its efficacy is not clear yet. Searching in Epistemonikos database, which is maintained by screening multiple databases, we identified two systematic reviews comprising six (...) trials addressing the question of this article. We extracted data, combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded leukotriene inhibitors might not decrease mortality levels on bronchiolitis patients and it is not clear whether they decrease length of hospital stay. They might reduce recurrent wheezing, but the certainty of the evidence is low, and they increase adverse effects.

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2017 Medwave

25. High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study)

High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study) PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

26. IV Magnesium Sulfate for Bronchiolitis: A Randomized Trial

IV Magnesium Sulfate for Bronchiolitis: A Randomized Trial The goal of this study was to determine if IV magnesium, useful for severe pediatric asthma, reduces time to medical readiness for discharge in patients with bronchiolitis when added to supportive care.We compared a single dose of 100 mg/kg of IV magnesium sulfate vs placebo for acute bronchiolitis. Patients received bronchodilator therapy, nebulized hypertonic saline, and 5 days of dexamethasone if there was eczema and/or a family (...) history of asthma. Time to medical readiness for discharge was the primary efficacy outcome. Bronchiolitis severity scores and need for infirmary or hospital admission and for clinic revisits within 2 weeks were secondary outcomes. Cardiorespiratory instability onset was the safety outcome.A total of 162 previously healthy infants diagnosed with bronchiolitis aged 22 days to 17.6 months (median, 3.7 months) were enrolled. Approximately one-half of patients had eczema and/or a family history of asthma

2017 EvidenceUpdates

27. High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial

High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

28. Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial

Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial Acute bronchiolitis is the leading cause of hospitalization among infants. Previous studies, underpowered to examine hospital admission, have found a limited benefit of nebulized hypertonic saline (HS) treatment in the pediatric emergency department (ED).To examine whether HS nebulization treatment would decrease the hospital admission rate (...) among infants with a first episode of acute bronchiolitis.The Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis (GUERANDE) study was a multicenter, double-blind randomized clinical trial on 2 parallel groups conducted during 2 bronchiolitis seasons (October through March) from October 15, 2012, through April 15, 2014, at 24 French pediatric EDs. Among the 2445 infants (6 weeks to 12 months of age) assessed for inclusion, 777 with a first episode of acute bronchiolitis with respiratory

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2017 EvidenceUpdates

29. Is Nebulized Hypertonic Saline Solution Effective for Acute Bronchiolitis?

Is Nebulized Hypertonic Saline Solution Effective for Acute Bronchiolitis? TAKE-HOME MESSAGE Hypertonic saline solution is possibly effective in decreasing hospital admission and length of stay for infants with bronchiolitis. Is Nebulized Hypertonic Saline Solution Effective for Acute Bronchiolitis? EBEM Commentators Jennifer H. Chao, MD Division of Pediatric Emergency Medicine Department of Emergency Medicine SUNY Downstate Medical Center Brooklyn, NY Richard Sinert, DO Division of Research (...) of stay and hospital admission with hypertonic saline solution, although theseresultsneedtobetempered by the presence of substantial heterogeneity across studies because of inconsistency in de?ningbronchiolitis.Bronchiolitisis a clinical syndrome as opposed to a speci?c pathologic process. In everyday practice, the clinical pre- sentation of bronchiolitis overlaps that of a simple upper respiratory infection with an asthma exacerba- tion. Zheng et al 1 concluded that nebulized hypertonic saline

2017 Annals of Emergency Medicine Systematic Review Snapshots

30. High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial. (PubMed)

High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial. Bronchiolitis is the most common lung infection in infants and treatment focuses on management of respiratory distress and hypoxia. High-flow warm humidified oxygen (HFWHO) is increasingly used, but has not been rigorously studied in randomised trials. We aimed to examine whether HFWHO provided enhanced respiratory support, thereby (...) shortening time to weaning off oxygen.In this open, phase 4, randomised controlled trial, we recruited children aged less than 24 months with moderate bronchiolitis attending the emergency department of the John Hunter Hospital or the medical unit of the John Hunter Children's Hospital in New South Wales, Australia. Patients were randomly allocated (1:1) via opaque sealed envelopes to HFWHO (maximum flow of 1 L/kg per min to a limit of 20 L/min using 1:1 air-oxygen ratio, resulting in a maximum FiO2 of 0

2017 Lancet

32. Respiratory bronchiolitis-associated interstitial lung disease (RB-ILD)

Respiratory bronchiolitis-associated interstitial lung disease (RB-ILD)

2017 DynaMed Plus

33. Viral bronchiolitis. (PubMed)

Viral bronchiolitis. Viral bronchiolitis is a common clinical syndrome affecting infants and young children. Concern about its associated morbidity and cost has led to a large body of research that has been summarised in systematic reviews and integrated into clinical practice guidelines in several countries. The evidence and guideline recommendations consistently support a clinical diagnosis with the limited role for diagnostic testing for children presenting with the typical clinical syndrome (...) of viral upper respiratory infection progressing to the lower respiratory tract. Management is largely supportive, focusing on maintaining oxygenation and hydration of the patient. Evidence suggests no benefit from bronchodilator or corticosteroid use in infants with a first episode of bronchiolitis. Evidence for other treatments such as hypertonic saline is evolving but not clearly defined yet. For infants with severe disease, the insufficient available data suggest a role for high-flow nasal cannula

2016 Lancet

34. Viral Bronchiolitis in Children. (PubMed)

Viral Bronchiolitis in Children. 27144864 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Viral Bronchiolitis in Children. 1793-4 10.1056/NEJMc1601509 Meissner H Cody HC eng Letter Comment United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2016 Jan 7;374(1):62-72 26735994 N Engl J Med. 2016 May 5;374(18):1791 27144865 N Engl J Med. 2016 May 5;374(18):1792-3 27144868 N Engl J Med. 2016 May 5;374(18):1792 27144867 N Engl J Med (...) . 2016 May 5;374(18):1791-2 27144866 N Engl J Med. 2016 Sep 22;375(12):1199-200 27653587 N Engl J Med. 2016 Sep 22;375(12):1199-200 27653586 Bronchiolitis, Viral Humans Respiratory Syncytial Virus Infections 2016 5 5 6 0 2016 5 6 6 0 2016 5 6 6 1 ppublish 27144864 10.1056/NEJMc1601509 10.1056/NEJMc1601509#SA5

2016 NEJM

35. Viral Bronchiolitis in Children. (PubMed)

Viral Bronchiolitis in Children. 27144865 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Viral Bronchiolitis in Children. 1791 10.1056/NEJMc1601509 DeVincenzo John P JP University of Tennessee College of Medicine, Memphis, TN jdevincenzo@uthsc.edu. Krilov Leonard R LR State University of New York at Stony Brook School of Medicine, Stony Brook, NY. Yogev Ram R Northwestern University Feinberg School of Medicine, Chicago, IL. eng Letter (...) Comment United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2016 Jan 7;374(1):62-72 26735994 N Engl J Med. 2016 May 5;374(18):1793-4 27144864 Bronchiolitis, Viral Humans Respiratory Syncytial Virus Infections 2016 5 5 6 0 2016 5 6 6 0 2016 5 6 6 1 ppublish 27144865 10.1056/NEJMc1601509 10.1056/NEJMc1601509#SA1

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2016 NEJM

36. Viral Bronchiolitis in Children. (PubMed)

Viral Bronchiolitis in Children. 27144867 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Viral Bronchiolitis in Children. 1792 10.1056/NEJMc1601509 Wall Michael M Oregon Health and Science University, Portland, OR wallm@ohsu.edu. eng Letter Comment United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2016 Jan 7;374(1):62-72 26735994 N Engl J Med. 2016 May 5;374(18):1793-4 27144864 Bronchiolitis, Viral Humans Respiratory

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2016 NEJM

37. Viral Bronchiolitis in Children. (PubMed)

Viral Bronchiolitis in Children. 27144866 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Viral Bronchiolitis in Children. 1791-2 10.1056/NEJMc1601509 Connors Thomas T Columbia University Medical Center, New York, NY tc2625@cumc.columbia.edu. Baird John J Columbia University Medical Center, New York, NY tc2625@cumc.columbia.edu. Farber Donna L DL Columbia University Medical Center, New York, NY tc2625@cumc.columbia.edu. eng Letter Comment (...) United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2016 Jan 7;374(1):62-72 26735994 N Engl J Med. 2016 May 5;374(18):1793-4 27144864 Bronchiolitis, Viral Humans Respiratory Syncytial Virus Infections 2016 5 5 6 0 2016 5 6 6 0 2016 5 6 6 1 ppublish 27144866 10.1056/NEJMc1601509 10.1056/NEJMc1601509#SA2

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2016 NEJM

38. Viral Bronchiolitis in Children. (PubMed)

Viral Bronchiolitis in Children. 27144868 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Viral Bronchiolitis in Children. 1792-3 10.1056/NEJMc1601509 Rossi Giovanni A GA Istituto Giannina Gaslini, Genoa, Italy giovannirossi@gaslini.org. Silvestri Michela M Istituto Giannina Gaslini, Genoa, Italy giovannirossi@gaslini.org. Colin Andrew A AA University of Miami, Miami, FL. eng Letter Comment United States N Engl J Med 0255562 0028-4793 AIM (...) IM N Engl J Med. 2016 Jan 7;374(1):62-72 26735994 N Engl J Med. 2016 Sep 22;375(12):1204 27653590 N Engl J Med. 2016 May 5;374(18):1793-4 27144864 Bronchiolitis, Viral Humans Respiratory Syncytial Virus Infections 2016 5 5 6 0 2016 5 6 6 0 2016 5 6 6 1 ppublish 27144868 10.1056/NEJMc1601509 10.1056/NEJMc1601509#SA4

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2016 NEJM

39. Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old. (PubMed)

Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old. This Cochrane review was first published in 2005 and updated in 2007, 2012 and now 2015. Acute bronchiolitis is the leading cause of medical emergencies during winter in children younger than two years of age. Chest physiotherapy is sometimes used to assist infants in the clearance of secretions in order to decrease ventilatory effort.To determine the efficacy of chest physiotherapy in infants aged (...) less than 24 months old with acute bronchiolitis. A secondary objective was to determine the efficacy of different techniques of chest physiotherapy (for example, vibration and percussion and passive forced exhalation).We searched CENTRAL (2015, Issue 9) (accessed 8 July 2015), MEDLINE (1966 to July 2015), MEDLINE in-process and other non-indexed citations (July 2015), EMBASE (1990 to July 2015), CINAHL (1982 to July 2015), LILACS (1985 to July 2015), Web of Science (1985 to July 2015) and Pedro

2016 Cochrane

40. Viral Bronchiolitis in Children. (PubMed)

Viral Bronchiolitis in Children. 26735994 2016 01 19 2016 05 05 1533-4406 374 1 2016 Jan 07 The New England journal of medicine N. Engl. J. Med. Viral Bronchiolitis in Children. 62-72 10.1056/NEJMra1413456 Meissner H Cody HC eng Journal Article Review United States N Engl J Med 0255562 0028-4793 0 Respiratory Syncytial Virus Vaccines AIM IM N Engl J Med. 2016 May 5;374(18):1792-3 27144868 N Engl J Med. 2016 May 5;374(18):1791-2 27144866 N Engl J Med. 2016 May 5;374(18):1791 27144865 N Engl J (...) Med. 2016 May 5;374(18):1792 27144867 N Engl J Med. 2016 May 5;374(18):1793-4 27144864 Asthma etiology Bronchiolitis, Viral complications immunology therapy virology Child, Preschool Humans Infant Respiratory Sounds etiology Respiratory Syncytial Virus Infections immunology therapy Respiratory Syncytial Virus Vaccines Risk Factors 2016 1 7 6 0 2016 1 7 6 0 2016 1 20 6 0 ppublish 26735994 10.1056/NEJMra1413456

2016 NEJM