Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for cardiac arrest
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on cardiac arrest or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on cardiac arrest and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via firstname.lastname@example.org
Targeted Temperature Management for CardiacArrest with Nonshockable Rhythm. Moderate therapeutic hypothermia is currently recommended to improve neurologic outcomes in adults with persistent coma after resuscitated out-of-hospital cardiacarrest. However, the effectiveness of moderate therapeutic hypothermia in patients with nonshockable rhythms (asystole or pulseless electrical activity) is debated.We performed an open-label, randomized, controlled trial comparing moderate therapeutic (...) hypothermia (33°C during the first 24 hours) with targeted normothermia (37°C) in patients with coma who had been admitted to the intensive care unit (ICU) after resuscitation from cardiacarrest with nonshockable rhythm. The primary outcome was survival with a favorable neurologic outcome, assessed on day 90 after randomization with the use of the Cerebral Performance Category (CPC) scale (which ranges from 1 to 5, with higher scores indicating greater disability). We defined a favorable neurologic
How Effective Are Epinephrine and Vasopressin for Improving Survival Among Patients in CardiacArrest? How Effective Are Epinephrine and Vasopressin for Improving Survival Among Patients in CardiacArrest? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page To read this article in full, please review your options for gaining access at the bottom of the page. Article in Press How Effective Are Epinephrine and Vasopressin (...) for Improving Survival Among Patients in CardiacArrest? x Michael Gottlieb , MD (EBEM Commentator) , x Vishal P. Jani , DO (EBEM Commentator) , x Yanina A. Purim-Shem-Tov , MD, MS (EBEM Commentator) Department of Emergency Medicine, Rush University Medical Center, Chicago, IL DOI: Publication History Published online: May 09, 2019 To view the full text, please login as a subscribed user or . Click to view the full text on ScienceDirect. Epinephrine is associated with improved overall survival rates
Sodium Bicarbonate Administration in CardiacArrest Sodium Bicarbonate Administration in CardiacArrest | Emergency Medicine | Washington University in St. Louis Open Menu Back Close Menu Search for: Loading... Welcome Our Team Sections Education Alumni Research ECRC Journal Club Events Jermyn Lectures Open Search Vignette You’re working a busy shift in TCC one Sunday afternoon when you get a page that EMS is bringing in a patient in cardiacarrest. The patient is a 57-year-old male (...) a laryngeal airway device with a good waveform on capnography. You defibrillate the patient, which results in PEA. he has now been in cardiacarrest for twenty minutes, and you begin to wonder what other management options you have. you consider whether you should give sodium bicarbonate or calcium chloride given his prolonged cardiacarrest, but your attending tells you that neither treatment is beneficial (though , and you keep giving that). After a total of thirty minutes of downtime, the patient
Community first responders for out-of-hospital cardiacarrest in adults and children. Mobilization of community first responders (CFRs) to the scene of an out-of-hospital cardiacarrest (OHCA) event has been proposed as a means of shortening the interval from occurrence of cardiacarrest to performance of cardiopulmonary resuscitation (CPR) and defibrillation, thereby increasing patient survival.To assess the effect of mobilizing community first responders (CFRs) to out-of-hospital cardiac (...) arrest events in adults and children older than four weeks of age, in terms of survival and neurological function.We searched the following databases for relevant trials in January 2019: CENTRAL, MEDLINE (Ovid SP), Embase (Ovid SP), and Web of Science. We also searched the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP) and ClinicalTrials.gov, and we scanned the abstracts of conference proceedings of the American Heart Association and the European Resuscitation
Time to delivery of an automated external defibrillator (AED) using a drone to improve out-of-hospital cardiacarrest (OHCA) mortality "Time to delivery of an automated external defibrillator (AED) using a " by Vivian Nguyen > > > > > Title Author Date of Graduation Summer 8-10-2019 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies Rights . Abstract Background: According to the American Heart Association (AHA), 2018 incidence of out-of-hospital cardiac (...) that control for many confounding factors in order to properly assess the efficacy of drone-delivered AEDs to OHCA mortality rate specifically. Keywords: Drones, AED(s), defibrillator(s) Recommended Citation Nguyen, Vivian, "Time to delivery of an automated external defibrillator (AED) using a drone to improve out-of-hospital cardiacarrest (OHCA) mortality" (2019). School of Physician Assistant Studies . 658. https://commons.pacificu.edu/pa/658 DOWNLOADS Since June 24, 2019 Share COinS Browse Search Enter
Prospective validation of the Good Outcome Following Attempted Resuscitation (GO-FAR) score for in-hospital cardiacarrest prognosis We aimed to prospectively validate the Good Outcome Following Attempted Resuscitation (GO-FAR) score, which predicts the likelihood of survival to discharge neurologically intact or with minimal deficits (conscious, alert, and able to work) after in-hospital cardiacarrest (IHCA).Inpatients experiencing an index episode of IHCA between 2010 and 2016 in hospitals
The effects of adrenaline in out of hospital cardiacarrest with shockable and non-shockable rhythms: Findings from the PACA and PARAMEDIC-2 randomised controlled trials Previous research suggests there may be differences in the effects of adrenaline related to the initial cardiacarrest rhythm. The aim of this study was to assess the effect of adrenaline compared with placebo according to whether the initial cardiacarrest rhythm was shockable or non-shockable.Return of spontaneous circulation (...) (ROSC), survival and neurological outcomes according to the initial arrest rhythm were compared amongst patients enrolled in the PARAMEDIC-2 randomised, placebo controlled trial. The results of the PARAMEDIC-2 and PACA out of hospital cardiacarrest trials were combined and meta-analysed.The initial rhythm was known for 3929 (98.2%) in the placebo arm and 3919 (97.6%) in the adrenaline arm. The effect on the rate of ROSC of adrenaline relative to placebo was greater in patients with non-shockable
Chiefs’ inquiry corner: monoclonal antibodies and clostridium difficile infection, outcomes after in-hospital cardiacarrest v out-of-hospital, dermatomyositis and malignancy, malignancy work up in unprovoked VTE. Chiefs’ Inquiry Corner – Clinical Correlations Search Chiefs’ Inquiry Corner June 10, 2019 3 min read Clostridium difficile (C diff) is the most common pathogen implicated in infectious diarrhea among hospitalized patients. Several antimicrobials, chief among them an oral formulation (...) was discontinued after interim analysis). Patients receiving bezlotoxumab-containing regimens demonstrated significantly reduced rates of recurrence within 12 weeks compared to placebo, suggesting a possible role for this monoclonal antibody in the prevention of recurrence when added to standard antimicrobial therapy. References: The epidemiology, etiology, and outcomes of in-hospital cardiacarrest (IHCA) are quite different from those of out-of-hospital cardiacarrest (OHCA). In contrast to OHCA, survival
Accuracy of nature of call screening tool in identifying patients requiring treatment for out of hospital cardiacarrest A new pre-triage screening tool, Nature of Call (NoC), has been introduced into the telephone triage system of UK ambulance services which employ National Health Service Pathways (NHSP). Its function is to provide rapid recognition of patients who may need immediate ambulance dispatch for out-of-hospital cardiacarrest (OHCA) and withholding dispatch for other calls while
Defibrillation energy dose during pediatric cardiacarrest: Systematic review of human and animal model studies To determine the initial defibrillation energy dose that is associated with sustained return of spontaneous circulation (ROSC) during paediatric cardiacarrest with ventricular fibrillation or pulseless ventricular tachycardia.A systematic review was performed using four databases (PROSPERO: CRD42016036734). Human studies and animal model studies of pediatric cardiacarrest involving
Vasopressors during adult cardiacarrest: A systematic review and meta-analysis To systematically review the literature on the use of vasopressors during adult cardiacarrest to inform an update of international guidelines.PRISMA guidelines were followed. We searched Medline, Embase, Web of Science, CINAHL, and the Cochrane Library for controlled trials and observational studies. The population included adults with cardiacarrest in any setting. Pairs of investigators reviewed studies (...) for relevance, extracted data, and assessed the risk of bias for individual studies. Certainty of evidence was evaluated using GRADE for controlled trials and meta-analyses were performed when at least two studies could be pooled.We included 15 controlled trials and 67 observational studies. The majority of studies included out-of-hospital cardiacarrest only. Meta-analyses were performed for two controlled trials comparing epinephrine to placebo, three comparing vasopressin to epinephrine, and three
Advanced airway management during adult cardiacarrest: A systematic review To systematically review the literature on advanced airway management during adult cardiacarrest in order to inform the International Liaison Committee of Resuscitation (ILCOR) consensus on science and treatment recommendations.The review was performed according to PRISMA guidelines and registered on PROSPERO (CRD42018115556). We searched Medline, Embase, and Evidence-Based Medicine Reviews for controlled trials (...) and observational studies published before October 30, 2018. The population included adult patients with cardiacarrest. Two investigators reviewed studies for relevance, extracted data, and assessed the risk of bias of individual studies.We included 78 observational studies and 11 controlled trials. Most of the observational studies and all of the controlled trials only included patients with out-of-hospital cardiacarrest. The risk of bias for individual observational studies was overall assessed as critical
Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital CardiacArrest: The PRINCESS Randomized Clinical Trial. Therapeutic hypothermia may increase survival with good neurologic outcome after cardiacarrest. Trans-nasal evaporative cooling is a method used to induce cooling, primarily of the brain, during cardiopulmonary resuscitation (ie, intra-arrest).To determine whether prehospital trans-nasal evaporative intra-arrest cooling improves (...) survival with good neurologic outcome compared with cooling initiated after hospital arrival.The PRINCESS trial was an investigator-initiated, randomized, clinical, international multicenter study with blinded assessment of the outcome, performed by emergency medical services in 7 European countries from July 2010 to January 2018, with final follow-up on April 29, 2018. In total, 677 patients with bystander-witnessed out-of-hospital cardiacarrest were enrolled.Patients were randomly assigned
Paediatric targeted temperature management post cardiacarrest: A systematic review and meta-analysis The International Liaison Committee on Resuscitation prioritized the need to update the review on the use of targeted temperature management (TTM) in paediatric post cardiacarrest care. In this meta-analysis, the effectiveness of TTM at 32-36 °C was compared with no target or a different target for comatose children who achieve a return of sustained circulation after cardiac arrest.Electronic (...) at 32-34 °C compared with a target at 36-37.5 °C did not statistically improve long-term good neurobehavioural survival (risk ratio: 1.15; 95% CI: 0.69-1.93), long-term survival (RR: 1.14; 95% CI: 0.93-1.39), or short-term survival (risk ratio: 1.14; 95% CI: 0.96-1.36). TTM at 32-34 °C did not show statistically increased risks of infection, recurrent cardiacarrest, serious bleeding, or arrhythmias. A novel analysis suggests that another small RCT might provide enough evidence to show benefit
Advanced airway interventions for paediatric cardiacarrest: A systematic review and meta-analysis To assess the use of advanced airway interventions (tracheal intubation (TI) or supraglottic airway (SGA) placement), compared with bag mask ventilation (BMV) alone, for resuscitation of children in cardiac arrest.We searched Medline, EMBASE, and Cochrane Controlled Register of Trials (CENTRAL) for human trials and observational studies published before September 24, 2018 for clinical trials (...) studies suitable for meta-analysis. The overall certainty of evidence was low to very low. For the critically important outcomes of survival to hospital discharge with good neurologic outcome and survival to hospital discharge results suggested better outcomes achieved with BMV than either TI or SGA; limited data favored SGA over TI. The majority of studies involved out-of-hospital cardiacarrest, with few studies of in-hospital cardiac arrest.TI or SGA are not superior to BMV for resuscitation
Early goal-directed haemodynamic optimization of cerebral oxygenation in comatose survivors after cardiacarrest: the Neuroprotect post-cardiacarrest trial During the first 6-12 h of intensive care unit (ICU) stay, post-cardiacarrest (CA) patients treated with a mean arterial pressure (MAP) 65 mmHg target experience a drop of the cerebral oxygenation that may cause additional cerebral damage. Therefore, we investigated whether an early goal directed haemodynamic optimization strategy (EGDHO
Does care at a cardiacarrest centre improve outcome after out-of-hospital cardiacarrest? - A systematic review To perform a systematic review to answer 'In adults with attempted resuscitation after non-traumatic cardiacarrest does care at a specialised cardiacarrest centre (CAC) compared to care in a healthcare facility not designated as a specialised cardiacarrest centre improve patient outcomes?'The PRISMA guidelines were followed. We searched bibliographic databases (Embase, MEDLINE (...) neurological outcomes. Secondary outcomes were survival to 30 days, survival to hospital discharge and return of spontaneous circulation (ROSC) post-hospital arrival for patients with ongoing resuscitation. This systematic review was registered in PROSPERO (CRD 42018093369) RESULTS: We included data from 17 observational studies on out-of-hospital cardiacarrest (OHCA) patients in meta-analyses. Overall, the certainty of evidence was very low. Pooling data from only adjusted analyses, care at CAC
In-Hospital CardiacArrest: A Review. In-hospital cardiacarrest is common and associated with a high mortality rate. Despite this, in-hospital cardiacarrest has received little attention compared with other high-risk cardiovascular conditions, such as stroke, myocardial infarction, and out-of-hospital cardiac arrest.In-hospital cardiacarrest occurs in over 290 000 adults each year in the United States. Cohort data from the United States indicate that the mean age of patients with in-hospital (...) cardiacarrest is 66 years, 58% are men, and the presenting rhythm is most often (81%) nonshockable (ie, asystole or pulseless electrical activity). The cause of the cardiacarrest is most often cardiac (50%-60%), followed by respiratory insufficiency (15%-40%). Efforts to prevent in-hospital cardiacarrest require both a system for identifying deteriorating patients and an appropriate interventional response (eg, rapid response teams). The key elements of treatment during cardiacarrest include chest
Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and CardiacArrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial. Catheter ablation is effective in restoring sinus rhythm in atrial fibrillation (AF), but its effects on long-term mortality and stroke risk are uncertain.To determine whether catheter ablation is more effective than conventional medical therapy for improving outcomes in AF.The Catheter Ablation vs (...) at the discretion of site investigators. The drug therapy group (n = 1096) received standard rhythm and/or rate control drugs guided by contemporaneous guidelines.The primary end point was a composite of death, disabling stroke, serious bleeding, or cardiacarrest. Among 13 prespecified secondary end points, 3 are included in this report: all-cause mortality; total mortality or cardiovascular hospitalization; and AF recurrence.Of the 2204 patients randomized (median age, 68 years; 37.2% female; 42.9% had