Latest & greatest articles for chlorhexidine

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on chlorhexidine or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on chlorhexidine and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for chlorhexidine

141. Chlorhexidine varnish has caries-reducing potential. (PubMed)

Chlorhexidine varnish has caries-reducing potential. A double-blind, randomised, placebo-controlled clinical trial was conducted.Children in the test group received 6-monthly applications of a 40% chlorhexidine varnish whereas children in the control group received a placebo varnish, over the course of 2 years. Clinical examination was undertaken at baseline and after 24 months by two calibrated dentists who did not know to which groups children were assigned.Decayed, missing, or primary filled (...) increment of the primary molars was 1.0 dmfs-molar in the test-group children and 1.6 dmfs-molar in the placebo group. The difference of 0.6 tooth surface equated to a 37.3% reduction in caries increment (number-needed-to-treat of 3), and was statistically significant (P 0.036; 95% confidence interval, 0.04-1.16). No side-effects (such as soft-tissue lesions and staining of teeth) were found at the 24-month examination.Six-monthly applications of chlorhexidine varnish were effective in reducing

Full Text available with Trip Pro

2007 Evidence-based dentistry

142. The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: a systematic review of the literature

The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: a systematic review of the literature Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2007 DARE.

143. Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysis

Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2007 DARE.

144. Topical applications of chlorhexidine to the umbilical cord for prevention of omphalitis and neonatal mortality in southern Nepal: a community-based, cluster-randomised trial. (PubMed)

Topical applications of chlorhexidine to the umbilical cord for prevention of omphalitis and neonatal mortality in southern Nepal: a community-based, cluster-randomised trial. Omphalitis contributes to neonatal morbidity and mortality in developing countries. Umbilical cord cleansing with antiseptics might reduce infection and mortality risk, but has not been rigorously investigated.In our community-based, cluster-randomised trial, 413 communities in Sarlahi, Nepal, were randomly assigned (...) to one of three cord-care regimens. 4934 infants were assigned to 4.0% chlorhexidine, 5107 to cleansing with soap and water, and 5082 to dry cord care. In intervention clusters, the newborn cord was cleansed in the home on days 1-4, 6, 8, and 10. In all clusters, the cord was examined for signs of infection (pus, redness, or swelling) on these visits and in follow-up visits on days 12, 14, 21, and 28. Incidence of omphalitis was defined under three sign-based algorithms, with increasing severity

Full Text available with Trip Pro

2006 Lancet

145. Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial. (PubMed)

Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial. Nosocomial infections are an important cause of morbidity and mortality after cardiac surgery. Decolonization of endogenous potential pathogenic microorganisms is important in the prevention of nosocomial infections.To determine the efficacy of perioperative decontamination of the nasopharynx and oropharynx with 0.12 (...) % chlorhexidine gluconate for reduction of nosocomial infection after cardiac surgery.A prospective, randomized, double-blind, placebo-controlled clinical trial conducted at the Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands, between August 1, 2003, and September 1, 2005. Of 991 patients older than 18 years undergoing elective cardiothoracic surgery during the study interval, 954 were eligible for analysis.Oropharyngeal rinse and nasal ointment containing either chlorhexidine gluconate

Full Text available with Trip Pro

2006 JAMA

146. Cost-effectiveness analysis of chlorhexidine gluconate compared with povidone-iodine solution for catheter-site care in Siriraj Hospital, Thailand

Cost-effectiveness analysis of chlorhexidine gluconate compared with povidone-iodine solution for catheter-site care in Siriraj Hospital, Thailand Cost-effectiveness analysis of chlorhexidine gluconate compared with povidone-iodine solution for catheter-site care in Siriraj Hospital, Thailand Cost-effectiveness analysis of chlorhexidine gluconate compared with povidone-iodine solution for catheter-site care in Siriraj Hospital, Thailand Maenthaisong R, Chaiyakunapruk N, Thamlikitkul V Record (...) Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study evaluated the cost-effectiveness of antiseptics such as chlorhexidine gluconate (CG) and povidone-iodine solution (PI) for the prevention of catheter-related bloodstream infections

2006 NHS Economic Evaluation Database.

147. Chlorhexidine varnish for preventing dental caries in children, adolescents and young adults: a systematic review

Chlorhexidine varnish for preventing dental caries in children, adolescents and young adults: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2006 DARE.

148. Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review

Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

149. Vaginal chlorhexidine during labour to prevent early-onset neonatal group B streptococcal infection. (PubMed)

Vaginal chlorhexidine during labour to prevent early-onset neonatal group B streptococcal infection. Early-onset group B beta-hemolytic streptococcus (GBS) infection accounts for approximately 30% of neonatal infections, has a high mortality rate and is acquired through vertical transmission from colonized mothers. Several trials have demonstrated the efficacy of intrapartum chemoprophylaxis (IPC) for preventing early-onset disease (EOD). Vaginal disinfection with chlorhexidine during labour (...) has been proposed as another strategy for preventing GBS EOD in the preterm and term neonate. Chlorhexidine has been found to have no impact on antibiotic resistance, is inexpensive, and applicable to poorly equipped delivery sites.To determine the effectiveness of vaginal disinfection with chlorhexidine during labour for preventing early-onset GBS infection in preterm and term neonates.We searched the Cochrane Pregnancy and Childbirth trials register (October 2003), the Cochrane Central Register

2004 Cochrane

150. Vascular catheter site care: the clinical and economic benefits of chlorhexidine gluconate compared with povidone iodine

Vascular catheter site care: the clinical and economic benefits of chlorhexidine gluconate compared with povidone iodine Vascular catheter site care: the clinical and economic benefits of chlorhexidine gluconate compared with povidone iodine Vascular catheter site care: the clinical and economic benefits of chlorhexidine gluconate compared with povidone iodine Chaiyakunapruk N, Veenstra D L, Lipsky B A, Sullivan S D, Saint S Record Status This is a critical abstract of an economic evaluation (...) that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of chlorhexidine gluconate and povidone iodine for vascular catheter insertion site care was investigated. Type of intervention Primary prevention. Economic study type Cost-effectiveness analysis. Study population The study population comprised

Full Text available with Trip Pro

2003 NHS Economic Evaluation Database.

151. Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis

Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis Chaiyakunapruk N, Veenstra D L, Lipsky B A, Saint S Authors' objectives To evaluate the efficacy of skin disinfection with chlorhexidine gluconate, compared with povidone-iodine solution (...) , in preventing vascular catheter-related bloodstream infection. Searching MEDLINE (1966 to 2001), CINAHL (1982 to 2001), Doctoral Dissertation Abstracts (1861 to 2001), International Pharmaceutical Abstracts (1970 to 2001), EMBASE, LexisNexis, ISI Web of Sciences and the Cochrane Library (dates not specified) were searched. The MeSH terms 'chlorhexidine' and 'catheterization' and the exploded keywords 'chlorhexidine' and 'catheter' were used for the searches. No language restrictions were applied. Index

2002 DARE.

152. A meta-analysis of clinical studies on the caries-inhibiting effect of chlorhexidine treatment

A meta-analysis of clinical studies on the caries-inhibiting effect of chlorhexidine treatment A meta-analysis of clinical studies on the caries-inhibiting effect of chlorhexidine treatment A meta-analysis of clinical studies on the caries-inhibiting effect of chlorhexidine treatment van Rijkom H M, Truin G J, van't Hof M A Authors' objectives To perform a meta-analysis on the caries-inhibiting effect of chlorhexidine treatment, and to explore potential modifying factors. Searching MEDLINE (...) was searched from 1975 to 1994 using the keywords 'chlorhexidine' and '(dental) caries'. The search was restricted to studies published in English, French or German. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs) in which treatment duration was of at least 1 year and incidence of surface caries was evaluated at the end of this time. Specific interventions included in the review Chlorhexidine applied as either a gel, paste or rinse. Participants

1996 DARE.

153. Prevention of excess neonatal morbidity associated with group B streptococci by vaginal chlorhexidine disinfection during labour. The Swedish Chlorhexidine Study Group. (PubMed)

Prevention of excess neonatal morbidity associated with group B streptococci by vaginal chlorhexidine disinfection during labour. The Swedish Chlorhexidine Study Group. Streptococcus agalactiae transmitted to infants from the vagina during birth is an important cause of invasive neonatal infection. We have done a prospective, randomised, double-blind, placebo-controlled, multi-centre study of chlorhexidine prophylaxis to prevent neonatal disease due to vaginal transmission of S agalactiae (...) . On arrival in the delivery room, swabs were taken for culture from the vaginas of 4483 women who were expecting a full-term single birth. Vaginal flushing was then done with either 60 ml chlorhexidine diacetate (2 g/l) (2238 women) or saline placebo (2245) and this procedure was repeated every 6 h until delivery. The rate of admission of babies to special-care neonatal units within 48 h of delivery was the primary end point. For babies born to placebo-treated women, maternal carriage of S agalactiae

1992 Lancet

154. Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. (PubMed)

Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. More than 90% of all intravascular device-related septicaemias are due to central venous or arterial catheters. To assess the efficacy of cutaneous antisepsis to prevent catheter-associated infection, we prospectively studied three antiseptics for disinfection of patients' central venous and arterial catheter insertion sites in a surgical (...) intensive care unit. 668 catheters were randomised to 10% povidone-iodine, 70% alcohol, or 2% aqueous chlorhexidine disinfection of the site before insertion and for site care every other day thereafter. Chlorhexidine was associated with the lowest incidence of local catheter-related infection (2.3 per 100 catheters vs 7.1 and 9.3 for alcohol and povidone-iodine, respectively, p = 0.02) and catheter-related bacteraemia (0.5 vs 2.3 and 2.6). Of the 14 infusion-related bacteraemias (4 due to contaminated

1991 Lancet