Latest & greatest articles for chronic kidney disease

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Top results for chronic kidney disease

181. Efficacy of Folic Acid Therapy on the Progression of Chronic Kidney Disease: The Renal Substudy of the China Stroke Primary Prevention Trial (PubMed)

Efficacy of Folic Acid Therapy on the Progression of Chronic Kidney Disease: The Renal Substudy of the China Stroke Primary Prevention Trial The efficacy of folic acid therapy on renal outcomes has not been previously investigated in populations without folic acid fortification.To test whether treatment with enalapril and folic acid is more effective in slowing renal function decline than enalapril alone across a spectrum of renal function at baseline from normal to moderate chronic kidney (...) disease (CKD) among Chinese adults with hypertension.In this substudy of eligible China Stroke Primary Prevention Trial (CSPPT), 15 104 participants with an estimated glomerular filtration rate (eGFR) 30 mL/min/1.73 m2 or greater, including 1671 patients with CKD, were recruited from 20 communities in Jiangsu province in China.Participants were randomized to receive a single tablet daily containing 10 mg enalapril and 0.8 mg folic acid (n = 7545) or 10 mg enalapril alone (n = 7559).The primary outcome

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2016 EvidenceUpdates

182. Lipidomic Signature of Progression of Chronic Kidney Disease in the Chronic Renal Insufficiency Cohort (PubMed)

Lipidomic Signature of Progression of Chronic Kidney Disease in the Chronic Renal Insufficiency Cohort Human studies report conflicting results on the predictive power of serum lipids on progression of chronic kidney disease (CKD). We aimed to systematically identify the lipids that predict progression to end-stage kidney disease.From the Chronic Renal Insufficiency Cohort, 79 patients with CKD stage 2 to 3 who progressed to ESKD over 6 years of follow up were selected and frequency-matched

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2016 Kidney international reports

183. Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population-based cohort (PubMed)

Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population-based cohort Previous studies have revealed inconsistent results regarding the association between occult hepatitis B virus (HBV) infection and chronic kidney disease (CKD). Therefore, we conducted a prospective cohort study to evaluate the association between occult HBV infection and CKD.A total of 4329 adults, aged 46.2 ± 13.7 years, without CKD at baseline were enrolled while undergoing (...) physical examinations. Occult HBV infection was defined as seropositivity for antibody to HBV core antigen. CKD was defined as decreased estimated glomerular filtration rate (eGFR < 60 ml·min-1·1.73 m-2) or presence of proteinuria ≥1+, assessed using a repeated dipstick method. eGFR was computed using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.The prevalence of occult HBV infection was 8.1% (352/4329). During 5 years of follow-up, 165 patients (3.8%) developed CKD

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2016 Chronic diseases and translational medicine

184. Trends in Prevalence of Chronic Kidney Disease in the United States. (PubMed)

Trends in Prevalence of Chronic Kidney Disease in the United States. Trends in the prevalence of chronic kidney disease (CKD) are important for health care policy and planning.To update trends in CKD prevalence.Repeated cross-sectional study.NHANES (National Health and Nutrition Examination Survey) for 1988 to 1994 and every 2 years from 1999 to 2012.Adults aged 20 years or older.Chronic kidney disease (stages 3 and 4) was defined as an estimated glomerular filtration rate (eGFR) of 15 to 59 mL (...) /min/1.73 m2, estimated with the Chronic Kidney Disease Epidemiology Collaboration equation from calibrated serum creatinine measurements. An expanded definition of CKD also included persons with an eGFR of at least 60 mL/min/1.73 m2 and a 1-time urine albumin-creatinine ratio of at least 30 mg/g.The unadjusted prevalence of stage 3 and 4 CKD increased from the late 1990s to the early 2000s. Since 2003 to 2004, however, the overall prevalence has largely stabilized (for example, 6.9% prevalence

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2016 Annals of Internal Medicine

185. Association of Fibroblast Growth Factor 23 With Atrial Fibrillation in Chronic Kidney Disease, From the Chronic Renal Insufficiency Cohort Study (PubMed)

Association of Fibroblast Growth Factor 23 With Atrial Fibrillation in Chronic Kidney Disease, From the Chronic Renal Insufficiency Cohort Study Levels of fibroblast growth factor 23 (FGF23) are elevated in chronic kidney disease (CKD) and strongly associated with left ventricular hypertrophy, heart failure, and death. Whether FGF23 is an independent risk factor for atrial fibrillation in CKD is unknown.To investigate the association of FGF23 with atrial fibrillation in CKD.Prospective cohort (...) study of 3876 individuals with mild to severe CKD who enrolled in the Chronic Renal Insufficiency Cohort Study between June 19, 2003, and September 3, 2008, and were followed up through March 31, 2013.Baseline plasma FGF23 levels.Prevalent and incident atrial fibrillation.The study cohort comprised 3876 participants. Their mean (SD) age was 57.7 (11.0) years, and 44.8% (1736 of 3876) were female. Elevated FGF23 levels were independently associated with increased odds of prevalent atrial fibrillation

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2016 JAMA cardiology

186. Implantation of Autologous Selected Renal Cells in Diabetic Chronic Kidney Disease Stages 3 and 4—Clinical Experience of a “First in Human” Study (PubMed)

Implantation of Autologous Selected Renal Cells in Diabetic Chronic Kidney Disease Stages 3 and 4—Clinical Experience of a “First in Human” Study Animal models of chronic kidney disease demonstrate that a redundant population of therapeutically bioactive selected renal cells (SRCs) can be delivered to the kidney through intraparenchymal injection and arrest disease progression. Direct injection of SRCs has been shown to attenuate nuclear factor-κB, which is known to drive tissue (...) inflammation, as well as the transforming growth factor-β-mediated plasminogen activator inhibitor-1 response that drives tissue fibrosis.We present experience from the first-in-human clinical study with SRCs. Seven male type 2 diabetic patients (63 ± 2 years of age) with chronic kidney disease stage 3 to 4 (estimated glomerular filtration rate 25 ± 2 ml/min) were recruited. After blood and urine sampling, iohexol clearance, magnetic resonance imaging, and renal scintigraphy, patients underwent ultrasound

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2016 Kidney international reports

187. Acupuncture and related interventions for symptoms of chronic kidney disease. (PubMed)

Acupuncture and related interventions for symptoms of chronic kidney disease. People living with chronic kidney disease (CKD) experience a range of symptoms and often have complex comorbidities. Many pharmacological interventions for people with CKD have known risks of adverse events. Acupuncture is widely used for symptom management in patients with chronic diseases and in other palliative care settings. However, the safety and efficacy of acupuncture for people with CKD remains largely (...) pre-dialysis stage 3 or 4 and end-stage kidney disease on either haemodialysis or peritoneal dialysis.None of the included studies assessed pain outcomes, nor formally addressed occurrence of serious adverse events, although three studies reported three participant deaths and three hospitalisations as reasons for attrition. Three studies reported minor acupuncture-related harms; the remainder did not report if those events occurred.All studies were assessed at high or unclear risk of bias in terms

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2016 Cochrane

188. Grape seed powder improves renal failure of chronic kidney disease patients (PubMed)

Grape seed powder improves renal failure of chronic kidney disease patients Chronic kidney disease (CKD) is a syndrome characterized by progressive and irreversible deterioration of renal function linked to slow destruction of renal parenchyma, eventually terminating in death when sufficient number of nephrons are damaged. Oxidative stress is commonly observed in CKD patients resulting from an imbalance between overproduction of reactive oxygen species (ROS) and impairment of defence mechanisms (...) filtration rate (GFR) and proteinuria, increased the anti-oxidant status as assessed by high plasma catalase and superoxide dismutase and also lowered lipoperoxidation and carbonylation. GSE ameliorated inflammation by decreasing CRP, triglyceridemia and counteracted anemia and thrombocytopenia. Supplementation with 2 g GSE/day for six months improved some kidney function parameters of CKD patients and this beneficial effect of GSE seems to be mediated at least partly by its antioxidant and anti

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2016 EXCLI journal

189. Ambulatory Blood Pressure in Chronic Kidney Disease: Ready for Prime Time? (PubMed)

Ambulatory Blood Pressure in Chronic Kidney Disease: Ready for Prime Time? Hypertension is common in patients with chronic kidney disease (CKD) and is the most important modifiable risk factor for CKD progression and adverse cardiovascular events in these patients. Diagnosis and successful management of hypertension are critically dependent on accurate blood pressure (BP) measurement. This is most relevant to CKD patients, in whom BP control is difficult to achieve and in whom early (...) antihypertensive treatment is imperative to prevent kidney and cardiovascular complications. Accumulated data indicate that ambulatory blood pressure monitoring (ABPM) is better in detecting hypertension than office BP measurement. ABPM is also a superior prognostic marker compared with office BP and has successfully identified hypertensive CKD patients at increased risk. Additionally, ABPM provides information on circadian BP variation and short-term BP variability, which is associated with cardiovascular

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2016 Kidney international reports

190. Sodium Excretion and the Risk of Cardiovascular Disease in Patients With Chronic Kidney Disease. (PubMed)

Sodium Excretion and the Risk of Cardiovascular Disease in Patients With Chronic Kidney Disease. Patients with chronic kidney disease (CKD) are at an increased risk of cardiovascular disease (CVD) compared with the general population. Prior studies have produced contradictory results on the association of dietary sodium intake with risk of CVD, and this relationship has not been investigated in patients with CKD.To evaluate the association between urinary sodium excretion and clinical CVD (...) events among patients with CKD.A prospective cohort study of patients with CKD from 7 locations in the United States enrolled in the Chronic Renal Insufficiency Cohort Study and followed up from May 2003 to March 2013.The cumulative mean of urinary sodium excretion from three 24-hour urinary measurements and calibrated to sex-specific mean 24-hour urinary creatinine excretion.A composite of CVD events defined as congestive heart failure, stroke, or myocardial infarction. Events were reported every 6

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2016 JAMA

191. Role of Bile Acid Regulated Nuclear Receptor FXR and G Protein Coupled Receptor TGR5 in Regulation of Cardiorenal Syndrome (Cardiovascular Disease and Chronic Kidney Disease) (PubMed)

Role of Bile Acid Regulated Nuclear Receptor FXR and G Protein Coupled Receptor TGR5 in Regulation of Cardiorenal Syndrome (Cardiovascular Disease and Chronic Kidney Disease) 27045028 2018 01 16 2018 12 02 1524-4563 67 6 2016 06 Hypertension (Dallas, Tex. : 1979) Hypertension Role of Bile Acid-Regulated Nuclear Receptor FXR and G Protein-Coupled Receptor TGR5 in Regulation of Cardiorenal Syndrome (Cardiovascular Disease and Chronic Kidney Disease). 1080-4 10.1161/HYPERTENSIONAHA.115.06417 Levi (...) Moshe M From the Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado AMC, Aurora. Moshe.Levi@ucdenver.edu. eng R01 AG026529 AG NIA NIH HHS United States R01 AG049493 AG NIA NIH HHS United States R01 DK098336 DK NIDDK NIH HHS United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review 2016 04 04 United States Hypertension 7906255 0194-911X 0 GPBAR1 protein, human 0 Receptors

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2016 Hypertension (Dallas, Tex. : 1979)

192. Acute kidney injury and chronic kidney disease: from the laboratory to the clinic (PubMed)

Acute kidney injury and chronic kidney disease: from the laboratory to the clinic Chronic kidney disease and acute kidney injury have traditionally been considered as separate entities with different etiologies. This view has changed in recent years, with chronic kidney disease recognized as a major risk factor for the development of new acute kidney injury, and acute kidney injury now accepted to lead to de novo or accelerated chronic and end stage kidney diseases. Patients with existing (...) chronic kidney disease appear to be less able to mount a complete 'adaptive' repair after acute insults, and instead repair maladaptively, with accelerated fibrosis and rates of renal functional decline. This article reviews the epidemiological studies in man that have demonstrated the links between these two processes. We also examine clinical and experimental research in areas of importance to both acute and chronic disease: acute and chronic renal injury to the vasculature, the pericyte

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2016 Nephrologie & therapeutique

193. Soluble Urokinase Receptor and Chronic Kidney Disease. (PubMed)

Soluble Urokinase Receptor and Chronic Kidney Disease. 26962914 2016 03 11 2018 12 02 1533-4406 374 9 2016 03 03 The New England journal of medicine N. Engl. J. Med. Soluble Urokinase Receptor and Chronic Kidney Disease. 891 10.1056/NEJMc1515787 Hayek Salim S SS Quyyumi Arshed A AA Reiser Jochen J eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Receptors, Urokinase Plasminogen Activator AIM IM N Engl J Med. 2015 Nov 12;373(20):1916-25 26539835 N Engl J Med. 2016 Mar 3;374(9 (...) ):890 26962915 N Engl J Med. 2016 Mar 3;374(9):890 26962916 Female Glomerular Filtration Rate Humans Kidney physiology Male Receptors, Urokinase Plasminogen Activator blood Renal Insufficiency, Chronic diagnosis 2016 3 11 6 0 2016 3 11 6 0 2016 3 12 6 0 ppublish 26962914 10.1056/NEJMc1515787 10.1056/NEJMc1515787#SA3

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2016 NEJM

194. Soluble Urokinase Receptor and Chronic Kidney Disease. (PubMed)

Soluble Urokinase Receptor and Chronic Kidney Disease. 26962915 2016 03 11 2018 12 02 1533-4406 374 9 2016 03 03 The New England journal of medicine N. Engl. J. Med. Soluble Urokinase Receptor and Chronic Kidney Disease. 890 10.1056/NEJMc1515787 Quaglia Marco M University of Piemonte Orientale, Novara, Italy claudio.musetti@med.uniupo.it. Musetti Claudio C University of Piemonte Orientale, Novara, Italy claudio.musetti@med.uniupo.it. Cantaluppi Vincenzo V University of Piemonte Orientale (...) , Novara, Italy claudio.musetti@med.uniupo.it. eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Receptors, Urokinase Plasminogen Activator AIM IM N Engl J Med. 2015 Nov 12;373(20):1916-25 26539835 N Engl J Med. 2016 Mar 3;374(9):891 26962914 Female Glomerular Filtration Rate Humans Kidney physiology Male Receptors, Urokinase Plasminogen Activator blood Renal Insufficiency, Chronic diagnosis 2016 3 11 6 0 2016 3 11 6 0 2016 3 12 6 0 ppublish 26962915 10.1056/NEJMc1515787 10.1056

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2016 NEJM

195. Soluble Urokinase Receptor and Chronic Kidney Disease. (PubMed)

Soluble Urokinase Receptor and Chronic Kidney Disease. 26962916 2016 03 11 2018 12 02 1533-4406 374 9 2016 03 03 The New England journal of medicine N. Engl. J. Med. Soluble Urokinase Receptor and Chronic Kidney Disease. 890 10.1056/NEJMc1515787 Schumacher Martin M University of Freiburg Medical Center, Freiburg, Germany ms@imbi.uni-freiburg.de. Wanner Christoph C Würzburg University Clinic, Würzburg, Germany. Beyersmann Jan J University of Ulm, Ulm, Germany. eng Letter Comment United States N (...) Engl J Med 0255562 0028-4793 0 Receptors, Urokinase Plasminogen Activator AIM IM N Engl J Med. 2015 Nov 12;373(20):1916-25 26539835 N Engl J Med. 2016 Mar 3;374(9):891 26962914 Female Glomerular Filtration Rate Humans Kidney physiology Male Receptors, Urokinase Plasminogen Activator blood Renal Insufficiency, Chronic diagnosis 2016 3 11 6 0 2016 3 11 6 0 2016 3 12 6 0 ppublish 26962916 10.1056/NEJMc1515787 10.1056/NEJMc1515787#SA2

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2016 NEJM

196. Metabolically Healthy Obesity and Development of Chronic Kidney Disease: A Cohort Study. (PubMed)

Metabolically Healthy Obesity and Development of Chronic Kidney Disease: A Cohort Study. The risk for chronic kidney disease (CKD) among obese persons without obesity-related metabolic abnormalities, called metabolically healthy obesity, is largely unexplored.To investigate the risk for incident CKD across categories of body mass index in a large cohort of metabolically healthy men and women.Prospective cohort study.Kangbuk Samsung Health Study, Kangbuk Samsung Hospital, Seoul, South Korea.62 (...) subgroups.Chronic kidney disease was identified by a single measurement at each visit.Overweight and obesity are associated with an increased incidence of CKD in metabolically healthy young and middle-aged participants. These findings show that metabolically healthy obesity is not a harmless condition and that the obese phenotype, regardless of metabolic abnormalities, can adversely affect renal function.None.

2016 Annals of Internal Medicine

197. Severe hypocalcemia and prolonged QT interval due to denosumab in an elderly woman with rheumatoid arthritis and chronic kidney disease (PubMed)

Severe hypocalcemia and prolonged QT interval due to denosumab in an elderly woman with rheumatoid arthritis and chronic kidney disease 27733948 2018 11 13 2147-9720 3 3 2016 Sep European journal of rheumatology Eur J Rheumatol Severe hypocalcemia and prolonged QT interval due to denosumab in an elderly woman with rheumatoid arthritis and chronic kidney disease. 144-145 Oiwa Hiroshi H Department of Rheumatology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan. Mokuda Sho S (...) Department of Rheumatology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan; Department of Immunology, Hiroshima University School of Biomedical and Health, Hiroshima, Japan. eng Journal Article 2016 01 29 Turkey Eur J Rheumatol 101656068 2147-9720 Dr. Oiwa reports personal fees from Daiichi Sankyo, during the conduct of the study. 2015 07 02 2015 08 01 2016 10 14 6 0 2016 10 14 6 0 2016 10 14 6 1 ppublish 27733948 10.5152/eurjrheum.2015.0049 ejr-3-3-144 PMC5058456 Am J Kidney Dis. 2009 Jun

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2016 European journal of rheumatology

198. The modifiers of chronic kidney disease in autosomal dominant polycystic kidney disease and the role of the endothelin-1 (PubMed)

The modifiers of chronic kidney disease in autosomal dominant polycystic kidney disease and the role of the endothelin-1 28197495 2019 01 09 2345-4202 5 1 2016 Journal of nephropharmacology J Nephropharmacol The modifiers of chronic kidney disease in autosomal dominant polycystic kidney disease and the role of the endothelin-1. 24-25 Einollahi Behzad B Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Lotfiazar Aidin A Nephrology and Urology (...) Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. eng Journal Article 2016 01 12 Iran J Nephropharmacol 101679372 2345-4202 Autosomal dominant polycystic kidney disease Chronic kidney disease Endothelin-1 2015 12 27 2016 01 10 2017 2 16 6 0 2017 2 16 6 0 2017 2 16 6 1 epublish 28197495 PMC5297502 Am J Kidney Dis. 1990 Nov;16(5):403-13 2239929 Iran J Kidney Dis. 2014 Jul;8(4):265-77 25001132 Lancet. 2007 Apr 14;369(9569):1287-301 17434405 J Am Soc Nephrol. 2013 May;24(6):1006

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2016 Journal of nephropharmacology

199. Systematic review with meta analysis: Erythropoietin corrects anaemia and reduces the risk of blood transfusion in people with chronic kidney disease, but has uncertain effects on other patient-level outcomes

Systematic review with meta analysis: Erythropoietin corrects anaemia and reduces the risk of blood transfusion in people with chronic kidney disease, but has uncertain effects on other patient-level outcomes Erythropoietin corrects anaemia and reduces the risk of blood transfusion in people with chronic kidney disease, but has uncertain effects on other patient-level outcomes | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you (...) Erythropoietin corrects anaemia and reduces the risk of blood transfusion in people with chronic kidney disease, but has uncertain effects on other patient-level outcomes Article Text Therapeutics/Prevention Systematic review with meta analysis Erythropoietin corrects anaemia and reduces the risk of blood transfusion in people with chronic kidney disease, but has uncertain effects on other patient-level outcomes David W Johnson Statistics from Altmetric.com Commentary on: Cody JD , Hodson EM . Recombinant

2016 Evidence-Based Medicine (Requires free registration)

200. Growth Monitoring for Children with Chronic Kidney Disease

Growth Monitoring for Children with Chronic Kidney Disease S Trace, E Cameron, C Inward, CP Burren, Jul 2016 Review date Jul 2018 Page 1 of 5 Bristol Royal Hospital for Children Growth Monitoring Guideline for Children with CKD Contents Page 1-2 Scope, Background, Rationale and Evidence base for guideline Page 2 Definition of Stages of Chronic Kidney Disease (CKD) Page 3 Notes on Growth Monitoring and Referral Page 4 Growth Monitoring Timetable Page 5 References The guideline scope extends (...) and reviews. Multiple measures are necessary 8,9 to give a broad and reliable picture of Clinical Guideline MONITORING GROWTH IN CHILDREN WITH CHRONIC KIDNEY DISEASE S Trace, E Cameron, C Inward, CP Burren, Jul 2016 Review date Jul 2018 Page 2 of 5 Bristol Royal Hospital for Children Growth Monitoring Guideline for Children with CKD growth and nutrition, and the frequency of measurement will depend on the child’s age and stage of CKD (see page2). Children displaying growth delay or unstable medical

2016 British Society for Paediatric Endocrinology and Diabetes