Latest & greatest articles for chronic pain

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on chronic pain or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on chronic pain and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for chronic pain

1. Effects of open-label placebo on pain, functional disability, and spine mobility in patients with chronic back pain: a randomized controlled trial

Effects of open-label placebo on pain, functional disability, and spine mobility in patients with chronic back pain: a randomized controlled trial Chronic back pain (CBP) is a major global health problem, while its treatment is hampered by a lack of efficacy and restricted safety profile of common frontline therapies. The present trial aims to determine whether a 3-week open-label placebo treatment reduces pain intensity and subjective and objective functional disability in patients with CBP (...) . This randomized controlled trial, following a pretest-posttest design, enrolled 127 patients with CBP (pain duration >12 weeks) from the Back Pain Center, Neurology, University Hospital Essen, Germany. Patients randomized to the open-label placebo group received a 3-week open-label placebo treatment. Patients in the treatment as usual (TAU) group received no intervention. Both groups continued TAU. Primary outcome was the change in pain intensity. Secondary outcomes included patient-reported functional

2019 EvidenceUpdates

2. Moderators of Internet-Delivered Cognitive-Behavioral Therapy for Adolescents With Chronic Pain: Who Benefits From Treatment at Long-Term Follow-Up?

Moderators of Internet-Delivered Cognitive-Behavioral Therapy for Adolescents With Chronic Pain: Who Benefits From Treatment at Long-Term Follow-Up? Cognitive behavioral therapy (CBT) is effective for pediatric chronic pain, but little is understood about which youth are most likely to benefit. The current study aimed to identify individual characteristics for which CBT yielded the greatest (and least) clinical benefit among adolescents with chronic pain participating in a multicenter (...) randomized controlled trial of Internet-delivered CBT (WebMAP2). A total of 273 adolescents ages 11 to 17 with chronic pain (M age = 14.7; 75.1% female) were randomly assigned to Internet-delivered CBT or Internet-delivered pain education and evaluated at pretreatment, post-treatment, and 2 longer term follow-up periods (6 and 12 months). Multilevel growth models tested several adolescent- and parent-level moderators of change in pain-related disability including 1) adolescent age, sex, pain

2019 EvidenceUpdates

3. Is a combined programme of manual therapy and exercise more effective than usual care in patients with non-specific chronic neck pain? A randomized controlled trial

Is a combined programme of manual therapy and exercise more effective than usual care in patients with non-specific chronic neck pain? A randomized controlled trial The aim of this study was to compare the effectiveness of a combined intervention of manual therapy and exercise (MET) versus usual care (UC), on disability, pain intensity and global perceived recovery, in patients with non-specific chronic neck pain (CNP).Randomized controlled trial.Outpatient care units.Sixty-four non-specific (...) CNP patients were randomly allocated to MET (n = 32) or UC (n = 32) groups.Participants in the MET group received 12 sessions of mobilization and exercise, whereas the UC group received 15 sessions of usual care in physiotherapy.The primary outcome was disability (Neck Disability Index). The secondary outcomes were pain intensity (Numeric Pain Rating Scale) and global perceived recovery (Patient Global Impression Change). Patients were assessed at baseline, three weeks, six weeks (end of treatment

2019 EvidenceUpdates

4. Couple Interventions for Chronic Pain: A Systematic Review

Couple Interventions for Chronic Pain: A Systematic Review Couple interventions for chronic pain have been shown to more effectively reduce pain intensity for individuals with chronic pain (ICPs) than individual behavioral interventions or usual care. This systematic review identified randomized controlled trials of couple interventions to highlight strategies that could be incorporated into psychotherapy with ICPs and their romantic partners.The authors identified articles reporting randomized (...) controlled trials of couple interventions for chronic pain. Three databases were searched (ie, PubMed, Embase, and PsycInfo), resulting in 18 studies and 22 articles.Couple interventions resulted in statistically significant improvements in pain intensity compared with other conditions in 8% to 40% of the studies depending on the comparator group (i.e., control, individual intervention, another couple intervention), and in statistically significant improvements on a pain-related outcome compared

2019 EvidenceUpdates

5. Pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome. (PubMed)

Pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common disorder in which the two main clinical features are pelvic pain and lower urinary tract symptoms. There are currently many approaches for its management, using both pharmacological and non-pharmacological interventions. The National Institute of Health - Chronic Prostatitis Symptom Index (NIH-CPSI) score is a validated measure (...) commonly used to measure CP/CPPS symptoms. We considered a 25% decrease of NIH-CPSI baseline score or a six-point reduction as MCID.To assess the effects of pharmacological therapies for chronic prostatitis/chronic pelvic pain syndrome.We performed a comprehensive search using CENTRAL, MEDLINE, Embase, PsycINFO, CINAHL, trial registries, grey literature and conference proceedings, with no restrictions on the language of publication or publication status. The date of the latest search of all databases

2019 Cochrane

6. Multidisciplinary Treatment Programs for Patients with Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines – An Update

Multidisciplinary Treatment Programs for Patients with Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines – An Update Multidisciplinary Treatment Programs for Patients with Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines – An Update | CADTH.ca Find the information you need Multidisciplinary Treatment Programs for Patients with Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost (...) -effectiveness, and Guidelines – An Update Multidisciplinary Treatment Programs for Patients with Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines – An Update Last updated: May 10, 2019 Project Number: RC1110-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of multidisciplinary treatment programs for patients with chronic, non-malignant pain

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

7. Tiered Care for Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Tiered Care for Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Tiered Care for Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Tiered Care for Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Tiered Care for Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-Effectiveness (...) , and Guidelines Last updated: February 12, 2019 Project Number: RC1074-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of tiered or stepped care for patients with chronic, non-malignant pain in outpatient settings? What is the cost-effectiveness of tiered or stepped care for patients with chronic, non-malignant pain in outpatient settings? What are the evidence-based guidelines regarding tiered

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

8. Cognitive Behavioural Therapy for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness

Cognitive Behavioural Therapy for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness Cognitive Behavioural Therapy for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness | CADTH.ca Find the information you need Cognitive Behavioural Therapy for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness Cognitive Behavioural Therapy for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness Last updated: September 16, 2019 Project Number: RC1181-000 Product Line: Research (...) Type: Non-Pharma Mental Health Intervention Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of cognitive behavioural therapy for chronic non-cancer pain? Key Message There were five systematic reviews included in this report, four of which were Cochrane reviews. Four of the five included systematic reviews had one weakness in the AMSTAR critical domains. The clinical effectiveness of cognitive behavioural therapy was assessed in several

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

9. Mindfulness Training and Yoga for the Management of Chronic Non-malignant Pain: A Review of Clinical Effectiveness and Cost-effectiveness

Mindfulness Training and Yoga for the Management of Chronic Non-malignant Pain: A Review of Clinical Effectiveness and Cost-effectiveness Mindfulness Training and Yoga for the Management of Chronic Non-malignant Pain: A Review of Clinical Effectiveness and Cost-effectiveness | CADTH.ca Find the information you need Mindfulness Training and Yoga for the Management of Chronic Non-malignant Pain: A Review of Clinical Effectiveness and Cost-effectiveness Mindfulness Training and Yoga (...) for the Management of Chronic Non-malignant Pain: A Review of Clinical Effectiveness and Cost-effectiveness Last updated: September 20, 2019 Project Number: RC1185-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of mindfulness training for chronic non-malignant pain in adults? What is the clinical effectiveness of yoga for chronic non-malignant pain in adults? What is the cost-effectiveness

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

10. Smaller Quantity Opioid Prescribing for Chronic Non-Cancer Pain: Clinical Effectiveness and Guidelines

Smaller Quantity Opioid Prescribing for Chronic Non-Cancer Pain: Clinical Effectiveness and Guidelines Smaller Quantity Opioid Prescribing for Chronic Non-Cancer Pain: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Smaller Quantity Opioid Prescribing for Chronic Non-Cancer Pain: Clinical Effectiveness and Guidelines Smaller Quantity Opioid Prescribing for Chronic Non-Cancer Pain: Clinical Effectiveness and Guidelines Last updated: June 28, 2019 Project Number (...) : RA1041-000 Product Line: Research Type: Drug Report Type: Reference List Result type: Report Question What is the clinical effectiveness of prescribing opioids in smaller quantities for patients with chronic non-cancer pain? What are the evidence-based guidelines associated with opioid prescribing for patients with chronic non-cancer pain? Key Message One non-randomized study and three evidence-based guidelines were identified regarding short-term prescribing of opioids for patient with chronic non

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

11. Yoga for Chronic Non-Malignant Pain Management: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines

Yoga for Chronic Non-Malignant Pain Management: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines Yoga for Chronic Non-Malignant Pain Management: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Yoga for Chronic Non-Malignant Pain Management: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines Yoga for Chronic Non-Malignant Pain Management: A Review of Clinical Effectiveness, Cost-Effectiveness (...) and Guidelines Last updated: July 8, 2019 Project Number: RC1139-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of yoga for chronic non-malignant pain in adults? What is the cost-effectiveness of yoga for chronic non-malignant pain in adults? What are the evidence-based guidelines regarding the use of yoga for chronic non-malignant pain in adults? Key Message Evidence of limited quality from one

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

12. Manual Therapy for Persistent or Chronic Non-Specific Neck Pain: Clinical Effectiveness, Cost-Effectiveness and Guidelines

Manual Therapy for Persistent or Chronic Non-Specific Neck Pain: Clinical Effectiveness, Cost-Effectiveness and Guidelines Manual Therapy for Persistent or Chronic Non-Specific Neck Pain: Clinical Effectiveness, Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Manual Therapy for Persistent or Chronic Non-Specific Neck Pain: Clinical Effectiveness, Cost-Effectiveness and Guidelines Manual Therapy for Persistent or Chronic Non-Specific Neck Pain: Clinical Effectiveness (...) , Cost-Effectiveness and Guidelines Last updated: September 24, 2019 Project Number: RA1070-000 Product Line: Research Type: Devices and Systems Report Type: Reference List Result type: Report Question What is the clinical effectiveness of manual therapies for non-cancer, non-specific neck pain? What is the cost-effectiveness of manual therapies for non-cancer, non-specific neck pain? What are the evidence based guidelines regarding manual therapies for non-cancer, non-specific neck pain? Key Message

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

13. Strength-based Exercise for Chronic Non-Cancer Back Pain: A Review of Clinical Effectiveness

Strength-based Exercise for Chronic Non-Cancer Back Pain: A Review of Clinical Effectiveness Strength-based Exercise for Chronic Non-Cancer Back Pain: A Review of Clinical Effectiveness | CADTH.ca Find the information you need Strength-based Exercise for Chronic Non-Cancer Back Pain: A Review of Clinical Effectiveness Strength-based Exercise for Chronic Non-Cancer Back Pain: A Review of Clinical Effectiveness Last updated: September 27, 2019 Project Number: RC1193-000 Product Line: Research (...) Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of strength-based exercise for chronic non-cancer back pain? Key Message No evidence was found regarding the clinical effectiveness of strength-based exercise alone compared with pharmacological interventions for chronic non-cancer back pain in non-pregnant people. Files Rapid Response Summary with Critical Appraisal Published : September 27, 2019 Follow us: © 2019

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

14. Medical Cannabis for the Treatment of Chronic Pain: A Review of Clinical Effectiveness and Guidelines

Medical Cannabis for the Treatment of Chronic Pain: A Review of Clinical Effectiveness and Guidelines Medical Cannabis for the Treatment of Chronic Pain: A Review of Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Medical Cannabis for the Treatment of Chronic Pain: A Review of Clinical Effectiveness and Guidelines Medical Cannabis for the Treatment of Chronic Pain: A Review of Clinical Effectiveness and Guidelines Last updated: July 24, 2019 Project Number: RC1153 (...) -000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of medical cannabis for the treatment of chronic pain? What are the evidence-based guidelines associated with the use of medical cannabis for the treatment of chronic pain? Key Message Based on four overviews (with overlapping systematic reviews), and one systematic review of guidelines,8 there is some suggestion of benefit with cannabis-based medicines

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

15. Non-pharmacological treatment of chronic neck-shoulder myofascial pain in patients with forward head posture. (PubMed)

Non-pharmacological treatment of chronic neck-shoulder myofascial pain in patients with forward head posture. Introduction: Today, chronic pain remains a pressing medical and socio-economic problem, despite the rapid development of medical technologies, the presence of a vast arsenal of drug and non-drug treatments. Estimates for chronic pain prevalence ranged from 8% to 60%. At the same time, about 40% of patients report insufficient effectiveness in the treatment of chronic pain syndrome (...) . The aim of the study was to compare the effectiveness of MTrPS management by biomechanical correction of the musculoskeletal system combined with therapeutic exercises, DN and TrPs-pressure release with the effectiveness of MTrPS management by therapeutic exercises combined with DN and TrPs-pressure release in patients with chronic neck-shoulder myofascial pain and FHP.Materials and methods: 87 patients (mean age - 39±4,9 years) with chronic neck-shoulder myofascial pain and FHP were randomly assigned

2019 Wiadomosci lekarskie (Warsaw, Poland : 1960) Controlled trial quality: uncertain

16. Clinical research on lumbar oblique-pulling manipulation in combination with sling exercise therapy for patients with chronic nonspecific low back pain. (PubMed)

Clinical research on lumbar oblique-pulling manipulation in combination with sling exercise therapy for patients with chronic nonspecific low back pain. To investigate clinical curative effects of lumbar oblique-pulling manipulation in combination with sling-exercise-therapy training on chronic nonspecific lower back pain.A total of 60 patients with chronic nonspecific lower back pain in the Outpatient Department were included in this study. These patients were randomly divided into two groups

Full Text available with Trip Pro

2019 Revista da Associacao Medica Brasileira (1992) Controlled trial quality: uncertain

17. Efficacy of a transdiagnostic emotion-focused exposure treatment for chronic pain patients with comorbid anxiety and depression: a randomized controlled trial

Efficacy of a transdiagnostic emotion-focused exposure treatment for chronic pain patients with comorbid anxiety and depression: a randomized controlled trial The comorbidity between chronic pain and emotional problems has proven difficult to address with current treatment options. This study addresses the efficacy of a transdiagnostic emotion-focused exposure treatment ("hybrid") for chronic pain patients with comorbid emotional problems. Adults (n = 115) with chronic musculoskeletal pain (...) and functional and emotional problems were included in a 2-centre, parallel randomized controlled, open-label trial comparing this treatment to an active control condition receiving a guided Internet-delivered pain management treatment based on CBT principles (iCBT). The hybrid treatment (n = 58, 10-16 sessions) integrates exposure in vivo for chronic pain based on the fear-avoidance model with an emotion-regulation approach informed by procedures in Dialectical Behavior Therapy. The iCBT (n = 57; 8

2019 EvidenceUpdates

18. Pharmacological interventions for chronic pain in children: an overview of systematic reviews

Pharmacological interventions for chronic pain in children: an overview of systematic reviews

2019 EvidenceUpdates

19. Pain Neuroscience Education for Adults With Chronic Musculoskeletal Pain: A Mixed-Methods Systematic Review and Meta-Analysis

Pain Neuroscience Education for Adults With Chronic Musculoskeletal Pain: A Mixed-Methods Systematic Review and Meta-Analysis Chronic musculoskeletal pain (CMP) is an urgent global public health concern. Pain neuroscience education (PNE) is an intervention used in the management of CMP aiming to reconceptualize an individual's understanding of their pain as less threatening. This mixed-methods review undertook a segregated synthesis of quantitative and qualitative studies to investigate (...) the clinical effectiveness, and patients' experience of, PNE for people with CMP. Electronic databases were searched for studies published between January 1, 2002, and June 14, 2018. Twelve randomized, controlled trials (n = 755 participants) that reported pain, disability, and psychosocial outcomes and 4 qualitative studies (n = 50 participants) that explored patients experience of PNE were included. The meta-analyzed pooled treatment effects for PNE versus control had low clinical relevance in the short

Full Text available with Trip Pro

2019 EvidenceUpdates

20. Evidence Brief - Benefits and Harms of Long-term Opioid Dose Reduction or Discontinuation in Patients with Chronic Pain

Evidence Brief - Benefits and Harms of Long-term Opioid Dose Reduction or Discontinuation in Patients with Chronic Pain Enter search terms Button to search HSRD ® Inside VA Budget and Performance Inside the News Room National Observances Special Events » » » » » Evidence Brief: Benefits and Harms of Long-term Opioid Dose Reduction or Discontinuation in Patients with Chronic Pain Health Services Research & Development Evidence Brief: Benefits and Harms of Long-term Opioid Dose Reduction (...) or Discontinuation in Patients with Chronic Pain to the ESP Report RSS feed Prepared by: Evidence Synthesis Program (ESP) Coordinating Center Portland VA Health Care System Portland, OR Mark Helfand, MD, MPH, MS, Director Recommended Citation: Mackey K, Anderson J, Bourne D, Chen E, Peterson K. Evidence Brief: Benefits and Harms of Long-term Opioid Dose Reduction or Discontinuation in Patients with Chronic Pain. Washington, DC: Evidence Synthesis Program, Health Services Research and Development Service, Office

2019 Veterans Affairs Evidence-based Synthesis Program Reports