Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for chronic pain
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on chronic pain or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on chronic pain and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via email@example.com
Antipsychotics for acute and chronicpain in adults. This is an updated version of the original Cochrane review published in Issue 4, 2008. The role of antipsychotics as adjuvant analgesics is a subject of longstanding controversy. Neuroleptanalgesia (that is a state of quiescence, altered awareness, and analgesia produced by a combination of taking an opioid analgesic and an antipsychotic), an established term for the management of acute pain, was shown to negatively influence disease course (...) and total mortality in unstable angina patients. Nevertheless, antipsychotics are used to treat chronicpain (for example chronic headache, fibromyalgia and diabetic neuropathia). With atypical antipsychotics, a new class of antipsychotics, both fewer extrapyramidal side effects and additional benefits may be available.To assess the analgesic efficacy and adverse effects of antipsychotics in acute or chronicpain in adults.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE
Opioids compared to placebo or other treatments for chronic low-back pain. The use of opioids in the long-term management of chronic low-back pain (CLBP) has increased dramatically. Despite this trend, the benefits and risks of these medications remain unclear. This review is an update of a Cochrane review first published in 2007.To determine the efficacy of opioids in adults with CLBP.We electronically searched the Cochrane Back Review Group's Specialized Register, CENTRAL, CINAHL and PsycINFO (...) opioids only.Two authors independently assessed the risk of bias and extracted data onto a pre-designed form. We pooled results using Review Manager (RevMan) 5.2. We reported on pain and function outcomes using standardized mean difference (SMD) or risk ratios with 95% confidence intervals (95% CI). We used absolute risk difference (RD) with 95% CI to report adverse effects.We included 15 trials (5540 participants). Tramadol was examined in five trials (1378 participants); it was found to be better
Opioids for chronic non-cancer pain: a protocol for a systematic review of randomized controlled trials. Opioids are prescribed frequently and increasingly for the management of chronic non-cancer pain (CNCP). Current systematic reviews have a number of limitations, leaving uncertainty with regard to the benefits and harms associated with opioid therapy for CNCP. We propose to conduct a systematic review and meta-analysis to summarize the evidence for using opioids in the treatment of CNCP (...) and the risk of associated adverse events.Eligible trials will include those that randomly allocate patients with CNCP to treatment with any opioid or any non-opioid control group. We will use the guidelines published by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) to inform the outcomes that we collect and present. We will use the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system to evaluate confidence in the evidence
Motor control exercises reduces pain and disability in chronic and recurrent low back pain: a meta-analysis Motor control exercises reduces pain and disability in chronic and recurrent low back pain: a meta-analysis Motor control exercises reduces pain and disability in chronic and recurrent low back pain: a meta-analysis Bystrom MG, Rasmussen-Barr E, Grooten WJ CRD summary This review found that motor control exercise seemed to be superior to several other treatments at reducing pain (...) and disability in patients with chronic or recurrent lower back pain. The limited number of trials in most analyses and the small size of the trials suggest that these results may not be reliable and the authors’ conclusions may be too strong. Authors' objectives To investigate the effectiveness of motor control exercise to reduce pain and disability in people with chronic and recurrent lower back pain. Searching PubMed, EMBASE, PEDro and CINAHL were searched to October 2011 for trials published in English
Lumbar spine fusion for chronic low back pain due to degenerative disc disease: a systematic review Systematic literature review.To categorize published evidence systematically for lumbar fusion for chronic low back pain (LBP) in order to provide an updated and comprehensive analysis of the clinical outcomes.Despite a large number of publications of outcomes of spinal fusion surgery for chronic LBP, there is little consensus on efficacy.A MEDLINE and Cochrane database search was performed (...) satisfaction averaged 71.1% (SD, 5.2%) across studies. Radiographical fusion rates averaged 89.1% (SD, 13.5%), and reoperation rates 12.5% (SD, 12.4%) overall, 9.2% (SD, 7.5%) at the index level. The results of the collective studies did not differ statistically in any of the outcome measures based on level of evidence (analysis of variance, P > 0.05).The body of literature supports fusion surgery as a viable treatment option for reducing pain and improving function in patients with chronic LBP refractory
Pharmacotherapy for the prevention of chronicpain after surgery in adults. Chronicpain can often occur after surgery, substantially impairing patients' health and quality of life. It is caused by complex mechanisms that are not yet well understood. The predictable nature of most surgical procedures has allowed for the conduct of randomized controlled trials of pharmacological interventions aimed at preventing chronic postsurgical pain.The primary objective was to evaluate the efficacy (...) of systemic drugs for the prevention of chronicpain after surgery by examining the proportion of patients reporting pain three months or more after surgery. The secondary objective was to evaluate the safety of drugs administered for the prevention of chronicpain after surgery.We identified randomized controlled trials (RCTs) of various systemically administered drugs for the prevention of chronicpain after surgery from CENTRAL, MEDLINE, EMBASE and handsearches of other reviews and trial registries
Urine drug screening in chronicpain patients on opioid therapy Urine drug screening in chronicpain patients on opioid therapy Urine drug screening in chronicpain patients on opioid therapy Leas B, Goldmann D Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Leas B, Goldmann D. Urine drug screening in chronicpain patients on opioid therapy. Philadelphia: Center (...) for Evidence-based Practice (CEP). 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Analgesics, Opioid; ChronicPain; Humans; Urinalysis Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence Center for Evidence-based Practice, University of Pennsylvania Health System, 3535 Market St. Suite 50, Philadelphia PA 19104 Email: Cep2@uphs.upenn.edu AccessionNumber 32013000421 Date
Controlled medication agreements for opioid use in chronicpain Controlled medication agreements for opioid use in chronicpain Controlled medication agreements for opioid use in chronicpain Leas B, Goldmann D Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Leas B, Goldmann D. Controlled medication agreements for opioid use in chronicpain. Philadelphia: Center (...) for Evidence-based Practice (CEP). 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Analgesics, Opioids; ChronicPain; Contracts; Drug Prescriptions; Medication Therapy Management Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence Center for Evidence-based Practice, University of Pennsylvania Health System, 3535 Market St. Suite 50, Philadelphia PA 19104 Email: Cep2
Nabilone for ChronicPain TITLE: Nabilone for ChronicPain: Clinical Effectiveness, Safety, and Guidelines DATE: 06 June 2013 RESEARCH QUESTIONS 1. What is the clinical effectiveness of nabilone in adults for chronicpain management? 2. What is the clinical evidence on the safety of nabilone in adults for chronicpain management? 3. What are the evidence-based guidelines and recommendations for the dosing of nabilone in adults for chronicpain management? KEY MESSAGE Two randomized controlled (...) trials were identified regarding the clinical effectiveness of nabilone in adults for chronicpain management. METHODS This report makes use of a literature search conducted for a previous CADTH report. The original literature search was conducted in October 2011 on key resources including PubMed, The Cochrane Library (2011, Issue 11), University of York Centre for Reviews and Dissemination (CRD) databases, Canadian and major international health technology agencies, as well as a focused Internet
Acupuncture for chronic low back pain: a multicenter, randomized, patient-assessor blind, sham-controlled clinical trial Multicenter, randomized, patient-assessor blind, sham-controlled clinical trial.To investigate the efficacy of acupuncture treatment with individualized setting for reduction of bothersomeness in participants with chronic low back pain (cLBP).Low back pain is one of the main reasons of disability among adults of working age. Acupuncture is known as an effective treatment (...) of cLBP. Secondary outcomes included VAS score for pain intensity and questionnaires including Oswestry Disability Index, general health status (Short Form-36), and Beck Depression Inventory (BDI).There were no baseline differences observed between the 2 groups, except in the Oswestry Disability Index. One hundred sixteen participants finished the treatments and 3- and 6-month follow-ups, with 14 subjects dropping out. Significant difference in VAS score for bothersomeness and pain intensity score
Osteopathic manual treatment and ultrasound therapy for chronic low back pain: a randomized controlled trial We studied the efficacy of osteopathic manual treatment (OMT) and ultrasound therapy (UST) for chronic low back pain.A randomized, double-blind, sham-controlled, 2 × 2 factorial design was used to study OMT and UST for short-term relief of nonspecific chronic low back pain. The 455 patients were randomized to OMT (n = 230) or sham OMT (n = 225) main effects groups, and to UST (n = 233 (...) to be very satisfied with their back care throughout the study (P <.001). Patients receiving OMT used prescription drugs for low back pain less frequently during the 12 weeks than did patients in the sham OMT group (use ratio = 0.66, 95% CI, 0.43-1.00; P = .048). Ultrasound therapy was not efficacious.The OMT regimen met or exceeded the Cochrane Back Review Group criterion for a medium effect size in relieving chronic low back pain. It was safe, parsimonious, and well accepted by patients.
Motor control exercises reduces pain and disability in chronic and recurrent low back pain: a meta-analysis Meta-analysis of randomized, controlled trials.To determine the short-term, intermediate, and long-term effectiveness of MCE, with regard to pain and disability, in patients with chronic and recurrent low-back pain.Previous meta-analyses have shown no difference between the effects of MCE and general exercise in the treatment of low back pain. Several high quality studies on this topic (...) during all time periods with regard to both pain (the WMDs ranged between -10.18 and -13.32) and disability (the WMDs ranged between -5.62 and -9.00).In patients with chronic and recurrent low back pain, MCE seem to be superior to several other treatments. More studies are, however, needed to investigate what subgroups of patients experiencing LBP respond best to MCE.
Construct and Predictive Validity of the ChronicPain Grade in Workers With Chronic Work-related Upper-extremity Disorders To evaluate the ability of ChronicPain Grade (CPG) questionnaire to predict upper-extremity physical disability, at-work disability, and work status in workers with chronic work-related upper-limb injuries.A total of 448 individuals with chronic work-related injuries were assessed at baseline and 6 months later. At each evaluation, 4 self-reported questionnaires were (...) a lack of CPG and work transition variability may have contributed to this finding. Extension of the upper end of CPG range might be investigated as a means to increase discrimination at the upper end spectrum of chronicpain, which predominate the population of patients with chronic musculoskeletal disorders.
Randomized clinical trial of chronicpain after the transinguinal preperitoneal technique compared with Lichtenstein`s method for inguinal hernia repair Preliminary experience has suggested that preperitoneal mesh positioning causes less chronicpain than Lichtenstein's technique for inguinal hernia repair. Therefore, a randomized clinical trial was conducted with the aim of evaluating the incidence of postoperative chronicpain after transinguinal preperitoneal (TIPP) mesh repair versus (...) Lichtenstein's technique.Patients with a primary unilateral inguinal hernia were randomized to either TIPP or Lichtenstein's repair in two training hospitals. The primary outcome was the number of patients with chronicpain after surgery. Secondary outcomes were adverse events. Follow-up was scheduled after 14 days, 3 months and 1 year. Patients and outcome assessors were blinded.A total of 302 patients were randomized to TIPP (143) or Lichtenstein (159) repair. Baseline characteristics were comparable
Percutaneous adhesiolysis in the management of chronic low back pain in post lumbar surgery syndrome and spinal stenosis: a systematic review Percutaneous adhesiolysis in the management of chronic low back pain in post lumbar surgery syndrome and spinal stenosis: a systematic review Percutaneous adhesiolysis in the management of chronic low back pain in post lumbar surgery syndrome and spinal stenosis: a systematic review Helm S, Benyamin RM, Chopra P, Deer TR, Justiz R CRD summary The review (...) concluded that there was fair evidence that percutaneous adhesiolysis was effective in relieving low back pain and/or leg pain due to post lumbar surgery syndrome or spinal stenosis. Given the paucity of the evidence base and limitations in the reporting the authors conclusions may not be reliable. Authors' objectives To assess the effectiveness of percutaneous adhesiolysis in the treatment of chronic (at least six months duration) low back and/or leg pain in post lumbar surgery syndrome or spinal
Effective delivery styles and content for self-management interventions for chronic musculoskeletal pain: a systematic literature review Effective delivery styles and content for self-management interventions for chronic musculoskeletal pain: a systematic literature review Effective delivery styles and content for self-management interventions for chronic musculoskeletal pain: a systematic literature review Carnes D, Homer KE, Miles CL, Pincus T, Underwood M, Rahman A, Taylor SJ CRD summary (...) The review concluded that shorter duration interventions delivered to groups of patients with chronic musculoskeletal pain, with healthcare professional input, potentially produced better outcomes. Evidence on the effectiveness of different intervention components was mixed. Given the limitations of the evidence, selected outcome reporting, and small treatment effects, the authors' conclusions may not be reliable. Authors' objectives To assess the effectiveness of different multi-component self
Cost effectiveness of epidural steroid injections to manage chronic lower back pain Cost effectiveness of epidural steroid injections to manage chronic lower back pain Cost effectiveness of epidural steroid injections to manage chronic lower back pain Whynes DK, McCahon RA, Ravenscroft A, Hardman J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The objective was to assess the cost-effectiveness of epidural steroid injections for the management of chronic low back pain. The authors concluded that steroid injections, in an out-patient setting, were a cost-effective means of managing chronic low back pain. The study was generally well reported, but there were some limitations in the methods, making the results uncertain
In A Patient Suffering From Chronic Closed Locked TMJ, There Are No Statistical Differences In Postoperative Pain Or Maximal Incisal Opening Values In Comparing Arthroscopic Lysis And Lavage Techniques With Arthroscopic Operative Surgery UTCAT2378, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title In A Patient Suffering From Chronic Closed Locked TMJ, There Are No Statistical Differences In Postoperative Pain Or Maximal (...) Incisal Opening Values In Comparing Arthroscopic Lysis And Lavage Techniques With Arthroscopic Operative Surgery Clinical Question In treating a patient suffering from chronic closed locked TMJ, how effective is arthroscopic lysis and lavage in comparison with arthroscopic operative surgery, in alleviating the pain and allowing for improved maximal incisal opening? Clinical Bottom Line Both lysis and lavage and operative arthroscopy are viable options to treat patients with CCL of the TMJ. According