Latest & greatest articles for clonidine

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Top results for clonidine

21. Efficacy and safety of clonidine as additive for caudal regional anesthesia: a quantitative systematic review of randomized controlled trials

Efficacy and safety of clonidine as additive for caudal regional anesthesia: a quantitative systematic review of randomized controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

22. The efficacy of intrathecal morphine with or without clonidine for postoperative analgesia after radical prostatectomy (PubMed)

The efficacy of intrathecal morphine with or without clonidine for postoperative analgesia after radical prostatectomy In this randomized study, we compared intrathecal (i.t.) morphine with or without clonidine and i.v. postoperative patient-controlled analgesia (PCA) morphine for analgesia after radical retropubic prostatectomy.Fifty patients were randomly divided into three groups. They were allocated to receive i.t. morphine (4 microg/kg) (M group), i.t. morphine and clonidine (1 microg/kg (...) pain score at rest and on coughing were lower in the M group until the 18th postoperative hour and until the 24th postoperative hour in the MC group. The first requests for PCA were delayed in these two groups. The need for intraoperative sufentanil was significantly lower in the MC group.IT morphine provided a significant reduction in morphine requirement during the first 48 postoperative hours after a radical prostatectomy. The addition of clonidine to i.t. morphine reduced intraoperative

2009 EvidenceUpdates

23. Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial. (PubMed)

Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial. To determine if oral clonidine would reduce the duration of opioid detoxification for neonatal abstinence syndrome.Infants with intrauterine exposure to methadone or heroin and neonatal abstinence syndrome (2 consecutive modified Finnegan scores of > or =9) were enrolled at 2 hospitals during 2002-2005 and followed until final hospital discharge. All enrolled infants (80) received oral (...) diluted tincture of opium according to a standardized algorithm and were randomly assigned to receive oral clonidine (1 microg/kg every 4 hours) (40 infants) or placebo (40 infants). Primary outcome was duration of opioid therapy. Secondary outcomes included the amount of opium required to control symptoms, number of treatment failures, and differences in blood pressure, heart rate, and oxygen saturation.The median length of therapy was 27% shorter in the clonidine group (11 [95% confidence interval

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2009 EvidenceUpdates

24. The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial (PubMed)

The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial Clonidine is an alpha(2) adrenoreceptor and imidazoline receptor agonist, which has analgesic, sedative, and minimum alveolar anesthetic concentration-sparing effects. It has been used orally, IV, and epidurally. In spinal surgery, there is a reluctance to use local anesthetic-based epidural analgesia postoperatively because of fears of masking important signs of nerve root or spinal cord (...) injury.We randomized 66 patients undergoing uncomplicated decompressive spinal surgery to receive an epidural infusion of either clonidine (Group C) or saline placebo (Group P) postoperatively. Morphine consumption by patient-controlled analgesia device was recorded for 36 h.Morphine consumption was significantly lower in Group C. The mean consumption at 36 h was 35 mg (95% confidence interval 21-50 mg) in Group C, compared with 61 mg (95% confidence interval 48-74 mg) in the control group. Nausea

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2009 EvidenceUpdates

25. Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials

Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

26. Clonidine and analgesic duration after popliteal fossa nerve blockade: randomized, double-blind, placebo-controlled study (PubMed)

Clonidine and analgesic duration after popliteal fossa nerve blockade: randomized, double-blind, placebo-controlled study We tested the hypothesis that 100 microg clonidine added to 0.375% bupivacaine would prolong the duration of analgesia from popliteal fossa nerve blockade.Ninety-nine patients scheduled for hospital admission after foot or ankle surgery entered this randomized, double-blind, placebo-controlled trial. Patients received a popliteal fossa block (nerve stimulator technique, via (...) the posterior approach) using 30 mL 0.375% bupivacaine, with epinephrine. Patients were randomized to receive no clonidine, 100 microg clonidine IM, or 100 microg clonidine with bupivacaine for the popliteal block. Patients also received a combined spinal-epidural anesthetic, a saphenous nerve block, and postoperative IV patient-controlled analgesia. The primary outcome was patient-reported duration of analgesia.Duration of analgesia was statistically longer in the block clonidine group (18 +/- 6 h

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2008 EvidenceUpdates

27. Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials

Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials Elia N, Culebras X, Mazza C, Schiffer E, Tramer M R CRD summary The authors concluded that adding clonidine to intrathecal local anaesthetic had beneficial effects (...) on some, but not all measures of motor and sensory block. Adding clonidine reduced intra-operative pain but increased the risk of arterial hypotension. Given the low quality of the included studies and the possibility of publication bias, the reliability of the results is questionable. Authors' objectives To assess the efficacy and harm associated with adding clonidine to intrathecal local anaesthetics for surgery. Searching MEDLINE, EMBASE, CINAHL, BIOSIS Previews, INDMED and Cochrane Central

2008 DARE.

28. Should we add clonidine to local anesthetic for peripheral nerve blockade: a qualitative systematic review of the literature

Should we add clonidine to local anesthetic for peripheral nerve blockade: a qualitative systematic review of the literature Should we add clonidine to local anesthetic for peripheral nerve blockade: a qualitative systematic review of the literature Should we add clonidine to local anesthetic for peripheral nerve blockade: a qualitative systematic review of the literature McCartney C J, Duggan E, Apatu E CRD summary Clonidine improved the duration of analgesia and anaesthesia when used (...) as an adjunct to intermediate-acting local anaesthetics for some peripheral nerve blocks. The authors' conclusions reflected the evidence presented, but in light of both a lack of reporting, and the presence of several methodological concerns with the review, the authors' conclusions may not be reliable. Authors' objectives To determine the effectiveness of adding clonidine to local anaesthetics for peripheral nerve block. Searching PubMed and EMBASE were searched from July 1991 to October 2006 for English

2007 DARE.

29. Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects

Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal (...) accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects Article Text Therapeutics Review: clonidine is more effective than placebo for long

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2006 Evidence-Based Medicine (Requires free registration)

30. Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trial. (PubMed)

Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trial. Rapid opioid detoxification with opioid antagonist induction using general anesthesia has emerged as an expensive, potentially dangerous, unproven approach to treat opioid dependence.To determine how anesthesia-assisted detoxification with rapid antagonist induction for heroin dependence compared with 2 alternative detoxification and antagonist induction methods.A (...) included if they had an American Society of Anesthesiologists physical status of I or II, were without major comorbid psychiatric illness, and were not dependent on other drugs or alcohol.Anesthesia-assisted rapid opioid detoxification with naltrexone induction, buprenorphine-assisted rapid opioid detoxification with naltrexone induction, and clonidine-assisted opioid detoxification with delayed naltrexone induction.Withdrawal severity scores on objective and subjective scales; proportions of patients

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2005 JAMA

31. Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal

Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our (...) . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal

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2004 Evidence-Based Mental Health

32. Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature

Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature Nishina K, Mikawa K, Uesugi T, Obara H, Maekawa M, Kamae I, Nishi N Authors' objectives To determine (...) whether clonidine premedication can reduce the occurrence of peri-operative myocardial ischaemia. Searching MEDLINE was searched from 1980 to 1999 using the following MeSH terms: 'myocardial ischaemia', 'coronary disease', 'myocardial infarction', 'coronary arteriosclerosis', 'coronary thrombosis', 'angina pectoris', 'prospective studies', 'clinical trials', 'randomized controlled trials', 'controlled clinical trials', 'intervention studies'. Only English language articles were considered. Personal

2002 DARE.

33. Can clonidine be used in effectively in epidural and intrathecal catheters?

Can clonidine be used in effectively in epidural and intrathecal catheters? Can clonidine be used in effectively in epidural and intrathecal catheters? Can clonidine be used in effectively in epidural and intrathecal catheters? Wasiak J Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Wasiak J. Can clonidine be used in effectively in epidural and intrathecal (...) catheters? Clayton, Victoria: Centre for Clinical Effectiveness (CCE) 2000: 17 Authors' objectives This aim of this report was to assess whether clondine can be used in effectively in epidural and intrathecal catheters. Authors' conclusions - The largest reported experience with clonidine for regional anaesthesia is with epidural administration. - Published reports of epidural clonidine have been in the areas of chronic pain, intra- and post-operative pain, and in obstetric and paediatric populations

2000 Health Technology Assessment (HTA) Database.

34. A meta-analysis of clonidine for symptoms of attention-deficit hyperactivity disorder

A meta-analysis of clonidine for symptoms of attention-deficit hyperactivity disorder Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

1999 DARE.

35. Meta-analysis of the efficacy of extradural clonidine to relieve postoperative pain: an impossible task

Meta-analysis of the efficacy of extradural clonidine to relieve postoperative pain: an impossible task Meta-analysis of the efficacy of extradural clonidine to relieve postoperative pain: an impossible task Meta-analysis of the efficacy of extradural clonidine to relieve postoperative pain: an impossible task Armand S, Langlade A, Boutros A, Lobjoit K, Monrigal C, Ramboatiana R, Rauss A, Bonnet F Authors' objectives To assess the efficacy of extradural clonidine in the relief of post-operative (...) pain, to determine whether anti-nociceptive effects and side-effects were dose-related, and to what extent the latter were deleterious. Searching The databases of MEDLINE and Excerpta Medica were searched from 1985 to 1997 using the following headings: regional analgesia; extradural clonidine; postoperative analgesia; and postoperative pain. Citations from articles were cross-referenced with those in the assessor's bibliography and those of the articles under review. Study selection Study designs

1998 DARE.

36. Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects

Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Curatolo M, Petersen-Felix S, Scaramozzino P, Zbinden A M (...) Authors' objectives To assess the effectiveness of adding fentanyl, adrenaline and clonidine to local anaesthetics for intra-operative epidural analgesia not combined with general anaesthesia. Searching MEDLINE (from 1966), Excerpta Medica (from 1974), and the Science Citation Index (from 1980) were searched using the keywords 'anesthetic techniques', 'epidural', fentanyl', 'epinephrine' and 'clonidine'. In addition, the authors' databases, abstracts of anaesthesia meetings (details listed

1998 DARE.

37. Pharmacy savings generated by preoperative administration of clonidine

Pharmacy savings generated by preoperative administration of clonidine Pharmacy savings generated by preoperative administration of clonidine Pharmacy savings generated by preoperative administration of clonidine Valles J, Samso E, Vilar X, Gallart L, Puig M M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical (...) assessment on the reliability of the study and the conclusions drawn. Health technology Preoperative administration of clonidine in patients undergoing total abdominal hysterectomy with inhalational anaesthesia. Type of intervention Anaesthesia; Treatment. Economic study type Cost-effectiveness analysis. Study population Women undergoing total abdominal hysterectomy (TAH) with inhalational anaesthesia. Setting Secondary care. The economic study was conducted in a university hospital in Barcelona, Spain

1998 NHS Economic Evaluation Database.

38. The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia

The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia Imai Y, Mammoto T, Murakami K, Kita T, Sakai T, Kagawa K, Kirita T, Sugimura M, Kishi Y Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion (...) on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of preanaesthetic oral clonidine or diazepam, administered to patients prior to propofol, to induce anaesthesia in minor breast conserving surgery. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised

1998 NHS Economic Evaluation Database.

39. Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis

Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis Rockemann M G (...) . Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis. Anesthesia and Analgesia 1997; 85(4): 864-869 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Adult; Aged; Analgesia, Epidural /economics; Analgesia, Patient-Controlled /economics; Analgesics /administration & Bupivacaine /administration & Clonidine /administration & Female; Health Care Costs; Humans; Male; Middle Aged; Morphine

1997 NHS Economic Evaluation Database.

40. A trial of clonidine to stop smoking. (PubMed)

A trial of clonidine to stop smoking. 2185371 1990 06 07 2016 10 17 0098-7484 263 20 1990 May 23-30 JAMA JAMA A trial of clonidine to stop smoking. 2746-7 eng Clinical Trial Comment Letter Randomized Controlled Trial United States JAMA 7501160 0098-7484 MN3L5RMN02 Clonidine AIM IM JAMA. 1989 Dec 1;262(21):3011-3 2681856 Behavior Therapy Clonidine administration & dosage therapeutic use Double-Blind Method Humans Randomized Controlled Trials as Topic Smoking drug therapy 1990 5 23 1990 5 23 0 1

1990 JAMA