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Latest & greatest articles for colorectal cancer
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on colorectal cancer or other clinical topics then use Trip today.
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Incidence of faecal occult blood test interval cancers in population-based colorectalcancer screening: a systematic review and meta-analysis Faecal immunochemical tests (FITs) are replacing guaiac faecal occult blood tests (gFOBTs) for colorectalcancer (CRC) screening. Incidence of interval colorectalcancer (iCRC) following a negative stool test result is not yet known. We aimed to compare incidence of iCRC following a negative FIT or gFOBT.We searched Ovid Medline, Embase, Cochrane Library
Colorectalcancer Top results for colorectalcancer - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (...) (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for colorectalcancer The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many
TRIPLETE: a randomised phase III study of modified FOLFOXIRI plus panitumumab versus mFOLFOX6 plus panitumumab as initial therapy for patients with unresectable RAS and BRAF wild-type metastatic colorectalcancer FOLFOXIRI plus bevacizumab is considered a standard option in the upfront treatment of clinically selected patients with metastatic colorectalcancer irrespective of RAS and BRAF molecular status. The randomised MACBETH and VOLFI studies showed that a modified FOLFOXIRI regimen (...) initially unresectable and previously untreated RAS and BRAF wild-type metastatic colorectalcancer patients are randomised to receive a standard treatment with mFOLFOX6 plus panitumumab or an experimental regimen with modified FOLFOXIRI (irinotecan 150 mg/m2, oxaliplatin 85 mg/m2, L-leucovorin 200 mg/m2, 5-fluoruracil 2400 mg/m2 48-hour continuous infusion) plus panitumumab up to 12 cycles, followed by panitumumab plus 5-fluorouracil and L-leucovorin until disease progression. The primary endpoint
Colorectalcancer Evidence Maps - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4
The Role of Primary Tumour Location in the Selection of Biologics for the Treatment of Unresectable Metastatic ColorectalCancer: An Endorsement of a Canadian Consensus Statement Guideline Endorsement 2-31 Guideline Endorsement 2-31 A Quality Initiative of the Program in Evidence-Based Care (PEBC), Cancer Care Ontario (CCO) The Role of Primary Tumour Location in the Selection of Biologics for the Treatment of Unresectable Metastatic ColorectalCancer: An Endorsement of a Canadian Consensus (...) Statement R. Goodwin, C. Agbassi, E. Kennedy, J. Biagi, R. Wong, S. Welch, S. Berry, and the Gastrointestinal Disease Site Group Report Date: July 3, 2018 This document describes the CCO- Gastrointestinal Cancer Disease Site Group endorsement of The predictive effect of primary tumour location in the treatment of metastatic colorectalcancer: a Canadian consensus statement published in 2017 by Abrahao et al. The original publication is available at Current Oncology Vol 24, No 6 (2017) For information
Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic ColorectalCancer: The FRESCO Randomized Clinical Trial. Patients with metastatic colorectalcancer (CRC) have limited effective and tolerable treatment options.To evaluate the efficacy and safety of oral fruquintinib, a vascular endothelial growth factor receptor (VEGFR) inhibitor, as third-line or later therapy in patients with metastatic CRC.FRESCO (Fruquintinib Efficacy and Safety in 3+ Line (...) ColorectalCancer Patients) was a randomized, double-blind, placebo-controlled, multicenter (28 hospitals in China), phase 3 clinical trial. From December 2014 to May 2016, screening took place among 519 patients aged 18 to 75 years who had metastatic CRC that progressed after at least 2 lines of chemotherapy but had not received VEGFR inhibitor therapy; 416 met the eligibility criteria and were stratified by prior anti-VEGF therapy and K-ras status. The final date of follow-up was January 17, 2017
Postoperative chemotherapy with single-agent fluoropyrimidines after resection of colorectalcancer liver metastases: a meta-analysis of randomised trials Surgical resection is the only option of cure for patients with metastatic colorectalcancer. Risk of recurrence after metastasectomy is around 75%. Use of adjuvant chemotherapy after metastasectomy is controversial.To address whether adjuvant systemic therapy after colorectalcancer metastasectomy offers any survival benefit compared
Role of chemotherapy in resectable liver metastases from colorectalcancer: food for thought from pooled evidence 29942665 2019 01 30 2059-7029 3 4 2018 ESMO open ESMO Open Role of chemotherapy in resectable liver metastases from colorectalcancer: food for thought from pooled evidence. e000367 10.1136/esmoopen-2018-000367 Mauri Davide D Department of Medical Oncology, University Medical School of Ioannina, Ioannina, Greece. Filis Panagiotis P Department of Medical Oncology, University Medical (...) School of Ioannina, Ioannina, Greece. Tsali Lampriani L Department of Internal Medicine, General Hospital of Arta, Arta, Greece. Zarkavelis George G Department of Medical Oncology, University Medical School of Ioannina, Ioannina, Greece. Pentheroudakis George G Department of Medical Oncology, University Medical School of Ioannina, Ioannina, Greece. eng Editorial 2018 06 19 England ESMO Open 101690685 2059-7029 colorectal liver metastasectomy chemotherapy Competing interests: None declared. 2018 04 30
Phase Ib/II trial evaluating the safety, tolerability and immunological activity of durvalumab (MEDI4736) (anti-PD-L1) plus tremelimumab (anti-CTLA-4) combined with FOLFOX in patients with metastatic colorectalcancer 5-Fluorouracil plus irinotecan or oxaliplatin alone or in association with target therapy are standard first-line therapy for metastatic colorectalcancer (mCRC). Checkpoint inhibitors targeting PD-1/PD-L1 demonstrated efficacy on mCRC with microsatellite instability but remain
Validation of the Survival Benefits of Metformin in Middle Eastern Patients With Type II Diabetes Mellitus and ColorectalCancer Purpose Epidemiologic data from several populations suggest that metformin may decrease cancer risk and mortality in patients with colorectalcancer (CRC) and type II diabetes mellitus (DM). Although type II DM and CRC are major health problems in the Middle East, no investigations have been performed to test the effect metformin has on the outcome of patients (...) with type II DM and CRC who are also treated with metformin. Materials and Methods We retrospectively reviewed the medical records of 1,902 patients diagnosed with CRC at King Hussein Cancer Center between January 2004 and December 2012, and identified 349 patients (18%) with type II DM; we censored the data of 28 patients because their antidiabetic medications were unknown. We then categorized these 321 patients into two groups: 192 patients treated with metformin (group A) and 129 patients treated
Clonal evolution of colorectalcancer in a patient with serially resected metastases and liquid biopsies: a case report and discussion of the literature Metastatic colorectalcancer represents a striking example of clonal heterogeneity and tumour evolution, which generates acquired resistance to therapy. Once hard to perform, the study of clonal heterogeneity is now significantly aided by the use of liquid biopsies.We herein report a case of a patient with colorectalcancer and serial
Assessing Clinical Outcomes in ColorectalCancer with Assays for Invasive Circulating Tumor Cells Colorectal carcinoma (CRC) is the second leading cause of cancer-related mortality. The goals of this study are to evaluate the association between levels of invasive circulating tumor cells (iCTCs) with CRC outcomes and to explore the molecular characteristics of iCTCs. Peripheral blood from 93 patients with Stage I⁻IV CRC was obtained and assessed for the detection and characterization of iCTCs
3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectalcancer (SCOT): an international, randomised, phase 3, non-inferiority trial 6 months of oxaliplatin-containing chemotherapy is usually given as adjuvant treatment for stage 3 colorectalcancer. We investigated whether 3 months of oxaliplatin-containing chemotherapy would be non-inferior to the usual 6 months of treatment.The SCOT study was an international, randomised, phase 3, non-inferiority trial (...) done at 244 centres. Patients aged 18 years or older with high-risk stage II and stage III colorectalcancer underwent central randomisation with minimisation for centre, choice of regimen, sex, disease site, N stage, T stage, and the starting dose of capecitabine. Patients were assigned (1:1) to receive 3 months or 6 months of adjuvant oxaliplatin-containing chemotherapy. The chemotherapy regimens could consist of CAPOX (capecitabine and oxaliplatin) or FOLFOX (bolus and infused fluorouracil
Modified XELIRI (capecitabine plus irinotecan) versus FOLFIRI (leucovorin, fluorouracil, and irinotecan), both either with or without bevacizumab, as second-line therapy for metastatic colorectalcancer (AXEPT): a multicentre, open-label, randomised, non- Studies of a modified XELIRI (mXELIRI; capecitabine plus irinotecan) regimen suggest promising efficacy and tolerability profiles in the first-line and second-line settings. Therefore, we aimed to compare the efficacy and safety of the mXELIRI (...) for metastatic colorectalcancer. We randomly assigned patients (1:1) to receive either mXELIRI with or without bevacizumab (irinotecan 200 mg/m2 intravenously on day 1 plus oral capecitabine 800 mg/m2 twice daily on days 1-14, repeated every 21 days, with or without bevacizumab 7·5 mg/kg intravenously on day 1) or FOLFIRI with or without bevacizumab (irinotecan 180 mg/m2 intravenously on day 1, leucovorin 200 mg/m2 intravenously on day 1, fluorouracil 400 mg/m2 intravenously on day 1, and a 46-h continuous
A data-driven, knowledge-based approach to biomarker discovery: application to circulating microRNA markers of colorectalcancer prognosis Recent advances in high-throughput technologies have provided an unprecedented opportunity to identify molecular markers of disease processes. This plethora of complex-omics data has simultaneously complicated the problem of extracting meaningful molecular signatures and opened up new opportunities for more sophisticated integrative and holistic approaches (...) . In this era, effective integration of data-driven and knowledge-based approaches for biomarker identification has been recognised as key to improving the identification of high-performance biomarkers, and necessary for translational applications. Here, we have evaluated the role of circulating microRNA as a means of predicting the prognosis of patients with colorectalcancer, which is the second leading cause of cancer-related death worldwide. We have developed a multi-objective optimisation method
Effect of More vs Less Frequent Follow-up Testing on Overall and ColorectalCancer-Specific Mortality in Patients With Stage II or III ColorectalCancer: The COLOFOL Randomized Clinical Trial. Intensive follow-up of patients after curative surgery for colorectalcancer is common in clinical practice, but evidence of a survival benefit is limited.To examine overall mortality, colorectalcancer-specific mortality, and colorectalcancer-specific recurrence rates among patients with stage II or III (...) colorectalcancer who were randomized after curative surgery to 2 alternative schedules for follow-up testing with computed tomography and carcinoembryonic antigen.Unblinded randomized trial including 2509 patients with stage II or III colorectalcancer treated at 24 centers in Sweden, Denmark, and Uruguay from January 2006 through December 2010 and followed up for 5 years; follow-up ended on December 31, 2015.Patients were randomized either to follow-up testing with computed tomography of the thorax
Association Between Intensity of Posttreatment Surveillance Testing and Detection of Recurrence in Patients With ColorectalCancer. Surveillance testing is performed after primary treatment for colorectalcancer (CRC), but it is unclear if the intensity of testing decreases time to detection of recurrence or affects patient survival.To determine if intensity of posttreatment surveillance is associated with time to detection of CRC recurrence, rate of recurrence, resection for recurrence (...) , or overall survival.A retrospective cohort study of patient data abstracted from the medical record as part of a Commission on Cancer Special Study merged with records from the National Cancer Database. A random sample of patients (n=8529) diagnosed with stage I, II, or III CRC treated at a Commission on Cancer-accredited facilities (2006-2007) with follow-up through December 31, 2014.Intensity of imaging and carcinoembryonic antigen (CEA) surveillance testing derived empirically at the facility level
Initial experience with the bispecific anti-CEA anti-CD3 antibody and its expected impact on future treatment for patients with colorectalcancer 29862052 2018 06 04 2059-7029 3 4 2018 ESMO open ESMO Open Initial experience with the bispecific anti-CEA anti-CD3 antibody and its expected impact on future treatment for patients with colorectalcancer. e000377 10.1136/esmoopen-2018-000377 Argiles Guillem G Gastrointestinal Malignancies Program, Vall d'Hebron University Hospital, Barcelona, Spain (...) . eng Journal Article 2018 05 20 England ESMO Open 101690685 2059-7029 colorectalcancer Competing interests: None declared. 2018 6 5 6 0 2018 6 5 6 0 2018 6 5 6 1 epublish 29862052 10.1136/esmoopen-2018-000377 esmoopen-2018-000377 PMC5976108
Association of Colonoscopy Adenoma Findings With Long-term ColorectalCancer Incidence. Individuals with adenomatous polyps are advised to undergo repeated colonoscopy surveillance to prevent subsequent colorectalcancer (CRC), but the relationship between adenomas at colonoscopy and long-term CRC incidence is unclear.To compare long-term CRC incidence by colonoscopy adenoma findings.Multicenter, prospective cohort study of participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO (...) -2.7], P = .68).Over a median of 13 years of follow-up, participants with an advanced adenoma at diagnostic colonoscopy prompted by a positive flexible sigmoidoscopy result were at significantly increased risk of developing colorectalcancer compared with those with no adenoma. Identification of nonadvanced adenoma may not be associated with increased colorectalcancer risk.clinicaltrials.gov Identifier: NCT00002540.