Latest & greatest articles for corticosteroids

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Top results for corticosteroids

721. Use of inhaled corticosteroids during pregnancy and risk of pregnancy induced hypertension: nested case-control study. Full Text available with Trip Pro

Use of inhaled corticosteroids during pregnancy and risk of pregnancy induced hypertension: nested case-control study. To determine whether the use of inhaled corticosteroids during pregnancy increases the risk of pregnancy induced hypertension and pre-eclampsia among asthmatic women.Nested case-control study.Three administrative health databases from Quebec: RAMQ, MED-ECHO, and Fichier des evenements demographiques.3505 women with asthma, totalling 4593 pregnancies, between 1990 and 2000 (...) .Pregnancy induced hypertension and pre-eclampsia.302 cases of pregnancy induced hypertension and 165 cases of pre-eclampsia were identified. Use of inhaled corticosteroids from conception until date of outcome was not associated with an increased risk of pregnancy induced hypertension (adjusted odds ratio 1.02, 95% confidence interval 0.77 to 1.34) or pre-eclampsia (1.06, 0.74 to 1.53). No significant dose-response relation was observed between inhaled corticosteroids and pregnancy induced hypertension

2005 BMJ

722. Corticosteroids for acute traumatic brain injury. Full Text available with Trip Pro

Corticosteroids for acute traumatic brain injury. Traumatic brain injury is a leading cause of death and disability. Corticosteroids have been widely used in treating people with traumatic brain injury.To quantify the effectiveness and safety of corticosteroids in the treatment of acute traumatic brain injury.Electronic sources: MEDLINE, EMBASE, Cochrane Library and specialised database searches. Additional hand searching and contact with trialists. Date of the most recent search October 2004 (...) .All randomised controlled trials of corticosteroid use in acute traumatic brain injury with adequate or unclear allocation concealment.Quality of allocation concealment was scored. Data on numbers of participants randomised, numbers lost to follow up, length of follow up, case fatality rates, disablement, infections and gastrointestinal bleeds were extracted independently and checked.We identified 20 trials with 12303 randomised participants. The effect of corticosteroids on the risk of death

2005 Cochrane

723. A cost consequences analysis of local corticosteroid injection and physiotherapy for the treatment of new episodes of unilateral shoulder pain in primary care

A cost consequences analysis of local corticosteroid injection and physiotherapy for the treatment of new episodes of unilateral shoulder pain in primary care Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 NHS Economic Evaluation Database.

724. Economic evaluation of treating chronic obstructive pulmonary disease with inhaled corticosteroids and long-acting beta 2-agonists in a health maintenance organization Full Text available with Trip Pro

Economic evaluation of treating chronic obstructive pulmonary disease with inhaled corticosteroids and long-acting beta 2-agonists in a health maintenance organization Economic evaluation of treating chronic obstructive pulmonary disease with inhaled corticosteroids and long-acting beta 2-agonists in a health maintenance organization Economic evaluation of treating chronic obstructive pulmonary disease with inhaled corticosteroids and long-acting beta 2-agonists in a health maintenance (...) (COPD). The options were: long-acting beta2-antagonists (LABA) alone (e.g. salmeterol); inhaled corticosteroids (ICS; e.g. fluticasone propionate); a combination of ICS and LABA (ICS+LABA); and a "comparison" treatment that excluded the administration of ICS and LABA but included other COPD drugs, namely short-acting beta-antagonists, xanthine, anticholinergic or combined bronchodilators. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study

2005 NHS Economic Evaluation Database.

725. Effect of initial corticosteroid therapy on coronary artery aneurysm formation in Kawasaki disease: a meta-analysis of 862 children

Effect of initial corticosteroid therapy on coronary artery aneurysm formation in Kawasaki disease: a meta-analysis of 862 children Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

726. Moderate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma

Moderate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

727. Practice parameter: corticosteroid treatment of Duchenne dystrophy. Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society Full Text available with Trip Pro

Practice parameter: corticosteroid treatment of Duchenne dystrophy. Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society Practice parameter: corticosteroid treatment of Duchenne dystrophy. Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society Practice parameter: corticosteroid treatment of Duchenne dystrophy. Report (...) of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society Moxley R T, Ashwal S, Pandya S, Connolly A, Florence J, Mathews K, Baumbach L, McDonald C, Sussman M, Wade C CRD summary This review assessed the effects of corticosteroids in boys with Duchenne dystrophy. It concluded that prednisone can improve muscle strength and function and pulmonary function, and that deflazacort also provides similar benefits. This conclusion

2005 DARE.

728. Hay fever and a single intramuscular injection of corticosteroid: a systematic review

Hay fever and a single intramuscular injection of corticosteroid: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

729. Effects of inhaled corticosteroids on mortality and hospitalisation in elderly asthma and chronic obstructive pulmonary disease patients: appraising the evidence

Effects of inhaled corticosteroids on mortality and hospitalisation in elderly asthma and chronic obstructive pulmonary disease patients: appraising the evidence Effects of inhaled corticosteroids on mortality and hospitalisation in elderly asthma and chronic obstructive pulmonary disease patients: appraising the evidence Effects of inhaled corticosteroids on mortality and hospitalisation in elderly asthma and chronic obstructive pulmonary disease patients: appraising the evidence Schmier J K (...) , Halpern M T, Jones M L CRD summary This review examined the mortality and hospitalisation rates associated with the use of inhaled corticosteroids (ICS) in elderly patients with chronic obstructive pulmonary disease. The authors concluded that lower rates of hospitalisation and mortality were found to be associated with ICS use. However, concerns about potential biases in the review data mean that the findings are unlikely to be robust. Authors' objectives To review mortality and hospitalisation rates

2005 DARE.

730. Role of combination inhaled corticosteroids and long acting beta agonists in the treatment of adult asthma

Role of combination inhaled corticosteroids and long acting beta agonists in the treatment of adult asthma Role of combination inhaled corticosteroids and long acting beta agonists in the treatment of adult asthma Role of combination inhaled corticosteroids and long acting beta agonists in the treatment of adult asthma Mayers I, Damant R Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation Mayers I, Damant R. Role of combination inhaled corticosteroids and long acting beta agonists in the treatment of adult asthma. Ottawa: Canadian Coordinating Office for Health Technology Assessment (CCOHTA) 2005: 4 Authors' objectives The aim of this report is review the available information on the use of inhaled corticosteroids, combined in an inhaler with a long acting beta agonist, for treatment of persistent asthma (fixed dose combinations

2005 Health Technology Assessment (HTA) Database.

731. Daily versus as-needed corticosteroids for mild persistent asthma. Full Text available with Trip Pro

Daily versus as-needed corticosteroids for mild persistent asthma. Although guidelines recommend daily therapy for patients with mild persistent asthma, prescription patterns suggest that most such patients use these so-called controller therapies intermittently. In patients with mild persistent asthma, we evaluated the efficacy of intermittent short-course corticosteroid treatment guided by a symptom-based action plan alone or in addition to daily treatment with either inhaled budesonide (...) ), and the number of symptom-free days (P=0.03), but not in post-bronchodilator FEV1 (P=0.29) or in the quality of life (P=0.18). Daily zafirlukast therapy did not differ significantly from intermittent treatment in any outcome measured.It may be possible to treat mild persistent asthma with short, intermittent courses of inhaled or oral corticosteroids taken when symptoms worsen. Further studies are required to determine whether this novel approach to treatment should be recommended.Copyright 2005

2005 NEJM Controlled trial quality: predicted high

732. Inhaled corticosteroids were safely stepped down in chronic, stable asthma Full Text available with Trip Pro

Inhaled corticosteroids were safely stepped down in chronic, stable asthma Inhaled corticosteroids were safely stepped down in chronic, stable asthma | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username (...) * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Inhaled corticosteroids were safely stepped down in chronic, stable asthma Article Text Therapeutics Inhaled corticosteroids were safely stepped down in chronic, stable asthma Free Jay I Peters , MD Statistics from Altmetric.com Hawkins G, McMahon

2005 Evidence-Based Medicine

733. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. (Abstract)

Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Corticosteroids have been used to treat head injuries for more than 30 years. In 1997, findings of a systematic review suggested that these drugs reduce risk of death by 1-2%. The CRASH trial--a multicentre international collaboration--aimed to confirm or refute such an effect by recruiting 20000 patients. In May, 2004 (...) , the data monitoring committee disclosed the unmasked results to the steering committee, which stopped recruitment.10008 adults with head injury and a Glasgow coma score (GCS) of 14 or less within 8 h of injury were randomly allocated 48 h infusion of corticosteroids (methylprednisolone) or placebo. Primary outcomes were death within 2 weeks of injury and death or disability at 6 months. Prespecified subgroup analyses were based on injury severity (GCS) at randomisation and on time from injury

2004 Lancet Controlled trial quality: predicted high

734. Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. (Abstract)

Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. By contrast with patients with asthma, those with chronic obstructive pulmonary disease (COPD) are poorly responsive to the anti-inflammatory actions of corticosteroids, and these drugs provide little clinical benefit. In both diseases, multiple inflammatory genes are activated, which results from acetylation of core histones around which DNA is wound. This acetylation opens up the chromatin (...) structure allowing gene transcription and synthesis of inflammatory proteins to proceed. Corticosteroids recruit histone deacetylase 2 (HDAC2) to the actively transcribing gene, which reverses this process and switches off inflammatory gene transcription. We propose that in patients with COPD, HDAC2 function is impaired by cigarette smoking and oxidative stress, leading to a pronounced reduction in responsiveness to corticosteroids. Oxidative stress could generate peroxynitrite, which impairs HDAC2

2004 Lancet

735. Corticosteroid injections for osteoarthritis of the knee: meta-analysis. Full Text available with Trip Pro

Corticosteroid injections for osteoarthritis of the knee: meta-analysis. To determine the efficacy of intra-articular corticosteroid injections for osteoarthritis of the knee and to identify numbers needed to treat.Cochrane controlled trials register, Medline (1966 to 2003), Embase (1980 to 2003), hand searches, and contact with authors.Randomised controlled trial in which the efficacy of intra-articular corticosteroid injections for osteoarthritis of the knee could be ascertained.In high (...) quality studies, the pooled relative risk for improvement in symptoms of osteoarthritis of the knee at 16-24 weeks after intra-articular corticosteroid injections was 2.09 (95% confidence interval 1.2 to 3.7) and the number needed to treat was 4.4. The pooled relative risk for improvement up to two weeks after injections was 1.66 (1.37 to 2.0). The numbers needed to treat to get one improvement in the statistically significant studies was 1.3 to 3.5 patients.Evidence supports short term (up to two

2004 BMJ

736. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. Full Text available with Trip Pro

Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. To assess the effects of corticosteroids on mortality in patients with severe sepsis and septic shock.Randomised and quasi-randomised trials of corticosteroids versus placebo (or supportive treatment alone) retrieved from the Cochrane infectious diseases group's trials register, the Cochrane central register of controlled trials, Medline, Embase, and LILACS.Two pairs of reviewers agreed on eligibility (...) of trials. One reviewer entered data on to the computer and four reviewers checked them. We obtained some missing data from authors of trials and assessed methodological quality of trials.16/23 trials (n = 2063) were selected. Corticosteroids did not change 28 day mortality (15 trials, n = 2022; relative risk 0.92, 95% confidence interval 0.75 to 1.14) or hospital mortality (13 trials, n = 1418; 0.89, 0.71 to 1.11). There was significant heterogeneity. Subgroup analysis on long courses (> or = 5 days

2004 BMJ

737. Frequency of application of topical corticosteroids for atopic eczema (TA81)

Frequency of application of topical corticosteroids for atopic eczema (TA81) Overview | Frequency of application of topical corticosteroids for atopic eczema | Guidance | NICE Frequency of application of topical corticosteroids for atopic eczema Technology appraisal guidance [TA81] Published date: 25 August 2004 Share Guidance on using topical corticosteroids for people with atopic eczema. Guidance development process Is this guidance up to date? . We found nothing new that affects

2004 National Institute for Health and Clinical Excellence - Technology Appraisals

738. Cost-effectiveness of inhaled corticosteroids for chronic obstructive pulmonary disease according to disease severity

Cost-effectiveness of inhaled corticosteroids for chronic obstructive pulmonary disease according to disease severity Cost-effectiveness of inhaled corticosteroids for chronic obstructive pulmonary disease according to disease severity Cost-effectiveness of inhaled corticosteroids for chronic obstructive pulmonary disease according to disease severity Sin D D, Golmohammadi K, Jacobs P Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion (...) on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study investigated the use (and no use) of inhaled corticosteroids in patients with varying severity of chronic obstructive pulmonary disease (COPD). The effects of inhaled corticosteroids were evaluated using four strategies: none of the patients were treated during the follow-up

2004 NHS Economic Evaluation Database.

739. Cost-utility of inhaled corticosteroids in patients with moderate-to-severe asthma

Cost-utility of inhaled corticosteroids in patients with moderate-to-severe asthma Cost-utility of inhaled corticosteroids in patients with moderate-to-severe asthma Cost-utility of inhaled corticosteroids in patients with moderate-to-severe asthma Marchetti M, Cavallo M C, Annoni E, Gerzeli S Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Four inhaled corticosteroids (ICS) for the treatment of moderate-to-severe asthma were studied. The ICS were beclomethasone (BDP), beclomethasone-extrafine (BDP-EF), fluticasone (FP) and budesonide (BUD). In patients with moderate asthma, the ICS were compared at daily doses of 1,000 microg BDP, 400 microg BDP-EF, 400 microg FP and 800 microg BUD. In patients with severe asthma

2004 NHS Economic Evaluation Database.

740. Corticosteroid injections for osteoarthritis of the knee: meta-analysis

Corticosteroid injections for osteoarthritis of the knee: meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2004 DARE.