Latest & greatest articles for corticosteroids

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Top results for corticosteroids

781. Randomised controlled trial of short bursts of a potent topical corticosteroid versus prolonged use of a mild preparation for children with mild or moderate atopic eczema. Full Text available with Trip Pro

Randomised controlled trial of short bursts of a potent topical corticosteroid versus prolonged use of a mild preparation for children with mild or moderate atopic eczema. To determine whether a three day burst of a potent corticosteroid is more effective than a mild preparation used for seven days in children with mild or moderate atopic eczema.Randomised, double blind, parallel group study of 18 weeks' duration.13 general practices and a teaching hospital in the Nottingham area.174 children (...) improvements in disease severity and quality of life compared with baseline.A short burst of a potent topical corticosteroid is just as effective as prolonged use of a milder preparation for controlling mild or moderate atopic eczema in children.

2002 BMJ Controlled trial quality: predicted high

782. Corticosteroids for the Prevention of Reintubation and Postextubation Stridor in Pediatric Patients: A Meta-Analysis

Corticosteroids for the Prevention of Reintubation and Postextubation Stridor in Pediatric Patients: A Meta-Analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2002 PedsCCM Evidence-Based Journal Club

783. Corticosteroids for Bell's palsy (idiopathic facial paralysis). (Abstract)

Corticosteroids for Bell's palsy (idiopathic facial paralysis). Inflammation and oedema of the facial nerve are implicated in causing Bell's palsy. Corticosteroids have a potent anti-inflammatory action which should minimise nerve damage and thereby improve the outcome of patients suffering from this condition.The objective of this review was to assess the effect of steroid therapy in the recovery of patients with Bell's palsy.We searched the Cochrane Neuromuscular Disease Group register (...) for randomised trials, as well as MEDLINE, EMBASE and LILACS (to December 2000). We contacted known experts in the field to identify additional published or unpublished trials.Randomised trials comparing different routes of administration and dosage schemes of corticosteroid or adrenocorticotrophic hormone therapy versus a control group where no therapy considered effective for this condition was administered, unless it was also given in a similar way to the experimental group.Two reviewers independently

2002 Cochrane

784. Inhaled corticosteroid effects on bone metabolism in asthma and mild chronic obstructive pulmonary disease. (Abstract)

Inhaled corticosteroid effects on bone metabolism in asthma and mild chronic obstructive pulmonary disease. Inhaled corticosteroids form the main therapy for asthma, but there is increasing concern about the potential systematic effects of long-term inhaled corticosteroids including their effect on bone metabolism and bone loss.To determine the effect of inhaled corticosteroids use on biochemical markers of bone turnover, bone mineral density and the development of fractures.We searched (...) the inclusion criteria. Three studies were in healthy subjects asthma or COPD. The patients were generally less than 60 years old and the male:female ratio was 2:1. There was no evidence of increased risk of loss of bone mineral density (BMD) or fractures. There was no significant change in osteocalcin at conventional doses of inhaled corticosteroids (Standardised Mean Difference [SMD] -0.34 (95% Confidence Interval [CI] -0.72, 0.04), although a statistically significant change was seen in those studies

2002 Cochrane

785. Dapsone as an oral corticosteroid sparing agent for asthma. (Abstract)

Dapsone as an oral corticosteroid sparing agent for asthma. Oral corticosteroids are used as a treatment for asthma, however they are often associated with serious side effects. Dapsone is a sulfone with anti-inflammatory properties, therefore it may have a beneficial effect in the treatment of asthma and act as a corticosteroid-sparing agent.The objective of this review is to assess the safety and efficacy of adding dapsone to oral corticosteroids in adults with stable asthma who are dependent (...) on oral corticosteroids with the intention of eventually minimizing or eliminating the use of these steroids.The Cochrane Airways group trials register and reference lists of potential articles were searched.Randomised controlled trials investigating the addition of dapsone compared to placebo in stable corticosteroid dependent asthmatics.No trials were found that met the selection criteria.No meta-analyses could be performed.No randomised controlled trials have been published, so there is no reliable

2002 Cochrane

786. Fortnightly review: Corticosteroid injections in tendon lesions. Full Text available with Trip Pro

Fortnightly review: Corticosteroid injections in tendon lesions. 11509432 2001 09 20 2018 11 13 0959-8138 323 7309 2001 Aug 18 BMJ (Clinical research ed.) BMJ Fortnightly review: Corticosteroid injections in tendon lesions. 382-6 Speed C A CA Rheumatology Unit, Department of Medicine, University of Cambridge, Cambridge CB2 2QQ. cas50@medschl.cam.ac.uk eng Journal Article Meta-Analysis England BMJ 8900488 0959-8138 0 Glucocorticoids AIM IM BMJ. 2002 Jan 5;324(7328):51 11777811 Achilles Tendon

2001 BMJ

787. Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. (Abstract)

Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. Long-acting beta(2)-agonists are prescribed for patients with persistent asthma and are sometimes used without inhaled corticosteroids (ICSs). No evidence exists, however, to support their use as monotherapy in adults with persistent asthma.To examine the effectiveness of salmeterol xinafoate, a long-acting beta(2)-agonist, as replacement

2001 JAMA Controlled trial quality: predicted high

788. Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. (Abstract)

Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. Inhaled long-acting beta(2)-agonists improve asthma control when added to inhaled corticosteroid (ICS) therapy.To determine whether ICS therapy can be reduced or eliminated in patients with persistent asthma after adding a long-acting beta(2)-agonist to their treatment regimen.A 24-week randomized, controlled, blinded, double-dummy, parallel-group trial

2001 JAMA Controlled trial quality: predicted high

789. Systematic review of clinical effectiveness of pressurised metered dose inhalers versus other hand held inhaler devices for delivering corticosteroids in asthma. Full Text available with Trip Pro

Systematic review of clinical effectiveness of pressurised metered dose inhalers versus other hand held inhaler devices for delivering corticosteroids in asthma. To determine the clinical effectiveness of pressurised metered dose inhalers (with or without spacer) compared with other hand held inhaler devices for the delivery of corticosteroids in stable asthma.Systematic review of randomised controlled trials.Cochrane Airways Group trials database (Medline, Embase, Cochrane controlled clinical (...) trials register, and hand searching of 18 relevant journals), pharmaceutical companies, and bibliographies of included trials.All trials in children or adults with stable asthma that compared a pressurised metered dose inhaler with any other hand held inhaler device delivering the same inhaled corticosteroid.24 randomised controlled trials were included. Significant differences were found for forced expiratory volume in one second, morning peak expiratory flow rate, and use of drugs for additional

2001 BMJ

790. Cost-effectiveness of inhaled corticosteroids in adults with mild-to-moderate asthma: results from the Asthma Policy Model

Cost-effectiveness of inhaled corticosteroids in adults with mild-to-moderate asthma: results from the Asthma Policy Model Cost-effectiveness of inhaled corticosteroids in adults with mild-to-moderate asthma: results from the Asthma Policy Model Cost-effectiveness of inhaled corticosteroids in adults with mild-to-moderate asthma: results from the Asthma Policy Model Paltiel A D, Fuhlbrigge A L, Kitch B T, Liljas B, Weiss S T, Neumann P J, Kuntz K M Record Status This is a critical abstract (...) of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of inhaled corticosteroid (ICS) therapy in treating asthma. Type of intervention Treatment. Economic study type Cost-utility analysis. Study population The hypothetical population was aged 18 years and over with mild

2001 NHS Economic Evaluation Database.

791. Should children with Bell's palsy be treated with corticosteroids: a systematic review

Should children with Bell's palsy be treated with corticosteroids: a systematic review Should children with Bell's palsy be treated with corticosteroids: a systematic review Should children with Bell's palsy be treated with corticosteroids: a systematic review Salman M S, MacGregor D L Authors' objectives To evaluate the effect of corticosteroids in the treatment of paediatric Bell's palsy. Searching MEDLINE (from 1966 to January 2000), EMBASE (from 1980 to March 1999) and the Cochrane (...) , although case series were excluded. The review included randomised controlled trials (RCTs) and non-randomised controlled trials (described as a parallel or historical control study design). Specific interventions included in the review Corticosteroids (prednisone) or corticotropin compared with a control group (not described). The drug dosages used were tabulated. Participants included in the review Children up to 16 years of age who had been diagnosed with acute idiopathic unilateral Bell's palsy

2001 DARE.

792. Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation

Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation Bennett M L, Fleischer A B, Chamlin S L, Frieden I J Authors' objectives To determine the efficacy of systemic corticosteroids in treating enlarging problematic cutaneous haemangiomas. Searching MEDLINE and PubMed were (...) searched for original articles on the combined topics of 'hemangiomas and corticosteroids'. In addition, the bibliographies of the identified studies were reviewed. Studies reported in any language were considered, and relevant foreign language articles were translated into English. Unpublished material was excluded. Study selection Study designs of evaluations included in the review Case series with at least five patients were eligible for inclusion, provided that there was sufficient information

2001 DARE.

793. Multiple courses of antenatal corticosteroids: a systematic review and meta-analysis

Multiple courses of antenatal corticosteroids: a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2001 DARE.

794. Do antenatal corticosteroids help in the setting of preterm rupture of membranes?

Do antenatal corticosteroids help in the setting of preterm rupture of membranes? Do antenatal corticosteroids help in the setting of preterm rupture of membranes? Do antenatal corticosteroids help in the setting of preterm rupture of membranes? Harding J E, Pang J, Knight D B, Liggins G C Authors' objectives To conduct a meta-analysis of studies investigating the use of corticosteroids before pre-term delivery in mothers with ruptured membranes. Searching The authors did not report how (...) of active treatment), with injections given 24 hours apart. Trials were excluded if corticosteroid administration was associated with a cointervention such as elective early delivery. Participants included in the review Mothers selected for having ruptured membrane at a defined point before pre-term delivery were included. Trials were excluded if women with rupture of membranes had been excluded from those trials. Outcomes assessed in the review The inclusion criteria pre-specified that clinical

2001 DARE.

795. Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery: A randomized controlled trial. (Abstract)

Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery: A randomized controlled trial. The practice of administering weekly courses of antenatal corticosteroids to pregnant women at risk of preterm delivery is widespread, but no randomized trial has established the efficacy or safety of this practice.To evaluate the efficacy of weekly administration of antenatal corticosteroids compared with a single course in reducing the incidence of neonatal morbidity (...) and to evaluate potential complications of weekly treatment.Randomized, double-blind, placebo-controlled intention-to-treat trial conducted in 13 academic centers in the United States from February 1996 through April 2000.A total of 502 pregnant women between 24 and 32 completed weeks' gestation who were at high risk of preterm delivery.All patients received a complete single course of antenatal corticosteroids (either betamethasone, 12 mg intramuscularly repeated once in 24 hours for 2 doses

2001 JAMA Controlled trial quality: predicted high

796. [Effectiveness and efficiency of an outpatient clinic for corticosteroid-dependent asthmatics]

[Effectiveness and efficiency of an outpatient clinic for corticosteroid-dependent asthmatics] Efectividad y eficiencia de una consulta externa monografica de asma corticodependiente [Effectiveness and efficiency of an outpatient clinic for corticosteroid-dependent asthmatics] Efectividad y eficiencia de una consulta externa monografica de asma corticodependiente [Effectiveness and efficiency of an outpatient clinic for corticosteroid-dependent asthmatics] Domingo Ribas C Record Status (...) This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology A specialist outpatient clinic for corticosteroid-dependent asthmatics was studied. Type of intervention Health care organisation. Economic study type Cost-effectiveness analysis. Study population The study

2001 NHS Economic Evaluation Database.

797. Addition of anti-leukotriene agents to inhaled corticosteroids for chronic asthma. (Abstract)

Addition of anti-leukotriene agents to inhaled corticosteroids for chronic asthma. Anti-leukotriene (AL) agents are being considered as "add-on" therapy to inhaled corticosteroids (ICS), in chronic asthma.To examine the safety and efficacy of daily AL plus ICS compared to ICS alone, and determine the corticosteroid-sparing effect of AL when added to ICS in chronic asthma.We searched Medline, Embase, Cinahl (all up to 2001), reference lists of review articles and trials, contacted international (...) of ICS was 300-2000 mcg beclomethasone-equivalent. In symptomatic adults, AL (at 2-4 times licensed dose) combined with ICS reduced the number of patients with exacerbations that required systemic corticosteroids, compared to ICS alone [Relative Risk (RR) = 0.34; 95% Confidence Interval (CI) 0.13, 0.88]. This equates to 20 patients (95% CI 1,100 patients) treated to prevent one needing systemic corticosteroids. There was no difference in side effects. No trials tested the efficacy of licensed doses

2001 Cochrane

798. Non-corticosteroid treatment for nephrotic syndrome in children. (Abstract)

Non-corticosteroid treatment for nephrotic syndrome in children. Eighty to ninety per cent children with steroid sensitive nephrotic syndrome (SSNS) have one or more relapses. About half of these children relapse frequently and are at risk of the adverse effects of corticosteroids. Non-corticosteroid immunosuppressive agents are used to prolong periods of remission in children, who relapse frequently. However these non-corticosteroid agents also have significant potential adverse effects (...) . Currently there is no consensus as to the most appropriate second line agent in children who are steroid sensitive, but who continue to relapse. In this systematic review of randomised controlled trials (RCTs), the benefits and harms of these immunosuppressive agents are evaluated.To evaluate the benefits and harms of non-corticosteroid immunosuppressive agents in relapsing SSNS in children.Published and unpublished randomised controlled trials were identified from the Cochrane Controlled Trials

2001 Cochrane

799. Gold as an oral corticosteroid sparing agent in stable asthma. (Abstract)

Gold as an oral corticosteroid sparing agent in stable asthma. Patients with chronic severe asthma are often dependent on the long term prescription of oral corticosteroids. The use of steroids is associated with serious side effects. Physicians treating such patients continue to search for alternative therapies that reduce the need for chronic dosing with oral steroids. Gold compounds are immunosuppressive agents and have benefits in the treatment of a number of inflammatory disorders

2001 Cochrane

800. Troleandomycin as an oral corticosteroid steroid sparing agent in stable asthma. (Abstract)

Troleandomycin as an oral corticosteroid steroid sparing agent in stable asthma. Patients with chronic severe asthma are often dependent on the long term prescription of oral corticosteroids. The use of steroids is associated with serious side effects. Physicians treating such patients continue to search for alternative therapies that reduce the need for chronic dosing with oral steroids. troleandomycin is a compound that is established as an effective antibiotic but may also have non

2001 Cochrane