Latest & greatest articles for corticosteroids

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Top results for corticosteroids

841. Effect of inhaled corticosteroids on bronchial responsiveness in patients with "corticosteroid naive" mild asthma: a meta-analysis

Effect of inhaled corticosteroids on bronchial responsiveness in patients with "corticosteroid naive" mild asthma: a meta-analysis Effect of inhaled corticosteroids on bronchial responsiveness in patients with "corticosteroid naive" mild asthma: a meta-analysis Effect of inhaled corticosteroids on bronchial responsiveness in patients with "corticosteroid naive" mild asthma: a meta-analysis van Grunsven P M, van Schayck C P, Molema J, Akkermans R P, van Weel C Authors' objectives To assess (...) the effects of inhaled corticosteroids on bronchial hyperresponsiveness (BHR) in patients with corticosteroid naive asthma by conventional meta-analysis. Searching MEDLINE (January 1966-June 1998) was searched, and the search terms were provided. The reference lists of the retrieved articles were also checked for additional references. Study selection Study designs of evaluations included in the review Only randomised controlled studies with a duration of at least two weeks were included. Specific

1999 DARE.

842. Long term effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis

Long term effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis Long term effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis Long term effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis van Grunsven P M, van Schayck C P, Derenne J P, Kerstjens H A, Renkema T E, Postma D S, Similowski T, Akkermans R P, Pasker-de Jong P C, Dekhuijzen P N, van Herwaarden C L, van Weel C (...) Authors' objectives To answer the question 'Are inhaled corticosteroids able to slow down the decline in lung function (forced expiratory volume in 1 second, FEV1) in chronic obstructive pulmonary disease (COPD)'. Searching The following electronic databases were searched: MEDLINE from 1983 to 1996; BIOSIS Previews from 1991 to 1996; On Line Contents from 1993 to 1996; Grey Literature in the Netherlands ('GLIN') from 1982 to 1996; the Cochrane Library; and EMBASE from 1993 to 1996. A free text

1999 DARE.

843. A meta-analysis of the use of corticosteroids in pregnancies complicated by preterm premature rupture of membranes

A meta-analysis of the use of corticosteroids in pregnancies complicated by preterm premature rupture of membranes A meta-analysis of the use of corticosteroids in pregnancies complicated by preterm premature rupture of membranes A meta-analysis of the use of corticosteroids in pregnancies complicated by preterm premature rupture of membranes Pattinson R C Authors' objectives To assess the use of corticosteroids in pregnancies complicated by preterm premature rupture of membranes (PPROM (...) ). Searching The author searched the MEDLINE electronic database (search dates and search terms not stated). The author also used the Cochrane Controlled Trials Register. Where the references were only available in conference proceedings, the data quoted in the Cochrane Library were used. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs). Specific interventions included in the review Corticosteroids with or without the concomitant use of antibiotics

1999 DARE.

844. Cost effectiveness of fluticasone propionate and flunisolide in the treatment of corticosteroid-naive patients with moderate asthma

Cost effectiveness of fluticasone propionate and flunisolide in the treatment of corticosteroid-naive patients with moderate asthma Cost effectiveness of fluticasone propionate and flunisolide in the treatment of corticosteroid-naive patients with moderate asthma Cost effectiveness of fluticasone propionate and flunisolide in the treatment of corticosteroid-naive patients with moderate asthma Volmer T, Kielhorn A, Weber H H, Wiessmann K J Record Status This is a critical abstract of an economic (...) evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Use of Fluticasone propionate (FP) or flunisolide (FL) in corticosteroid-naive patients with asthma of moderate severity. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Corticosteroid-naive

1999 NHS Economic Evaluation Database.

845. Inhaled budesonide in addition to oral corticosteroids to prevent asthma relapse following discharge from the emergency department: a randomized controlled trial. (Abstract)

Inhaled budesonide in addition to oral corticosteroids to prevent asthma relapse following discharge from the emergency department: a randomized controlled trial. Relapses of acute asthma following emergency department (ED) discharge can be reduced with systemic corticosteroid treatment. However, whether inhaled corticosteroids (ICSs) provide additional benefit is not known. Objective To determine whether the addition of ICSs to oral corticosteroid treatment would reduce relapses in patients (...) with acute asthma discharged from the ED.Placebo-controlled, double-blind, randomized clinical trial conducted in a community teaching hospital ED in Canada between November 1995 and September 1997, with a 21-day follow-up.A total of 1006 consecutive patients aged 16 to 60 years presented to the ED with acute asthma; after excluding those using oral and/or inhaled corticosteroids as well as those meeting other exclusion criteria, 188 were included in the study.Patients were discharged with a nontapering

1999 JAMA Controlled trial quality: predicted high

846. Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial. (Abstract)

Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial. The role of oral corticosteroids in treating patients with exacerbations of chronic obstructive pulmonary disease (COPD) remains contentious. We assessed in a prospective, randomised, double-blind, placebo-controlled trial the effects of oral corticosteroid therapy in patients with exacerbations of COPD requiring hospital admission.We (...) stay was analysed by intention to treat and forced expiratory volume in 1 s (FEV1) according to protocol.FEV1 after bronchodilation increased more rapidly and to a greater extent in the corticosteroid-treated group: percentage predicted FEV1 after bronchodilation rose from 25.7% (95% CI 21.0-30.4) to 32.2% (27.3-27.1) in the placebo group (p<0.0001) compared with 28.2% (23.5-32.9) to 41.5% (35.8-47.2) in the corticosteroid-treated group (p<0.0001). Up to day 5 of hospital stay, FEV1 after

1999 Lancet Controlled trial quality: predicted high

847. Pragmatic randomised controlled trial of local corticosteroid injection and naproxen for treatment of lateral epicondylitis of elbow in primary care. Full Text available with Trip Pro

Pragmatic randomised controlled trial of local corticosteroid injection and naproxen for treatment of lateral epicondylitis of elbow in primary care. To compare the clinical effectiveness of local corticosteroid injection, standard non-steroidal anti-inflammatory drugs, and simple analgesics for the early treatment of lateral epicondylitis in primary care.Multicentre pragmatic randomised controlled trial.23 general practices in North Staffordshire and South Cheshire.164 patients aged 18-70 (...) to injection, 53 to naproxen, and 58 to placebo. Prognostic variables were similar between groups at baseline. At 4 weeks, 48 patients (92%) in the injection group were completely better or improved compared with 30 (57%) in the naproxen group (P<0.001) and 28 (50%) in the placebo group (P<0.001). At 12 months, 43 patients (84%) in the injection group had pain scores 0.05).Early local corticosteroid injection

1999 BMJ Controlled trial quality: predicted high

848. Randomised, placebo controlled trial of effect of a leukotriene receptor antagonist, montelukast, on tapering inhaled corticosteroids in asthmatic patients. Full Text available with Trip Pro

Randomised, placebo controlled trial of effect of a leukotriene receptor antagonist, montelukast, on tapering inhaled corticosteroids in asthmatic patients. To determine the ability of montelukast, a leukotriene receptor antagonist, to allow tapering of inhaled corticosteroids in clinically stable asthmatic patients.Double blind, randomised, placebo controlled, parallel group study. After a single blind placebo run in period, during which (at most) two inhaled corticosteroids dose decreases (...) occurred, qualifying, clinically stable patients were allocated randomly to receive montelukast (10 mg tablet) or matching placebo once daily at bedtime for up to 12 weeks.23 academic asthma centres in United States, Canada, and Europe.226 clinically stable patients with chronic asthma receiving high doses of inhaled corticosteroids (113 randomised to montelukast and 113 to placebo).Every 2 weeks, the inhaled corticosteroids dose was tapered, maintained, or increased (rescue) based on a standardised

1999 BMJ Controlled trial quality: predicted high

849. Corticosteroids in IgA nephropathy: a randomised controlled trial. (Abstract)

Corticosteroids in IgA nephropathy: a randomised controlled trial. IgA nephropathy is progressive in most cases and has no established therapy. In this randomised trial, we assessed the efficacy and safety of a 6-month course of steroids in this disorder.Between July, 1987, and September, 1995, we enrolled 86 consecutive patients from seven renal units in Italy. Eligible patients had biopsy-proven IgA nephropathy, urine protein excretion of 1.0-3.5 g daily, and plasma creatinine concentrations

1999 Lancet Controlled trial quality: predicted high

850. Methods to encourage the use of antenatal corticosteroid therapy for fetal maturation: a randomized controlled trial. (Abstract)

Methods to encourage the use of antenatal corticosteroid therapy for fetal maturation: a randomized controlled trial. Antenatal corticosteroids for fetal maturation have been underused, despite evidence for their benefits in cases of preterm birth.To evaluate dissemination strategies aimed at increasing appropriate use of this therapy.Twenty-seven tertiary care institutions were randomly assigned to either usual dissemination of practice recommendations (n = 14) or usual dissemination plus (...) and a nurse coordinator at each facility, consisting of grand rounds, a chart reminder system, group discussion of case scenarios, monitoring, and feedback.Use or nonuse of antenatal corticosteroids was abstracted from medical records of eligible women delivering at the participating hospitals in the 12 months immediately prior to release of the NIH recommendations (average number of records abstracted, 130) and in the 12 months following their release (average number of records abstracted, 122).Active

1999 JAMA Controlled trial quality: uncertain

851. Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials

Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials Weiner J M, Abramson M J, Puy R M Authors' objectives To determine whether intranasal (...) corticosteroids are superior to oral H1 receptor antagonists (antihistamines) in the treatment of allergic rhinitis. Searching MEDLINE and EMBASE were searched for randomised controlled trials published between 1966 and 1997. The search terms were not given. Review articles identified were surveyed for additional and earlier citations. HealthGate and Winspirs software were used to search MEDLINE for more recently published studies. Where relevant abstracts were identified in conference proceedings, MEDLINE

1998 DARE.

852. Dose response to inhaled corticosteroids: benefits and risks

Dose response to inhaled corticosteroids: benefits and risks Dose response to inhaled corticosteroids: benefits and risks Dose response to inhaled corticosteroids: benefits and risks Lipworth B J, Wilson A M Authors' objectives To systematically review the dose-response effects of inhaled corticosteroids in terms of their antiasthmatic efficacy and systemic adverse effects. Searching MEDLINE, EMBASE, and BIDS were searched from 1966 to 1997. Search terms are listed. Papers with subject headings (...) (p=0.25). The slope gradient for the dose-response relationship of fluticasone propionate was significantly higher from that for beclomethasone dipropionate, budesonide or triamcinolone acetonide. Growth effects: For most children with mild to moderate asthma effective long term control may be attained using low doses of inhaled corticosteroids <400 microgram/day, that are not associated with any significant systemic bioactivity or effects on growth. Short term studies measuring lower leg length

1998 DARE.

853. Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials. Full Text available with Trip Pro

Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials. To determine whether intranasal corticosteroids are superior to oral H1 receptor antagonists (antihistamines) in the treatment of allergic rhinitis.Meta-analysis of randomised controlled trials comparing intranasal corticosteroids with oral antihistamines.Randomised controlled trials conducted worldwide and published between 1966 and 1997.2267 subjects (...) corticosteroids produced significantly greater relief than oral antihistamines of nasal blockage (standardised mean difference 0.63, 95% confidence interval - 0.73 to - 0.53), nasal discharge (-0.5, - 0.6 to - 0.4), sneezing (- 0.49, - 0.59 to - 0.39), nasal itch (- 0.38,- 0.49 to - 0.21), postnasal drip (- 0.24,- 0.42 to - 0.06), and total nasal symptoms (- 0.42,- 0.53 to - 0.32), and global ratings gave an odds ratio for deterioration of symptoms of 0.26 (0.08 to 0.8). There were no significant differences

1998 BMJ

854. Effectiveness of corticosteroid injections versus physiotherapy for treatment of painful stiff shoulder in primary care: randomised trial. Full Text available with Trip Pro

Effectiveness of corticosteroid injections versus physiotherapy for treatment of painful stiff shoulder in primary care: randomised trial. To compare the effectiveness of corticosteroid injections with physiotherapy for the treatment of painful stiff shoulder.Randomised trial.40 general practices.109 patients consulting general practitioners for shoulder pain were enrolled in the trial.Patients were randomly allocated to 6 weeks of treatment either with corticosteroid injections (53 (...) with 26 (46%) out of 56 treated with physiotherapy (difference between groups 31%, 95% confidence interval 14% to 48%). The difference in improvement favoured those treated with corticosteroids in nearly all outcome measures; these differences were statistically significant. At 26 and 52 weeks differences between the groups were comparatively small. Adverse reactions were generally mild. However, among women receiving treatment with corticosteroids adverse reactions were more troublesome: facial

1998 BMJ Controlled trial quality: predicted high

855. A pragmatic cost-effectiveness study of routine epidural corticosteroid injections for lumbosciatic syndrome requiring inhospital management

A pragmatic cost-effectiveness study of routine epidural corticosteroid injections for lumbosciatic syndrome requiring inhospital management A pragmatic cost-effectiveness study of routine epidural corticosteroid injections for lumbosciatic syndrome requiring inhospital management A pragmatic cost-effectiveness study of routine epidural corticosteroid injections for lumbosciatic syndrome requiring inhospital management Lafuma A, Bouvenot G, Cohen C, Eschwege E, Fagnani F, Vignon E Record Status (...) This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Routine epidural corticosteroid injections for lumbosciatic syndrome requiring in-hospital management. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Male

1997 NHS Economic Evaluation Database.

856. Rectal corticosteroids versus alternative treatments in ulcerative colitis: a meta-analysis

Rectal corticosteroids versus alternative treatments in ulcerative colitis: a meta-analysis Rectal corticosteroids versus alternative treatments in ulcerative colitis: a meta-analysis Rectal corticosteroids versus alternative treatments in ulcerative colitis: a meta-analysis Marshall J K, Irvine E J Authors' objectives To examine the role of rectal corticosteroids in the management of active ulcerative colitis. Searching MEDLINE was searched from 1966 to 1996 and EMBASE from 1985 to 1996 using (...) 14 to 56 days. Specific interventions included in the review Rectal corticosteroids including hydrocortisone, prednisolone, betamethasone, budesonide, methylprednisolone, prednisolone metasulphobenzoate and beclomethasone were studied. Comparison treatments included rectal aminosalicylates (4-ASA and 5-ASA), oral corticosteroids, placebo and rectal budesonide. Rectal preparations included suppositories, foam and liquid enemas. Participants included in the review Patients were included if they had

1997 DARE.

857. Limited bone loss due to corticosteroids: a systematic review of prospective studies in rheumatoid arthritis and other diseases

Limited bone loss due to corticosteroids: a systematic review of prospective studies in rheumatoid arthritis and other diseases Limited bone loss due to corticosteroids: a systematic review of prospective studies in rheumatoid arthritis and other diseases Limited bone loss due to corticosteroids: a systematic review of prospective studies in rheumatoid arthritis and other diseases Verhoeven A C, Boers M Authors' objectives To clarify the relationship between changes in bone density, the treated (...) disease and dose of corticosteroids prescribed. Searching The authors provide an outline of 3 clusters of structured keyword searches which they used to locate relevant studies. MEDLINE (from January 1966 to December 1995) was the only database searched. The authors state that no language restrictions applied. A bibliographic search of '6 key reviews' and an additional search of citations in selected studies were also carried out. In addition, the authors inquired amongst colleagues to elicit further

1997 DARE.

858. Corticosteroids in acute traumatic brain injury: systematic review of randomised controlled trials. Full Text available with Trip Pro

Corticosteroids in acute traumatic brain injury: systematic review of randomised controlled trials. To quantify the effectiveness and safety of corticosteroids in the treatment of acute traumatic brain injury.Systematic review of randomised controlled trials of corticosteroids in acute traumatic brain injury. Summary odds ratios were estimated as an inverse variance weighted average of the odds ratios for each study.Randomised trials available by March 1996.The included trials with outcome data (...) comprised 2073 randomised participants.The effect of corticosteroids on the risk of death was reported in 13 included trials. The pooled odds ratio for the 13 trials was 0.91 (95% confidence interval 0.74 to 1.12). Pooled absolute risk reduction was 1.8% (-2.5% to 5.7%). For the 10 trials that reported death or disability the pooled odds ratio was 0.90 (0.72 to 1.11). For infections of any type the pooled odds ratio was 0.92 (0.69 to 1.23) and for the seven trials reporting gastrointestinal bleeding

1997 BMJ

859. Effect of inhaled corticosteroids on episodes of wheezing associated with viral infection in school age children: randomised double blind placebo controlled trial. Full Text available with Trip Pro

Effect of inhaled corticosteroids on episodes of wheezing associated with viral infection in school age children: randomised double blind placebo controlled trial. To determine the effect of regular prophylactic inhaled corticosteroids on wheezing episodes associated with viral infection in school age children.Randomised, double blind, placebo controlled trial.Community based study in Southampton.104 children aged 7 to 9 years who had had wheezing in association with symptoms of upper and lower

1997 BMJ Controlled trial quality: predicted high

860. Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus. (Abstract)

Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus. Although epidural corticosteroid injections are commonly used for sciatica, their efficacy has not been established.In a randomized, double-blind trial, we administered up to three epidural injections of methylprednisolone acetate (80 mg in 8 ml of isotonic saline) or isotonic saline (1 ml) to 158 patients with sciatica due to a herniated nucleus pulposus. All patients had Oswestry disability scores higher than

1997 NEJM Controlled trial quality: predicted high