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Latest & greatest articles for corticosteroids
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on corticosteroids or other clinical topics then use Trip today.
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Comparison of physiotherapy, manipulation, and corticosteroid injection for treating shoulder complaints in general practice: randomised, single blind study. To compare the efficacy of physiotherapy, manipulation, and corticosteroid injection for treating patients with shoulder complaints in general practice.Randomised, single blind study.Seven general practices in the Netherlands.198 patients with shoulder complaints, of whom 172 were divided, on the basis of physical examination, into two (...) diagnostic groups: a shoulder girdle group (n = 58) and a synovial group (n = 114).Patients in the shoulder girdle group were randomised to manipulation or physiotherapy, and patients in the synovial group were randomised to corticosteroid injection, manipulation, or physiotherapy.Duration of shoulder complaints analysed by survival analysis.In the shoulder girdle group duration of complaints was significantly shorter after manipulation compared with physiotherapy (P < 0.001). Also the number of patients
Intermittent etidronate therapy to prevent corticosteroid-induced osteoporosis. Osteoporosis is a recognized complication of corticosteroid therapy. Whether it can be prevented is not known. We conducted a 12-month, randomized, placebo-controlled study of intermittent etidronate (400 mg per day for 14 days) followed by calcium (500 mg per day for 76 days), given for four cycles, in 141 men and women (age, 19 to 87 years) who had recently begun high-dose corticosteroid therapy. The primary (...) . 7 of 32 patients, P = 0.05), and the etidronate-treated postmenopausal women also had significantly fewer vertebral fractures per patient (P = 0.04).Intermittent etidronate therapy prevents the loss of vertebral and trochanteric bone in corticosteroid-treated patients.
Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. The role of long-acting, inhaled beta2-agonists in treating asthma is uncertain. In a double-blind study, we evaluated the effects of adding inhaled formoterol to both lower and higher doses of the inhaled glucocorticoid budesonide.After a four-week run-in period of treatment with budesonide (800 microg twice daily), 852 patients being
Efficacy and cost benefit of inhaled corticosteroids in patients considered to have mild asthma in primary care practice Efficacy and cost benefit of inhaled corticosteroids in patients considered to have mild asthma in primary care practice Efficacy and cost benefit of inhaled corticosteroids in patients considered to have mild asthma in primary care practice O'Byrne P, Cuddy L, Taylor D W, Birch S, Morris J, Syrotuik J Record Status This is a critical abstract of an economic evaluation (...) that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Inhaled corticosteroids (budesonide) for the prevention of asthmatic attacks and the reduction of associated symptoms. Type of intervention Secondary prevention and treatment. Economic study type Cost-benefit analysis. Study population Adults aged 18 years
Impact of inhaled corticosteroids on acute asthma hospitalization in Sweden Impact of inhaled corticosteroids on acute asthma hospitalization in Sweden Impact of inhaled corticosteroids on acute asthma hospitalization in Sweden Gerdtham U G, Hertzman P, Jonsson B, Boman G Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed (...) critical assessment on the reliability of the study and the conclusions drawn. Health technology Inhaled corticosteroids in the treatment of asthmatic patients. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Swedish inhabitants. Setting Clinic. The economic study was carried out in Sweden. Dates to which data relate The effectiveness and resource utilisation data were collected between 1978 and 1991 (except for 1984 in-patient care data which were
Low-dose corticosteroids in rheumatoid arthritis: a meta-analysis of their moderate-term effectiveness Low-dose corticosteroids in rheumatoid arthritis: a meta-analysis of their moderate-term effectiveness Low-dose corticosteroids in rheumatoid arthritis: a meta-analysis of their moderate-term effectiveness Saag K G, Criswell L A, Sems K M, Nettleman M D, Kolluri S Authors' objectives To compare the effectiveness of prednisolone to placebo and active drug controls, and to compare the relative (...) effectiveness of prednisolone to second line agents in the treatment of rheumatoid arthritis (RA). Searching Clinical studies published in the English language were identified by searching MEDLINE from 1966 to 1994 using the subject headings 'corticosteroids' and 'rheumatoid arthritis', and by handsearching Arthritis and Rheumatism and the Scandinavian Journal of Rheumatology from inception through 1994; all abstracts of Arthritis and Rheumatism over the past 15 years were also examined for unpublished
Corticosteroid injections for lateral epicondylitis: a systematic overview Corticosteroid injections for lateral epicondylitis: a systematic overview Corticosteroid injections for lateral epicondylitis: a systematic overview Assendelft W J, Hay E M, Adshead R, Bouter L M Authors' objectives To assess the effectiveness of corticosteroid injections in the treatment of lateral epicondylitis. Searching MEDLINE was searched from 1966 to 1994 and EMBASE from 1980 to 1994 using the subject headings (...) and keywords 'epicondylitis', 'tenditis', 'elbow' and 'injection'. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs) were included. Specific interventions included in the review Corticosteroid injections, using hydrocortisone, betamethasone or triamcinolone. Participants included in the review Patients suffering from lateral epicondylitis. No other details (e.g. age, sex) of the participants in the individual primary studies are given, though
A meta-analysis on the efficacy of epidural corticosteroids in the treatment of sciatica A meta-analysis on the efficacy of epidural corticosteroids in the treatment of sciatica A meta-analysis on the efficacy of epidural corticosteroids in the treatment of sciatica Watts R W, Silagy C A Authors' objectives To investigate the efficacy of epidural corticosteroids in the treatment of sciatica. Searching MEDLINE was searched from 1966 to the present. The terms searched were: 'epidural, caudal (...) corticosteroids' or 'methyl prednisolone', 'treatment of sciatica' ('lumbosacral radiculopathy'), in combination with 'randomised, double blind, controlled prospective trial'. Published reviews were examined, as were reference lists from clinical trials. The makers of Depomedrol and recently published authors in the field were contacted to identify unpublished trials. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs) were included. The follow-up period
Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature Cronin L, Cook D J, Carlet J, Heyland D K, King D, Lansang M A, Fisher C J Authors' objectives To determine the effect of corticosteroid therapy on morbidity and mortality in patients with sepsis. Searching MEDLINE (...) and EMBASE were searched from 1966 to 1993 using the following MeSH terms: 'sepsis' and 'steroids' or 'corticosteroids', and 'septic shock and 'steroids' or 'corticosteroids'. The Science Citation Index was searched using the terms 'sepsis' and (explode) 'corticosteroid', and 'septic shock' and (explode) 'corticosteroid'. Index Medicus was handsearched from 1951 onwardusing the terms 'corticosteroids', 'steroids', 'sepsis' and 'septic shock'. Personal files, reference lists of relevant primary and review
Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. European Mycophenolate Mofetil Cooperative Study Group. Preliminary studies suggested that mycophenolate mofetil (MMF), which inhibits proliferation of T and B cells, may reduce the frequency of acute rejection after renal transplantation. Our randomised, double-blind, multicentre, placebo-controlled study compared the efficacy and safety of MMF with placebo (...) for prevention of acute rejection episodes after first or second cadaveric renal allograft transplantation. 491 patients were enrolled; 166 were assigned placebo, 165 MMF 2 g, and 160 MMF 3 g. Patients also received cyclosporin and corticosteroids. Significantly fewer (p < or = 0.001) patients had biopsy-proven rejection or withdrew early from the trial (for any reason) during the first 6 months after transplantation with MMF 2 g (30.3%) or 3 g (38.8%) than with placebo (56.0%). The corresponding percentages
1995LancetControlled trial quality: predicted high
A meta-analysis of the effect of oral and inhaled corticosteroids on growth A meta-analysis of the effect of oral and inhaled corticosteroids on growth A meta-analysis of the effect of oral and inhaled corticosteroids on growth Allen D B, Mullen M, Mullen B Authors' objectives To assess the effect of inhaled and oral corticosteroids on linear growth, i.e. height. Searching The authors state that an 'exhaustive literature search of leading medical journals' was performed from 1956 to 1993 (...) , although the actual sources were not stated. Study selection Study designs of evaluations included in the review Studies using qualitatively different measurements of growth such as knemometry, and those using parametric statistics to analyse average heights, were excluded. Any remaining study capable of supplying the outcomes information appears to have been included. Specific interventions included in the review The specific corticosteroids were grouped into 3 classes: inhaled beclomethasone
Lack of effect of intraarticular corticosteroids for chronic pain in the cervical zygapophyseal joints. Chronic pain in the cervical zygapophyseal joints is a common problem after a whiplash injury. Treatment with intraarticular injections of corticosteroid preparations has been advocated, but the value of this approach has not been established. We compared the efficacy of a depot injection of a corticosteroid preparation with the efficacy of an injection of a local anesthetic agent in patients (...) percent of the preinjection level. The time from treatment to a 50 percent return of pain was compared in the two groups with the use of a survival analysis.Less than half the patients reported relief of pain for more than one week, and less than one in five patients reported relief for more than one month, irrespective of the treatment received. The median time to a return of 50 percent of the preinjection level of pain was 3 days in the 21 patients in the corticosteroid group and 3.5 days in the 20
Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen & Hanburys Limited UK Study Group. Guidelines on asthma management recommend that in patients who still have symptoms on treatment with low-dose inhaled corticosteroids the first step should be an increase in inhaled corticosteroid dose. The addition of long-acting inhaled beta 2-adrenoceptor agonists is another option. We have compared these two strategies
1994LancetControlled trial quality: predicted high
Prevention of corticosteroid osteoporosis. A comparison of calcium, calcitriol, and calcitonin. Prolonged corticosteroid therapy increases the risk of osteoporosis and fracture. We studied whether corticosteroid-induced osteoporosis could be prevented by treatment with calcium, calcitriol (1,25-dihydroxyvitamin D3), and calcitonin.One hundred three patients starting long-term corticosteroid therapy were randomly assigned to receive 1000 mg of calcium per day orally and either calcitriol (0.5 (...) to 1.0 microgram per day orally) plus salmon calcitonin (400 IU per day intranasally), calcitriol plus a placebo nasal spray, or double placebo for one year. Data on treatment efficacy were available for 92 of these patients. Bone density was measured every four months for two years by photon absorptiometry. There were no significant differences between groups with respect to age, underlying disease, initial bone density, or corticosteroid dose during the first year.Calcitriol (mean dose, 0.6
The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group. Optic neuritis is often the first clinical manifestation of multiple sclerosis, but little is known about the effect of corticosteroid treatment for optic neuritis on the subsequent risk of multiple sclerosis.We conducted a multicenter study in which 389 patients with acute optic neuritis (and without known multiple sclerosis) were randomly assigned
Trial of cyclosporin in corticosteroid-dependent chronic severe asthma. The treatment of chronic severe asthma is unsatisfactory for many patients. In a randomised, double-blind, placebo-controlled, crossover trial we have tested whether cyclosporin, which is thought to act primarily by inhibition of T lymphocyte activation, improves lung function in corticosteroid-dependent asthmatics. After a 4-week run-in period, 33 patients with longstanding asthma (mean duration 27 years), and who had (...) required continuous oral corticosteroids for a mean of 9.3 years, were randomised to receive either cyclosporin (initial dose 5 mg/kg per day) or placebo for 12 weeks, crossing over after a 2-week washout period. Mean baseline forced expiratory volume in 1 s (FEV1) was 60.1% of the predicted value. 2 patients failed to complete the protocol and 1 withdrew because of hypertrichosis. Cyclosporin therapy resulted in a mean increase above placebo of 12.0% in morning peak expiratory flow rate (PEFR; p less
1992LancetControlled trial quality: predicted high
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group. The use of corticosteroids to treat optic neuritis is controversial. At 15 clinical centers, we randomly assigned 457 patients with acute optic neuritis to receive oral prednisone (1 mg per kilogram of body weight per day) for 14 days; intravenous methylprednisolone (1 g per day) for 3 days, followed by oral prednisone (1 mg per kilogram per day) for 11 days; or oral
Levamisole for corticosteroid-dependent nephrotic syndrome in childhood. British Association for Paediatric Nephrology. In children with corticosteroid-responsive nephrotic syndrome who are dependent on high-dose prednisolone, alkylating therapy often fails to maintain a remission, and long-term immunosuppression may be hazardous. An alternative approach to treatment is to use an immunostimulant such as levamisole. 61 children with frequently relapsing corticosteroid sensitive and dependent (...) nephrotic syndrome were randomly allocated to receive levamisole, 2.5 mg/kg on alternate days (31 patients) or placebo (30 patients) for a maximum of 112 days. After entry to the trial, prednisolone was progressively reduced and was stopped by 56 days. The two groups were well matched for age and sex distribution, indices of corticosteroid toxicity, and previous alkylating therapy. 14 patients in the levamisole group and 4 in the placebo group remained in remission at 112 days (log rank analysis p less