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Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. After hip replacement surgery, prophylaxis following discharge from hospital is recommended to reduce the risk of venous thromboembolism. Our aim was to assess the oral, direct thrombin inhibitor dabigatran etexilate for such prophylaxis.In this double-blind study, we randomised 3494 patients undergoing total hip replacement to treatment (...) for 28-35 days with dabigatran etexilate 220 mg (n=1157) or 150 mg (1174) once daily, starting with a half-dose 1-4 h after surgery, or subcutaneous enoxaparin 40 mg once daily (1162), starting the evening before surgery. The primary efficacy outcome was the composite of total venous thromboembolism (venographic or symptomatic) and death from all causes during treatment. On the basis of the absolute difference in rates of venous thromboembolism with enoxaparin versus placebo, the non-inferiority
Dabigatran etexilate for primary deep vein thrombosis prevention post hip and knee surgery: horizon scanning technology briefing Dabigatran etexilate for primary deep vein thrombosis prevention post hip and knee surgery: horizon scanning technology briefing Dabigatran etexilate for primary deep vein thrombosis prevention post hip and knee surgery: horizon scanning technology briefing NHSC Record Status This is a bibliographic record of a published health technology assessment from a member (...) of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation NHSC. Dabigatran etexilate for primary deep vein thrombosis prevention post hip and knee surgery: horizon scanning technology briefing. Birmingham: National Horizon Scanning Centre (NHSC). 2006 Authors' objectives This study examines the use of dabigatran etexilate for primary deep vein thrombosis prevention post hip and knee surgery. Timeliness warning Available on request from NHSC. Final