Latest & greatest articles for diclofenac

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Top results for diclofenac

21. Voltarene (diclofenac sodium)

Voltarene (diclofenac sodium) HAS - Medical, Economic and Public Health Assessment Division 1/40 The legally binding text is the original French version T TR RA AN NS SP PA AR RE EN NC CY Y C CO OM MM MI IT TT TE EE E Opinion 5 February 2014 VOLTARENE 25 mg, gastro-resistant coated tablet B/30 (CIP: 34009 338 144 5 8) VOLTARENE 50 mg, gastro-resistant coated tablet B/30 (CIP: 34009 323 511 7 6) VOLTARENE LP 75 mg, prolonged-release coated tablet B/30 (CIP: 34009 335 920 4 2) VOLTARENE LP 100 mg (...) , prolonged-release coated tablet B/15 (CIP: 34009 324 604 9 6) VOLTARENE ENFANT, suppository B/10 (CIP: 34009 322 395 3 5) VOLTARENE 100 mg, suppository B/10 (CIP: 34009 322 143 4 1) VOLTARENE 75 mg/3 ml, solution for injection B/2 (CIP: 34009 324 522 2 4) Applicant: NOVARTIS PHARMA SAS INN diclofenac sodium ATC code (2012) M01AB05 (Antiinflammatory and antirheumatic products, non-steroids) Reason for the review Re-assessment of the Actual Benefit of all systemically administered diclofenac-based

2014 Haute Autorite de sante

22. Voltarendolo (diclofenac potassium) - Symptomatic treatment of painful conditions of mild to moderate intensity and/or fever

Voltarendolo (diclofenac potassium) - Symptomatic treatment of painful conditions of mild to moderate intensity and/or fever HAS - Medical, Economic and Public Health Assessment Division 1/39 The legally binding text is the original French version T TR RA AN NS SP PA AR RE EN NC CY Y C CO OM MM MI IT TT TE EE E Opinion 5 February 2014 VOLTARENDOLO 12.5 mg, coated tablet B/30 tablets (CIP: 34009 359 411 2 1) Applicant: NOVARTIS SANTÉ FAMILIALE S.A.S. INN diclofenac potassium ATC Code (2012 (...) ): N02BG (Other analgesics and antipyretics) Reason for the review Re-assessment of the Actual Benefit of all medicines based on diclofenac administered systemically at the request of the Committee, pursuant to Article R-163-21 of the French Social Security Code Renewal of inclusion on the list of medicinal products refundable by National Health Insurance Lists concerned National Health Insurance (French Social Security Code L.162 17) Hospital use (French Public Health Code L.5123-2) Indication

2014 Haute Autorite de sante

23. Diclofenac

Diclofenac USE OF DICLOFENAC IN PREGNANCY 0344 892 0909 USE OF DICLOFENAC IN PREGNANCY (Date of issue: July 2014 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) used (...) to treat acute and chronic pain (including dysmenorrhoea) and in the management of rheumatoid arthritis. Some studies have suggested that use of NSAIDs in early pregnancy may be associated with an increased risk of spontaneous abortion. Data regarding diclofenac use are insufficient to assess the risk for this specific NSAID. NSAID use in pregnancy has been associated with increased risks of various different congenital malformations, including cardiovascular defects and oral clefts. No association

2014 UK Teratology Information Service

24. Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel-group, multicentre phase III randomised clinical trial (PubMed)

Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel-group, multicentre phase III randomised clinical trial Tanezumab, a monoclonal antibody, inhibits nerve growth factor and reduces chronic pain. This randomised, double-blind, controlled multicentre study was conducted to evaluate the efficacy and safety of tanezumab added to oral diclofenac sustained release (DSR) in patients (...) not confirm osteonecrosis in any patient.Addition of tanezumab to DSR resulted in significant improvements in pain, function and global assessments in patients with OA. Although no new safety signals were observed, the higher incidence of adverse events in the tanezumab+diclofenac group suggests that combination therapy is unfavourable. Further investigations of tanezumab monotherapy for OA pain treatment are required.NCT00864097.Published by the BMJ Publishing Group Limited. For permission to use (where

2013 EvidenceUpdates

25. Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: A multicentre, randomised, blinded, controlled and non-inferiority trial (PubMed)

Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: A multicentre, randomised, blinded, controlled and non-inferiority trial Acute ankle sprains are common and activity limiting injuries, and topical diclofenac gel has proven efficacy in alleviating pain and restoring function. This trial aimed to compare a topical natural agent, Traumeel with topical diclofenac gel (1%) in the management of acute ankle sprain.This prospective, multicentre (...) , randomised, blinded, active-control and non-inferiority study involved 449 physically active adults sustaining unilateral grade 1 or 2 ankle sprain within the past 24 h. Participants were randomised to receive 2 g of Traumeel ointment (T-O) (n = 152) or Traumeel gel (T-G) (n = 150) or diclofenac gel (D-G) (n = 147), administered topically to the ankle three times a day for 14 days, with 6-weeks follow up.Day 7 median percentage reductions in Visual Analogue Scale pain score were 60.6%, 71.1% and 68.9

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2013 EvidenceUpdates

26. The cost-effectiveness of celecoxib vs diclofenac in the treatment of osteoarthritis in the UK: an update to the NICE model using data from the CONDOR trial

The cost-effectiveness of celecoxib vs diclofenac in the treatment of osteoarthritis in the UK: an update to the NICE model using data from the CONDOR trial The cost-effectiveness of celecoxib vs diclofenac in the treatment of osteoarthritis in the UK: an update to the NICE model using data from the CONDOR trial The cost-effectiveness of celecoxib vs diclofenac in the treatment of osteoarthritis in the UK: an update to the NICE model using data from the CONDOR trial Brereton N, Winn B, Akehurst (...) R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study evaluated the cost-effectiveness of celecoxib plus a proton pump inhibitor (PPI), compared with diclofenac plus a PPI, for patients with osteoarthritis. The authors

2013 NHS Economic Evaluation Database.

27. Diclofenac: public consultation on availability as a pharmacy medicine

Diclofenac: public consultation on availability as a pharmacy medicine Diclofenac: public consultation on availability as a pharmacy medicine - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Diclofenac: public consultation on availability as a pharmacy medicine Public consultation launched on the continued availability of oral diclofenac as a pharmacy (P) medicine and on risk-minimisation measures advised by the Commission on Human Medicines. Published 11 December 2014 From (...) : Therapeutic area: Article date: August 2013 We have launched a public consultation on the continued availability of oral diclofenac as a pharmacy (P) medicine and in particular on risk-minimisation measures advised by the Commission on Human Medicines. Any comments can be emailed to ; alternatively they may be addressed to: Colette McCreedy, Self Medication Specialist and Unit Manager, MHRA, 3rd Floor, 151 Buckingham Palace Road, London SW1W 9SZ. Comments must arrive no later than 28 October 2013

2013 MHRA Drug Safety Update

28. Diclofenac: new contraindications and warnings

Diclofenac: new contraindications and warnings Diclofenac: new contraindications and warnings - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Diclofenac: new contraindications and warnings New recommendations after a Europe-wide review of cardiovascular safety. Published 11 December 2014 From: Therapeutic area: , , Contents Article date: June 2013 An increased risk of heart attack and stroke with some non-selective non-steroidal anti-inflammatory drugs (NSAIDs (...) )—such as diclofenac—is well recognised, particularly with long-term use of high doses and in patients who are already at high risk. Warnings for healthcare professionals and patients have been included in the product information and in the British National Formulary for some years. The European Medicines Agency’s Pharmacovigilance Risk Assessment Committee has recently recommended updates to the treatment advice for diclofenac in light of the findings of a Europe-wide review of the cardiovascular safety of NSAIDs

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2013 MHRA Drug Safety Update

29. Topical Administration of Diclofenac is as Effective as Systemic Administration in Alleviating Ailments of Temporomandibular Joint Disorder

Topical Administration of Diclofenac is as Effective as Systemic Administration in Alleviating Ailments of Temporomandibular Joint Disorder UTCAT2225, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Topical Administration of Diclofenac is as Effective as Systemic Administration in Alleviating Ailments of Temporomandibular Joint Disorder Clinical Question In a patient suffering from Temporomandibular Joint Disorder (...) , is topical administration of treatment as effective when compared to systemic administration of treatment in alleviating ailments? Clinical Bottom Line Topical administration of diclofenac is as effective as systemic administration in alleviating ailments of temporomandibular joint disorder. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Di Rienzo/2004 36 adult patients diagnosed with dysfunction of the TMJ

2012 UTHSCSA Dental School CAT Library

30. Efficacy of Oral Enzyme Combination vs. Diclofenac in the Management of Large Joint Osteoarthritis: A Systematic Review

Efficacy of Oral Enzyme Combination vs. Diclofenac in the Management of Large Joint Osteoarthritis: A Systematic Review "Efficacy of Oral Enzyme Combination vs. Diclofenac in the Management o" by Scott T. Hall < > > > > > Title Author Date of Graduation Summer 8-9-2012 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Mark Pedemonte, MD Second Advisor Annjanette Sommers PA-C, MS Rights . Abstract Background: Osteoarthritis is the most common (...) and trypsin. The purpose of this review is to evaluate the efficacy of oral enzyme combinations to the potent NSAID diclofenac in the management of osteoarthritis. Method: An extensive literature search was done using CINHAL, Medline, Evidence-Based Medicine Reviews Multifile, and Web of Science. The search included the terms Bromelain, Arthritis and Non-Steroidal Anti-inflammatory agents. Results: Five randomized control trials met the inclusion criteria. Each study was very similar with respect to study

2012 Pacific University EBM Capstone Project

31. Safety profile of topical diclofenac: a meta-analysis of blinded, randomized, controlled trials in musculoskeletal conditions

Safety profile of topical diclofenac: a meta-analysis of blinded, randomized, controlled trials in musculoskeletal conditions Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

32. Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. (PubMed)

Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Cyclo-oxygenase (COX)-2-selective non-steroidal anti-inflammatory drugs (NSAIDs) and non-selective NSAIDs plus a proton-pump inhibitor (PPI) have similar upper gastrointestinal outcomes, but risk of clinical outcomes across the entire gastrointestinal tract might be lower with selective drugs than with non-selective drugs. We aimed to compare risk of gastrointestinal (...) events associated with celecoxib versus diclofenac slow release plus omeprazole.We undertook a 6-month, double-blind, randomised trial in patients with osteoarthritis or rheumatoid arthritis at increased gastrointestinal risk at 196 centres in 32 countries or territories. Patients tested negative for Helicobacter pylori and were aged 60 years and older or 18 years and older with previous gastroduodenal ulceration. We used a computer-generated randomisation schedule to assign patients in a 1:1 ratio

2010 Lancet

33. Review of the efficacy and tolerability of the diclofenac epolamine topical patch 1.3% in patients with acute pain due to soft tissue injuries

Review of the efficacy and tolerability of the diclofenac epolamine topical patch 1.3% in patients with acute pain due to soft tissue injuries Review of the efficacy and tolerability of the diclofenac epolamine topical patch 1.3% in patients with acute pain due to soft tissue injuries Review of the efficacy and tolerability of the diclofenac epolamine topical patch 1.3% in patients with acute pain due to soft tissue injuries Kuehl KS CRD summary The review concluded that diclofenac epolamine (...) topical patch 1.3% significantly reduced pain in patients with soft tissue injuries and was well tolerated. Given the potential for bias in the review and the limitations of the small evidence base (such as uncertain quality and heterogeneity), the author's conclusions should be interpreted with caution. Authors' objectives To assess the efficacy and tolerability of the diclofenac epolamine topical patch 1.3% in the treatment of patients with acute pain due to soft tissue injuries. Searching MEDLINE

2010 DARE.

34. Topical diclofenac for the treatment of musculoskeletal pain unrelated to osteoarthritis: a review of the clinical effectiveness

Topical diclofenac for the treatment of musculoskeletal pain unrelated to osteoarthritis: a review of the clinical effectiveness Topical diclofenac for the treatment of musculoskeletal pain unrelated to osteoarthritis: a review of the clinical effectiveness Topical diclofenac for the treatment of musculoskeletal pain unrelated to osteoarthritis: a review of the clinical effectiveness Tsakonas E, Argaez C Record Status This is a bibliographic record of a published health technology assessment (...) from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Tsakonas E, Argaez C. Topical diclofenac for the treatment of musculoskeletal pain unrelated to osteoarthritis: a review of the clinical effectiveness. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). 2009 Authors' conclusions The studies reviewed for this report suggest that in general, topical diclofenac (in gel and patch formulations), is safe and effective

2009 Health Technology Assessment (HTA) Database.

35. Lower gastrointestinal events in a double-blind trial of the cyclo-oxygenase-2 selective inhibitor etoricoxib and the traditional nonsteroidal anti-inflammatory drug diclofenac (PubMed)

Lower gastrointestinal events in a double-blind trial of the cyclo-oxygenase-2 selective inhibitor etoricoxib and the traditional nonsteroidal anti-inflammatory drug diclofenac Nonsteroidal anti-inflammatory drugs (NSAIDs) cause lower gastrointestinal (GI) clinical events such as bleeding. Cyclo-oxygenase (COX)-2 selective inhibitors decrease upper GI events, but no prospective trial has prespecified assessment of lower GI clinical events.Patients >or=50 years old with osteoarthritis (...) or rheumatoid arthritis were randomly assigned to etoricoxib (60 or 90 mg qd) or diclofenac (150 mg qd). Lower GI clinical events, confirmed by a blinded adjudication committee, included perforation or obstruction requiring hospitalization or bleeding (gross or occult rectal bleeding without upper GI cause associated with hypotension, orthostatic changes in heart rate [>20 beats per minute] or blood pressure [>20 mmHg systolic or >10 mmHg diastolic], hemoglobin drop >or=2 g/dl, or transfusion; or observed

2008 EvidenceUpdates

36. Gastrointestinal tolerability of etoricoxib in rheumatoid arthritis patients: results of the etoricoxib vs diclofenac sodium gastrointestinal tolerability and effectiveness trial (EDGE-II) (PubMed)

Gastrointestinal tolerability of etoricoxib in rheumatoid arthritis patients: results of the etoricoxib vs diclofenac sodium gastrointestinal tolerability and effectiveness trial (EDGE-II) A randomised, double-blind study to compare the gastrointestinal (GI) tolerability, safety and efficacy of etoricoxib and diclofenac in patients with rheumatoid arthritis (RA).A total of 4086 patients (mean age 60.8 years) diagnosed with RA were enrolled and received etoricoxib 90 mg daily (n = 2032 (...) ) or diclofenac 75 mg twice daily (n = 2054). Use of gastroprotective agents and low-dose aspirin was allowed. The prespecified primary end point consisted of the cumulative rate of patient discontinuations due to clinical and laboratory GI adverse experiences (AEs). General safety was also assessed, including adjudicated thrombotic cardiovascular event data. Efficacy was evaluated using the Patient Global Assessment of Disease Status (PGADS; 0-4 point scale).Mean (SD; maximum) duration of treatment was 19.3

2008 EvidenceUpdates

37. Adjunctive diclofenac and spinal manipulation did not speed recovery of acute low back pain

Adjunctive diclofenac and spinal manipulation did not speed recovery of acute low back pain Adjunctive diclofenac and spinal manipulation did not speed recovery of acute low back pain | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Adjunctive diclofenac and spinal manipulation did not speed recovery of acute low back pain Article Text Therapeutics Adjunctive diclofenac and spinal manipulation did not speed recovery of acute low back pain

2008 Evidence-Based Medicine (Requires free registration)

38. Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. (PubMed)

Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. Upper gastrointestinal safety of cyclo-oxygenase (COX)-2 selective inhibitors versus traditional non-steroidal anti-inflammatory drugs (NSAIDs) has not been assessed in trials that simulate standard clinical practice. Our aim was to assess the effects (...) of these drugs on gastrointestinal outcomes in a population that includes patients taking gastrointestinal protective therapy.A prespecified pooled intent-to-treat analysis of three double-blind randomised comparisons of etoricoxib (60 or 90 mg daily) and diclofenac (150 mg daily) in 34 701 patients with osteoarthritis or rheumatoid arthritis was done for upper gastrointestinal clinical events (bleeding, perforation, obstruction, or ulcer) and the subset of complicated events (perforation, obstruction

2007 Lancet

39. Assessment of diclofenac or spinal manipulative therapy, or both, in addition to recommended first-line treatment for acute low back pain: a randomised controlled trial. (PubMed)

Assessment of diclofenac or spinal manipulative therapy, or both, in addition to recommended first-line treatment for acute low back pain: a randomised controlled trial. We aimed to investigate whether the addition of non-steroidal anti-inflammatory drugs or spinal manipulative therapy, or both, would result in faster recovery for patients with acute low back pain receiving recommended first-line care.240 patients with acute low back pain who had seen their general practitioner and had been (...) given advice and paracetamol were randomly allocated to one of four groups in our community-based study: diclofenac 50 mg twice daily and placebo manipulative therapy (n=60); spinal manipulative therapy and placebo drug (n=60); diclofenac 50 mg twice daily and spinal manipulative therapy (n=60); or double placebo (n=60). The primary outcome was days to recovery from pain assessed by survival curves (log-rank test) in an intention-to-treat analysis. This trial was registered with the Australian

2007 Lancet

40. Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the knee

Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the knee Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the knee | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using (...) your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the knee Article Text

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2006 Evidence-Based Medicine (Requires free registration)