Latest & greatest articles for epilepsy

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Top results for epilepsy

21. Cannabis derivative may reduce seizures in some severe drug-resistant epilepsies, but adverse events increase

Cannabis derivative may reduce seizures in some severe drug-resistant epilepsies, but adverse events increase Seizures may be reduced in some severe drug-resistant epilepsies by a cannabis derivative Discover Portal Discover Portal Cannabis derivative may reduce seizures in some severe drug-resistant epilepsies, but adverse events increase Published on 26 June 2018 doi: In people with some types of severe, drug-resistant epilepsy, adding cannabidiol to their treatment may reduce seizure (...) frequency and improve quality of life compared with a placebo. The likelihood of being free from seizures for more than a year was still low, about 8%. However, an additional 12% of people had serious adverse effects with cannabidiol. These findings come from a systematic review, which included six trials in 555 patients. Most were children and adolescents with rare forms of epilepsy, and findings may not apply to other forms of the condition. The included trials were poorly reported and show some bias

2019 NIHR Dissemination Centre

22. A range of anti-epilepsy drugs are effective as first-line treatment

A range of anti-epilepsy drugs are effective as first-line treatment A range of anti-epilepsy drugs are effective as first-line treatment Discover Portal Discover Portal A range of anti-epilepsy drugs are effective as first-line treatment Published on 12 September 2017 doi: Lamotrigine and levetiracetam are emerging as first-line treatments for epilepsy, which people may be more likely to keep taking than carbamazepine. Reducing the risk of adverse events and treatment withdrawal is important (...) when selecting an anti-epilepsy drug as it usually will need to be taken long-term. This study reviewed evidence on anti-epilepsy drugs in adults and children. The drugs were compared directly or indirectly with each other. The main outcome of interest was time to withdrawal from treatment, which indicates effectiveness and tolerability. The findings support NICE recommendations to use carbamazepine or lamotrigine as first-line therapies for epilepsy with partial seizures, with levetiracetam

2019 NIHR Dissemination Centre

23. Topiramate for juvenile myoclonic epilepsy. Full Text available with Trip Pro

Topiramate for juvenile myoclonic epilepsy. Topiramate is a newer broad-spectrum antiepileptic drug (AED). Some studies have shown the benefits of topiramate in the treatment of juvenile myoclonic epilepsy (JME). However, there are no current systematic reviews to determine the efficacy and tolerability of topiramate in people with JME. This is an update of a Cochrane Review first published in 2015, and last updated in 2017.To evaluate the efficacy and tolerability of topiramate (...) in the treatment of JME.For the latest update, on 10 July 2018 we searched the Cochrane Register of Studies (CRS Web), which includes the Cochrane Epilepsy Group's Specialized Register and the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (Ovid 1946- ), and ClinicalTrials.gov. We also searched ongoing trials registers, reference lists and relevant conference proceedings, and contacted study authors and pharmaceutical companies.We included randomized controlled trials (RCTs) investigating

2019 Cochrane

24. Epilepsy in adults. (Abstract)

Epilepsy in adults. Epilepsy is one of the most common serious brain conditions, affecting over 70 million people worldwide. Its incidence has a bimodal distribution with the highest risk in infants and older age groups. Progress in genomic technology is exposing the complex genetic architecture of the common types of epilepsy, and is driving a paradigm shift. Epilepsy is a symptom complex with multiple risk factors and a strong genetic predisposition rather than a condition with a single (...) expression and cause. These advances have resulted in the new classification of epileptic seizures and epilepsies. A detailed clinical history and a reliable eyewitness account of a seizure are the cornerstones of the diagnosis. Ancillary investigations can help to determine cause and prognosis. Advances in brain imaging are helping to identify the structural and functional causes and consequences of the epilepsies. Comorbidities are increasingly recognised as important aetiological and prognostic

2019 Lancet

25. Brivaracetam (Briviact) for use in the treatment of patients with refractory epilepsy

Brivaracetam (Briviact) for use in the treatment of patients with refractory epilepsy Brivaracetam (Briviact ® ). Reference number 3387. Page 1 of 3 AWMSG Secretariat Assessment Report – Limited submission Brivaracetam (Briviact ® ? ) 10 mg, 25 mg, 50 mg, 75 mg and 100 mg film-coated tablets; 10 mg/ml oral solution; 10 mg/ml solution for injection/infusion Company: UCB Pharma Ltd Licensed indication under consideration: As adjunctive therapy in the treatment of partial onset seizures (...) with or without secondary generalisation in children from 4 to = 15 years of age with epilepsy. Brivaracetam (Briviact ® ) should be restricted to use in the treatment of patients with refractory epilepsy, who remain uncontrolled with, or are intolerant to, other adjunctive anti-epileptic medicines. ? This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. Date

2019 All Wales Medicines Strategy Group

26. A Prediction Model to Determine Childhood Epilepsy After 1 or More Paroxysmal Events Full Text available with Trip Pro

A Prediction Model to Determine Childhood Epilepsy After 1 or More Paroxysmal Events The clinical profile of children who had possible seizures is heterogeneous, and accuracy of diagnostic testing is limited. We aimed to develop and validate a prediction model that determines the risk of childhood epilepsy by combining available information at first consultation.We retrospectively collected data of 451 children who visited our outpatient department for diagnostic workup related to 1 or more (...) paroxysmal event(s). At least 1 year of follow-up was available for all children who were diagnosed with epilepsy or in whom diagnosis remained inconclusive. Clinical characteristics (sex, age of first seizure, event description, medical history) and EEG report were used as predictor variables for building a multivariate logistic regression model. Performance was validated in an external cohort (n = 187).Model discrimination was excellent, with an area under the receiver operating characteristic curve

2019 EvidenceUpdates

27. Surgical outcomes for medically intractable epilepsy in low- and middle-income countries: a systematic review and meta-analysis Full Text available with Trip Pro

Surgical outcomes for medically intractable epilepsy in low- and middle-income countries: a systematic review and meta-analysis OBJECTIVEThe aim of this study was to describe the current state of epilepsy surgery and establish estimates of seizure outcomes following surgery for medically intractable epilepsy (MIE) in low- and middle-income countries (LMICs).METHODSThe MEDLINE and Embase databases were searched without publication date restriction. This search was supplemented by a manual screen (...) of key epilepsy and neurosurgical journals (January 2005 to December 2016). Studies that reported outcomes for at least 10 patients of any age undergoing surgery for MIE in LMICs over a defined follow-up period were included. A meta-analysis with a random-effects model was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement and MOOSE (Meta-analysis of Observational Studies in Epidemiology) guidelines. Pooled estimates of seizure

2019 EvidenceUpdates

28. The role of resting state fMRI for language mapping in patients undergoing glioma and epilepsy surgery: a systematic review

The role of resting state fMRI for language mapping in patients undergoing glioma and epilepsy surgery: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2019 PROSPERO

29. The role of preoperative diffusion tensor imaging in predicting and improving functional outcome in paediatric patients undergoing epilepsy surgery: a systematic review

The role of preoperative diffusion tensor imaging in predicting and improving functional outcome in paediatric patients undergoing epilepsy surgery: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2019 PROSPERO

30. Efficacy and safety of Responsive Neurostimulation (RNS) in drug-resistant epilepsy patients: a systematic review and meta-analysis

Efficacy and safety of Responsive Neurostimulation (RNS) in drug-resistant epilepsy patients: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2019 PROSPERO

31. Analysis of the use of medicinal cannabis for patients with epilepsy: a systematic review of the literature

Analysis of the use of medicinal cannabis for patients with epilepsy: a systematic review of the literature Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation

2019 PROSPERO

32. Characterisation of phenotypes and causes of epilepsies in low- and middle-income countries

Characterisation of phenotypes and causes of epilepsies in low- and middle-income countries Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address

2019 PROSPERO

33. Physical activity in children and adults with epilepsy - a systematic review

Physical activity in children and adults with epilepsy - a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

34. What is the effectiveness of genetic testing in determining the aetiology of epilepsy?

What is the effectiveness of genetic testing in determining the aetiology of epilepsy? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

35. Treatments for peri-menstrual seizures in catamenial epilepsy [Cochrane protocol]

Treatments for peri-menstrual seizures in catamenial epilepsy [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

36. Epilepsy

Epilepsy Epilepsy - NICE CKS Share Epilepsy - Summary A seizure is the transient occurrence of signs or symptoms due to abnormal excessive or synchronous neuronal activity in the brain. Epilepsy is a disease of the brain defined by any of the following: At least two unprovoked seizures occurring more than 24 hours apart. One unprovoked seizure and a probability of further seizures similar to the general recurrence risk after two unprovoked seizures, occurring over the next 10 years. Diagnosis (...) of an epilepsy syndrome. Convulsive status epilepticus is a prolonged convulsive seizure for 5 minutes or longer, or recurrent seizures one after the other without recovery in between. A cause of epilepsy is only identified in about one third of people with the disorder. Causes include structural, genetic, infectious, metabolic, and immune. In the UK, the prevalence of epilepsy is estimated to be 5–10 cases per 1000. It is more common in people with learning disabilities. Clinical features of epilepsy

2019 NICE Clinical Knowledge Summaries

37. Effectiveness of AEDs for childhood epilepsy with centrotemporal spikes (CECTS)

Effectiveness of AEDs for childhood epilepsy with centrotemporal spikes (CECTS) Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

38. Interventions that influence outcomes of epilepsy in mitochondrial disease: a systematic review

Interventions that influence outcomes of epilepsy in mitochondrial disease: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

39. Feasibility of quality-of-life patient-reported outcome measurement in epilepsy clinics: a systematic review

Feasibility of quality-of-life patient-reported outcome measurement in epilepsy clinics: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

40. Stimulant and non-stimulant drug therapy for people with attention deficit hyperactivity disorder and epilepsy [Cochrane protocol]

Stimulant and non-stimulant drug therapy for people with attention deficit hyperactivity disorder and epilepsy [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2019 PROSPERO