Latest & greatest articles for epilepsy

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Top results for epilepsy

421. Intravenous immunoglobulins for epilepsy. (Abstract)

Intravenous immunoglobulins for epilepsy. Epilepsy is a common neurological condition, with an estimated incidence of 50 per 100,000 persons. People with epilepsy may present with various types of immunological abnormalities, such as low serum IgA level, lack of IgG subclass and identification of certain types of antibodies. Intravenous immunoglobulin (IVIg) treatment may represent a valuable approach and its efficacy has important implications for epilepsy management.To examine the effects (...) of IVIg on the frequency and duration of seizures, quality of life and adverse effects, when used as monotherapy or as add-on treatment for people with epilepsy.We searched the Cochrane Epilepsy Group Specialized Register (14 June 2010), the Cochrane Central Register of Controlled Trials (Issue 2 of 4, The Cochrane Library, 2010), MEDLINE (1950 to June 2010), Web of Science (14 June 2010), Current Controlled Trials (11 June 2010), the National Research Register (NRR) archive (11 June 2010), the US

2011 Cochrane

422. Retigabine for the adjunctive treatment of partial onset seizures in epilepsy (TA232)

Retigabine for the adjunctive treatment of partial onset seizures in epilepsy (TA232) Retigabine for the adjunctive treatment of partial onset seizures in epilepsy | Guidance | NICE Retigabine for the adjunctive treatment of partial onset seizures in epilepsy Technology appraisal guidance [TA232] Published date: 27 July 2011 Guidance The guidance has been withdrawn because GlaxoSmithKline has discontinued retigabine (Trobalt) due to limited usage. Explore © NICE [year]. All rights reserved

2011 National Institute for Health and Clinical Excellence - Technology Appraisals

423. Vagus nerve stimulation for epilepsy

Vagus nerve stimulation for epilepsy Vagus nerve stimulation for epilepsy; additional work commissioned to encompass an update of evidence A WEST MIDLANDS COMMISSIONING SUPPORT UNIT REPORT Report commissioned by: West Midlands Specialised Commissioning Team Produced by: West Midlands Commissioning Support Unit Public Health, Epidemiology and Biostatistics School of Health and Population Sciences The University of Birmingham Authors: Martin Connock, Systematic Reviewer Zulian Liu, Systematic (...) practitioners, policy- makers and researchers involved in healthcare commissioning and policy development. This report is from our series of rapid evidence reviews examining the clinical effectiveness and cost-effectiveness of health care interventions. ACKNOWLEDGEMENTS We thank Ann Massey for assistance in obtaining full texts of publications. 3 IMPLICATION OF THE FINDINGS OF THIS REPORT ON THE CURRENT WEST MIDLANDS SPECIALISED COMMISSIONING TEAM POSITION ON VAGUS NERVE STIMULATION FOR EPILEPSY Context

2011 West Midlands Clinical Support Unit

424. Effectiveness and safety of antiepileptic medications in patients with epilepsy

Effectiveness and safety of antiepileptic medications in patients with epilepsy Effectiveness and safety of antiepileptic medications in patients with epilepsy Effectiveness and safety of antiepileptic medications in patients with epilepsy Talati R, Scholle JM, Phung OJ, Baker WL, Baker EL, Ashaye A, Kluger J, Quercia R, Mather J, Giovenale S, Coleman CI, White CM CRD summary The authors concluded that some older antiepileptic medications had some efficacy advantages over newer antiepileptic (...) medications and others had similar efficacy. All older medications had more adverse events. Innovator and generic versions of an antiepileptic medication showed similar efficacy and safety. This was a well-conducted review. The authors’ conclusions reflect the evidence presented and are likely to be reliable. Authors' objectives To compare the effectiveness, safety and tolerability of antiepileptic medications in patients with epilepsy. Searching MEDLINE, Cochrane Central Register of Controlled Trials

2011 DARE.

425. Risk of sudden unexpected death in epilepsy in patients given adjunctive antiepileptic treatment for refractory seizures: a meta-analysis of placebo-controlled randomised trials

Risk of sudden unexpected death in epilepsy in patients given adjunctive antiepileptic treatment for refractory seizures: a meta-analysis of placebo-controlled randomised trials Risk of sudden unexpected death in epilepsy in patients given adjunctive antiepileptic treatment for refractory seizures: a meta-analysis of placebo-controlled randomised trials Risk of sudden unexpected death in epilepsy in patients given adjunctive antiepileptic treatment for refractory seizures: a meta-analysis (...) of placebo-controlled randomised trials Ryvlin P, Cucherat M, Rheims S CRD summary This review concluded that risk of sudden unexpected death in epilepsy in adult patients with refractory epilepsy in trials of add-on antiepileptic drugs was lower with antiepileptic drugs at efficacious doses compared to placebo. Despite some uncertainty regarding the quality of the trials, the authors' conclusions reflect the evidence and are likely to be reliable. Authors' objectives To investigate whether patients

2011 DARE.

426. Lacosamide (Vimpat) for epilepsy ? first and second line

Lacosamide (Vimpat) for epilepsy ? first and second line Lacosamide (Vimpat) for epilepsy – first and second line Lacosamide (Vimpat) for epilepsy – first and second line NHSC Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation NHSC. Lacosamide (Vimpat) for epilepsy – first and second line. Birmingham: National Horizon Scanning Centre (NHSC (...) ). Horizon Scanning Review. 2011 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Acetamides; Anticonvulsants; Epilepsys Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence The NIHR Horizon Scanning Centre, Department of Public Health, Epidemiology, and Biostatistics, School of Health and Population Sciences, University of Birmingham, 90 Vincent Drive, Edgbaston, Birmingham, B15 2SP

2011 Health Technology Assessment (HTA) Database.

427. Generalized Epilepsy with Febrile Seizures Plus (GEFS+)

Generalized Epilepsy with Febrile Seizures Plus (GEFS+) Generalized Epilepsy with Febrile Seizures Plus (GEFS+) Generalized Epilepsy with Febrile Seizures Plus (GEFS+) Citation Generalized Epilepsy with Febrile Seizures Plus (GEFS+) Lansdale: HAYES, Inc.. Genetic Testing Publication. 2011 Authors' conclusions Febrile seizures (seizures triggered by fever) occur in 2% to 5% of children in the general population, generally occurring between the ages of 6 months and 6 years, with spontaneous (...) remission by the age of 6. The persistence of febrile seizures beyond 6 years of age, or febrile seizures in conjunction with afebrile convulsions, is referred to as febrile seizures plus (FS+). A heritable disorder characterized by febrile seizures is known as generalized epilepsy with febrile seizures plus (GEFS+). GEFS+ is a spectrum disorder typified by febrile seizures or FS+ in multiple family members, some of whom progress to epilepsy. The range of seizure types that may occur in families

2011 Health Technology Assessment (HTA) Database.

428. Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates

Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

429. Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response

Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

430. Current use of antiepileptic drugs is associated with an increased risk of suicidality in people with depression but not in people with epilepsy or bipolar disorder

Current use of antiepileptic drugs is associated with an increased risk of suicidality in people with depression but not in people with epilepsy or bipolar disorder Current use of antiepileptic drugs is associated with an increased risk of suicidality in people with depression but not in people with epilepsy or bipolar disorder | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your (...) with an increased risk of suicidality in people with depression but not in people with epilepsy or bipolar disorder Article Text Aetiology Current use of antiepileptic drugs is associated with an increased risk of suicidality in people with depression but not in people with epilepsy or bipolar disorder Statistics from Altmetric.com Question Question Are antiepileptic drugs (AEDs) associated with an increased risk of attempted or completed suicide? Population 5 130 795 people enrolled with a general practice

2011 Evidence-Based Mental Health

431. Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy (Abstract)

Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy This study assessed the efficacy and safety of the neuronal potassium channel opener ezogabine (US adopted name; EZG)/retigabine (international nonproprietary name; RTG) as adjunctive therapy for refractory partial-onset seizures.This was a multicenter, randomized, double-blind, placebo-controlled trial in adults with ≥4 partial-onset seizures per month receiving 1 to 3 antiepileptic drugs. EZG (RTG

2011 EvidenceUpdates Controlled trial quality: predicted high

432. [Criteria for indication and surgical treatment in Parkinson´s disease and epilepsy]

[Criteria for indication and surgical treatment in Parkinson´s disease and epilepsy] Malaltia de Parkinson i epilèpsia:criteris d'indicació i tractament quirúrgic [Criteria for indication and surgical treatment in Parkinson´s disease and epilepsy] Malaltia de Parkinson i epilèpsia:criteris d'indicació i tractament quirúrgic [Criteria for indication and surgical treatment in Parkinson´s disease and epilepsy] Rodríguez MG, Espallargues M, Fité A, Gironell A, Rocamora R, Rumia J, Toledo M (...) , Montalbán X Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Rodríguez MG, Espallargues M, Fité A, Gironell A, Rocamora R, Rumia J, Toledo M, Montalbán X. Malaltia de Parkinson i epilèpsia:criteris d'indicació i tractament quirúrgic. [Criteria for indication and surgical treatment in Parkinson´s disease and epilepsy] Barcelona: Catalan Agency

2011 Health Technology Assessment (HTA) Database.

433. Long-term mortality in childhood-onset epilepsy. (Abstract)

Long-term mortality in childhood-onset epilepsy. There are few studies on long-term mortality in prospectively followed, well-characterized cohorts of children with epilepsy. We report on long-term mortality in a Finnish cohort of subjects with a diagnosis of epilepsy in childhood.We assessed seizure outcomes and mortality in a population-based cohort of 245 children with a diagnosis of epilepsy in 1964; this cohort was prospectively followed for 40 years. Rates of sudden, unexplained death (...) were estimated. The very high autopsy rate in the cohort allowed for a specific diagnosis in almost all subjects.Sixty subjects died (24%); this rate is three times as high as the expected age- and sex-adjusted mortality in the general population. The subjects who died included 51 of 107 subjects (48%) who were not in 5-year terminal remission (i.e., ≥5 years seizure-free at the time of death or last follow-up). A remote symptomatic cause of epilepsy (i.e., a major neurologic impairment or insult

2010 NEJM

434. Care delivery and self-management strategies for children with epilepsy. (Abstract)

Care delivery and self-management strategies for children with epilepsy. Epilepsy care for children has been criticised for its lack of impact. Various service models and strategies have been developed in response to perceived inadequacies in care provision for children and their families.We set out to compare the effectiveness of specialist or dedicated teams or individuals in the care of children with epilepsy with usual care services.We searched the Cochrane Central Register of Controlled (...) selected studies, extracted data and assessed the quality of included studies.Four trials and five reports are included in this review. They report on four different education and counselling programmes for children, children and parents, or teenagers and parents. Each programme showed some benefits for the well-being of children with epilepsy, but each trial had methodological flaws and no single programme was evaluated by more than one study.While each of the programmes in this review showed some

2010 Cochrane

435. Should a child with ADHD and epilepsy be given Ritalin?

Should a child with ADHD and epilepsy be given Ritalin? BestBets: Should a child with ADHD and epilepsy be given Ritalin? Should a child with ADHD and epilepsy be given Ritalin? Report By: Caroline Boyes - Specialist Registrar in Paediatrics Institution: General Paediatrics, Bradford Royal Infirmary, Bradford, West Yorkshire, UK Date Submitted: 28th October 2010 Date Completed: 28th October 2010 Last Modified: 28th October 2010 Status: Green (complete) Three Part Question In [a child (...) with epilepsy and ADHD] does [methylphenidate (MPH)compared with placebo or no MPH] increase [the number of seizures]? Clinical Scenario A 10-year-old boy with well controlled epilepsy on sodium valproate attends your clinic. On a previous clinic visit his mother complained that he was hyperactive, impulsive and could not concentrate. This was affecting his school work. You sent Conners' Questionnaires to his parents and the school, and asked the attention deficit hyperactivity disorder (ADHD) nurse

2010 BestBETS

436. WITHDRAWN: Self-management education for adults with epilepsy. (Abstract)

WITHDRAWN: Self-management education for adults with epilepsy. Self-management education has been shown to improve the quality of life of people with chronic illnesses. It has been suggested that self-management education may improve seizure control and other outcomes in people with epilepsy.To review systematically the research literature on the effectiveness of self-management education in improving health outcomes for adults with epilepsy.We searched MEDLINE (Ovid) (1966 to April 2005 (...) ), EMBASE (Ovid) (1980 to April 2005), CINAHL (Dialog) (1980 to April 2005), PsycINFO (Dialog) (1887 to April 2005), and the Cochrane Epilepsy Group's Specialised Register (April 2005). We also handsearched Epilepsia and conference abstracts and proceedings. Experts in the field were contacted to identify any additional trials. We did not impose any language restriction. We re-ran the searches in February 2007 and added the identified references to the 'Studies awaiting assessment' table.Randomised

2010 Cochrane

437. WITHDRAWN: Self-management education for children with epilepsy. (Abstract)

WITHDRAWN: Self-management education for children with epilepsy. Self-management education has been shown to improve the quality of life of children and young people with chronic illnesses. It has been suggested that self-management education may improve seizure control and other outcomes in children and young people with epilepsy.To review systematically the research literature on the effectiveness of self-management education in improving health outcomes for children and young people (...) with epilepsy.We searched the Cochrane Epilepsy Group's Specialised Register (February 2007), MEDLINE (Ovid) (1966 to February 2007), EMBASE (Ovid) (1980 to February 2007), CINAHL (Dialog) (1980 to February 2007), and PsycINFO (Dialog) (1887 to February 2007). We also handsearched Epilepsia and conference abstracts and proceedings. Experts in the field were contacted to identify any additional trials. No language restriction was imposed.Randomised trials of self-management education programmes for children

2010 Cochrane

438. Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy Full Text available with Trip Pro

Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy To compare intranasal midazolam, using a Mucosal Atomization Device (IN-MMAD), with rectal diazepam (RD) for the home treatment of seizures in children with epilepsy.Prospective randomized study.Patients' homes and a freestanding children's hospital that serves as a referral center for 5 states.A total of 358 pediatric patients who visited a pediatric neurology clinic from July (...) in complications were found between treatment groups. Caretakers were more satisfied with IN-MMAD and report that it was easier to give than RD.There was no detectable difference in efficacy between IN-MMAD and RD as a rescue medication for terminating seizures at home in pediatric patients with epilepsy. Ease of administration and overall satisfaction was higher with IN-MMAD compared with RD. Trial Registration clinicaltrials.gov Identifier: NCT00326612.

2010 EvidenceUpdates Controlled trial quality: predicted high

439. Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: systematic review and meta-analysis

Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

440. Long-term developmental outcome of children of women with epilepsy, unexposed or exposed prenatally to antiepileptic drugs: a meta-analysis of cohort studies

Long-term developmental outcome of children of women with epilepsy, unexposed or exposed prenatally to antiepileptic drugs: a meta-analysis of cohort studies Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.