Latest & greatest articles for epilepsy

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Top results for epilepsy

481. Cost-effectiveness of add-on therapy with pregabalin in patients with refractory partial epilepsy Full Text available with Trip Pro

Cost-effectiveness of add-on therapy with pregabalin in patients with refractory partial epilepsy Cost-effectiveness of add-on therapy with pregabalin in patients with refractory partial epilepsy Cost-effectiveness of add-on therapy with pregabalin in patients with refractory partial epilepsy Vera-Llonch M, Brandenburg N A, Oster G Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The objective was to examine the cost-effectiveness of pregabalin as an additional therapy in comparison with usual care in patients with refractory partial epilepsy. The authors concluded that the cost-effectiveness of pregabalin compared favourably with the published estimates of the cost-effectiveness of other add-on antiepileptic drugs. The study

2008 NHS Economic Evaluation Database.

482. The epilepsy treatment gap in developing countries: a systematic review of the magnitude, causes, and intervention strategies Full Text available with Trip Pro

The epilepsy treatment gap in developing countries: a systematic review of the magnitude, causes, and intervention strategies The epilepsy treatment gap in developing countries: a systematic review of the magnitude, causes, and intervention strategies The epilepsy treatment gap in developing countries: a systematic review of the magnitude, causes, and intervention strategies Mbuba CK, Ngugi AK, Newton CR, Carter JA CRD summary This review assessed the interventions used for addressing (...) the epilepsy treatment gap in developing countries and concluded that some causes of the treatment gap can be addressed through educational interventions and supply of anti-epileptic drugs. Inadequate reporting of results, coupled with a lack of randomised trial evidence, means the authors' conclusions should be interpreted with caution. Authors' objectives To investigate the magnitude and causes of the epilepsy treatment gap in developing countries, and to determine the effectiveness of intervention

2008 DARE.

483. Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug-resistant partial epilepsy

Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug-resistant partial epilepsy Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2008 DARE.

484. Prenatal exposure to maternal infections and epilepsy in childhood: a population-based cohort study (Abstract)

Prenatal exposure to maternal infections and epilepsy in childhood: a population-based cohort study We estimated the association between prenatal exposure to maternal infections and the subsequent risk for epilepsy in childhood.We included 90,619 singletons who were born between September 1997 and June 2003 in the Danish National Birth Cohort and followed them up to December 2005. Information on maternal infections during pregnancy (cystitis, pyelonephritis, diarrhea, coughs lasting >1 week (...) , vaginal yeast infection, genital herpes, venereal warts, and herpes labialis) was prospectively reported by mothers in 2 computer-assisted telephone interviews in early and midgestation; information on maternal cystitis and pyelonephritis during late period of pregnancy was also collected in a third interview after birth. Children who received a diagnosis of epilepsy as inpatients or outpatients were retrieved from the Danish National Hospital Register. We identified 646 children with a diagnosis

2008 EvidenceUpdates

485. Non-pharmacological interventions for epilepsy in people with intellectual disabilities. (Abstract)

Non-pharmacological interventions for epilepsy in people with intellectual disabilities. Approximately 30% of epilepsy patients remain refractory to drug treatment and continue to experience seizures whilst taking one or more antiepileptic drugs. There are a number of non-pharmacological interventions available to refractory patients which may be used in conjunction with or as an alternative to antiepileptic medication. In view of the fact that seizures in intellectually disabled people (...) are often complex and refractory to pharmacological interventions it is evident that good quality randomised controlled trials (RCTs) assessing the efficacy of alternatives or adjuncts to pharmacological interventions are needed in this population.The aim of our study was to assess the data available from randomised controlled trials of non-pharmacological interventions in patients with epilepsy and intellectual disabilities.We searched The Cochrane Central Register of Controlled Trials (CENTRAL

2007 Cochrane

486. Epilepsy in adults.

Epilepsy in adults. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund You are here Guidelines and Measures Funding for the National Guideline Clearinghouse (NGC) has ended. Learn more

2007 Singapore Ministry of Health

487. Self-management education for adults with epilepsy. (Abstract)

Self-management education for adults with epilepsy. Self-management education has been shown to improve the quality of life of people with chronic illnesses. It has been suggested that self-management education may improve seizure control and other outcomes in people with epilepsy.To review systematically the research literature on the effectiveness of self-management education in improving health outcomes for adults with epilepsy.We searched MEDLINE (Ovid) (1966 to April 2005), EMBASE (Ovid (...) ) (1980 to April 2005), CINAHL (Dialog) (1980 to April 2005), PsycINFO (Dialog) (1887 to April 2005), and the Cochrane Epilepsy Group's Specialised Register (April 2005). We also handsearched Epilepsia and conference abstracts and proceedings. Experts in the field were contacted to identify any additional trials. We did not impose any language restriction. We re-ran the searches in February 2007 and added the identified references to the 'Studies awaiting assessment' table.Randomised trials of self

2007 Cochrane

488. Self-management education for children with epilepsy. (Abstract)

Self-management education for children with epilepsy. Self-management education has been shown to improve the quality of life of children and young people with chronic illnesses. It has been suggested that self-management education may improve seizure control and other outcomes in children and young people with epilepsy.To review systematically the research literature on the effectiveness of self-management education in improving health outcomes for children and young people with epilepsy.We (...) searched the Cochrane Epilepsy Group's Specialised Register (April 2007), MEDLINE (Ovid) (1966 to February 2007), EMBASE (Ovid) (1980 to February 2007), CINAHL (Dialog) (1980 to February 2007), and PsycINFO (Dialog) (1887 to February 2007). We also handsearched Epilepsia and conference abstracts and proceedings. Experts in the field were contacted to identify any additional trials. No language restriction was imposed.Randomised trials of self-management education programmes for children or young people

2007 Cochrane

489. Epilepsy or a family history of epilepsy increases the risk of schizophrenia or schizophrenia-like psychosis Full Text available with Trip Pro

Epilepsy or a family history of epilepsy increases the risk of schizophrenia or schizophrenia-like psychosis Epilepsy or a family history of epilepsy increases the risk of schizophrenia or schizophrenia-like psychosis | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Epilepsy or a family history of epilepsy increases the risk of schizophrenia or schizophrenia-like psychosis Article Text Aetiology Epilepsy or a family history of epilepsy

2007 Evidence-Based Mental Health

490. Therapeutic monitoring of antiepileptic drugs for epilepsy. Full Text available with Trip Pro

Therapeutic monitoring of antiepileptic drugs for epilepsy. The aim of drug treatment for epilepsy is to prevent seizures without causing adverse effects. To achieve this, drug dosages need to be individualised. Measuring antiepileptic drug levels in body fluids (therapeutic drug monitoring) is frequently used to optimise drug dosage for individual patients.To review the evidence regarding the effects of therapeutic drug monitoring upon outcomes in epilepsy.We searched the Cochrane Epilepsy (...) the aid of therapeutic drug monitoring.We based this review on published aggregate data. The main outcomes measured were the proportions of patients achieving a 12-month remission from seizures, reporting adverse effects, and being withdrawn from the treatment they had been randomised to receive.Only one study met the inclusion criteria for the review. In this open study, 180 patients with newly-diagnosed, untreated epilepsy were randomised to treatment with the antiepileptic drug selected

2007 Cochrane

491. Corticosteroids including ACTH for childhood epilepsy other than epileptic spasms. (Abstract)

Corticosteroids including ACTH for childhood epilepsy other than epileptic spasms. Epilepsy is a disorder with recurrent epileptic seizures. Corticosteroids have been used in the treatment of children with epilepsy and have significant adverse effects. Their efficacy and tolerability have not been not clearly established.To determine the efficacy of corticosteroids in terms of seizure control, improvements in cognition and in quality of life and tolerability of steroids compared to placebo (...) or other antiepileptic drugs.We searched the following databases: The Cochrane Epilepsy Group Specialized Register (September 2006); Cochrane Central Register of Controlled Trials (CENTRAL)(The Cochrane Library Issue 2, 2006); MEDLINE (1966 - April 2004); EMBASE (1966 - December 2004); Database of Abstracts of Reviews of Effectiveness (DARE) (December 2004). We checked the reference lists of retrieved studies for additional reports of relevant studies.All randomized controlled trials of administration

2007 Cochrane

492. The cost effectiveness of zonisamide as adjunctive therapy in adult partial seizure epilepsy

The cost effectiveness of zonisamide as adjunctive therapy in adult partial seizure epilepsy The cost effectiveness of zonisamide as adjunctive therapy in adult partial seizure epilepsy The cost effectiveness of zonisamide as adjunctive therapy in adult partial seizure epilepsy Spackman D E, Yeates A, Rentz A M, Hutton J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study evaluated the cost-effectiveness of zonisamide as treatment for adults with uncontrolled partial epilepsy in Scotland. The authors concluded that zonisamide was a cost-effective treatment for adults with refractory partial epilepsy. The methodology of the study appears appropriate and, on the whole, was clearly reported. The authors' conclusions reflect

2007 NHS Economic Evaluation Database.

493. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial

The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2007 NHS Economic Evaluation Database.

494. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial

The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2007 NHS Economic Evaluation Database.

495. A cost-effectiveness decision model for antiepileptic drug treatment in newly diagnosed epilepsy patients

A cost-effectiveness decision model for antiepileptic drug treatment in newly diagnosed epilepsy patients A cost-effectiveness decision model for antiepileptic drug treatment in newly diagnosed epilepsy patients A cost-effectiveness decision model for antiepileptic drug treatment in newly diagnosed epilepsy patients Knoester P D, Deckers C L, Termeer E H, Boendermaker A J, Kotsopoulos I A, de Krom M C, Keyser T, Renier W O, Hekster Y A, Severens H L Record Status This is a critical abstract (...) of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study assessed the cost-effectiveness of six antiepileptic drugs for the treatment of newly diagnosed epilepsy patients, including carbamezepine (CBZ), lamotrigine (LTG) and valproate (VPA) as first- and second-line drugs. The study

2007 NHS Economic Evaluation Database.

496. Usefulness of SPECT in epilepsy

Usefulness of SPECT in epilepsy Usefulness of SPECT in epilepsy Usefulness of SPECT in epilepsy Colantonio L, Augustovski F, Pichon Riviere A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Colantonio L, Augustovski F, Pichon Riviere A. Usefulness of SPECT in epilepsy. Buenos Aires: Institute for Clinical Effectiveness and Health Policy (...) (IECS). Informe Tecnico Breve No.32. 2007 Authors' objectives The objective of the report was to to analyze the use of SPECT for the pre-surgical evaluation of patients with epilepsy. Authors' conclusions In general, the quality of the studies associated with educational treatment programs for autistic children are methodologically poor and Floor Time therapy is not an exception. However, it seems that there is a certain degree of benefit from these interventions. There is not enough evidence

2007 Health Technology Assessment (HTA) Database.

497. The cost-effectiveness of newer drugs as add-on therapy for children with focal epilepsies Full Text available with Trip Pro

The cost-effectiveness of newer drugs as add-on therapy for children with focal epilepsies The cost-effectiveness of newer drugs as add-on therapy for children with focal epilepsies The cost-effectiveness of newer drugs as add-on therapy for children with focal epilepsies Frew E J, Sandercock J, Whitehouse W P, Bryan S Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) . Study population The study population comprised children (aged 3 to 18 years old) with newly diagnosed epilepsy. Setting The setting was outpatient care. The economic study was carried out in the UK. Dates to which data relate The clinical effectiveness and resource use data were derived from a paper published in 2006. The price year was 2002. Source of effectiveness data The clinical data used in the model included the probability of each stage in the treatment strategy resulting in each of the six

2007 NHS Economic Evaluation Database.

498. Side effects of phenobarbital and carbamazepine in childhood epilepsy: randomised controlled trial. Full Text available with Trip Pro

Side effects of phenobarbital and carbamazepine in childhood epilepsy: randomised controlled trial. To compare the behavioural side effects associated with two commonly used antiepilepsy drugs-phenobarbital and carbamazepine-in children in Bangladesh.Prospective randomised controlled single centre trial.Specialist children's hospital in Dhaka, Bangladesh.108 children aged 2-15 with generalised tonic-clonic (n=51) or partial and secondary generalised seizures (n=57).Seizure control (...) group and three in the carbamazepine group). Independent t tests, however, showed no difference between the two trial drugs.There was no excess in behavioural side effects with phenobarbital in children with epilepsy in a country with limited resources. Trial registration NCT00381537.

2007 BMJ Controlled trial quality: uncertain

499. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Full Text available with Trip Pro

The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Carbamazepine is widely accepted as a drug of first choice for patients with partial onset seizures. Several newer drugs possess efficacy against these seizure types but previous randomised controlled trials have failed to inform a choice between these drugs. We aimed to assess efficacy with regards to longer-term

2007 Lancet Controlled trial quality: predicted high

500. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Full Text available with Trip Pro

The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Valproate is widely accepted as a drug of first choice for patients with generalised onset seizures, and its broad spectrum of efficacy means it is recommended for patients with seizures that are difficult to classify. Lamotrigine and topiramate are also thought to possess broad spectrum activity. The SANAD study aimed to compare (...) were time to treatment failure, and time to 1-year remission, and analysis was by both intention to treat and per protocol. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN38354748.For time to treatment failure, valproate was significantly better than topiramate (hazard ratio 1.57 [95% CI 1.19-2.08]), but there was no significant difference between valproate and lamotrigine (1.25 [0.94-1.68]). For patients with an idiopathic generalised epilepsy

2007 Lancet Controlled trial quality: predicted high