Latest & greatest articles for epilepsy

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Top results for epilepsy

521. Newer drugs for epilepsy in adults

Newer drugs for epilepsy in adults Newer drugs for epilepsy in adults Newer drugs for epilepsy in adults National Institute for Clinical Excellence Citation National Institute for Clinical Excellence. Newer drugs for epilepsy in adults. London: National Institute for Clinical Excellence (NICE). Technology Appraisal Guidance 76. 2004 Authors' objectives To provide guidance on the use of newer drugs for epilepsy in adults. Authors' conclusions 1.1 The newer antiepileptic drugs gabapentin (...) , lamotrigine, levetiracetam, oxcarbazepine, tiagabine, topiramate and vigabatrin, within their licensed indications, are recommended for the management of epilepsy in people who have not benefited from treatment with the older antiepileptic drugs such as carbamazepine or sodium valproate, or for whom the older antiepileptic drugs are unsuitable because: - there are contraindications to the drugs - they could interact with other drugs the person is taking (notably oral contraceptives) - they are already

2004 Health Technology Assessment (HTA) Database.

522. Seizure recurrence after planned discontinuation of antiepileptic drugs in seizure-free patients after epilepsy surgery: a review of current clinical experience

Seizure recurrence after planned discontinuation of antiepileptic drugs in seizure-free patients after epilepsy surgery: a review of current clinical experience Seizure recurrence after planned discontinuation of antiepileptic drugs in seizure-free patients after epilepsy surgery: a review of current clinical experience Seizure recurrence after planned discontinuation of antiepileptic drugs in seizure-free patients after epilepsy surgery: a review of current clinical experience Schmidt D (...) , Baumgartner C, Loscher W CRD summary This review assessed the risk of seizure recurrence after the planned discontinuation of antiepileptic drugs (AEDs) following surgery for epilepsy. The authors concluded that one in three patients were at risk of seizure recurrence after discontinuing AEDs. The results were based on potentially biased retrospective studies, and the authors' conclusions do not adequately reflect the limitations of this evidence. Authors' objectives To assess the risk of seizure

2004 DARE.

523. Positron emission tomography (PET) for epilepsy

Positron emission tomography (PET) for epilepsy Positron emission tomography (PET) for epilepsy Positron emission tomography (PET) for epilepsy Medical Services Advisory Committee Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Medical Services Advisory Committee. Positron emission tomography (PET) for epilepsy. Canberra: Medical Services (...) Advisory Committee (MSAC) 2004: 65 Authors' objectives This report is a systematic review of literature on positron emission tomography (PET) imaging using the radionuclide 2-[18F]fluoro-2-deoxy-D-glucose (FDG) for the indication of epilepsy. Authors' conclusions In relation to positron emission tomography prior to surgery in patients with refractory epilepsy, where there is no focus with concordant results on usual structural imaging and electroencephalogram, this assessment finds the technology

2004 Health Technology Assessment (HTA) Database.

524. The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care

The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care National Institute for Clinical Excellence Record Status This is a bibliographic record of a published health technology assessment. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation National Institute for Clinical Excellence. The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care. London: National Institute for Clinical Excellence (NICE) 2004: 73 Authors' objectives This report aims to provide guidelines on the diagnosis and management of the epilepsies in adults and children in primary and secondary care. Authors' conclusions Diagnosis - All

2004 Health Technology Assessment (HTA) Database.

525. Newer drugs for epilepsy in children

Newer drugs for epilepsy in children Newer drugs for epilepsy in children Newer drugs for epilepsy in children National Institute for Clinical Excellence Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation National Institute for Clinical Excellence. Newer drugs for epilepsy in children. London: National Institute for Clinical Excellence (NICE). Technology Appraisal (...) Guidance 79. 2004 Authors' objectives To provide guidance on the use of newer drugs for epilepsy in children. Authors' conclusions 1.1 The newer antiepileptic drugs gabapentin, lamotrigine, oxcarbazepine, tiagabine, topiramate, and vigabatrin (as an adjunctive therapy for partial seizures), within their licensed indications, are recommended for the management of epilepsy in children who have not benefited from treatment with the older antiepileptic drugs such as carbamazepine or sodium valproate

2004 Health Technology Assessment (HTA) Database.

526. Cardiac arrhythmias in focal epilepsy: a prospective long-term study. (Abstract)

Cardiac arrhythmias in focal epilepsy: a prospective long-term study. Patients with epilepsy are at risk of sudden unexpected death. Neurogenic cardiac arrhythmias have been postulated as a cause. Electrocardiograms (ECG) can be monitored by use of an implantable loop recorder for up to 18 months. We aimed to determine the frequency of cardiac arrhythmias in patients with refractory focal seizures over an extended period.20 patients received an implantable loop recorder at one hospital (...) at greatest risk of sudden unexpected death in epilepsy. Asystole might underlie many of these deaths, which would have important implications for the investigation of similar patients and affect present cardiac-pacing policies.

2004 Lancet

527. Common antiepileptic drugs in pregnancy in women with epilepsy. (Abstract)

Common antiepileptic drugs in pregnancy in women with epilepsy. The potential adverse effects of antiepileptic drug (AED) exposure in pregnancy have been well recognised but the relative risks of specific antiepileptic drug exposures remain poorly understood.To assess the adverse effects of commonly used antiepileptic drugs on maternal and fetal outcomes in pregnancy in women with epilepsy. Comparison of outcomes following specific antiepileptic drug exposures in utero to unexposed pregnancies (...) in the general population or women with epilepsy are described. The current manuscript reports the first phase of this review which focuses upon neurodevelopmental outcomes in children exposed to antiepileptic drugs in utero.We searched MEDLINE, Pharmline, EMBASE, Reprotox and TERIS from 1966 to December 2003. Review articles and conference abstracts were also hand searched.All randomized controlled trials, prospective cohorts of children of pregnant women with and without epilepsy and case control studies

2004 Cochrane

528. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. Full Text available with Trip Pro

Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. One third of patients with epilepsy have drug-resistant epilepsy, which is associated with an increased risk of death and debilitating psychosocial consequences. Because this form is resistant to multiple antiepileptic drugs, the mode of resistance must be nonspecific, involving drug-efflux transporters such as ATP-binding cassette sub-family B member 1 (ABCB1, also known as MDR1 and P (...) -glycoprotein 170). We hypothesized that the CC genotype at the ABCB1 C3435T polymorphism, which is associated with increased expression of the protein, influences the response to antiepileptic-drug treatment.ABCB1 3435 was genotyped in 315 patients with epilepsy, classified as drug-resistant in 200 and drug-responsive in 115, and 200 control subjects without epilepsy. Recently devised methods were used to control for population stratification, and linkage disequilibrium was calculated across the gene.As

2003 NEJM

529. A Markov model of treatment of newly diagnosed epilepsy in the UK

A Markov model of treatment of newly diagnosed epilepsy in the UK A Markov model of treatment of newly diagnosed epilepsy in the UK A Markov model of treatment of newly diagnosed epilepsy in the UK Remak E, Hutton J, Price M, Peeters K, Adriaenssen I Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment (...) on the reliability of the study and the conclusions drawn. Health technology The use of topiramate (TPM) as monotherapy for treating newly diagnosed adult epilepsy patients. Type of intervention Treatment. Economic study type Cost-utility analysis. Study population The study population comprised a hypothetical cohort of adult patients with newly diagnosed epilepsy. Setting The setting was secondary care. The economic study was conducted in the UK. Dates to which data relate The effectiveness data were derived

2003 NHS Economic Evaluation Database.

530. Management of treatment-resistant epilepsy. Volumes 1: evidence report and appendices. Volume 2: evidence tables. Diagnosis

Management of treatment-resistant epilepsy. Volumes 1: evidence report and appendices. Volume 2: evidence tables. Diagnosis Management of treatment-resistant epilepsy. Volumes 1: evidence report and appendices. Volume 2: evidence tables. Diagnosis Management of treatment-resistant epilepsy. Volumes 1: evidence report and appendices. Volume 2: evidence tables. Diagnosis Chapell R, Reston J, Snyder D, Treadwell J, Tregear S, Turkelson C CRD summary This review planned to evaluate which methods (...) of re-evaluating refractory epilepsy can lead to improved patient outcomes. The authors addressed a different question, and concluded it was unclear whether blood prolactin levels can differentiate between epileptic and non-eplieptic seizures. The conclusion seems appropriate given that it was based on only five poor-quality trials and no review methodology was reported. Authors' objectives To determine which methods of rediagnosing or re-evaluating treatment-resistant epilepsy lead to, or can

2003 DARE.

531. Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Non-drug treatment strategies

Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Non-drug treatment strategies Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Non-drug treatment strategies Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Non-drug treatment strategies Chapell R, Reston J, Snyder D, Treadwell J, Tregear S, Turkelson C CRD (...) summary This review evaluated non-drug treatments for patients with treatment-resistant epilepsy, and concluded that effective treatments are available, but all have disadvantages. Given the exclusion of several interventions, the paucity of good-quality data for those included, and the limitations of the review, the conclusions should be viewed with caution. Authors' objectives To determine which methods of non-drug treatment for epilepsy, after initial treatment failure, lead to improved outcomes

2003 DARE.

532. Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Drug treatment strategies

Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Drug treatment strategies Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Drug treatment strategies Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Drug treatment strategies Chapell R, Reston J, Snyder D, Treadwell J, Tregear S, Turkelson C CRD summary (...) This review concluded that polytherapy is clinically preferable to sequential monotherapy, and monotherapy is more likely to be harmful than beneficial, for patients with treatment-resistant epilepsy. The potential for publication and language bias, and error and bias during the review process, should be kept in mind when considering the conclusions. Authors' objectives To determine which drug treatment strategy (sequential monotherapy, polytherapy, or optimised current therapy) leads to improved outcomes

2003 DARE.

533. Epilepsy surgery

Epilepsy surgery Epilepsy surgery Epilepsy surgery Pichon Riviere A, Augustovski F, Cernadas C, Ferrante D, Regueiro A, Garcia Marti S Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Pichon Riviere A, Augustovski F, Cernadas C, Ferrante D, Regueiro A, Garcia Marti S. Epilepsy surgery. Ciudad de Buenos Aires: Institute for Clinical (...) Effectiveness and Health Policy (IECS) 2003 Authors' objectives This study aims to summarise the available evidence on epilepsy surgery. Authors' conclusions It is important to point out that, in general, reports come from state-of-the-art centers with wide experience in this surgical field. On the other hand, these procedures are not adverse-event-free, in many cases severe and disabling; consequently, patient selection should be carefully carried out once more conservative therapeutic approaches have been

2003 Health Technology Assessment (HTA) Database.

534. Cost-utility analysis of vagus nerve stimulators for adults with medically refractory epilepsy

Cost-utility analysis of vagus nerve stimulators for adults with medically refractory epilepsy Cost-utility analysis of vagus nerve stimulators for adults with medically refractory epilepsy Cost-utility analysis of vagus nerve stimulators for adults with medically refractory epilepsy Forbes R B, MacDonald S, Eljamel S, Roberts R C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of vagus nerve stimulators (VNS) for the treatment of medically refractory epilepsy (MRE). The comparator was not explicitly stated, but it appears to have been no implantation of the device. Type of intervention Treatment and palliative care. Economic study type Cost-utility analysis. Study population The target population comprised

2003 NHS Economic Evaluation Database.

535. Ketogenic diet for epilepsy. Full Text available with Trip Pro

Ketogenic diet for epilepsy. The ketogenic diet is a diet high in fat but low in carbohydrate and it is suggested that this diet reduces seizure frequency. Currently, this diet is used mainly for children who continue to have seizures despite treatment with antiepileptic drugs.To overview the evidence from randomized controlled trials regarding the effects of ketogenic diets.We searched the Cochrane Epilepsy Group trials register (26 March 2003), the Cochrane Central Register of Controlled (...) Trials (The Cochrane Library issue 1, 2003), MEDLINE (January 1966 to March 2003) and EMBASE (1980 to March 2003).Randomized controlled trials of ketogenic diets for people with epilepsy.We planned for two reviewers to independently apply inclusion criteria and extract data.No randomized controlled trials were found.There is no reliable evidence from randomized controlled trials to support the use of ketogenic diets for people with epilepsy. There are large observational studies, some prospective

2003 Cochrane

536. Socioeconomic variation in incidence of epilepsy: prospective community based study in south east England. Full Text available with Trip Pro

Socioeconomic variation in incidence of epilepsy: prospective community based study in south east England. To determine the incidence of epilepsy in a general practice population and its variation with socioeconomic deprivation.Prospective surveillance for new cases over an 18 or 24 month period.All patients on practice registers categorised for deprivation with the Carstairs score of their postcode.20 general practices in London and south east England.Confirmed diagnosis of epilepsy.190 new (...) cases of epilepsy were identified during 369 283 person years of observation (crude incidence 51.5 (95% confidence interval 44.4 to 59.3) per 100 000 per year). The incidence was 190 (138 to 262) per 100 000 in children aged 0-4 years, 30.8 (21.3 to 44.6) in those aged 45-64 years, and 58.7 (42.5 to 81.0) in those aged > or =65 years. There was no apparent difference in incidence between males and females. The incidence showed a strong association with socioeconomic deprivation, the age and sex

2002 BMJ

537. Prevalence of epilepsy in prisoners: systematic review. Full Text available with Trip Pro

Prevalence of epilepsy in prisoners: systematic review. 12077036 2002 07 12 2018 11 30 1756-1833 324 7352 2002 Jun 22 BMJ (Clinical research ed.) BMJ Prevalence of epilepsy in prisoners: systematic review. 1495 Fazel Seena S Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX. Vassos Evangelos E Danesh John J eng Journal Article Research Support, Non-U.S. Gov't Review Systematic Review England BMJ 8900488 0959-8138 AIM IM Adult Canada epidemiology Epilepsy

2002 BMJ

538. Death in children with epilepsy: a population-based study. (Abstract)

Death in children with epilepsy: a population-based study. Families of children with newly diagnosed epilepsy worry about death during a seizure. We aimed to assess the frequency and causes of death of children with epilepsy.We did a population-based cohort study. The Nova Scotia epilepsy cohort includes all children who developed epilepsy during 1977-85. In 1999, we matched names and birth dates with provincial health-care, death, and marriage registries. We examined death certificates (...) , necropsy reports, and physician records of children who had died and contacted families if sudden unexpected death in epilepsy could have occurred. We measured the effect of sex, age, epilepsy type, and disorder sufficient to cause functional neurological deficit on death rate. We compared cohort mortality with rates in a reference population matched for age and sex.26 (3.8%) of 692 children with epilepsy died. Frequency of death was 5.3 times higher (95% CI 2.29-8.32) than in the reference population

2002 Lancet

539. Diffusion tensor imaging in refractory epilepsy. (Abstract)

Diffusion tensor imaging in refractory epilepsy. Diffusion tensor imaging is an imaging method that is sensitive to the molecular movement of water, which indicates cellular integrity and pathology. A patient with refractory epilepsy and normal conventional MRI was examined with diffusion tensor imaging. An area of abnormal diffusion in the right frontal lobe was identified and surgically resected. The patient had a good clinical outcome. Histopathological examination of the resected tissue

2002 Lancet

540. The effectiveness of psychological interventions for patients with relatively well-controlled epilepsy

The effectiveness of psychological interventions for patients with relatively well-controlled epilepsy The effectiveness of psychological interventions for patients with relatively well-controlled epilepsy The effectiveness of psychological interventions for patients with relatively well-controlled epilepsy Engelberts N H, Klein M, Kasteleijn-Nolst Trenite D G, Heimans J J, van der Ploeg H M Authors' objectives To assess the effectiveness of psychological interventions in participants (...) with relatively well-controlled epilepsy. Searching MEDLINE and PsycINFO were searched from inception to March 2002 for studies published in English in peer-reviewed journals, book chapters or editorials; the search terms were reported. Only English language publications were included in the review. Study selection Study designs of evaluations included in the review No inclusion criteria were stated in relation to study design. The included studies were randomised controlled trials (RCTs), cross-sectional

2002 DARE.