Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for fatigue
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on fatigue or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on fatigue and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via email@example.com
Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials. Objective To gain insight on how exercise affects the outcomes of prostate cancer patients treated with androgen deprivation therapy, specifically cancer-related fatigue (CRF) and quality of life (QoL).Methods Systematic searches for randomized clinical trials (RCTs) evaluating the effects of exercise on CRF and QoL
Recruitment of reviewers is becoming harder at some journals: a test of the influence of reviewer fatigue at six journals in ecology and evolution It is commonly reported by editors that it has become harder to recruit reviewers for peer review and that this is because individuals are being asked to review too often and are experiencing reviewer fatigue. However, evidence supporting these arguments is largely anecdotal.We examine responses of individuals to review invitations for six journals (...) being sent to prospective reviewers and the proportion of individuals being invited more than once per year has not changed much over these 13 years, despite substantial increases in the total number of review invitations being sent by these journals-the reviewer base has expanded concomitant with this growth in review requests.The proportion of review invitations that lead to a review being submitted has been declining steadily for four of the six journals examined here, but reviewer fatigue
Cytokine Inhibition in Patients With Chronic Fatigue Syndrome: A Randomized Trial. Interleukin-1 (IL-1), an important proinflammatory cytokine, is suspected to play a role in chronic fatigue syndrome (CFS).To evaluate the effect of subcutaneous anakinra versus placebo on fatigue severity in female patients with CFS.Randomized, placebo-controlled trial from July 2014 to May 2016. Patients, providers, and researchers were blinded to treatment assignment. (ClinicalTrials.gov: NCT02108210 (...) ).University hospital in the Netherlands.50 women aged 18 to 59 years with CFS and severe fatigue leading to functional impairment.Participants were randomly assigned to daily subcutaneous anakinra, 100 mg (n = 25), or placebo (n = 25) for 4 weeks and were followed for an additional 20 weeks after treatment (n = 50).The primary outcome was fatigue severity, measured by the Checklist Individual Strength subscale (CIS-fatigue) at 4 weeks. Secondary outcomes were level of impairment, physical and social
Improvements in Fatigue in 1536 Patients with Rheumatoid Arthritis and Correlation with Other Treatment Outcomes: A Post Hoc Analysis of Three Randomized Controlled Trials of Abatacept A post hoc analysis of three randomized controlled trials of abatacept in rheumatoid arthritis (RA) was conducted to explore the effect of abatacept on fatigue in RA and its correlation with other outcomes.In this analysis of AGREE (early RA) and AIM and ATTAIN (established RA), changes in baseline fatigue (0-100 (...) mm scale), pain, sleep (AIM and ATTAIN only) and Disease Activity Score (DAS) 28 (C-reactive protein; CRP) were calculated at days 29, 85, and 169. Agreement between improvements ≥minimum clinically important differences (MCID) in fatigue and other outcomes were evaluated using agreement statistics (kappa) in each study and at each time point.Of 1536 patients (mean disease duration: 6.2 months [AGREE], 8.5 years [AIM], 12.2 years [ATTAIN]), mean (SE) decreases in fatigue from baseline to day 169
The impact of exercise during adjuvant radiotherapy for breast cancer on fatigue and quality of life: A systematic review and meta-analysis. Adjuvant radiation therapy (RT) in breast cancer treatment has been proven to enhance outcome, improving recurrence and mortality rates. RT, however, gives rise to unfavourable side-effects, fatigue the most frequent. The aim of this study was to assess the effect of exercise (and different exercise prescription parameters) during adjuvant RT on fatigue (...) among breast cancer patients. Quality of life was a secondary outcome.Randomised controlled trials that investigated the effect of exercise during adjuvant RT on fatigue for breast cancer patients were searched using MEDLINE, EMBASE, Google Scholar, CINAHL, AMED and ClinicalTrials.gov. Reference lists of included studies and relevant reviews were also checked.Nine studies (802 participants) were included. A meta-analysis, including results for 738 participants, revealed that exercise
Poststroke Fatigue: Emerging Evidence and Approaches to Management: A Scientific Statement for Healthcare Professionals From the American Heart Association Cardiopulmonary Resuscitation in Adults and Children With Mechanical Circulatory Support: A Scientific Statement From the American Heart Association | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search March 2019 March 2019 March 2019 March 2019 March 2019 February 2019 February 2019 February 2019 (...) and is subject to wear, damage, or kinking, which can result in device malfunction ( ). Although driveline wiring has built-in redundancy as a safety measure, driveline trauma can cause internal damage and lead to pump failure. Damage can be acute such as a cutting or crush injury or the result of chronic stress/fatigue on the line. In these settings, there will often be alarms preceding or accompanying the pump stoppage, but alarms will cease once the batteries are drained. There is a risk of de novo
Exercise therapy for chronic fatigue syndrome. Chronic fatigue syndrome (CFS) is characterised by persistent, medically unexplained fatigue, as well as symptoms such as musculoskeletal pain, sleep disturbance, headaches and impaired concentration and short-term memory. CFS presents as a common, debilitating and serious health problem. Treatment may include physical interventions, such as exercise therapy, which was last reviewed in 2004.The objective of this review was to determine the effects (...) therapy (one study), supportive listening (one study), pacing (one study), pharmacological treatment (one study) and combination treatment (one study). Risk of bias varied across studies, but within each study, little variation was found in the risk of bias across our primary and secondary outcome measures.Investigators compared exercise therapy with 'passive' control in eight trials, which enrolled 971 participants. Seven studies consistently showed a reduction in fatigue following exercise therapy
Fatigue, Sleep Disturbances, and Their Influence on Quality of Life in Cervical Dystonia Patients Nonmotor symptoms (NMS) are highly prevalent in cervical dystonia (CD). In general, fatigue and sleep are important NMS that determine a decreased health-related quality of life (HR-QoL), but their influence in CD is unknown. The authors systematically investigated fatigue, excessive daytime sleepiness (EDS), and sleep quality in patients with CD and controls and assessed the influence (...) of psychiatric comorbidity, pain, and dystonia motor severity. They also examined the predictors of HR-QoL.The study included 44 patients with CD and 43 matched controls. Fatigue, EDS, and sleep quality were assessed with quantitative questionnaires and corrected for depression and anxiety using analysis of covariance. The Toronto Western Spasmodic Torticollis Rating Scale and the Clinical Global Impression Scale-jerks/tremor subscale were used to score motor severity and to assess whether motor
Educational interventions for the management of cancer-related fatigue in adults. Cancer-related fatigue is reported as the most common and distressing symptom experienced by patients with cancer. It can exacerbate the experience of other symptoms, negatively affect mood, interfere with the ability to carry out everyday activities, and negatively impact on quality of life. Educational interventions may help people to manage this fatigue or to cope with this symptom, and reduce its overall (...) burden. Despite the importance of education for managing cancer-related fatigue there are currently no systematic reviews examining this approach.To determine the effectiveness of educational interventions for managing cancer-related fatigue in adults.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), and MEDLINE, EMBASE, CINAHL, PsycINFO, ERIC, OTseeker and PEDro up to 1st November 2016. We also searched trials registries.We included randomised controlled trials (RCTs
CJEM Infographic: Bystander Fatigue and CPR Quality by Older Adults CJEM Infographic: Bystander Fatigue and CPR Quality by Older Adults - CanadiEM CJEM Infographic: Bystander Fatigue and CPR Quality by Older Adults In , by Simon Huang November 15, 2016 This month CanadiEM is featuring an article from the Canadian Journal of Emergency Medicine (CJEM) that compares the effectiveness of the continuous chest compression (CCC) and 30:2 compressions to ventilation (30:2) methods of CPR in an older (...) bystander population. Considering that most cardiac arrests occur at home where both the victim and bystander (spouse) are aged in their sixties, there is merit in evaluating these two methods in terms of fatigue and CPR quality for this population. To compare these two methods, Liu et al . 1 conducted a randomized crossover trial with 59 participants over the age of 55 who were physically capable of performing CPR. Study participants were instructed on both methods of CPR and allowed to practice for 5
The effects of a home-based arm ergometry exercise programme on physical fitness, fatigue and activity in Polio survivors: A randomised controlled trial To investigate the effect of an eight-week home-based arm ergometry aerobic exercise programme on physical fitness, fatigue, activity and quality of life in Polio Survivors.An assessor blinded randomised controlled trial.Home-based exercise.Fifty-five Polio survivors randomised to exercise or control groups.Home-based arm ergometry (...) at an intensity of 50%-70% maximum heart rate, compared with usual physiotherapy care.The Six-minute Arm Test, Fatigue Severity Scale, Physical Activity Scale for Individuals with Physical Disabilities and SF-36. Assessments were completed at baseline and at eight weeks.There was no significant difference in the primary outcome, exercising heart rate during the Six-minute Arm Test, between the groups at follow-up [97.6 (SD10.1) compared to 102.4 (SD13.7) beats per minute ( P=0.20)]. Blood pressure
The association between borderline personality disorder, fibromyalgia and chronic fatigue syndrome: systematic review. Overlap of aetiological factors and demographic characteristics with clinical observations of comorbidity has been documented in fibromyalgia syndrome, chronic fatigue syndrome (CFS) and borderline personality disorder (BPD).The purpose of this study was to assess the association of BPD with fibromyalgia syndrome and CFS. The authors reviewed literature on the prevalence of BPD
Experiences and management of fatigue in everyday life among adult patients living with heart failure: a systematic review of qualitative evidence. Fatigue, a common and distressing symptom of heart failure, is a non-specific, invisible and subjective experience, which is difficult to describe and for which there are no effective interventions. Fatigue negatively impacts on patients' everyday life, prognosis and quality of life, therefore it is important that patients can manage, monitor (...) and respond to changes in fatigue. To cope with fatigue patients may need or seek advice on self-management strategies.To synthesize the best available evidence on the experiences and management of fatigue in everyday life among adult patients with stable heart failure.Adults with confirmed and stable heart failure.Studies exploring the experiences and management of fatigue in everyday life among adults with heart failure.Qualitative studies focusing on qualitative data, including, but not limited
Effect of Processed Honey and Royal Jelly on Cancer-Related Fatigue: A Double-Blind Randomized Clinical Trial. Cancer-related fatigue (CRF) is experienced by 50% to 90% of cancer patients and can severely affect their quality of life and functional capacity. Several randomized trials have recommended various ways to alleviate the symptoms of CRF with or without recourse to medications.The aim of this study is to evaluate the effectiveness of processed honey and royal jelly on the symptoms (...) . Both groups were assessed at the beginning of the study, after 2 weeks, and then at the end of 4 weeks of treatment. Fatigue was measured using a visual analogue fatigue scale (VAFS) and fatigue severity scale (FSS). The results were compared between the two arms of study, and equality of probability distributions was assessed using a Kolmogorov-Smirnov test.The mean age of the 52 patients was 54.84. After two and four weeks of treatment with processed honey and royal jelly, VAFS and FSS due
A case report of shoulder fatigue imbalance in wheelchair rugby: implications to pain and injury The purpose of this case-control study was to examine potential agonist-antagonist fatigue imbalance during wheelchair rugby activity. A 16-channel NORAXON electromyography (EMG) system 1400A with telemetry was used to assess EMG activity in a 39-year-old male with a C6 complete spinal cord injury (American Spinal Injury Association Impairment Scale (AIS) A), 17.5 years post injury. Mean amplitude (...) continuous pushing. The current study is one of the first to document sport fatigue through electromyography during intermittent, live play rather than clinical conditions (that is, continuous pushing).
Exploring Fatigue Trajectories in Early Symptomatic Knee and Hip Osteoarthritis: 6-year Results from the CHECK Study To examine whether different groups of fatigue trajectories can be identified among patients with early symptomatic osteoarthritis (OA) of the knee or hip, to describe the level of fatigue severity within each of these fatigue groups, and to investigate the involvement of age, sex, use of medication, comorbidity, and OA severity in relation to group membership.Six years (...) of followup data on fatigue (Medical Outcomes Study Short Form-36 Vitality scale) came from the Cohort Hip and Cohort Knee (CHECK) cohort. Growth mixture modeling was applied to identify distinct fatigue trajectories as well as to take into account the effects of the patient characteristics.Three fatigue trajectories were identified: low fatigue, low-to-high fatigue, and high fatigue. Latter trajectories showed considerable overlap from years 2 to 6, but differed in some patient characteristics
Identification and Symptom Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome IDENTIFICATION AND SYMPTOM MANAGEMENT OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME Clinical Practice Guideline | January 2016 These recommendations are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. They should be used as an adjunct to sound clinical decision making. OBJECTIVE Alberta clinicians (...) will have the information and tools necessary to detect key symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and manage these symptoms over the long term. TARGET POPULATION Adults and children EXCLUSIONS None PRACTICE POINT Illness severity in ME/CFS ranges from mild (still able to work with effort) to extreme (bedbound needing 24 hour care). Pathological fatigue and post exertional malaise – out of proportion to exertion and taking more than 24 hours to recover – is the key
Exercise therapy for chronic fatigue syndrome. Chronic fatigue syndrome (CFS) is characterised by persistent, medically unexplained fatigue, as well as symptoms such as musculoskeletal pain, sleep disturbance, headaches and impaired concentration and short-term memory. CFS presents as a common, debilitating and serious health problem. Treatment may include physical interventions, such as exercise therapy, which was last reviewed in 2004.The objective of this review was to determine the effects (...) ), supportive listening (one study), pacing (one study), pharmacological treatment (one study) and combination treatment (one study). Risk of bias varied across studies, but within each study, little variation was found in the risk of bias across our primary and secondary outcome measures.Investigators compared exercise therapy with 'passive' control in eight trials, which enrolled 971 participants. Seven studies consistently showed a reduction in fatigue following exercise therapy at end of treatment, even
Treatment of Fatigue in Parkinson Disease. Which pharmacological and nonpharmacological interventions are associated with improvement in general, physical, or mental fatigue and minimal adverse effects in patients with Parkinson disease (PD)?Rasagiline, modafinil, and doxepin are associated with improvement in fatigue and are not associated with increased risk of adverse effects in patients with PD. However, the quality of evidence is limited and does not provide a clear basis for treatment