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Latest & greatest articles for fatigue
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Modafinil for Sleep Disorders and Fatigue Secondary to Multiple Sclerosis: A Review of the Clinical Efficacy and Safety Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources and a summary of the best evidence on the topic that CADTH could identify using all reasonable (...) , provided that attribution is given to CADTH. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions. TITLE: Modafinil for Sleep Disorders and Fatigue Secondary to Multiple Sclerosis: A Review of the Clinical Efficacy and Safety DATE: 27 July 2012 CONTEXT AND POLICY ISSUES Modafinil is a central nervous
Cognitive and graded activity training can alleviate persistent fatigue after stroke: a randomized, controlled trial Fatigue is a common, persistent consequence of stroke, and no evidence-based treatments are currently available to alleviate fatigue. A new treatment combining cognitive therapy (CO) with graded activity training (GRAT), called COGRAT, was developed to alleviate fatigue and fatigue-related symptoms. This study compared the effectiveness of the COGRAT intervention with a CO-only (...) intervention after a 3-month qualification period without intervention.This randomized, controlled, assessor-blind clinical trial was conducted in 8 rehabilitation centers. Eighty-three stroke patients (>4 months after stroke) were randomly assigned to 12 weeks of CO or COGRAT after qualification. Seventy-three patients completed treatment and 68 were available at follow-up. Primary outcomes (Checklist Individual Strength-subscale Fatigue (CIS-f); self-observation list-fatigue (SOL-f)) and secondary
Carnitine for fatigue in multiple sclerosis. Fatigue is reported to occur in up to 92% of patients with multiple sclerosis (MS) and has been described as the most debilitating of all MS symptoms by 28% to 40% of MS patients.To assess whether carnitine (enteral or intravenous) supplementation can improve the quality of life and reduce the symptoms of fatigue in patients with MS-related fatigue and to identify any adverse effects of carnitine when used for this purpose.A literature search (...) and a manufacturer (Source Naturals, United States) of carnitine formulation was contacted to determine if they knew of other clinical trials. No language restrictions were applied.Full reports of published and unpublished randomized controlled trials and quasi-randomized trials of any carnitine intervention in adults affected by multiple sclerosis with a clinical diagnosis of fatigue associated with multiple sclerosis were included.Data from the eligible trials was extracted and coded using a standardized data
A Progressive Postresection Walking Program Significantly Improves Fatigue and Health-Related Quality of Life in Pancreas and Periampullary Cancer Patients As patients with pancreas and periampullary cancer (PPC) experience improved survival rates and longevity, the focus shifts toward living life while surviving cancer. Fatigue is the most commonly reported symptom in all cancer patients. Exercise has been found to effectively decrease fatigue levels and improve physical functioning in cancer (...) patients.One hundred two patients with resected PPC consented to participate in this study and were randomized to either an intervention group (IG) or a usual care group (UCG). Subjects completed visual analog scales, the FACIT-Fatigue Scale and the Short Form-36v2 after surgery and again 3 to 6 months after hospital discharge.Patients in the IG and UCG were comparable with regard to demographics, comorbidities, cancer type and staging, type of resection, preoperative fatigue and pain levels, adjuvant
Effect of biotherapies on fatigue in rheumatoid arthritis: a systematic review of the literature and meta-analysis To assess the effect of biotherapies vs placebo on fatigue in two situations: inadequate response to conventional treatments (IR-DMARD) and inadequate response to anti-TNF (IR-anti-TNF) in RA.A systematic review of the literature and meta-analysis were performed. We included randomized controlled trials (RCTs) assessing the effect of biotherapies vs placebo on fatigue (...) , in combination with DMARDs. Fatigue was measured using the functional assessment of chronic illness therapy-fatigue (FACIT-F) or short-form 36 (SF-36) vitality scores at baseline and at Week 24. The results were in effect size (ES) for each biotherapy (or class of biotherapy) vs placebo. An ES of <0.5 was considered as small, between 0.5 and 0.8 as moderate and >0.8 as important.From the 763 published studies, 10 RCTs were included in the analysis: seven involved IR-DMARD RA and three IR-anti-TNF. Among
Supporting Staff at Risk for Compassion Fatigue Supporting Staff at Risk for Compassion Fatigue Prepared for Region of Peel Public Health Elizabeth Walker, RN BScN, CCHN(C) Cheryl Morin, RN, BScN Nicole Labrie, RN, BScN, CCHN(C) October 1, 2012 ii Table of Contents Key Take Home Messages 1 Executive Summary 2 1 Issue 5 2 Context 7 3 Literature Search 11 4 Applicability and Transferability 19 5 Recommendations 24 References 26 Appendices 27 Appendix A: Concept Model 28 Appendix B: Search (...) Strategy 30 Appendix C: Literature Search Flowchart 35 Appendix D: Data Extraction Tables for Two Systematic Reviews 36 1 Key Take Home Messages • Staff working in the Healthy Babies Healthy Children program are reporting increases in work-related stress, including compassion fatigue. • Current strategies to reduce compassion fatigue, including reflective practice and self-care, may be insufficient. • Identifying milestones encountered when working with families, and describing situations where
Cost-effectiveness of counselling, graded-exercise and usual care for chronic fatigue: evidence from a randomised trial in primary care Cost-effectiveness of counselling, graded-exercise and usual care for chronic fatigue: evidence from a randomised trial in primary care Cost-effectiveness of counselling, graded-exercise and usual care for chronic fatigue: evidence from a randomised trial in primary care Sabes-Figuera R, McCrone P, Hurley M, King M, Donaldson AN, Ridsdale L Record Status (...) This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study evaluated the cost-effectiveness of three treatments for chronic fatigue, lasting more than three months. The authors concluded that no clear economic advantage was found for any therapy; counselling
Effectiveness of internet-based cognitive behavioural treatment for adolescents with chronic fatigue syndrome (FITNET): a randomised controlled trial. Chronic fatigue syndrome is characterised by persistent fatigue and severe disability. Cognitive behavioural therapy seems to be a promising treatment, but its availability is restricted. We developed Fatigue In Teenagers on the interNET (FITNET), the first dedicated internet-based therapeutic program for adolescents with this disorder (...) , and compared its effectiveness with that of usual care.Adolescents aged 12-18 years with chronic fatigue syndrome were assigned to FITNET or usual care in a 1:1 ratio at one tertiary treatment centre in the Netherlands by use of a computer-generated blocked randomisation allocation schedule. The study was open label. Primary outcomes were school attendance, fatigue severity, and physical functioning, and were assessed at 6 months with computerised questionnaires. Analysis was by intention to treat
Body composition, physical fitness, functional performance, quality of life, and fatigue benefits of exercise for prostate cancer patients: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: a meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Systematic review of the impact of erythropoiesis-stimulating agents on fatigue in dialysis patients Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
[Treatment of chronic fatigue syndrome CFS/ME] Behandling av kronisk utmattelsessyndrom CFS/ME [Treatment of chronic fatigue syndrome CFS/ME] Behandling av kronisk utmattelsessyndrom CFS/ME [Treatment of chronic fatigue syndrome CFS/ME] Larun L, Brurberg KG, Fonhus MS, Kirkerhei I Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Larun L (...) , Brurberg KG, Fonhus MS, Kirkerhei I. Behandling av kronisk utmattelsessyndrom CFS/ME. [Treatment of chronic fatigue syndrome CFS/ME] Oslo: Norwegian Knowledge Centre for the Health Services (NOKC). Rapid Reviews. 2011 Authors' conclusions Cognitive behavioural therapy and graded exercise therapy is likely to be effective for people with chronic fatigue syndrome. For other treatment strategies the quality of evidence is very low or even non-existing implying that more research is needed before we can
Insufficient evidence for interventions for post-stroke fatigue PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Insufficient evidence for interventions for post-stroke fatigue Clinical question How effective are interventions for post-stroke fatigue? Bottom line This review found 3 small, randomised controlled trials that recruited people with a stroke to 3 treatments - 2 different drug (...) treatments (fluoxetine and tirilazad) and one chronic disease self-management programme. At follow-up, there was no difference in fatigue levels between the patients who received the active treatments and those who received usual care or placebo. However, the trials were too small to provide firm conclusions and further trials are required. Currently, there is insufficient evidence to guide practice in treating fatigue following stroke. Caveat There were only 3 completed studies, providing data
Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Trial findings show cognitive behaviour therapy (CBT) and graded exercise therapy (GET) can be effective treatments for chronic fatigue syndrome, but patients' organisations have reported that these treatments can be harmful and favour pacing and specialist health care. We aimed to assess effectiveness and safety of all (...) four treatments.In our parallel-group randomised trial, patients meeting Oxford criteria for chronic fatigue syndrome were recruited from six secondary-care clinics in the UK and randomly allocated by computer-generated sequence to receive specialist medical care (SMC) alone or with adaptive pacing therapy (APT), CBT, or GET. Primary outcomes were fatigue (measured by Chalder fatigue questionnaire score) and physical function (measured by short form-36 subscale score) up to 52 weeks after
Preventing and Mitigating Nurse Fatigue in Health Care BEST PRACTICE GUIDELINES WWW.RNAO.ORG AUGUST 2011 Preventing and Mitigating Nurse Fatigue in Health Care Healthy Work Environments Best Practice GuidelinesPreventing and Mitigating Nurse Fatigue in Health Care Disclaimer These guidelines are not binding on nurses or the organizations that employ them. The use of these guidelines should be flexible based on individual needs and local circumstances. They neither constitute a liability nor (...) and Mitigating Nurse Fatigue in Health Care Healthy Work Environments Best Practice Guideline. T oronto, ON: Registered Nurses’ Association of Ontario. This Program is funded by the Ministry of Health and Long-T erm Care. Contact Information Registered Nurses’ Association of Ontario 158 Pearl Street, T oronto, Ontario M5H 1L3 Website: www.rnao.org/bestpractices1 Preventing and Mitigating Nurse Fatigue in Health Care BEST PRACTICE GUIDELINES WWW.RNAO.ORG Greetings from Doris Grinspun, Executive Director
Exercise is an effective treatment modality for reducing cancer-related fatigue and improving physical capacity in cancer patients and survivors: a meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Cancer-related fatigue and rehabilitation: a randomized controlled multicenter trial comparing physical training combined with cognitive-behavioral therapy with physical training only and with no intervention Research suggests that cancer rehabilitation reduces fatigue in survivors of cancer. To date, it is unclear what type of rehabilitation is most beneficial.This randomized controlled trial compared the effect on cancer-related fatigue of physical training combined with cognitive behavioral (...) was included.The study was conducted at 4 rehabilitation centers in the Netherlands.All patients were survivors of cancer.Physical training consisting of 2 hours of individual training and group sports took place twice weekly, and cognitive-behavioral therapy took place once weekly for 2 hours.Fatigue was assessed with the Multidimensional Fatigue Inventory before and immediately after intervention (12 weeks after enrollment). The WLC group completed questionnaires at the same time points.Baseline fatigue did
Effect of retirement on major chronic conditions and fatigue: French GAZEL occupational cohort study. To determine, using longitudinal analyses, if retirement is followed by a change in the risk of incident chronic diseases, depressive symptoms, and fatigue. Design Prospective study with repeat measures from 7 years before to 7 years after retirement.Large French occupational cohort (the GAZEL study), 1989-2007. Participants 11 246 men and 2858 women.Respiratory disease, diabetes, coronary (...) heart disease and stroke, mental fatigue, and physical fatigue, measured annually by self report over the 15 year observation period; depressive symptoms measured at four time points.The average number of repeat measurements per participant was 12.1. Repeated measures logistic regression with generalised estimating equations showed that the cumulative prevalence of self reported respiratory disease, diabetes, and coronary heart disease and stroke increased with age, with no break in the trend around