Latest & greatest articles for gestational diabetes

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Top results for gestational diabetes

81. Immediate delivery or expectant management in gestational diabetes at term: the GINEXMAL randomised controlled trial

Immediate delivery or expectant management in gestational diabetes at term: the GINEXMAL randomised controlled trial To evaluate maternal and perinatal outcomes after induction of labour versus expectant management in pregnant women with gestational diabetes at term.Multicentre open-label randomised controlled trial.Eight teaching hospitals in Italy, Slovenia, and Israel.Singleton pregnancy, diagnosed with gestational diabetes by the International Association of Diabetes and Pregnancy Study (...) diabetes, without other maternal or fetal conditions, no difference was detected in birth outcomes regardless of the approach used (i.e. active versus expectant management). Although the study was underpowered, the magnitude of the between-group difference was very small and without clinical relevance.Immediate delivery or expectant management in gestational diabetes at term?© 2016 Royal College of Obstetricians and Gynaecologists.

2016 EvidenceUpdates

82. Regular Exercise to Prevent the Recurrence of Gestational Diabetes Mellitus: A Randomized Controlled Trial

Regular Exercise to Prevent the Recurrence of Gestational Diabetes Mellitus: A Randomized Controlled Trial To investigate the effect of a supervised home-based exercise program on the recurrence and severity of gestational diabetes mellitus (GDM) together with other aspects of maternal health and obstetric and neonatal outcomes.This randomized controlled trial allocated women with a history of GDM to an exercise intervention (14-week supervised home-based stationary cycling program (...) ) or to a control group (standard care) at 13±1 weeks of gestation. The primary outcome was a diagnosis of GDM. Secondary outcomes included maternal fitness, psychological well-being, and obstetric and neonatal outcomes. A sample size of 180 (90 in each group) was required to attain 80% power to detect a 40% reduction in the incidence of GDM.Between June 2011 and July 2014, 205 women provided written consent and completed baseline assessments. Of these, 33 (16%) were subsequently excluded as a result

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2016 EvidenceUpdates

83. Exercise improves glycaemic control in women diagnosed with gestational diabetes mellitus: a systematic review

Exercise improves glycaemic control in women diagnosed with gestational diabetes mellitus: a systematic review Does exercise improve postprandial glycaemic control in women diagnosed with gestational diabetes mellitus?A systematic review of randomised trials.Pregnant women diagnosed with gestational diabetes mellitus.Exercise, performed more than once a week, sufficient to achieve an aerobic effect or changes in muscle metabolism.Postprandial blood glucose, fasting blood glucose, glycated (...) with exercise.Aerobic or resistance exercise, performed at a moderate intensity at least three times per week, safely helps to control postprandial blood glucose levels and other measures of glycaemic control in women diagnosed with gestational diabetes mellitus.PROSPERO CRD42015019106. [Harrison AL, Shields N, Taylor NF, Frawley HC (2016) Exercise improves glycaemic control in women diagnosed with gestational diabetes mellitus: a systematic review.Journal of Physiotherapy62: 188-196].Copyright © 2016 Australian

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2016 EvidenceUpdates

84. Dietary supplementation with myo-inositol in women during pregnancy for treating gestational diabetes. (PubMed)

Dietary supplementation with myo-inositol in women during pregnancy for treating gestational diabetes. Gestational diabetes mellitus (GDM) is any degree of glucose intolerance that first presents and is recognised during pregnancy and usually resolves after the birth of the baby. GDM is associated with increased short- and long-term morbidity for the mother and her baby. Treatment usually includes lifestyle modification and/or pharmacological therapy (oral antidiabetic agents or insulin (...) of myo-inositol for the treatment of gestational diabetes, with no data to examine the majority of outcomes in this review. There do not appear to be any benefits for the infant associated with exposure to myo-inositol such as reduced risk of being born large-for-gestational age. Although the risk of neonatal hypoglycaemia is reduced for the myo-inositol group, there is evidence of imprecision. Evidence from two studies suggested that myo-inositol was associated with a reduced change in maternal BMI

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2016 Cochrane

85. Risk perception and unrecognized type 2 diabetes in women with previous gestational diabetes mellitus. (PubMed)

Risk perception and unrecognized type 2 diabetes in women with previous gestational diabetes mellitus. Women with a history of gestational diabetes mellitus (GDM) have a high chance of developing type 2 diabetes mellitus (T2DM) following the index pregnancy, however, little is known of women's perception of this risk. The objectives were to (1) determine women's perception of risk of future development of T2DM following a GDM pregnancy and (2) describe the prevalence of undetected dysglycaemia (...) in a Canadian population. The study was designed as a 9-11 year follow-up study of women previously enrolled in a randomized controlled trial of tight versus minimal intervention for GDM. Women's perception of future risk of diabetes was determined by questionnaire. Fasting lipid profile, height and weight were performed on all participants. Oral glucose tolerance tests were performed on all women without prior history of diabetes mellitus type 2 (DM2). The study was conducted at Ottawa Hospital General

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2016 Obstetric medicine

86. External validation of prognostic models to predict risk of gestational diabetes mellitus in one Dutch cohort: prospective multicentre cohort study. (PubMed)

External validation of prognostic models to predict risk of gestational diabetes mellitus in one Dutch cohort: prospective multicentre cohort study.  To perform an external validation and direct comparison of published prognostic models for early prediction of the risk of gestational diabetes mellitus, including predictors applicable in the first trimester of pregnancy. External validation of all published prognostic models in large scale, prospective, multicentre cohort study. 31 independent (...) midwifery practices and six hospitals in the Netherlands. Women recruited in their first trimester (<14 weeks) of pregnancy between December 2012 and January 2014, at their initial prenatal visit. Women with pre-existing diabetes mellitus of any type were excluded. Discrimination of the prognostic models was assessed by the C statistic, and calibration assessed by calibration plots. 3723 women were included for analysis, of whom 181 (4.9%) developed gestational diabetes mellitus in pregnancy. 12

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2016 BMJ

87. Lactation and Progression to Type 2 Diabetes Mellitus After Gestational Diabetes Mellitus (PubMed)

Lactation and Progression to Type 2 Diabetes Mellitus After Gestational Diabetes Mellitus 27538169 2017 12 07 2018 12 02 1539-3704 165 4 2016 08 16 Annals of internal medicine Ann. Intern. Med. Lactation and Progression to Type 2 Diabetes Mellitus After Gestational Diabetes Mellitus. 299-300 10.7326/L16-0106 Gunderson Erica P EP Study of Women, Infant Feeding and Type 2 Diabetes After GDM Pregnancy Investigators eng R01 HD050625 HD NICHD NIH HHS United States Journal Article Comment United (...) States Ann Intern Med 0372351 0003-4819 AIM IM Ann Intern Med. 2015 Dec 15;163(12):889-98 26595611 Ann Intern Med. 2016 Aug 16;165(4):299 27538168 Breast Feeding Diabetes Mellitus, Type 2 Diabetes, Gestational Disease Progression Female Humans Lactation Pregnancy 2016 8 19 6 0 2016 8 19 6 0 2017 12 8 6 0 ppublish 27538169 2544588 10.7326/L16-0106 PMC5613933 NIHMS906750 Am J Psychiatry. 2001 Jun;158(6):848-56 11384888 Matern Child Health J. 2009 May;13(3):334-42 18473131 BMC Public Health. 2011 Dec

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2016 Annals of Internal Medicine

88. Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus (PubMed)

Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus To characterize physiologic subtypes of gestational diabetes mellitus (GDM).Insulin sensitivity and secretion were estimated in 809 women at 24-30 weeks' gestation, using oral glucose tolerance test-based indices. In women with GDM (8.3%), defects in insulin sensitivity or secretion were defined below the 25th percentile in women with normal glucose tolerance (NGT). GDM subtypes were defined (...) outcomes similar to those in women with NGT.Heterogeneity of physiologic processes underlying hyperglycemia exists among women with GDM. GDM with impaired insulin sensitivity confers a greater risk of adverse outcomes.© 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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2016 EvidenceUpdates

89. Different intensities of glycaemic control for women with gestational diabetes mellitus. (PubMed)

Different intensities of glycaemic control for women with gestational diabetes mellitus. Gestational diabetes mellitus (GDM) has major short- and long-term implications for both the mother and her baby. GDM is defined as a carbohydrate intolerance resulting in hyperglycaemia or any degree of glucose intolerance with onset or first recognition during pregnancy from 24 weeks' gestation onwards and which resolves following the birth of the baby. Rates for GDM can be as high as 25% depending (...) diagnosed with GDM. Data from 171 of the 180 women were published as a conference abstract and no full report has been identified. The overall risk of bias of the single included study was judged to be unclear.The included trial did not report on any of this review's primary outcomes. For the mother, these were hypertension disorders of pregnancy or subsequent development of type 2 diabetes. For the infant, our primary outcomes were (perinatal (fetal and neonatal) mortality; large-for-gestational age

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2016 Cochrane

90. Short-term risk of cancer among women with previous gestational diabetes: a population-based study (PubMed)

Short-term risk of cancer among women with previous gestational diabetes: a population-based study To evaluate the relationship between gestational diabetes (GDM) and incidence of cancer in women within the first decade postpartum.This population-based retrospective cohort study compared the risk of cancer in women with GDM with that of a matched control group comprising pregnant women without diabetes. We included women from Ontario, Canada aged 20-50 years with no history of cancer who had (...) given birth between 1995 and 2008 (N = 149 049). Women with GDM (N = 49 684) were matched on age and year of giving birth, in a ratio of 1:2, to pregnant women without diabetes (N = 99 365).Over a median 8-year follow-up, there were a total of 2927 (1.5%) cancers. After adjustment for covariates, we found no significant difference in overall risk of cancer between women with GDM and matched control subjects; however, GDM was associated with a significantly greater risk of thyroid cancer (adjusted

2016 EvidenceUpdates

91. Pre-pregnancy potato consumption and risk of gestational diabetes mellitus: prospective cohort study. (PubMed)

Pre-pregnancy potato consumption and risk of gestational diabetes mellitus: prospective cohort study. What is the association between potato consumption before pregnancy and the risk of gestational diabetes mellitus (GDM)?This prospective cohort study included 15,632 women from the Nurses' Health Study II (1991-2001). They had no previous GDM or chronic diseases before pregnancy. Consumption of potatoes and other foods was assessed every four years. Incident first time GDM was ascertained from (...) % lower risk of GDM. Consumption and diabetes were self reported, and severity of diabetes was unknown. More than 90% of women were white. A causal association cannot be assumed.Higher levels of potato consumption before pregnancy are associated with greater risk of GDM, and substitution of potatoes with other vegetables, legumes, or whole grain foods might lower the risk.Funding was received from the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health

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2016 BMJ

92. Randomized clinical trial: Detemir is non-inferior to NPH insulin in women with pregestational type 2 diabetes and gestational diabetes mellitus

Randomized clinical trial: Detemir is non-inferior to NPH insulin in women with pregestational type 2 diabetes and gestational diabetes mellitus Detemir is non-inferior to NPH insulin in women with pregestational type 2 diabetes and gestational diabetes mellitus | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see (...) our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Detemir is non-inferior to NPH insulin in women with pregestational type 2 diabetes and gestational diabetes mellitus Article

2016 Evidence-Based Medicine (Requires free registration)

93. The Comparative Effectiveness of Diabetes Prevention Strategies to Reduce Postpartum Weight Retention in Women With Gestational Diabetes Mellitus: The Gestational Diabetes' Effects on Moms (GEM) Cluster Randomized Controlled Trial (PubMed)

The Comparative Effectiveness of Diabetes Prevention Strategies to Reduce Postpartum Weight Retention in Women With Gestational Diabetes Mellitus: The Gestational Diabetes' Effects on Moms (GEM) Cluster Randomized Controlled Trial To compare the effectiveness of diabetes prevention strategies addressing postpartum weight retention for women with gestational diabetes mellitus (GDM) delivered at the health system level: mailed recommendations (usual care) versus usual care plus a Diabetes (...) Prevention Program (DPP)-derived lifestyle intervention.This study was a cluster randomized controlled trial of 44 medical facilities (including 2,280 women with GDM) randomized to intervention or usual care. The intervention included mailed gestational weight gain recommendations plus 13 telephone sessions between 6 weeks and 6 months postpartum. Primary outcomes included the following: proportion meeting the postpartum goals of 1) reaching pregravid weight if pregravid BMI <25.0 kg/m(2) or 2) losing 5

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2016 EvidenceUpdates

94. Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes. (PubMed)

Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes. Gestational diabetes, glucose intolerance with onset or first recognition during pregnancy, is a rising problem worldwide. Both non-pharmacological and pharmacological approaches to the prevention of gestational diabetes have been, and continue to be explored. Myo-inositol, an isomer of inositol, is a naturally occurring sugar commonly found in cereals, corn, legumes and meat (...) . It is one of the intracellular mediators of the insulin signal and correlated with insulin sensitivity in type 2 diabetes. The potential beneficial effect on improving insulin sensitivity suggests that myo-inositol may be useful for women in preventing gestational diabetes.To assess if antenatal dietary supplementation with myo-inositol is safe and effective, for the mother and fetus, in preventing gestational diabetes.We searched the Pregnancy and Childbirth Group's Trials Register, ClinicalTrials.gov

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2015 Cochrane

95. Large-for-Gestational-Age Ultrasound Diagnosis and Risk for Cesarean Delivery in Women With Gestational Diabetes Mellitus (PubMed)

Large-for-Gestational-Age Ultrasound Diagnosis and Risk for Cesarean Delivery in Women With Gestational Diabetes Mellitus To assess the accuracy of a large-for-gestational-age (LGA) ultrasound diagnosis and the subsequent risk for cesarean delivery associated with ultrasound diagnosis of LGA among women with gestational diabetes mellitus.This was a retrospective cohort study of 903 women with GDM who delivered after 36 weeks of gestation with an ultrasound-estimated fetal weight within 31 days (...) delivery (adjusted odds ratio [OR] 3.13, 95% confidence interval [CI] 2.10-4.67, P<.001) after adjusting for relevant covariates. Stratified analyses demonstrated that ultrasound diagnosis of LGA was associated with an increased risk for cesarean delivery whether the birth weight was between 2,500 and 3,499 g (OR 2.82, 95% CI 1.62-4.84, P<.001) or between 3,500 and 4,500 g (OR 3.47, 95% CI 2.06-5.88, P<.001).Ultrasonography significantly overestimates the prevalence of LGA in women with gestational

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2015 EvidenceUpdates

96. Lifestyle intervention for gestational diabetes mellitus prevention: A cluster-randomized controlled study (PubMed)

Lifestyle intervention for gestational diabetes mellitus prevention: A cluster-randomized controlled study The study was to examine whether gestational diabetes mellitus (GDM) can be prevented by early trimester lifestyle counseling in a high-risk population.From September 2012 to January 2013, 1664 pregnancies in the Department of Obstetrics and Gynecology of First Hospital of Peking University were enrolled in the study during their first prenatal care visit before the 8 gestational weeks (...) on maternal anthropometrics were offered. Both groups were followed until 75 g oral glucose tolerance test (OGTT) testing at 24-28 gestational weeks. The weight gain after intervention and the prevalence of GDM were used to evaluate the effect.(1) According to the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria, the positive rate of GDM for the intervention group was 17.16% (23/134), lower than the control group which was 23.91% (33/138), P = 0.168. (2) The weight gain

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2015 Chronic diseases and translational medicine

97. Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): A Randomized Controlled Trial (PubMed)

Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): A Randomized Controlled Trial To assess whether gestational diabetes mellitus (GDM) can be prevented by a moderate lifestyle intervention in pregnant women who are at high risk for the disease.Two hundred ninety-three women with a history of GDM and/or a prepregnancy BMI of ≥30 kg/m(2) were enrolled in the study at <20 weeks of gestation and were randomly (...) % in the intervention group and 21.6% in the control group ([95% CI 0.40-0.98%]; P = 0.044, after adjustment for age, prepregnancy BMI, previous GDM status, and the number of weeks of gestation). Gestational weight gain was lower in the intervention group (-0.58 kg [95% CI -1.12 to -0.04 kg]; adjusted P = 0.037). Women in the intervention group increased their leisure time physical activity more and improved their dietary quality compared with women in the control group.A moderate individualized lifestyle

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2015 EvidenceUpdates

98. Diet and exercise interventions for preventing gestational diabetes mellitus. (PubMed)

Diet and exercise interventions for preventing gestational diabetes mellitus. Gestational diabetes mellitus (GDM) is associated with a wide range of adverse health consequences for women and their babies in the short and long term. With an increasing prevalence of GDM worldwide, there is an urgent need to assess strategies for GDM prevention, such as combined diet and exercise interventions.To assess the effects of combined diet and exercise interventions for preventing GDM and associated (...) as being of moderate risk of bias overall.When comparing women receiving a diet and exercise intervention with those receiving no intervention, there was no clear difference in the risk of developing GDM (average risk ratio (RR) 0.92, 95% confidence interval (CI) 0.68 to 1.23; 11 trials, 3744 women), caesarean section (RR 0.92, 95% CI 0.83 to 1.01; seven trials, 3246 women), or large-for-gestational age (RR 0.90, 95% CI 0.77 to 1.05; 2950 infants). Only one trial reported on perinatal mortality

2015 Cochrane

99. Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis. (PubMed)

Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis. To summarize short term outcomes in randomized controlled trials comparing glibenclamide or metformin versus insulin or versus each other in women with gestational diabetes requiring drug treatment.Systematic review and meta-analysis.Randomized controlled trials that fulfilled all the following: (1) published as full text; (2) addressed women with gestational diabetes (...) diabetes requiring drug treatment, glibenclamide is clearly inferior to both insulin and metformin, while metformin (plus insulin when required) performs slightly better than insulin. According to these results, glibenclamide should not be used for the treatment of women with gestational diabetes if insulin or metformin is available.Systematic review registration NCT01998113.© Balsells et al 2015.

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2015 BMJ

100. Different strategies for diagnosing gestational diabetes to improve maternal and infant health. (PubMed)

Different strategies for diagnosing gestational diabetes to improve maternal and infant health. Gestational diabetes mellitus (GDM) is carbohydrate intolerance resulting in hyperglycaemia with onset or first recognition during pregnancy. If untreated, perinatal morbidity and mortality may be increased. Accurate diagnosis allows appropriate treatment. Use of different tests and different criteria will influence which women are diagnosed with GDM.To evaluate and compare different testing (...) strategies for diagnosis of gestational diabetes mellitus to improve maternal and infant health while assessing their impact on healthcare service costs.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 October 2014) and reference lists of retrieved studies.We included randomised trials if they evaluated tests carried out to diagnose GDM. We excluded studies that used a quasi-random model.Two review authors independently assessed trials for inclusion and risk of bias

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2015 Cochrane