Latest & greatest articles for heparin

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Top results for heparin

61. Should we avoid heparin to eliminate HIT? (PubMed)

Should we avoid heparin to eliminate HIT? 29296689 2018 01 03 2473-9529 1 1 2016 Nov 29 Blood advances Blood Adv Should we avoid heparin to eliminate HIT? 4 10.1182/bloodadvances.2016000083 Arepally Gowthami Morey GM Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC. eng Journal Article 2016 11 22 United States Blood Adv 101698425 2473-9529 Conflict-of-interest disclosure: G.M.A. has received consultancy fees from Momenta and Apotex Pharmaceuticals (...) , makers of generic low-molecular-weight heparins. 2018 1 4 6 0 2016 11 22 0 0 2016 11 22 0 1 epublish 29296689 10.1182/bloodadvances.2016000083 000083 PMC5744050

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2016 Blood advances

62. Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia (PubMed)

Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of recurrent thromboembolism persists after heparin is cleared and platelet activation leading to release of PF4 has dissipated. We asked whether antigenic complexes between polyphosphates and PF4 released from (...) activated platelets might intensify or sustain the prothrombotic phenotype of HIT. PF4 forms stable, ultralarge complexes with polyphosphates of various sizes, including those released from platelets, which are recognized by the HIT-like monoclonal KKO, an immunoglobulin G2bκ monoclonal heparin/PF4 binding antibody, and by human HIT antibodies. KKO helps to protect PF4/polyphosphate complexes from degradation by phosphatases. Complement is activated when HIT antibodies bind to PF4/polyphosphate

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2016 Blood advances

63. Heparin for the treatment of thrombosis in neonates. (PubMed)

Heparin for the treatment of thrombosis in neonates. Among pediatric patients, newborns are at highest risk of developing thromboembolism. Neonatal thromboembolic (TE) events may consist of both venous and arterial thromboses and often iatrogenic complications (eg, central catheterization). Treatment guidelines for pediatric patients with TE events most often are extrapolated from the literature regarding adults. Options for the management of neonatal TE events include expectant management (...) ; nitroglycerin ointment; thrombolytic therapy or anticoagulant therapy, or a combination of the two; and surgery. Since the 1990s, low molecular weight heparin (LMWH) has become the neonatal anticoagulant of choice. Reasons for its appeal include predictable dose response, no need for venous access, and limited monitoring requirements. The overall major complication rate is around 5%. Whether preterm infants are at increased risk is unclear. No data are available on the frequency of osteoporosis, heparin

2016 Cochrane

64. Blood transfusion and filter set requirements with citrate anticoagulation compared with heparin in renal replacement therapy (PubMed)

Blood transfusion and filter set requirements with citrate anticoagulation compared with heparin in renal replacement therapy 28979523 2018 11 13 1751-1437 17 4 2016 Nov Journal of the Intensive Care Society J Intensive Care Soc Blood transfusion and filter set requirements with citrate anticoagulation compared with heparin in renal replacement therapy. 357 10.1177/1751143716647395 Taylor Nick N Department of Intensive Care, Royal Surrey County Hospital, Guildford, UK. Walter Edward E

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2016 Journal of the Intensive Care Society

65. Five-year outcomes following a randomized trial of femorofemoral and femoropopliteal bypass grafting with heparin-bonded or standard polytetrafluoroethylene grafts (PubMed)

Five-year outcomes following a randomized trial of femorofemoral and femoropopliteal bypass grafting with heparin-bonded or standard polytetrafluoroethylene grafts Cohort studies suggest superior long-term patency of luminal heparin-bonded polytetrafluoroethylene (Hb-PTFE) bypass grafts compared with standard PTFE grafts. The aim of this study was to compare the outcomes of Hb-PTFE grafts with those of standard PTFE grafts 5 years after a randomized trial.Patients with intermittent claudication

2016 EvidenceUpdates

66. Bivalirudin or unfractionated heparin in patients with acute coronary syndromes managed invasively with and without ST elevation (MATRIX): randomised controlled trial. (PubMed)

Bivalirudin or unfractionated heparin in patients with acute coronary syndromes managed invasively with and without ST elevation (MATRIX): randomised controlled trial.  To test the optimal antithrombotic regimen in patients with acute coronary syndrome. Randomised controlled trial. Patients with acute coronary syndrome with and without ST segment elevation in 78 centres in Italy, the Netherlands, Spain, and Sweden. 7213 patients with acute coronary syndrome and planned percutaneous coronary (...) intervention: 4010 with ST segment elevation and 3203 without ST segment elevation. The primary study results in the overall population have been reported previously. Patients were randomly assigned, in an open label fashion, to one of two regimens: bivalirudin with glycoprotein IIb/IIIa inhibitors restricted to procedural complications or heparin with or without glycoprotein IIb/IIIa inhibitors. Primary endpoints were the occurrence of major adverse cardiovascular events, defined as death, myocardial

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2016 BMJ

67. Intravenous heparin during ruptured abdominal aortic aneurysmal repair. (PubMed)

Intravenous heparin during ruptured abdominal aortic aneurysmal repair. There have been enormous advances in the screening, diagnosis, intervention and overall prognosis of abdominal aortic aneurysms (AAAs) in the last decade, but despite these, ruptured AAAs (rAAAs) still cause around 3500 to 6000 deaths in England and Wales each year. Open repair remains standard treatment for rAAA in most centres but increasingly endovascular aneurysm repair (EVAR) is being adopted. This has a 30-day (...) postoperative mortality of 40%. This has remained static despite surgical, anaesthetic and critical care advances.One significant change to current practice for elective repairs of AAAs, as opposed to emergency repairs of rAAAs, has been the introduction of intravenous heparin. This provides a protective effect against cardiac and thrombotic disease in the postoperative period. This practice has not gained widespread acceptance for emergency repairs of rAAA even though a reduction in mortality and morbidity

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2016 Cochrane

68. Increased unfractionated heparin requirements with decreasing body mass index in pregnancy (PubMed)

Increased unfractionated heparin requirements with decreasing body mass index in pregnancy Pregnant women receiving low-molecular-weight heparin for therapeutic anticoagulation are often converted to unfractionated heparin in anticipation of labor. We aim to characterize the impact of maternal body mass index on attainment of target anticoagulation during the conversion process.We conducted a five-year retrospective study of a pregnancy cohort converted from low-molecular-weight heparin (...) to unfractionated heparin in the third trimester. Patient demographics, anticoagulation regimens, and clinical outcomes were extracted from the medical record. Nonparametric statistical methods were used for analysis by body mass index (<30, 30-35, and >35).Thirty-one subjects were evenly distributed by body mass index (p = 0.97). Linear regression revealed an inverse correlation between patient body mass index and unfractionated heparin dose needed to achieve therapeutic anticoagulation (p = 0.04). Subjects

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2016 Obstetric medicine

69. The Effect of Extended Injection of Subcutaneous Heparin on Pain Intensity and Bruising Incidence (PubMed)

The Effect of Extended Injection of Subcutaneous Heparin on Pain Intensity and Bruising Incidence Reducing patients' pain is one of the main goals of providing clinical services, which requires nursing skill. As a simple technique, increasing the duration of subcutaneous heparin injection may affect the intensity of pain and bruising.The aim of this study was to assess the effect of increasing the heparin injection time on pain intensity and bruising associated with subcutaneous injection.The (...) present quasi-experimental study consisted of 86 patients, admitted to our hospital, who were treated with subcutaneous heparin injection. A McGill pain intensity questionnaire was used to measure pain severity in a purposive sampling. All of the subjects received subcutaneous heparin twice for 10 seconds. They also were injected twice with heparin infusion, although it was for 30 seconds this time. The interval between the two injections was 24 h, and the intensity of the pain was measured after each

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2016 Electronic physician

70. Heparin versus 0.9% sodium chloride intermittent flushing for the prevention of occlusion in long term central venous catheters in infants and children: A systematic review (PubMed)

Heparin versus 0.9% sodium chloride intermittent flushing for the prevention of occlusion in long term central venous catheters in infants and children: A systematic review Around the world, guidelines and clinical practice for the prevention of complications associated with central venous catheters (CVC) vary greatly. To prevent occlusion, most institutions recommend the use of heparin when the CVC is not in use. However, there is debate regarding the need for heparin and evidence to suggest (...) normal saline may be as effective. The use of heparin is not without risk, may be unnecessary and is also associated with increased costs.To assess the clinical effects (benefits and harms) of heparin versus normal saline to prevent occlusion in long-term central venous catheters in infants, children and adolescents.A Cochrane systematic review of randomised controlled trials was undertaken.The Cochrane Vascular Group Specialised Register (including MEDLINE, CINAHL, EMBASE and AMED) and the Cochrane

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2016 EvidenceUpdates

71. Heparin for the prevention of intraventricular haemorrhage in preterm infants. (PubMed)

Heparin for the prevention of intraventricular haemorrhage in preterm infants. Preterm birth remains the major risk factor for the development of intraventricular haemorrhage, an injury that occurs in 25% of very low birth weight infants. Intraventricular haemorrhage is thought to be venous in origin and intrinsic thromboses in the germinal matrix are likely to play a triggering role. Heparin activates antithrombin and promotes the inactivation of thrombin and other target proteinases (...) . The administration of anticoagulants such as heparin may offset the increased risk of developing intraventricular haemorrhage and may also reduce the risk of developing parenchymal venous infarct, a condition known to complicate intraventricular haemorrhage.To assess whether the prophylactic administration of heparin reduces the incidence of germinal matrix-intraventricular haemorrhage in very preterm neonates when compared to placebo, no treatment, or other anticoagulants.We searched the Cochrane Central

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2016 Cochrane

72. Thromboprophylaxis with low molecular weight heparin versus unfractionated heparin in intensive care patients: a systematic review with meta-analysis and trial sequential analysis

Thromboprophylaxis with low molecular weight heparin versus unfractionated heparin in intensive care patients: a systematic review with meta-analysis and trial sequential analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club

73. Effect of oral factor Xa inhibitor and low-molecular-weight heparin on surgical complications following total hip arthroplasty (PubMed)

Effect of oral factor Xa inhibitor and low-molecular-weight heparin on surgical complications following total hip arthroplasty This prospective study was conducted to report the effect of oral factor Xa inhibitor and low-molecular-weight heparin (LMWH) on surgical complications following total hip arthroplasty (THA). The patients with an age < 60 years were randomly assigned to three groups (rivaroxaban, enoxaparin, and placebo) and the patients with an age ≥ 60 years were assigned to two

2016 EvidenceUpdates

74. Randomised controlled trial: Low-molecular-weight heparin for the treatment of acute venous thromboembolism in patients with active cancer

Randomised controlled trial: Low-molecular-weight heparin for the treatment of acute venous thromboembolism in patients with active cancer Low-molecular-weight heparin for the treatment of acute venous thromboembolism in patients with active cancer | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Low-molecular-weight heparin for the treatment of acute venous thromboembolism in patients with active cancer Article Text Therapeutics

2016 Evidence-Based Medicine (Requires free registration)

75. An individual patient data meta-analysis of low molecular weight heparin for prevention of placenta-mediated pregnancy complications (AFFIRM)

An individual patient data meta-analysis of low molecular weight heparin for prevention of placenta-mediated pregnancy complications (AFFIRM) Untitled Document PROSPERO will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2016 PROSPERO

76. Low-molecular-weight heparins for managing vaso-occlusive crises in people with sickle cell disease. (PubMed)

Low-molecular-weight heparins for managing vaso-occlusive crises in people with sickle cell disease. Sickle cell disease is one of the most common and severe genetic disorders in the world. It can be broadly divided into two distinct clinical phenotypes characterized by either haemolysis or vaso-occlusion. Pain is the most prominent symptom of vaso-occlusion, and hypercoagulability is a well-established pathogenic phenomenon in people with sickle cell disease. Low-molecular-weight heparins (...) might control this hypercoagulable state through their anticoagulant effect. This is an update of a previously published version of this review.To assess the effects of low-molecular-weight heparins for managing vaso-occlusive crises in people with sickle cell disease.We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Haemoglobinopathies Trials Register comprising references identified from comprehensive electronic database searches. We also searched abstract books of conference

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2015 Cochrane

77. Heparin for Maintaining Patency of Peripherally Inserted Central Catheters in Neonates: Evidence-Based Guidelines

Heparin for Maintaining Patency of Peripherally Inserted Central Catheters in Neonates: Evidence-Based Guidelines Heparin for Maintaining Patency of Peripherally Inserted Central Catheters in Neonates: Evidence-Based Guidelines | CADTH.ca Find the information you need Heparin for Maintaining Patency of Peripherally Inserted Central Catheters in Neonates: Evidence-Based Guidelines Heparin for Maintaining Patency of Peripherally Inserted Central Catheters in Neonates: Evidence-Based Guidelines (...) Published on: November 24, 2015 Project Number: RB0937-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What are the evidence-based guidelines regarding the appropriate dose of heparin required to maintain patency of peripherally inserted central catheters (PICC) for neonatal patients? Key Message No relevant literature was identified regarding the appropriate dose of heparin required to maintain patency of peripherally inserted central catheters

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

78. Heparin versus 0.9% sodium chloride intermittent flushing for the prevention of occlusion in long term central venous catheters in infants and children. (PubMed)

Heparin versus 0.9% sodium chloride intermittent flushing for the prevention of occlusion in long term central venous catheters in infants and children. Guidelines and clinical practice for the prevention of complications associated with central venous catheters (CVC) around the world vary greatly. Most institutions recommend the use of heparin to prevent occlusion, however there is debate regarding the need for heparin and evidence to suggest 0.9% sodium chloride (normal saline) may (...) be as effective. The use of heparin is not without risk, may be unnecessary and is also associated with increased cost.To assess the clinical effects (benefits and harms) of intermittent flushing of heparin versus normal saline to prevent occlusion in long term central venous catheters in infants and children.The Cochrane Vascular Trials Search Co-ordinator searched the Specialised Register (last searched April 2015) and the Cochrane Register of Studies (Issue 3, 2015). We also searched the reference lists

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2015 Cochrane

79. Heparin-Induced Thrombocytopenia. (PubMed)

Heparin-Induced Thrombocytopenia. 26535525 2015 11 06 2018 12 02 1533-4406 373 19 2015 11 05 The New England journal of medicine N. Engl. J. Med. Heparin-Induced Thrombocytopenia. 1883-4 10.1056/NEJMc1510993 Greinacher Andreas A eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Antithrombins 0 Pipecolic Acids 9005-49-6 Heparin AIM IM N Engl J Med. 2015 Jul 16;373(3):252-61 26176382 N Engl J Med. 2015 Nov 5;373(19):1882-3 26535526 N Engl J Med. 2015 Nov 5;373(19):1883 26535527 (...) Antithrombins therapeutic use Female Heparin adverse effects Humans Pipecolic Acids therapeutic use Thrombocytopenia chemically induced 2015 11 5 6 0 2015 11 5 6 0 2015 11 7 6 0 ppublish 26535525 10.1056/NEJMc1510993 10.1056/NEJMc1510993#SA3

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2015 NEJM

80. Heparin-Induced Thrombocytopenia. (PubMed)

Heparin-Induced Thrombocytopenia. 26535526 2015 11 06 2018 12 02 1533-4406 373 19 2015 11 05 The New England journal of medicine N. Engl. J. Med. Heparin-Induced Thrombocytopenia. 1882-3 10.1056/NEJMc1510993 Klarenbeek Naomi B NB Eikenboom Jeroen C J JC eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Antithrombins 0 Pipecolic Acids 9005-49-6 Heparin AIM IM N Engl J Med. 2015 Jul 16;373(3):252-61 26176382 N Engl J Med. 2015 Nov 5;373(19):1883-4 26535525 Antithrombins (...) therapeutic use Female Heparin adverse effects Humans Pipecolic Acids therapeutic use Thrombocytopenia chemically induced 2015 11 5 6 0 2015 11 5 6 0 2015 11 7 6 0 ppublish 26535526 10.1056/NEJMc1510993 10.1056/NEJMc1510993#SA1

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2015 NEJM