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Elvitegravir/cobicistat/emtricitabine/ tenofovir disoproxil (HIV-1 in adolescents) ? Benefit assessment according to §35a Social Code Book (SGB) V Extract 1 Translation of Sections 2.1 to 2.6 of the dossier assessment Elvitegravir/Cobistat/Emtricitabin/ Tenofovirdisoproxil (HIV-Infektion bei Jugendlichen) – Nutzenbewertung gemäß § 35a SGB V (Version 1.0; Status: 7 February 2018). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely (...) the German original text is absolutely authoritative and legally binding. IQWiG Reports – Commission No. A17-59 Elvitegravir/cobicistat/ emtricitabine/tenofovir disoproxil (HIV infection in adolescents) – Benefit assessment according to §35a Social Code Book V 1 Extract of dossier assessment A17-59 Version 1.0 EVG/COBI/FTC/TDF (HIV infection in adolescents) 7 February 2017 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency
HIV, Sexually Transmitted Infection, and Substance Use Continuum of Care Interventions Among Criminal Justice-Involved Black Men Who Have Sex With Men: A Systematic Review Because Black men who have sex with men (BMSM) experience high rates of both HIV and incarceration relative to other groups, the various stages of criminal justice involvement may serve as important intervention points for addressing HIV and related conditions in this group. Although systematic reviews of HIV interventions (...) targeting MSM in general and BMSM in particular exist, no review has explored the range and impact of HIV, sexually transmitted infection (STI), and substance use prevention and care continuum interventions focused on criminal justice-involved (CJI) populations.To describe the range and impact of published HIV, STI, and related substance use interventions for US-based CJI populations and to understand their relevance for BMSM.We conducted systematic searches in the following databases: PubMed, MEDLINE
Bictegravir, emtricitabine and tenofovir alafenamide (Biktarvy) - for the treatment of human immunodeficiency virus-1 (HIV-1) Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product. The for is located
Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life ABamford,*ATurkova,*HLyall, CFoster, NKlein, DBastiaans, DBurger, SBernardi, KButler, EChiappini, 1 2 3 3 4 5 5 6 7 8 P Clayden, 9 M Della Negra, 10 V Giacomet, 11 C (...) Institute of Child Health, University College London, London, UK, 5 Radboud University Medical Center, Nijmegan, The Netherlands, 6 University Department of Immunology and Infectious Disease, Bambino Gesù Children’s Hospital, Rome, Italy, 7 Our Lady’s Children’s Hospital Crumlin & University College Dublin, Dublin, Ireland, 8 Meyer University Hospital, Florence University, Florence, Italy, 9 HIV i-Base, London, UK, 10 Emilio Ribas Institute of Infectious Diseases, Sao Paulo, Brazil, 11 Paediatric
Preparing HIV-infected children and adolescents for travel 1 Guideline: Preparing HIV-infected children and adolescents for travel Authors: Natalie Prevatt Date of preparation: February 2017 Next review date: February 2019 Contents Summary 2 Introduction to the guideline 2 General travel health and safety advice for travel 2 Traveller’s diarrhoea: prevention and treatment 4 Malaria prevention 4 Personal protection 6 Chemoprophylaxis 6 Important interactions between antimalarials and ART 7 (...) the basics, and the additional considerations required for a HIV- infected traveller. • The following website provides regularly updated country specific guidance for professionals: www.nathnac.org • Telephone advice can be gained from the National Travel Health Network and Centre (NaTHNac) telephone advice line (0845 602 6712) General travel health and safety advice for travel The following advice for HIV-infected children and families planning to travel should be given in clinic: • Seek early expert
Antiretroviral / HIV Drug Dosing for Paediatrics Antiretroviral / HIV Drug Dosing for Paediatrics 2018-19(v2) - Imperial College Healthcare NHS Trust (NOT for neonatal vertical transmission post exposure prophylaxis – see local / BHIVA guidelines) Agent Recommended dosage, class side effects and contraindications & warnings Formulation Comment Intake Advice Nucleoside Reverse Transcriptase Inhibitors (NRTI): lactic acidosis, steatosis, Lipoatrophy (effects of mitochondrial toxicity) Lamivudine (...) is intended to be used by practitioners experienced in paediatric HIV care. Please do not use this outside these recommendations. The table will be reviewed in June 2019 Tel: Family clinic: 020-3312-6349, Paed HIV Pharmacist: 020-3312-7617 Authors: Caroline Foster, Hermione Lyall, Gareth Tudor-Williams and Neil Tickner Please email feedback to: firstname.lastname@example.org Version 4.1
Assessment of HIV-related mental status changes Assessment of HIV-related mental status changes - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Assessment of HIV-related mental status changes Last reviewed: February 2019 Last updated: October 2018 Summary Altered mental status and allied cognitive disorders have devastating consequences for HIV-infected individuals and their carers. Neuropsychological deficits also (...) have a negative impact on the quality of life. Pandya R, Krentz HB, Gill MJ, et al. HIV-related neurological syndromes reduce health-related quality of life. Can J Neurol Sci. 2005 May;32(2):201-4. http://www.ncbi.nlm.nih.gov/pubmed/16018155?tool=bestpractice.com These may arise as a direct effect of HIV infection: for example, as part of a spectrum of HIV-associated neurocognitive disorders (HAND) or as a psychiatric comorbidity (e.g., depression or alcohol/substance abuse). While HIV-related
â€˜Why would you promote something that is less percent safer than a condom?â€™: Perspectives on partially effective HIV prevention technologies among key populations in South Africa New biomedical prevention technologies (NPTs) for HIV, including oral Pre-Exposure Prophylaxis, and vaginal and rectal microbicides and HIV vaccines in development, may contribute substantially to controlling the HIV epidemic. However, their effectiveness is contingent on product acceptability and adherence. We
â€˜They care rudely!â€™: resourcing and relational health system factors that influence retention in care for people living with HIV in Zambia Despite access to free antiretroviral therapy (ART), many HIV-positive Zambians disengage from HIV care. We sought to understand how Zambian health system 'hardware' (tangible components) and 'software' (work practices and behaviour) influenced decisions to disengage from care among 'lost-to-follow-up' patients traced by a larger study on their current (...) health status.We purposively selected 12 facilities, from 4 provinces. Indepth interviews were conducted with 69 patients across four categories: engaged in HIV care, disengaged from care, transferred to another facility and next of kin if deceased. We also conducted 24 focus group discussions with 158 lay and professional healthcare workers (HCWs). These data were triangulated against two consecutive days of observation conducted in each facility. We conducted iterative multilevel analysis using
An evaluation of the innovative potentials of a HIV pilot exploring medical pluralism in rural South Africa This article reflects on an internal evaluation undertaken to estimate the potentials of a community-university pilot project to be developed into a bonafide innovation that can be applied at scale. The focus of the community-university partnership has been to reduce the unintended consequences of medical pluralism on the HIV and AIDS epidemic in Waterberg district, Limpopo Province (...) , South Africa. Despite promising outputs from the partnership - including an increase in adherence to antiretroviral therapy and a reduction in stigma among traditionalists living with HIV - the partnership wished to establish whether further funding should be applied for to take the pilot from its current prototype status to a more established innovation. In order to evaluate the innovative potentials of the pilot, the opportunity vacuum model of innovation was adapted and applied. The findings
Mechanisms That Contribute to a Profound Reduction of the HIV-1 Reservoir After Allogeneic Stem Cell Transplant. This article has been corrected. The original version (PDF) is appended to this article as a Supplement.The multifactorial mechanisms associated with radical reductions in HIV-1 reservoirs after allogeneic hematopoietic stem cell transplant (allo-HSCT), including a case of HIV cure, are not fully understood.To investigate the mechanism of HIV-1 eradication associated with allo (...) -HSCT.Nested case series within the IciStem observational cohort.Multicenter European study.6 HIV-infected, antiretroviral-treated participants who survived more than 2 years after allo-HSCT with CCR5 wild-type donor cells.HIV DNA analysis, HIV RNA analysis, and quantitative viral outgrowth assay were performed in blood, and HIV DNA was also measured in lymph nodes, ilea, bone marrow, and cerebrospinal fluid. A humanized mouse model was used for in vivo detection of the replication-competent blood cell
Determinants of disclosure and non-disclosure of HIV-positive status, byÂ pregnant women in rural South Africa Disclosure of HIV status remains one of the major challenges to the effectiveness of the prevention of mother to child transmission of HIV in rural areas in South Africa. This study aimed at assessing the determinants of HIV status disclosure among HIV infected pregnant women who have disclosed their HIV status to someone, as well as among those who have disclosed to their partners (...) . Cross-sectional data was collected from 673 HIV sero-positive pregnant women receiving antenatal care services at 12 Community Health Centers in Mpumalanga province. Results indicated that over two-thirds (72.1%) disclosed their status to someone, while just over half (58.4%) disclosed to their partners. Multivariate analysis showed that both disclosure of ones HIV status to someone and to their male partners was significantly associated with increase in antiretroviral therapy (ART) adherence
Effects of adolescent exposure to behaviour change interventions on their HIV risk reduction in Northern Malawi: a situation analysis Understanding adolescents' translation of HIV and AIDS-related behaviour change interventions (BCI) knowledge and skills into expected behavioural outcomes helps us appreciate behaviour change dynamics among young people and informs evidence-based programming. We explored the effects of adolescents' exposure to BCI on their HIV risk reduction in selected schools (...) model isolated sexual experience ([Beta = .727, p = .0001, p < .05]) as having the strongest correlation with the dependent variable - risk reduction. BCI exposure was stepwise excluded ([Beta = -.082, p = .053, p > .05]). There was therefore no evidence against the null hypothesis of no relationship between adolescent exposure to BCI and their HIV risk reduction. Overall there was limited BCI knowledge and skills translation to behavioural risk reduction. The study points to the need to evaluate
Doravirine (Pifeltro) - To treat HIV-1 infection in adult patients Drug Approval Package: PIFELTRO (doravirine) U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: PIFELTRO (doravirine) Company: Merck Sharp & Dohme Corp. Application Number: 210806 & 210807 Approval Date: 08/30/2018 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application
Using strategic information for action: lessons from the HIV/AIDS response in Vietnam 30294455 2018 11 14 2059-7908 3 5 2018 BMJ global health BMJ Glob Health Using strategic information for action: lessons from the HIV/AIDS response in Vietnam. e000793 10.1136/bmjgh-2018-000793 Son Vo Hai VH Vietnam Administration on HIV/AIDS Control, Vietnam Ministry of Health, Hanoi, Vietnam. Abdul-Quader Abu A Center for Global Health, Centers for Disease Control and Prevention, Hanoi, Viet Nam. Suthar (...) Amitabh Bipin AB 0000-0001-9756-6593 Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. eng Journal Article 2018 09 26 England BMJ Glob Health 101685275 2059-7908 Hiv epidemiology geographic information systems health systems Competing interests: None declared. 2018 02 21 2018 05 07 2018 07 13 2018 10 9 6 0 2018 10 9 6 0 2018 10 9 6 1 epublish 30294455 10.1136/bmjgh-2018-000793 bmjgh-2018-000793 PMC6169661 Bull World Health Organ. 2010 Jan;88(1):58-65 20428354
Exploring the acceptability of Option B plus among HIV-positive Nigerian women engaged and not engaged in the prevention of mother-to-child transmission of HIV cascade: a qualitative study The acceptability of lifelong antiretroviral therapy (ART) among HIV-positive women in high-burden Nigeria, is not well-known. We explored readiness of users and providers of prevention of mother-to-child transmission of HIV (PMTCT) services to accept lifelong ART -before Option B plus was implemented (...) in Nigeria. We conducted 142 key informant interviews among 100 PMTCT users (25 pregnant-newly-diagnosed, 26 pregnant-in-care, 28 lost-to-follow-up (LTFU) and 21 postpartum women living with HIV) and 42 PMTCT providers in rural North-Central Nigeria. Qualitative data were manually analyzed via Grounded Theory. PMTCT users had mixed views about lifelong ART, strongly influenced by motivation to prevent infant HIV and by presence or absence of maternal illness. Newly-diagnosed women were most enthusiastic
Stick To It: pilot study results of an intervention using gamification to increase HIV screening among young men who have sex with men in California In the United States, young men who have sex with men (YMSM) experience a disproportionate burden of HIV and sexually transmitted infections (STIs). Mobile health (mHealth) interventions, including those that incorporate elements of games ("gamification"), have the potential to improve YMSM engagement in desirable sexual health services (...) and behaviors. Gamification leverages theory and tools from behavioral science to motivate people to engage in a behavior in a context of fun. The objective of the study was to determine whether an intervention using gamification is acceptable to YMSM in California and potentially increases repeat HIV screening.Eligible YMSM were: (I) 18-26 years, (II) born as and/or self-identified as male, (III) reported male sexual partners, and (IV) lived in a zip code adjacent to one of the two study clinics in Oakland
Factors associated with knowledge and awareness of HIV/AIDS among married women in Bangladesh: evidence from a nationally representative survey Women in Bangladesh share a greater risk of Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) infection compared to men. Levels of knowledge and awareness largely contribute to the prevalence of the HIV epidemic and its consequences. So, it is required to conduct studies based on most recent data to explore the determinants (...) of HIV awareness. Therefore, we aimed to find the awareness level and factors influencing HIV related awareness among the married women in Bangladesh. We used data from 2014 Bangladesh Demographic and Health Survey (BDHS). About two-third of total respondents who heard about the HIV/AIDS were selected and interviewed successfully (n = 12,593) about 11 basic questions related to individual's awareness. A score of the respondent's knowledge and awareness was determined based on these questions. We used
Integration of HIV and reproductive health services in public sector facilities: analysis of client flow data over time in Kenya Integration of HIV/AIDS with reproductive health (RH) services can increase the uptake and efficiency of services, but gaps in knowledge remain about the practice of integration, particularly how provision can be expanded and performance enhanced. We assessed the extent and nature of service integration in public sector facilities in four districts in Kenya.Between (...) 2009 and 2012, client flow assessments were conducted at six time points in 24 government facilities, purposively selected as intervention or comparison sites. A total of 25 539 visits were tracked: 15 270 in districts where 6 of 12 facilities received an intervention to strengthen HIV service integration with family planning (FP); and 10 266 visits in districts where half the facilities received an HIV-postnatal care intervention in 2009-2010. We tracked the proportion of all visits in which: (1
Health-related quality of life and associated factors in adults living with HIV in Rwanda In Rwanda, as in other sub-Saharan African (SSA) countries, life expectancy of people living with HIV (PLWH) has increased dramatically as a result of combined antiretroviral therapy (cART). People living with HIV can now live longer but with increasing rates of non-communicable diseases (NCDs). Thus, prevention of NCD comorbidities in PWLHI is crucial to maintain and gain health-related benefits (...) and to maximise the health-related quality of life (HRQOL) in the long-term management of PLWH. This study determines the association between physical and mental health-related dimensions of quality of life (QOL) with behavioural and biological risk factors, after controlling socio-demographic and HIV-related factors in adults living with HIV in Rwanda. A cross-sectional study using the WHO STEPwise approach and Kinyarwanda version of the MOS-HIV Health Survey, risk factors for NCDs and HRQOL were analysed