Latest & greatest articles for ibuprofen

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Top results for ibuprofen

21. Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial (PubMed)

Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial Oral morphine for postoperative pain after minor pediatric surgery, while increasingly popular, is not supported by evidence. We evaluated whether oral morphine was superior to ibuprofen for at-home management of children's postoperative pain.We conducted a randomized superiority trial comparing oral morphine (0.5 mg/kg) with ibuprofen (10 mg/kg) in children 5 to 17 (...) and ibuprofen groups. Both interventions decreased pain scores with no difference in efficacy. The median difference in pain score before and after the first dose of medication was 1 (interquartile range 0-1) for both morphine and ibuprofen (p = 0.2). For doses 2 to 8, the median differences in pain score before and after the dose were not significantly different between groups. Significantly more participants taking morphine reported adverse effects (45/65 [69%] v. 26/67 [39%], p < 0.001), most commonly

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2017 EvidenceUpdates

22. Pain relief of sore throat with a new anti-inflammatory throat lozenge, ibuprofen 25 mg: A randomised, double-blind, placebo-controlled, international phase III study

Pain relief of sore throat with a new anti-inflammatory throat lozenge, ibuprofen 25 mg: A randomised, double-blind, placebo-controlled, international phase III study The aim of this study was to compare the efficacy and safety of a new oromucosal ibuprofen form, ibuprofen 25 mg lozenge, in single and repeat dosing for up to 4 days, to the matched placebo, in the treatment of acute sore throat pain in adults.In this randomised, double-blind, placebo-controlled trial, adult patients with non (...) -streptococcal sore throat and signs of moderate-to-severe associated pain (≥5 on the objective Tonsillo-Pharyngitis Assessment 21-point scale and ≥60 mm on the subjective 0-100 mm visual analogue Sore Throat Pain Intensity Scale [STPIS]) were assigned ibuprofen 25 mg (n=194) or matching placebo (n=191) lozenge treatment. Efficacy was assessed (at the investigating centre up to 2 hours after first dosing, then on an ambulatory basis) by parameters derived from patient's scores on scales of pain relief, pain

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2017 EvidenceUpdates

23. Combination Therapy of Acetaminophen and Ibuprofen Is the Most Effective Treatment for Patients with Post-Endodontic Pain

Combination Therapy of Acetaminophen and Ibuprofen Is the Most Effective Treatment for Patients with Post-Endodontic Pain UTCAT3197, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Combination Therapy of Acetaminophen and Ibuprofen Is the Most Effective Treatment for Patients with Post-Endodontic Pain Clinical Question In patients with post-operative endodontic pain, does the combination of non-steroidal anti (...) -inflammatory drugs (NSAIDs) with acetaminophen provide more pain relief than individual NSAIDs or acetaminophen or placebo? Clinical Bottom Line For patients with post-operative endodontic pain, post-operative combination therapy of ibuprofen and acetaminophen provides more pain relief than acetaminophen alone or placebo. Acetaminophen alone did not provide more post-operative endodontic pain relief than placebo, suggesting that acetaminophen should only be used in combination with other NSAIDs for post

2017 UTHSCSA Dental School CAT Library

24. The effectiveness of ibuprofen and lorazepam combination therapy in treating the symptoms of acute Migraine: A randomized clinical trial (PubMed)

The effectiveness of ibuprofen and lorazepam combination therapy in treating the symptoms of acute Migraine: A randomized clinical trial Migraine is a common, episodic and debilitating disease. The migraineur not only suffers from pain, but also lives with a diminished to poor quality of life. Several medicinal therapies are used to abate the debilitating symptoms of this disease.The present study was conducted to determine the effectiveness of Ibuprofen and Lorazepam combination therapy (...) randomly divided into three groups of 30. The first group was administered 200 mg Ibuprofen capsules, the second group 400 mg Ibuprofen capsules and the third group a combination of 200 mg Ibuprofen capsules and 1 mg Lorazepam tablets. The medications were taken in the presence of the researcher. A checklist was used to assess the severity of headache and other migraine symptoms such as nausea, vomiting, photophobia and phonophobia in the patients, before and two hours after the intervention. Data were

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2017 Electronic physician

25. Ibuprofen plus paracetamol versus ibuprofen in acute low back pain: a randomized open label multicenter clinical study. (PubMed)

Ibuprofen plus paracetamol versus ibuprofen in acute low back pain: a randomized open label multicenter clinical study. to estimate whether combination of ibuprofen and paracetamol is more effective than ibuprofen in monotherapy, in the treatment of acute low back pain.80 adult patients with acute low back pain were randomized into two subgroups. In the first subgroup, 40 patients were treated with ibuprofen 400mg three times a day (TID), whilst patients in the second subgroup (n=40) were (...) treated with a fixed-dose combination tablet of ibuprofen 200mg plus paracetamol 325mg TID, for three consecutive days. Patients were followed for another 7 days. Efficacy and tolerability of both treatment options was assessed.A statistically significant decrease in pain intensity, assessed using a visual analogue scale (p<0.001), as well as the 5-point Likert scale, was noticed in both subgroups of patients. However, intensity of pain on Day 4 was significantly lower in patients treated

2016 Acta reumatologica portuguesa

26. Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis. (PubMed)

Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis. The cardiovascular safety of celecoxib, as compared with nonselective nonsteroidal antiinflammatory drugs (NSAIDs), remains uncertain.Patients who required NSAIDs for osteoarthritis or rheumatoid arthritis and were at increased cardiovascular risk were randomly assigned to receive celecoxib, ibuprofen, or naproxen. The goal of the trial was to assess the noninferiority of celecoxib with regard to the primary composite (...) group (852±103 mg), or the ibuprofen group (2045±246 mg) for a mean treatment duration of 20.3±16.0 months and a mean follow-up period of 34.1±13.4 months. During the trial, 68.8% of the patients stopped taking the study drug, and 27.4% of the patients discontinued follow-up. In the intention-to-treat analyses, a primary outcome event occurred in 188 patients in the celecoxib group (2.3%), 201 patients in the naproxen group (2.5%), and 218 patients in the ibuprofen group (2.7%) (hazard ratio

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2016 NEJM

27. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. (PubMed)

Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking.In a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 children (age range (...) , 12 to 59 months) with mild persistent asthma and assigned them to receive either acetaminophen or ibuprofen when needed for the alleviation of fever or pain over the course of 48 weeks. The primary outcome was the number of asthma exacerbations that led to treatment with systemic glucocorticoids. Children in both groups received standardized asthma-controller therapies that were used in a simultaneous, factorially linked trial.Participants received a median of 5.5 doses (interquartile range, 1.0

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2016 NEJM

28. 400 mg Ibuprofen/1000 mg Acetaminophen (Paracetamol) Is Suggested Effective Dosage for Ibuprofen/Acetaminophen Combination Therapy in Postoperative Pain Reduction

400 mg Ibuprofen/1000 mg Acetaminophen (Paracetamol) Is Suggested Effective Dosage for Ibuprofen/Acetaminophen Combination Therapy in Postoperative Pain Reduction UTCAT2994, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title 400 mg Ibuprofen/1000 mg Acetaminophen (Paracetamol) Is Suggested Effective Dosage for Ibuprofen/Acetaminophen Combination Therapy in Postoperative Pain Reduction Clinical Question In patients (...) receiving acetaminophen (paracetamol) and ibuprofen combination therapy, what is the effective dosage to relieve postoperative pain? Clinical Bottom Line For patients with postoperative pain, 400 mg ibuprofen/1000 mg acetaminophen (paracetamol) is the suggested effective dosage for short-term pain management. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Mehlisch/2010 234 patients post extraction

2016 UTHSCSA Dental School CAT Library

29. Esophageal ulcer induced by ibuprofen tablets (PubMed)

Esophageal ulcer induced by ibuprofen tablets 29063015 2018 11 13 2095-882X 1 4 2015 Dec Chronic diseases and translational medicine Chronic Dis Transl Med Esophageal ulcer induced by ibuprofen tablets. 245-246 10.1016/j.cdtm.2015.11.004 Xu Xiao-Ling XL Department of Gastroenterology, Subei People's Hospital, Clinical Medical School, Yangzhou University Affiliated Hospital, Yangzhou, Jiangsu, China. Zhu Hai-Hang HH Department of Gastroenterology, Subei People's Hospital, Clinical Medical School (...) , Yangzhou University Affiliated Hospital, Yangzhou, Jiangsu, China. Yin Jian J Department of Gastroenterology, Subei People's Hospital, Clinical Medical School, Yangzhou University Affiliated Hospital, Yangzhou, Jiangsu, China. eng Journal Article 2016 01 21 China Chronic Dis Transl Med 101679934 2095-882X Esophageal ulcer Ibuprofen Non-steroidal antiinflammatory drugs 2015 09 01 2017 10 25 6 0 2016 1 21 0 0 2016 1 21 0 1 epublish 29063015 10.1016/j.cdtm.2015.11.004 S2095-882X(15)00070-5 PMC5643597

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2016 Chronic diseases and translational medicine

30. Systematic review: Ibuprofen for the treatment of TTH

Systematic review: Ibuprofen for the treatment of TTH Ibuprofen for the treatment of TTH | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search (...) for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Ibuprofen for the treatment of TTH Article Text Therapeutics/Prevention Systematic review Ibuprofen for the treatment of TTH Roy G Beran Statistics from Altmetric.com Commentary on: Derry S , Wiffen PJ , Moore RA , et al . Ibuprofen for acute treatment of episodic tension-type headache in adults

2016 Evidence-Based Medicine (Requires free registration)

31. Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen

Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Prescrire IN ENGLISH - Spotlight ''Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen'', 1 January 2016 {1} {1} {1} | | > > > Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |  (...)  |   |   |   |   |   |   |  Spotlight Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen When pain medication is required, paracetamol (alias acetaminophen) is the reference drug. Among the nonsteroidal anti-inflammatories (NSAIDs), naproxen or ibuprofen (not exceeding 1200 mg a day) are the drugs that carry the least exposure to cardiac disorders. When pain medication is needed

2016 Prescrire

32. Systematic review with meta analysis: The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults

Systematic review with meta analysis: The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults Article Text Therapeutics

2016 Evidence-Based Medicine (Requires free registration)

33. Ibuprofen Versus Indomethacin for Medical Closure of the Patent Arterial Duct: A Pooled Analysis by Route of Administration. (PubMed)

Ibuprofen Versus Indomethacin for Medical Closure of the Patent Arterial Duct: A Pooled Analysis by Route of Administration. Preterm infants are at increased risk of having a patent arterial duct (PAD). PADs may cause congestive heart failure, respiratory distress, necrotizing enterocolitis, and renal impairment. Consequently, in some infants, it becomes necessary to attempt closure of the PAD. Surgical closure can be difficult in small infants and is not without its risks; thus, medical (...) closure offers advantages. Cyclooxygenase inhibitors have been used for medical closure of the PAD with both ibuprofen and indomethacin having been used clinically.We performed a systematic review of the literature to identify all studies comparing ibuprofen and indomethacin. Studies comparing ibuprofen and indomethacin for closure of the PAD in premature infants were included in the meta-analysis. A subanalysis was performed to compare the route of administration. Efficacy endpoints studied were PAD

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2015 Curēus

34. Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults. (PubMed)

Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults. There is good evidence that combining two different analgesics in fixed doses in a single tablet can provide better pain relief in acute pain and headache than either drug alone, and that the drug-specific benefits are essentially additive. This appears to be broadly true in postoperative pain and migraine headache across a range of different drug combinations, and when tested in the same and different trials (...) . Adding caffeine to analgesics also increases the number of people obtaining good pain relief. Combinations of ibuprofen and caffeine are available without prescription in some parts of the world.To assess the analgesic efficacy and adverse effects of a single oral dose of ibuprofen plus caffeine for moderate to severe postoperative pain, using methods that permit comparison with other analgesics evaluated in standardised trials using almost identical methods and outcomes.We searched the Cochrane

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2015 Cochrane

35. High-dose ibuprofen (?2400mg/day): small increase in cardiovascular risk

High-dose ibuprofen (?2400mg/day): small increase in cardiovascular risk High-dose ibuprofen (≥2400mg/day): small increase in cardiovascular risk - GOV.UK GOV.UK uses cookies to make the site simpler. or Search High-dose ibuprofen (≥2400mg/day): small increase in cardiovascular risk EU review confirms that the cardiovascular risk of high-dose ibuprofen (≥2400mg/day) is similar to COX 2 inhibitors and diclofenac. Published 26 June 2015 From: Therapeutic area: , , , Contents When prescribing (...) or dispensing ibuprofen: avoid use of high-dose ibuprofen (≥2400 mg per day) in patients with established: ischaemic heart disease peripheral arterial disease cerebrovascular disease congestive heart failure (New York Heart Association [NYHA] classification II-III) uncontrolled hypertension review the treatment of patients with the above conditions who are taking high-dose ibuprofen at their next routine appointment carefully consider the benefits and risks before starting long-term ibuprofen treatment

2015 MHRA Drug Safety Update

36. Fracture pain relief for kids? Ibuprofen does it better

Fracture pain relief for kids? Ibuprofen does it better Fracture pain relief for kids? Ibuprofen does it better Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Fracture pain relief for kids? Ibuprofen does it better View/ Open Date 2010-05 Format Metadata Abstract Use ibuprofen instead of acetaminophen with codeine

2015 PURLS

37. Randomised controlled trial: Postfracture pain in children can be adequately managed with ibuprofen

Randomised controlled trial: Postfracture pain in children can be adequately managed with ibuprofen Postfracture pain in children can be adequately managed with ibuprofen | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Postfracture pain in children can be adequately managed with ibuprofen Article Text Therapeutics/Prevention Randomised controlled trial Postfracture pain in children can be adequately managed with ibuprofen Kevin B L

2015 Evidence-Based Medicine (Requires free registration)

38. For Post-Dental Extraction Pain, Co-therapy with Acetaminophen and Ibuprofen is More Effective in Pain Management than Acetaminophen or Ibuprofen Alone

For Post-Dental Extraction Pain, Co-therapy with Acetaminophen and Ibuprofen is More Effective in Pain Management than Acetaminophen or Ibuprofen Alone UTCAT2734, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title For Post-Dental Extraction Pain, Co-therapy with Acetaminophen and Ibuprofen is More Effective in Pain Management than Acetaminophen or Ibuprofen Alone Clinical Question In patients following a dental extraction (...) is the post-operative administration of combined acetaminophen and ibuprofen better than therapy with acetaminophen or ibuprofen alone for pain management? Clinical Bottom Line The post-operative use combined acetaminophen and ibuprofen provides superior pain relief compared to acetaminophen or ibuprofen alone. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Bailey/2013 Patient Group 2,241 patients ages 16-65

2014 UTHSCSA Dental School CAT Library

39. Ibuprofen

Ibuprofen USE OF IBUPROFEN IN PREGNANCY 0344 892 0909 USE OF IBUPROFEN IN PREGNANCY (Date of issue: December 2013 , Version: 1.1 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used (...) to treat acute and chronic pain, and in the management of rheumatoid arthritis. Studies of NSAIDs as a group have identified an association between use in pregnancy and congenital malformation, specifically cardiovascular defects. However, the available data are conflicting and limited, and firm associations are yet to be concluded. Data specifically relating to maternal ibuprofen use in pregnancy are confounded and conflicting. Studies which have investigated overall rates of malformation have

2014 UK Teratology Information Service

40. Randomised controlled trial: Neither ibuprofen nor steam improves symptom control compared with paracetamol in patients with acute respiratory tract infections in primary care

Randomised controlled trial: Neither ibuprofen nor steam improves symptom control compared with paracetamol in patients with acute respiratory tract infections in primary care Neither ibuprofen nor steam improves symptom control compared with paracetamol in patients with acute respiratory tract infections in primary care | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser (...) at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Neither ibuprofen nor steam improves symptom control compared

2014 Evidence-Based Medicine (Requires free registration)