Latest & greatest articles for ibuprofen

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on ibuprofen or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on ibuprofen and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for ibuprofen

41. Systematic review and meta-analysis: Limited evidence that single-dose oral ibuprofen plus codeine is more effective for postoperative pain than either drug alone

Systematic review and meta-analysis: Limited evidence that single-dose oral ibuprofen plus codeine is more effective for postoperative pain than either drug alone Limited evidence that single-dose oral ibuprofen plus codeine is more effective for postoperative pain than either drug alone | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use (...) cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Limited evidence that single-dose oral ibuprofen plus codeine is more effective for postoperative pain than

Full Text available with Trip Pro

2014 Evidence-Based Nursing

42. Cohort study: Ibuprofen does not seem to increase global malformation risk but NSAID use in late pregnancy remains a concern

Cohort study: Ibuprofen does not seem to increase global malformation risk but NSAID use in late pregnancy remains a concern Ibuprofen does not seem to increase global malformation risk but NSAID use in late pregnancy remains a concern | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Ibuprofen does not seem to increase global malformation risk but NSAID use in late pregnancy remains a concern Article Text Aetiology Cohort study

2014 Evidence-Based Medicine (Requires free registration)

43. Ibuprofen, paracetamol, and steam for patients with respiratory tract infections in primary care: pragmatic randomised factorial trial. (PubMed)

Ibuprofen, paracetamol, and steam for patients with respiratory tract infections in primary care: pragmatic randomised factorial trial. To assess strategies for advice on analgesia and steam inhalation for respiratory tract infections.Open pragmatic parallel group factorial randomised controlled trial.Primary care in United Kingdom.Patients aged ≥ 3 with acute respiratory tract infections.889 patients were randomised with computer generated random numbers in pre-prepared sealed numbered (...) envelopes to components of advice or comparator advice: advice on analgesia (take paracetamol, ibuprofen, or both), dosing of analgesia (take as required v regularly), and steam inhalation (no inhalation v steam inhalation).Primary: mean symptom severity on days 2-4; symptoms rated 0 (no problem) to 7 (as bad as it can be). Secondary: temperature, antibiotic use, reconsultations.Neither advice on dosing nor on steam inhalation was significantly associated with changes in outcomes. Compared

Full Text available with Trip Pro

2013 BMJ

44. Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults. (PubMed)

Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults. This review is an update of a previously published review in The Cochrane Database of Systematic Reviews Issue 3, 2009 on single dose oral dexibuprofen (S(+)-ibuprofen) for acute postoperative pain in adults.Dexibuprofen is a non-steroidal anti-inflammatory drug (NSAID) licensed for use in rheumatic disease and other musculoskeletal disorders in the UK, and widely available in other countries worldwide (...) . It is an active isomer of ibuprofen. This review sought to evaluate the efficacy and safety of oral dexibuprofen in acute postoperative pain, using clinical studies in patients with established pain, and with outcomes measured primarily over four to six hours, using standard methods. This type of study has been used for many decades to establish that drugs have analgesic properties.To assess the efficacy and adverse effects of single dose oral dexibuprofen for acute postoperative pain using methods

Full Text available with Trip Pro

2013 Cochrane

45. A Prophylactic Single Dose of 200mg Ibuprofen or 20mg Tenoxicam Administration Before Endodontic Treatment reduces Postoperative Pain at 6 hours after Treatment

A Prophylactic Single Dose of 200mg Ibuprofen or 20mg Tenoxicam Administration Before Endodontic Treatment reduces Postoperative Pain at 6 hours after Treatment UTCAT2593, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title A Prophylactic Single Dose of 200mg Ibuprofen or 20mg Tenoxicam Administration Before Endodontic Treatment Reduces Postoperative Pain at 6 Hours After Treatment Clinical Question Do preoperative pain (...) medications reduce pain in patients with endodontic treatment compared with patients with no postoperative pain? Clinical Bottom Line 200mg Ibuprofen or 20mg of tenoxicam reduces postoperative pain at 6 hours after Endodontic treatment but no significant difference at 12,24,48 and 72 hours. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Arslan/2011 48 Randomized double-blinded clinical trail Key results 48

2013 UTHSCSA Dental School CAT Library

46. Prophylactic Compared With Therapeutic Ibuprofen Analgesia in First-Trimester Medical Abortion: A Randomized Controlled Trial (PubMed)

Prophylactic Compared With Therapeutic Ibuprofen Analgesia in First-Trimester Medical Abortion: A Randomized Controlled Trial To compare the effectiveness of two oral analgesic regimens in first-trimester medical abortion.We randomly assigned 250 participants undergoing first-trimester abortion with mifepristone and misoprostol at three clinics to two ibuprofen regimens: therapeutic (800 mg every 4-6 hours as needed for pain) or prophylactic (800 mg starting 1 hour before the misoprostol dose (...) , then every 4-6 hours for 48 hours regardless of pain, then as needed). We asked each participant to record her maximum pain on a scale of 0-10 daily thereafter.Of participants assigned to the prophylactic and therapeutic regimens, 111 of 123 (90%) and 117 of 127 (92%), respectively, provided follow-up data. More than 80% of the participants in each group complied with their assigned treatment. Participants in the prophylactic group used substantially more ibuprofen than those in the therapeutic group

Full Text available with Trip Pro

2013 EvidenceUpdates

47. Enteral Feeding during Indomethacin and Ibuprofen Treatment of a Patent Ductus Arteriosus (PubMed)

Enteral Feeding during Indomethacin and Ibuprofen Treatment of a Patent Ductus Arteriosus To test the hypothesis that infants who are just being introduced to enteral feedings will advance to full enteral nutrition at a faster rate if they receive "trophic" (15 mL/kg/d) enteral feedings while receiving indomethacin or ibuprofen treatment for patent ductus arteriosus.Infants were eligible for the study if they were 23(1/7)-30(6/7) weeks' gestation, weighed 401-1250 g at birth, received maximum (...) enteral volumes ≤60 mL/kg/d, and were about to be treated with indomethacin or ibuprofen. A standardized "feeding advance regimen" and guidelines for managing feeding intolerance were followed at each site (N = 13).Infants (N = 177, 26.3 ± 1.9 weeks' mean ± SD gestation) were randomized at 6.5 ± 3.9 days to receive "trophic" feeds ("feeding" group, n = 81: indomethacin 80%, ibuprofen 20%) or no feeds ("fasting [nil per os]" group, n = 96: indomethacin 75%, ibuprofen 25%) during the drug administration

Full Text available with Trip Pro

2013 EvidenceUpdates

48. Single dose oral ibuprofen plus codeine for acute postoperative pain in adults. (PubMed)

Single dose oral ibuprofen plus codeine for acute postoperative pain in adults. There is good evidence that combining two different analgesics in fixed doses in a single tablet can provide better pain relief in acute pain and headache than either drug alone, and that the drug-specific effects are essentially additive. This appears to be broadly true in postoperative pain and migraine headache across a range of different drug combinations and when tested in the same and different trials. Some (...) combinations of ibuprofen and codeine are available without prescription (but usually only from a pharmacy) where the dose of codeine is lower, and with a prescription when the dose of codeine is higher.To assess the analgesic efficacy and adverse effects of a single oral dose of ibuprofen plus codeine for moderate to severe postoperative pain. We compared ibuprofen plus codeine with placebo and with the same dose of ibuprofen alone.We searched the Cochrane Central Register of Controlled Trials (CENTRAL

2013 Cochrane

49. For Patients With Dental Pain, Combination Therapy With Ibuprofen And Acetaminophen Is More Effective In Producing Analgesia Than Monotherapy With Ibuprofen Alone

For Patients With Dental Pain, Combination Therapy With Ibuprofen And Acetaminophen Is More Effective In Producing Analgesia Than Monotherapy With Ibuprofen Alone UTCAT2379, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title For Patients With Dental Pain, Combination Therapy With Ibuprofen And Acetaminophen Is More Effective In Producing Analgesia Than Monotherapy With Ibuprofen Alone Clinical Question In patients (...) with inflammatory pain, does the combination of ibuprofen and acetaminophen compared to ibuprofen alone produce greater analgesia? Clinical Bottom Line Combination therapy with ibuprofen and acetaminophen produces greater analgesia than ibuprofen alone in patients with inflammatory pain. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Daniels/2011 678 patients at least 16 years old with at least 3 impacted 3rd

2013 UTHSCSA Dental School CAT Library

50. Randomised controlled trial: Single-tablet double-dose famotidine plus ibuprofen decreases endoscopic upper GI ulcers compared with ibuprofen alone

Randomised controlled trial: Single-tablet double-dose famotidine plus ibuprofen decreases endoscopic upper GI ulcers compared with ibuprofen alone Single-tablet double-dose famotidine plus ibuprofen decreases endoscopic upper GI ulcers compared with ibuprofen alone | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please (...) see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Single-tablet double-dose famotidine plus ibuprofen decreases endoscopic upper GI ulcers compared with ibuprofen alone

2013 Evidence-Based Medicine (Requires free registration)

51. Ibuprofen, paracetamol, and steam for patients with respiratory tract infections in primary care: pragmatic randomised factorial trial. (PubMed)

Ibuprofen, paracetamol, and steam for patients with respiratory tract infections in primary care: pragmatic randomised factorial trial. To assess strategies for advice on analgesia and steam inhalation for respiratory tract infections.Open pragmatic parallel group factorial randomised controlled trial.Primary care in United Kingdom.Patients aged ≥ 3 with acute respiratory tract infections.889 patients were randomised with computer generated random numbers in pre-prepared sealed numbered (...) envelopes to components of advice or comparator advice: advice on analgesia (take paracetamol, ibuprofen, or both), dosing of analgesia (take as required v regularly), and steam inhalation (no inhalation v steam inhalation).Primary: mean symptom severity on days 2-4; symptoms rated 0 (no problem) to 7 (as bad as it can be). Secondary: temperature, antibiotic use, reconsultations.Neither advice on dosing nor on steam inhalation was significantly associated with changes in outcomes. Compared

Full Text available with Trip Pro

2013 BMJ

52. Does Combination Treatment With Ibuprofen and Acetaminophen Improve Fever Control?

Does Combination Treatment With Ibuprofen and Acetaminophen Improve Fever Control? SystematicReviewSnapshot TAKE-HOME MESSAGE Combination treatment with ibuprofen and acetaminophen is bene?cial over either agent alone for sustained fever reduction in children older than 6 months. METHODS DATA SOURCES The author searched MEDLINE (1948 to May 2011) and EMBASE (1980 to May 2011). Additional hand searches of references from the UK National Institute for Health and Clinical Excellence guidelines (...) Standards of Re- porting Trials (CONSORT) crite- ria to score the quality of the included trials and abstract the data. Does Combination Treatment With Ibuprofen and Acetaminophen Improve Fever Control? EBEM Commentator Rohith R. Malya, MD, MSc Department of Emergency Medicine University of Texas at Houston Houston, TX Results Seventrialswereretrievedandallmet the inclusion criteria and most of the itemsontheCONSORTchecklist.Dif- ferences in dosing interval limited di- rect comparison between any 2

2013 Annals of Emergency Medicine Systematic Review Snapshots

53. Ibuprofen Prevents Altitude Illness: A Randomized Controlled Trial for Prevention of Altitude Illness With Nonsteroidal Anti-inflammatories (PubMed)

Ibuprofen Prevents Altitude Illness: A Randomized Controlled Trial for Prevention of Altitude Illness With Nonsteroidal Anti-inflammatories Acute mountain sickness occurs in more than 25% of the tens of millions of people who travel to high altitude each year. Previous studies on chemoprophylaxis with nonsteroidal anti-inflammatory drugs are limited in their ability to determine efficacy. We compare ibuprofen versus placebo in the prevention of acute mountain sickness incidence and severity (...) on ascent from low to high altitude.Healthy adult volunteers living at low altitude were randomized to ibuprofen 600 mg or placebo 3 times daily, starting 6 hours before ascent from 1,240 m (4,100 ft) to 3,810 m (12,570 ft) during July and August 2010 in the White Mountains of California. The main outcome measures were acute mountain sickness incidence and severity, measured by the Lake Louise Questionnaire acute mountain sickness score with a diagnosis of ≥ 3 with headache and 1 other symptom.Eighty

2012 EvidenceUpdates

54. Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants

Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants Jones LJ, Craven PD, Attia J, Thakkinstian A, Wright I CRD summary This review found intravenous indomethacin or ibuprofen promoted ductal closure in pre-term infants with linked pulmonary artery and aorta (...) , but other short-term benefits were not seen; ibuprofen may increase chronic lung disease rates. Some caution is needed in interpretation of the results given the small amount of data available, widespread use of indomethacin by control groups, and diverse study populations. Authors' objectives To compare the benefits and harms of indomethacin, ibuprofen and placebo in pre-term infants with patent ductus arteriosus (an open channel between the pulmonary artery and the aorta). Searching MEDLINE, EMBASE

2012 DARE.

55. Advil (sodium ibuprofen)

Advil (sodium ibuprofen) Drug Approval Package: Advil (sodium ibuprofen) NDA #201803 Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Advil (sodium ibuprofen) tablet, 256 mg Company: Pfizer Consumer Healthcare Application No.: 201803 Approval Date: 06/12/2012 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date

2012 FDA - Drug Approval Package

56. Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone (PubMed)

Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone To evaluate the evidence surrounding the use of combinations of paracetamol and ibuprofen in the treatment of fever.Systematic narrative review of randomised controlled trials using the UK Economic and Social Research Council guidance on the conduct of narrative synthesis.Inpatient, outpatient and home care.Children with fever.The effect of combination treatments of paracetamol (...) and ibuprofen on fever and comfort, and identification of side effects.Seven studies were identified, six of which provided useful data for the evaluation of the effect of treatment on temperature. Overall these studies showed limited benefit from the combined treatment until around 4 h, after which there was a statistically but only marginally clinically significant benefit. Two studies contained data directly relating to comfort; these suggest a marginal benefit from the combined treatment

Full Text available with Trip Pro

2012 EvidenceUpdates

57. A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain (PubMed)

A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain To compare the efficacy and safety of single versus combination non-prescription oral analgesics in community-derived people aged 40 years and older with chronic knee pain.A randomised, double-blind, four-arm, parallel-group, active controlled trial investigating short-term (day 10) and long-term (week 13) benefits and side-effects of four regimens (...) , each taken three times a day: ibuprofen (400 mg); paracetamol (1000 mg); one fixed-dose combination tablet (ibuprofen 200 mg/paracetamol 500 mg); two fixed-dose combination tablets (ibuprofen 400 mg/paracetamol 1000 mg).There were 892 participants (mean age 60.6, range 40-84 years); 63% had radiographic knee osteoarthritis and 85% fulfilled American College of Rheumatology criteria for osteoarthritis. At day 10, two combination tablets were superior to paracetamol (p<0.01) for pain relief

Full Text available with Trip Pro

2011 EvidenceUpdates

58. The effects of oral ibuprofen and celecoxib in preventing pain, improving recovery outcomes and patient satisfaction after ambulatory surgery (PubMed)

The effects of oral ibuprofen and celecoxib in preventing pain, improving recovery outcomes and patient satisfaction after ambulatory surgery Nonsteroidal antiinflammatory drugs have become increasingly popular as part of multimodal analgesic regimens for pain management in the ambulatory setting. We designed this randomized, double-blind, placebo-controlled study to evaluate the effect of postoperative administration of either a nonselective nonsteroidal antiinflammatory drug (ibuprofen (...) placebo tablet (matching ibuprofen) in the recovery room and 1 placebo tablet at bedtime on the day of surgery, followed by 1 placebo capsule or tablet 3 times a day for 3 days after discharge; group 2 (celecoxib) received celecoxib 400 mg (2 capsules) orally in the recovery room and 1 placebo capsule and tablet at bedtime on the day of surgery, followed by celecoxib 200 mg (1 capsule) twice a day + placebo capsule every day at bedtime for 3 days after surgery; or group 3 (ibuprofen) received

2011 EvidenceUpdates

59. Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants (PubMed)

Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants To evaluate the effects of indomethacin or ibuprofen compared with placebo on closure, morbidity and mortality in preterm infants <37 weeks' gestation with echocardiographically and/or clinically important patent ductus arteriosus (PDA) at >24 h of life.MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, CINAHL, Cochrane Library, clinicaltrials.gov, controlled-trials.com, American (...) Pediatric and European Paediatric Research Societies and Effective Care of the Newborn Infant.Systematic review with network meta-analysis of randomised studies comparing intravenous indomethacin, ibuprofen or placebo for PDA in preterm infants at >24 h of life.Ten trials compared intravenous indomethacin versus intravenous ibuprofen, nine intravenous indomethacin versus placebo and one intravenous ibuprofen versus placebo. Both intravenous indomethacin (pooled RR 2.39 (95% CI 2.05 to 2.78

2011 EvidenceUpdates

60. Is A Prophylactic Dose Of A Cox-2 Inhibitor Better Than Ibuprofen In Preventing Post-Endodontic Pain?

Is A Prophylactic Dose Of A Cox-2 Inhibitor Better Than Ibuprofen In Preventing Post-Endodontic Pain? UTCAT814, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title A Prophylactic Dose Of A Cox-2 Inhibitor is Better Than Ibuprofen In Preventing Post-Endodontic Pain 12-24 hours Post Pulpectomy Clinical Question Does a prophylactic dose of a Cox-2 inhibitor reduce pain more than ibuprofen for post-endodontic pain? Clinical (...) Bottom Line At short duration (4 to 8 hrs after pulpectomy) rofecoxib did not provide significantly better pain relief than ibuprofen, but at longer duration (12 to 24 hrs), rofecoxib demonstrated significantly better pain relief than both ibuprofen and placebo. (See Comments on the CAT below) Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Gopikrishna/2003 45 patients Double blind with randomization Key

2011 UTHSCSA Dental School CAT Library