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Latest & greatest articles for influenza
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on influenza or other clinical topics then use Trip today.
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Exercise prior to influenza vaccination for limiting influenza incidence and its related complications in adults. Influenza is an infectious virus affecting both humans and animals. In humans, symptoms present as fever, cough, sore throat, runny nose, headache, muscle and joint pain, and malaise. The epidemiological profile of influenza is influenced by multiple factors, including transmissibility of the virus and the susceptibility of the population. Annually, influenza is estimated to infect (...) 5% to 10% of adults, with higher rates in winter seasons in countries with seasonal variation. Exercise could be an intervention to enhance immune response and limit influenza incidence and its related complications.To assess the efficacy and safety of short and long-term exercise prior to influenza vaccination in enhancing influenza prevention in adults.We searched CENTRAL (2015, Issue 11), which contains the Cochrane Acute Respiratory Infections Group's Specialised Register, MEDLINE (1966 to 3
Seroconversion and immunogenicity evaluation of seasonal influenza vaccine in mice model Influenza virus is epidemiologically very important due to the antigenic variations occurring in it. In present study isolation and identification of influenza virus was attempted from Kasauli and adjoining areas. 71 clinical samples i.e. throat washings were processed and inoculated into the eggs for virus isolation. The isolated strains of H3N2, H1N1 and Influenza B were identified, purified and passaged (...) in eggs. The harvested virus was inactivated by 0.03 % formalin and three formulations of crude, inactivated, whole virus monovalent vaccine for H3N2, H1N1 and influenza B as well as a trivalent vaccine was prepared. The immunogenicity study of the vaccine was performed in the mouse model by using varying dilutions of four types of vaccines for a period of 40 days. The impact of booster dose was also analyzed in the study. A significant seroconversion was observed in the mice sera verifying
Live Attenuated Versus Inactivated Influenza Vaccine in Hutterite Children: A Cluster Randomized Blinded Trial. Whether vaccinating children with intranasal live attenuated influenza vaccine (LAIV) is more effective than inactivated influenza vaccine (IIV) in providing both direct protection in vaccinated persons and herd protection in unvaccinated persons is uncertain. Hutterite colonies, where members live in close-knit, small rural communities in which influenza virus infection regularly (...) occurs, offer an opportunity to address this question.To determine whether vaccinating children and adolescents with LAIV provides better community protection than IIV.A cluster randomized blinded trial conducted between October 2012 and May 2015 over 3 influenza seasons. (ClinicalTrials.gov: NCT01653015).52 Hutterite colonies in Alberta and Saskatchewan, Canada.1186 Canadian children and adolescents aged 36 months to 15 years who received the study vaccine and 3425 community members who did
Differential proteomic analysis of respiratory samples from patients suffering from influenza The exact molecular pathways involved in the pathogenesis of influenza are yet unclear. In the present study we investigated the upper respiratory proteome in influenza patients. 200 nasal and throat swab samples were collected from patients suffering from acute respiratory illness. These samples were confirmed for influenza pandemic A/H1N1/2009 and influenza type B using qRT-PCR. 10 similar swabs were (...) -signaling, transport, and tumor suppression constituted 10 % each, where as 5 % of proteins each belong to Nicotinic acetylcholine receptor, Protein Synthesis and anti-bacterial proteins. 10 % of the proteins have not been described previously. This is the first report on respiratory proteome profile in Influenza patients. The study emphasizes the role of such profiling studies using multiple platforms for bio-marker discoveries, especially non-invasive diagnostic marker in Influenza and other
Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumoniaâ€”a new therapeutic strategy? Influenza viruses (IVs) circulate seasonally and are a common cause of respiratory infections in pediatric and adult patients. Additionally, recurrent pandemics cause massive morbidity and mortality worldwide. Infection may result in rapid progressive viral pneumonia with fatal outcome. Since accurate treatment strategies are still missing, research refocuses
The Use of a Recombinant Canarypox-Based Equine Influenza Vaccine during the 2007 Australian Outbreak: A Systematic Review and Summary. In 2007, Australia experienced the most extensive equine influenza outbreak observed in recent years. Extraordinary measures were rapidly implemented in order to control and prevent the spread of this highly contagious disease. The control strategy involved stringent movement restriction and disease surveillance, seconded by emergency post-outbreak vaccination (...) strategies. Sixteen months after the first case and 12 months following the last reported case, Australia regained its equine influenza-free OIE status. This systematic review reports and summarises information relating to the implementation of emergency vaccination during the 2007 Australian equine influenza outbreak, including the choice of vaccine and implementation strategies.
Influenza vaccination for healthcare workers who care for people aged 60 or older living in long-term care institutions. A systematic review found that 3% of working adults who had received influenza vaccine and 5% of those who were unvaccinated had laboratory-proven influenza per season; in healthcare workers (HCWs) these percentages were 5% and 8% respectively. Healthcare workers may transmit influenza to patients.To identify all randomised controlled trials (RCTs) and non-RCTs assessing (...) the effects of vaccinating healthcare workers on the incidence of laboratory-proven influenza, pneumonia, death from pneumonia and admission to hospital for respiratory illness in those aged 60 years or older resident in long-term care institutions (LTCIs).We searched CENTRAL (2015, Issue 9), MEDLINE (1966 to October week 3, 2015), EMBASE (1974 to October 2015) and Web of Science (2006 to October 2015), but Biological Abstracts only from 1969 to March 2013 and Science Citation Index-Expanded from 1974
Neuraminidase inhibitors for influenza: a systematic review and meta-analysis of regulatory and mortality data Neuraminidase inhibitors for influenza: a systematic review and meta- analysis of regulatory and mortality data Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information (...) of Regulatory and Mortality Data for Zanamivir (Relenza) and Oseltamivir (Tamiflu) The authors of a new review of the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir (Tamiflu) found that these drugs minimally shorten the duration of influenza-like illness by about a day and that oseltamivir did not affect the number of hospitalizations.  The new review  confirmed a previous review done by many of the same authors in 2014  and the FDA’s definitive reviews of these drugs done in 1999
Pandemic influenza vaccine H5N1 MedImmune 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact 01 April 2016 EMA/CHMP/323530/2016 Committee for Medicinal Products for Human Use (CHMP) Assessment report Pandemic influenza vaccine H5N1 MedImmune Common name: pandemic influenza vaccine (H5N1) (live attenuated, nasal) Procedure No. EMEA (...) aminotransferase ANC absolute neutrophil count AOM acute otitis media ASC antibody secreting cell AST aspartate aminotransferase att attenuated ca cold-adapted CAIV-T influenza virus vaccine, trivalent, types A and B, live cold-adapted CDC Centers for Disease Control and Prevention CI confidence interval CMI cell-mediated immunity CSR clinical study report CRADA cooperative research and development agreement CTL cytotoxic T-lymphocyte DOD Department of Defense ELISA enzyme-linked immunosorbent assay ELISPOT
Seasonal Influenza Infections and Cardiovascular Disease Mortality Cardiovascular deaths and influenza epidemics peak during winter in temperate regions.To quantify the temporal association between population increases in seasonal influenza infections and mortality due to cardiovascular causes and to test if influenza incidence indicators are predictive of cardiovascular mortality during the influenza season.Time-series analysis of vital statistics records and emergency department visits in New (...) York City, among cardiovascular deaths that occurred during influenza seasons between January 1, 2006, and December 31, 2012. The 2009 novel influenza A(H1N1) pandemic period was excluded from temporal analyses.Emergency department visits for influenza-like illness, grouped by age (≥0 years and ≥65 years) and scaled by laboratory surveillance data for viral types and subtypes, in the previous 28 days.Mortality due to cardiovascular disease, ischemic heart disease, and myocardial infarction.Among
Interventions in live poultry markets for the control of avian influenza: a systematic review. 27213177 2018 11 13 2352-7714 2 2016 Dec One health (Amsterdam, Netherlands) One Health Interventions in live poultry markets for the control of avian influenza: a systematic review. 55-64 Offeddu Vittoria V WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative (...) Region, China. Cowling Benjamin J BJ WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. Malik Peiris J S JS WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China; Centre of Influenza Research
Antiviral activity of the oseltamivir and Melissa officinalis L. essential oil against avian influenza A virus (H9N2) Lemon balm derivatives are going to acquire a novelty as natural and potent remedy for treatment of viral infections since the influenza viruses are developing resistance to the current antivirals widely. Oseltamivir, Melissa officinalis essential oil (MOEO) and their synergistic efficacy against avian influenza virus (AIV) subtype H9N2 were evaluated in vitro in MDCK cells (...) and Its main constituents were identified as monoterpenaldehydes citral a, citral b. In conclusion, the findings of the study showed that lemon balm essential oil could inhibit influenza virus replication through different replication cycle steps especially throughout the direct interaction with the virus particles.
Concordance of interim and final estimates of influenza vaccine effectiveness: a systematic review. The World Health Organization's Global Influenza Surveillance and Response System meets twice a year to generate a recommendation for the composition of the seasonal influenza vaccine. Interim vaccine effectiveness (VE) estimates provide a preliminary indication of influenza vaccine performance during the season and may be useful for decision making. We reviewed 17 pairs of studies reporting 33 (...) estimates was found for 18 of 33 reported pairs of estimates, including six of 12 pairs reporting VE against any influenza, six of 10 for influenza A(H1N1)pdm09, four of seven for influenza A(H3N2) and two of four for influenza B. While we identified inconsistencies in the methods, the similarities between interim and final estimates support the utility of generating and disseminating preliminary estimates of VE while virus circulation is ongoing.
The emergence and consistency of influenza strains causing influenza like illness in Himachal Pradesh, India The present study offers the status of ongoing surveillance influenza at National Influenza Surveillance Centre (NISC), Central Research Institute (CRI), Kasauli for the emergence and consistency of influenza strains for current as well as over a period of three decades in Solan, Himachal Pradesh. From 1980 to 2015, various clinical centers of Himachal reported counts of influenza-like (...) illness (fever including cough or sore throat). During these years, the respiratory specimens of 6581 patients showing influenza-like illness were collected. The incidence of visits had been calculated for influenza-like illness using the size of the patient population, and the incidence attributable to influenza was extrapolated from the proportion of patients with positive tests. Up to 2008 the egg inoculation method was used for the isolation and detection of influenza strains but in 2009 a RT-PCR
Oseltamivir (Tamiflu) - for the treatment of infants less than 1 year of age including full term neonates who present with symptoms typical of influenza Final Appraisal Recommendation Advice No: 0316 – February 2016 Oseltamivir (Tamiflu ® ) 30 mg, 45 mg and 75 mg capsules, and 6 mg/ml powder for oral suspension Limited submission by Roche Products Ltd Additional note(s): • Please refer to the Summary of Product Characteristics for the full licensed indication. In reaching the above (...) including full term neonates who present with symptoms typical of influenza, when influenza virus is circulating in the community. Efficacy has been demonstrated when treatment is initiated within two days of first onset of symptoms.
Safety of Seasonal Influenza Vaccination in Hospitalized Surgical Patients: A Cohort Study. Despite recommendations to vaccinate surgical inpatients against influenza, vaccination rates remain low in this population, due in part to concerns about potential negative effects on postsurgical care.To evaluate whether influenza vaccination in the perioperative period increases health care utilization and evaluations for postsurgical infection after discharge.Retrospective cohort study.Members (...) of Kaiser Permanente Southern California.Patients aged 6 months or older who had inpatient surgery with admission and discharge between 1 September and 31 March from 2010 to 2013.All influenza vaccinations administered between 1 August and 30 April in the 2010-2011, 2011-2012, and 2012-2013 influenza seasons. Outcomes included rates of outpatient visits, readmission, emergency department (ED) visits, fever (temperature ≥38.0 °C), and clinical laboratory evaluations for infection (urine culture, complete
Corticosteroids as adjunctive therapy in the treatment of influenza. Specific treatments for influenza are limited to neuraminidase inhibitors and adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions, most likely due to their anti-inflammatory and immunomodulatory properties. Although commonly prescribed for severe influenza, there is uncertainty over their potential benefit or harm.To systematically assess the effectiveness and potential adverse effects (...) of corticosteroids as adjunctive therapy in the treatment of influenza, taking into account differences in timing and doses of corticosteroids.We searched CENTRAL (2015, Issue 5), MEDLINE (1946 to June week 1, 2015), EMBASE (1974 to June 2015), CINAHL (1981 to June 2015), LILACS (1982 to June 2015), Web of Science (1985 to June 2015), abstracts from the last three years of major infectious disease and microbiology conferences, and references of included articles.We included randomised controlled trials (RCTs
Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis. Cystic fibrosis is the most common, life-threatening, recessively inherited disease of Caucasian populations. It is a multisystem disorder caused by a mutation in the gene encoding the cystic fibrosis transmembrane conductance regulator protein which is important in producing sweat, digestive juices and mucus.The impaired or absent function of this protein results in the production of viscous mucus (...) within the lungs and an environment that is susceptible to chronic airway obstruction and pulmonary colonization by a range of pathogenic bacteria. Morbidity and mortality of cystic fibrosis is related to chronic pulmonary sepsis and its complications by these bacteria.Influenza can worsen the course of the disease in cystic fibrosis by increasing the risk of pneumonia and secondary respiratory complications. Antiviral agents form an important part of influenza management and include