Latest & greatest articles for influenza

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Top results for influenza

61. Vaccines for preventing influenza in healthy adults. (PubMed)

Vaccines for preventing influenza in healthy adults. The consequences of influenza in adults are mainly time off work. Vaccination of pregnant women is recommended internationally. This is an update of a review published in 2014. Future updates of this review will be made only when new trials or vaccines become available. Observational data included in previous versions of the review have been retained for historical reasons but have not been updated due to their lack of influence on the review (...) conclusions.To assess the effects (efficacy, effectiveness, and harm) of vaccines against influenza in healthy adults, including pregnant women.We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 12), MEDLINE (January 1966 to 31 December 2016), Embase (1990 to 31 December 2016), the WHO International Clinical Trials Registry Platform (ICTRP; 1 July 2017), and ClinicalTrials.gov (1 July 2017), as well as checking the bibliographies of retrieved articles.Randomised controlled

2018 Cochrane

62. Vaccines for preventing influenza in the elderly. (PubMed)

Vaccines for preventing influenza in the elderly. The consequences of influenza in the elderly (those age 65 years or older) are complications, hospitalisations, and death. The primary goal of influenza vaccination in the elderly is to reduce the risk of death among people who are most vulnerable. This is an update of a review published in 2010. Future updates of this review will be made only when new trials or vaccines become available. Observational data included in previous versions (...) of the review have been retained for historical reasons but have not been updated because of their lack of influence on the review conclusions.To assess the effects (efficacy, effectiveness, and harm) of vaccines against influenza in the elderly.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library 2016, Issue 11), which includes the Cochrane Acute Respiratory Infections Group's Specialised Register; MEDLINE (1966 to 31 December 2016); Embase (1974 to 31 December

2018 Cochrane

63. Influenza vaccines in immunosuppressed adults with cancer. (PubMed)

Influenza vaccines in immunosuppressed adults with cancer. This is an update of the Cochrane review published in 2013, Issue 10.Immunosuppressed cancer patients are at increased risk of serious influenza-related complications. Guidelines, therefore, recommend influenza vaccination for these patients. However, data on vaccine effectiveness in this population are lacking, and the value of vaccination in this population remains unclear.To assess the effectiveness of influenza vaccine (...) in immunosuppressed adults with malignancies. The primary review outcome is all-cause mortality, preferably at the end of the influenza season. Influenza-like illness (ILI, a clinical definition), confirmed influenza, pneumonia, any hospitalisations, influenza-related mortality and immunogenicity were defined as secondary outcomes.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase and LILACS databases up to May 2017. We searched the following conference proceedings: ICAAC

2018 Cochrane

64. Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection. (PubMed)

Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection. Acute myocardial infarction can be triggered by acute respiratory infections. Previous studies have suggested an association between influenza and acute myocardial infarction, but those studies used nonspecific measures of influenza infection or study designs that were susceptible to bias. We evaluated the association between laboratory-confirmed influenza infection and acute myocardial infarction.We used the self (...) -controlled case-series design to evaluate the association between laboratory-confirmed influenza infection and hospitalization for acute myocardial infarction. We used various high-specificity laboratory methods to confirm influenza infection in respiratory specimens, and we ascertained hospitalization for acute myocardial infarction from administrative data. We defined the "risk interval" as the first 7 days after respiratory specimen collection and the "control interval" as 1 year before and 1 year

2018 NEJM

65. Accuracy and Discomfort of Different Types of Intranasal Specimen Collection Methods for Molecular Influenza Testing in Emergency Department Patients

Accuracy and Discomfort of Different Types of Intranasal Specimen Collection Methods for Molecular Influenza Testing in Emergency Department Patients While development is under way of accurate, point-of-care molecular tests for influenza infection, the optimal specimen type for molecular tests remains unclear. Compared with standard nasopharyngeal swab specimens, less invasive nasal swab and midturbinate swab specimens may cause less patient discomfort and be more suitable for routine emergency (...) department (ED) testing, although possibly at the expense of diagnostic accuracy. We compare both the accuracy of a polymerase chain reaction molecular influenza test and discomfort between these 3 intranasal specimen types.A convenience sample of adult and pediatric patients with influenza-like illness and presenting to 2 Northern California EDs and 2 EDs in Santiago, Chile, was prospectively enrolled during the 2015 to 2016 influenza season. Research nurses collected nasopharyngeal swab, midturbinate

2018 EvidenceUpdates

66. Early risk assessment: What to expect of the 2017/18 influenza season in Norway

Early risk assessment: What to expect of the 2017/18 influenza season in Norway What to expect of the 2017/18 influenza season in Norway - NIPH Selected items added to basket Close Search for: Søk Meny Infectious diseases & Vaccines Close Mental & Physical health Close Environment & Lifestyle Close Health in Norway Close Quality & Knowledge Close Research & Access to data Close About NIPH Close What to expect of the 2017/18 influenza season in Norway Have you found an error? Order Download (...) : Summary The report is based on data from a late-summer serosurvey, early-season surveillance data, vaccine sales and experience from previous influenza seasons. The report is meant to support capacity planning in the health services, provide background information to infection control and other health-care and public health personnel, as well as to provide in-depth information on influenza outbreaks in general. At this point, as the 2017-2018 outbreak is beginning to unfold, it is of particular

2018 Norwegian Institute of Public Health

67. Influenza infection

Influenza infection Influenza infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Influenza infection Last reviewed: February 2019 Last updated: March 2019 Summary Characterised by upper and lower respiratory tract symptoms of rhinorrhoea, cough, fever, chills, headache, and myalgia. Typically presents in winter season. Can occur in local community outbreaks, epidemics, and, rarely, pandemics. Vaccination (...) for prevention is available. Definition Acute respiratory tract infection typically caused by seasonal influenza A or B virus. The virus is transmitted by inhalation of infected respiratory secretions that have been aerosolised through coughing, sneezing, or talking. Brankston G, Gitterman L, Hirji Z, et al. Transmission of influenza A in human beings. Lancet Infect Dis. 2007;7:257-265. http://www.ncbi.nlm.nih.gov/pubmed/17376383?tool=bestpractice.com History and exam winter season current influenza outbreak

2018 BMJ Best Practice

68. Avian influenza A (H7N9) virus infection

Avian influenza A (H7N9) virus infection Avian influenza A (H7N9) virus infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Avian influenza A (H7N9) virus infection Last reviewed: February 2019 Last updated: June 2018 Summary The epidemic has been geographically focused in China, and is associated with exposure to infected poultry. The risk to public health is low; however, the pandemic potential of this virus (...) of respiratory tract samples is the recommended diagnostic test. Treatment involves supportive care, specialised intensive-care management, and administration of a neuraminidase inhibitor. Definition Avian influenza A viruses are generally confined to birds but have infected other mammals and some viruses have crossed the species barrier to sporadically infect humans. Highly pathogenic avian influenza (HPAI) A(H5N1) virus is capable of causing severe multi-system disease in birds, humans, and other mammals

2018 BMJ Best Practice

69. Influenza

Influenza Influenza - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Influenza Note: Prescribing of oral antiviral agents is authorized ONLY during an epidemic or pandemic declared by the Chief Medical Health Officer for Saskatchewan Influenza is an acute viral respiratory tract infection caused by influenza A or B viruses (family Orthomyxoviridae ) Influenza-like illness (ILI) refers to any acute illness having symptoms (...) typical of influenza. Viruses such as adenovirus, parainfluenza or respiratory syncytial virus can cause similar symptoms Influenza causes outbreaks and epidemics worldwide, primarily during the late fall and winter Transmission of the Influenza virus may occur via airborne droplets or by contact or both. Symptoms can be quite incapacitating but for most people influenza is a self-limited infection and resolves without treatment in 4 to 7 days Affects an estimated 10% to 20% of the Canadian population

2018 medSask

70. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. (PubMed)

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Estimates of influenza-associated mortality are important for national and international decision making on public health priorities. Previous estimates of 250 000-500 000 annual influenza deaths are outdated. We updated the estimated number of global annual influenza-associated respiratory deaths using country-specific influenza-associated excess respiratory mortality estimates from 1999-2015.We (...) estimated country-specific influenza-associated respiratory excess mortality rates (EMR) for 33 countries using time series log-linear regression models with vital death records and influenza surveillance data. To extrapolate estimates to countries without data, we divided countries into three analytic divisions for three age groups (<65 years, 65-74 years, and ≥75 years) using WHO Global Health Estimate (GHE) respiratory infection mortality rates. We calculated mortality rate ratios (MRR) to account

2017 Lancet

71. Integrative gene network analysis identifies key signatures, intrinsic networks and host factors for influenza virus A infections (PubMed)

Integrative gene network analysis identifies key signatures, intrinsic networks and host factors for influenza virus A infections Influenza A virus, with the limited coding capacity of 10-14 proteins, requires the host cellular machinery for many aspects of its life cycle. Knowledge of these host cell requirements not only reveals molecular pathways exploited by the virus or triggered by the immune system, but also provides further targets for antiviral drug development. To uncover novel (...) pathways and key targets of influenza infection, we assembled a large amount of data from 12 cell-based gene-expression studies of influenza infection for an integrative network analysis. We systematically identified differentially expressed genes and gene co-expression networks induced by influenza infection. We revealed the dedicator of cytokinesis 5 (DOCK5) played potentially an important role for influenza virus replication. CRISPR/Cas9 knockout of DOCK5 reduced influenza virus replication

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2017 NPJ systems biology and applications

72. Real-time modelling of a pandemic influenza outbreak

Real-time modelling of a pandemic influenza outbreak Real-time modelling of a pandemic influenza outbreak Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline

2017 NIHR HTA programme

73. Zoonotic influenza viruses: antigenic and genetic characteristics and development of candidate vaccine viruses for pandemic preparedness –Virus grippaux zoonotiques: caractéristiques génétiques et antigéniques et mise au point de virus vaccinaux candidat

Zoonotic influenza viruses: antigenic and genetic characteristics and development of candidate vaccine viruses for pandemic preparedness –Virus grippaux zoonotiques: caractéristiques génétiques et antigéniques et mise au point de virus vaccinaux candidat Zoonotic influenza viruses: antigenic and genetic characteristics and development of candidate vaccine viruses for pandemic preparedness –Virus grippaux zoonotiques: caractéristiques génétiques et antigéniques et mise au point de virus (...) vaccinaux candidats pour se préparer à une pandémie JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links Zoonotic influenza viruses: antigenic and genetic characteristics and development of candidate vaccine viruses for pandemic preparedness –Virus grippaux zoonotiques: caractéristiques génétiques et antigéniques et mise au point de virus vaccinaux candidats pour se préparer à une pandémie

2017 WHO

74. Influenza vaccines for preventing acute otitis media in infants and children. (PubMed)

Influenza vaccines for preventing acute otitis media in infants and children. Acute otitis media (AOM) is one of the most common infectious diseases in children. It has been reported that 64% of infants have an episode of AOM by the age of six months and 86% by one year. Although most cases of AOM are due to bacterial infection, it is commonly triggered by a viral infection. In most children AOM is self limiting, but it does carry a risk of complications. Since antibiotic treatment increases (...) the risk of antibiotic resistance, influenza vaccines might be an effective way of reducing this risk by preventing the development of AOM.To assess the effectiveness of influenza vaccine in reducing the occurrence of acute otitis media in infants and children.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, LILACS, Web of Science, the WHO International Clinical Trials Registry Platform, and ClinicalTrials.gov (15 February 2017). We also searched

2017 Cochrane

75. H1N1 Influenza Induced Acute Respiratory Distress Syndrome Rescued by Extracorporeal Membrane Oxygenation: a Case Report (PubMed)

H1N1 Influenza Induced Acute Respiratory Distress Syndrome Rescued by Extracorporeal Membrane Oxygenation: a Case Report Extracorporeal Membrane Oxygenation (ECMO) is now a recognized revolutionary technology, which has emerged as a life-saving therapeutic option for patients with potentially reversible severe respiratory failure who fail to respond positively with the conventional ventilation therapy. Severe acute respiratory distress syndrome (ARDS) is associated with high morbidity (...) and mortality, and ECMO has been proven to increase the survival rates in these patients by improving the gas exchange and thus preventing the further hypoxia and catecholamine induced multi-organ damage. The authors present a case of H1N1 influenza related severe ARDS who was successfully rescued by the early use of ECMO. The authors recommend the early use of ECMO to be incorporated in the management of severe refractory ARDS caused due to a potentially reversible cause.

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2017 Journal of translational internal medicine

76. Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice (PubMed)

Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice Elderly humans over 65 years old are at great risk to pathogenesis by influenza virus infection. However, although influenza vaccines provide effective protection in healthy young adults, protection of elderly adults is substantially lower even with a good match between the vaccine and the circulating influenza virus. To gain insight of the underlying mechanism (...) for the reduced immunogenicity of influenza vaccines in the aged population, we investigated immunogenicity of influenza virus-like particle vaccines in aged mice, which represent a useful model for studying aging associated impairment in immune responses. Specifically, we investigated the effect of inhibiting regulatory T cells in aged mice on induction of protective immune responses by influenza vaccines. Our results showed that injecting anti-CD25 antibodies could down-regulate CD25 on the surface

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2017 Microbes and infection

77. Influenza. (PubMed)

Influenza. Influenza is an acute viral respiratory disease that affects persons of all ages and is associated with millions of medical visits, hundreds of thousands of hospitalizations, and thousands of deaths during annual winter epidemics of variable severity in the United States. Elderly persons have the highest influenza-associated hospitalization and mortality rates. The primary method of prevention is annual vaccination. Early antiviral treatment has the greatest clinical benefit

2017 Annals of Internal Medicine

78. Diagnostic Accuracy of Novel and Traditional Rapid Tests for Influenza Infection Compared With Reverse Transcriptase Polymerase Chain Reaction: A Systematic Review and Meta-analysis. (PubMed)

Diagnostic Accuracy of Novel and Traditional Rapid Tests for Influenza Infection Compared With Reverse Transcriptase Polymerase Chain Reaction: A Systematic Review and Meta-analysis. Rapid and accurate influenza diagnostics can improve patient care.To summarize and compare accuracy of traditional rapid influenza diagnostic tests (RIDTs), digital immunoassays (DIAs), and rapid nucleic acid amplification tests (NAATs) in children and adults with suspected influenza.6 databases from (...) their inception through May 2017.Studies in English, French, or Spanish comparing commercialized rapid tests (that is, providing results in <30 minutes) with reverse transcriptase polymerase chain reaction reference standard for influenza diagnosis.Data were extracted using a standardized form; quality was assessed using QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2) criteria.162 studies were included (130 of RIDTs, 19 of DIAs, and 13 of NAATs). Pooled sensitivities for detecting influenza

2017 Annals of Internal Medicine

79. Influenza Vaccine Effectiveness in the United States during the 2015-2016 Season. (PubMed)

Influenza Vaccine Effectiveness in the United States during the 2015-2016 Season. The A(H1N1)pdm09 virus strain used in the live attenuated influenza vaccine was changed for the 2015-2016 influenza season because of its lack of effectiveness in young children in 2013-2014. The Influenza Vaccine Effectiveness Network evaluated the effect of this change as part of its estimates of influenza vaccine effectiveness in 2015-2016.We enrolled patients 6 months of age or older who presented with acute (...) respiratory illness at ambulatory care clinics in geographically diverse U.S. sites. Using a test-negative design, we estimated vaccine effectiveness as (1-OR)×100, in which OR is the odds ratio for testing positive for influenza virus among vaccinated versus unvaccinated participants. Separate estimates were calculated for the inactivated vaccines and the live attenuated vaccine.Among 6879 eligible participants, 1309 (19%) tested positive for influenza virus, predominantly for A(H1N1)pdm09 (11

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2017 NEJM

80. First Trimester Influenza Vaccination and Risks for Major Structural Birth Defects in Offspring

First Trimester Influenza Vaccination and Risks for Major Structural Birth Defects in Offspring To examine risks for major structural birth defects in infants after first trimester inactivated influenza vaccine (IIV) exposures.In this observational study, we used electronic health data from 7 Vaccine Safety Datalink sites to examine risks for selected major structural defects in infants after maternal IIV exposure. Vaccine exposures for women with continuous insurance enrollment through

2017 EvidenceUpdates