Latest & greatest articles for influenza

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Top results for influenza

81. History and current trends in influenza virus infections with special reference to Sri Lanka (Full text)

History and current trends in influenza virus infections with special reference to Sri Lanka The World Health Organization (WHO) estimates that approximately one billion people are infected and up to 500,000 people die from influenza each year in the world. Influenza is considered to be the greatest killer of the human populations, due to the 1918 Spanish flu, which killed millions around the world. Despite the effective treatment available against influenza, it still contributes to significant (...) morbidity and mortality. Currently circulating influenza strains in humans include influenza A (H1N1)pdm09, influenza A (H3N2) and influenza B viruses, (B/Victoria and B/Yamagata). Influenza has been prevalent in Sri Lanka from 1969, since then it continued to cause morbidity and mortality in children and adults. The current global influenza surveillance network monitors the global influenza activity through WHO collaborating centres. The Medical Research Institute monitors and diagnoses influenza cases

2017 Virusdisease PubMed

82. The Use of Antivirals for Influenza Prophylaxis: A Review of the Clinical Effectiveness

The Use of Antivirals for Influenza Prophylaxis: A Review of the Clinical Effectiveness The Use of Antivirals for Influenza Prophylaxis: A Review of the Clinical Effectiveness | CADTH.ca Find the information you need The Use of Antivirals for Influenza Prophylaxis: A Review of the Clinical Effectiveness The Use of Antivirals for Influenza Prophylaxis: A Review of the Clinical Effectiveness Published on: July 5, 2017 Project Number: RC0890-000 Product Line: Research Type: Drug Report Type (...) : Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness regarding the use of antivirals for seasonal influenza? What is the clinical effectiveness regarding the use of antivirals for pandemic influenza? Key Message The evidence suggested that influenza prophylaxis with oseltamivir or zanamivir was effective in preventing symptomatic influenza at the individual and household levels, including healthy individuals of various ages exposed to seasonal or pandemic

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

83. The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial. (Full text)

The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial. Microneedle patches provide an alternative to conventional needle-and-syringe immunisation, and potentially offer improved immunogenicity, simplicity, cost-effectiveness, acceptability, and safety. We describe safety, immunogenicity, and acceptability of the first-in-man study on single, dissolvable (...) microneedle patch vaccination against influenza.The TIV-MNP 2015 study was a randomised, partly blinded, placebo-controlled, phase 1, clinical trial at Emory University that enrolled non-pregnant, immunocompetent adults from Atlanta, GA, USA, who were aged 18-49 years, naive to the 2014-15 influenza vaccine, and did not have any significant dermatological disorders. Participants were randomly assigned (1:1:1:1) to four groups and received a single dose of inactivated influenza vaccine (fluvirin: 18 μg

2017 Lancet PubMed

84. Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older. (PubMed)

Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older. Improved influenza vaccines are needed to control seasonal epidemics. This trial compared the protective efficacy in older adults of a quadrivalent, recombinant influenza vaccine (RIV4) with a standard-dose, egg-grown, quadrivalent, inactivated influenza vaccine (IIV4) during the A/H3N2-predominant 2014-2015 influenza season, when antigenic mismatch between circulating and vaccine influenza strains resulted (...) in the reduced effectiveness of many licensed vaccines.We conducted a randomized, double-blind, multicenter trial of RIV4 (45 μg of recombinant hemagglutinin [HA] per strain, 180 μg of protein per dose) versus standard-dose IIV4 (15 μg of HA per strain, 60 μg of protein per dose) to compare the relative vaccine efficacy against reverse-transcriptase polymerase-chain-reaction (RT-PCR)-confirmed, protocol-defined, influenza-like illness caused by any influenza strain starting 14 days or more after vaccination

2017 NEJM

85. Seasonal Influenza Immunization of Health Care Workers for the Prevention of Influenza in Patients: A Review of the Clinical Effectiveness

Seasonal Influenza Immunization of Health Care Workers for the Prevention of Influenza in Patients: A Review of the Clinical Effectiveness Seasonal Influenza Immunization of Health Care Workers for the Prevention of Influenza in Patients: A Review of the Clinical Effectiveness | CADTH.ca Find the information you need Seasonal Influenza Immunization of Health Care Workers for the Prevention of Influenza in Patients: A Review of the Clinical Effectiveness Seasonal Influenza Immunization of Health (...) Care Workers for the Prevention of Influenza in Patients: A Review of the Clinical Effectiveness Published on: June 19, 2017 Project Number: RC0889-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of seasonal influenza immunization of health care workers to prevent the spread of influenza to patients? Key Message One overview of systematic reviews and two non-randomized studies were

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

86. Haemophilus influenzae oral vaccination for preventing acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease. (PubMed)

Haemophilus influenzae oral vaccination for preventing acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease. Chronic bronchitis and chronic obstructive pulmonary disease (COPD) are serious conditions in which patients are predisposed to viral and bacterial infections resulting in potentially fatal acute exacerbations. Chronic obstructive pulmonary disease is defined as a lung disease characterised by obstruction to lung airflow that interferes with normal (...) breathing. Antibiotic therapy has not been particularly useful in eradicating bacteria such as non-typeable Haemophilus influenzae (NTHi) because they are naturally occurring flora of the upper respiratory tract in many people. However, they can cause opportunistic infection. An oral NTHi vaccine has been developed to protect against recurrent infective acute exacerbations in chronic bronchitis.To assess the effectiveness of an oral, whole-cell NTHi vaccine in protecting against recurrent episodes

2017 Cochrane

87. Canadian immunization guide chapter on influenza and statement on seasonal influenza vaccine for 2017-2018

Canadian immunization guide chapter on influenza and statement on seasonal influenza vaccine for 2017-2018 | STATEMENT ON SEASONAL INFLUENZA VACCINE FOR 2017–2018 An Advisory Committee Statement (ACS) National Advisory Committee on Immunization (NACI) Canadian Immunization Guide Chapter on Influenza and Statement on Seasonal Influenza Vaccine for 2017–2018 TO PROMOTE AND PROTECT THE HEALTH OF CANADIANS THROUGH LEADERSHIP, PARTNERSHIP, INNOVATION AND ACTION IN PUBLIC HEALTH. —Public Health (...) may be reproduced for personal or internal use only without permission provided the source is fully acknowledged. However, multiple copy reproduction of this publication in whole or in part for purposes of resale or redistribution requires the prior written permission from the Minister of Public Works and Government Services Canada, Ottawa, Ontario K1A 0S5 or copyright.droitdauteur@pwgsc.gc.ca. Cat.: HP37-25E-PDF ISBN: 2371-5375 Pub.: 1700101 | STATEMENT ON SEASONAL INFLUENZA VACCINE FOR 2017–2018

2017 CPG Infobase

88. Synergistic effects of influenza and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be eliminated by the use of influenza therapeutics: experimental evidence for the multi-hit hypothesis (Full text)

Synergistic effects of influenza and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be eliminated by the use of influenza therapeutics: experimental evidence for the multi-hit hypothesis Central Nervous System inflammation has been implicated in neurodegenerative disorders including Parkinson's disease (Ransohoff, Science 353: 777-783, 2016; Kannarkat et al. J. Parkinsons Dis. 3: 493-514, 2013). Here, we examined if the H1N1 influenza virus (Studahl et al. Drugs 73: 131-158, 2013 (...) from the additive effects of H1N1 or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine alone (p < 0.001). No synergistic effects were found in microglial activation. The synergistic dopaminergic neuron loss is eliminated by influenza vaccination or treatment with oseltamivir carboxylate. This work shows that multiple insults can induce synergistic effects; and even these small changes can be significant as it might allow one to cross a phenotypic disease threshold that would not occur from individual

2017 NPJ Parkinson's disease PubMed

89. Mutation signature in neuraminidase gene of avian influenza H9N2/G1 in Egypt (Full text)

Mutation signature in neuraminidase gene of avian influenza H9N2/G1 in Egypt The low pathogenic avian influenza (LPAI) H9N2 subtype has become the most prevalent and widespread in many Asian and Middle Eastern countries. It causes an enzootic situation in commercial poultry and known as a potential facilitator virus that can be transmitted to human from birds. The neuraminidase (NA) gene plays an important role the release and spread of the virus from infected cells and throughout the bird (...) that the Egyptian H9N2 viruses have seven glycosylation sites like the most recorded H9N2 viruses in the country, except A/Q/Egypt/14864V/2014 virus which has only six. The NA has four amino acid substitutions distributed in different parts of the hemadsorbing site. The most characteristic substitutions in this site were S372A and W403R these substitutions were a distinctive feature resembling to human H9N2, H2N2 and H3N2 viruses but differs from the other avian influenza viruses. These Special features

2017 Virusdisease PubMed

90. Pulmonary immune cells and inflammatory cytokine dysregulation are associated with mortality of IL-1R1-/-mice infected with influenza virus (H1N1) (Full text)

Pulmonary immune cells and inflammatory cytokine dysregulation are associated with mortality of IL-1R1-/-mice infected with influenza virus (H1N1) Respirovirus infection can cause viral pneumonia and acute lung injury (ALI). The interleukin-1 (IL-1) family consists of proinflammatory cytokines that play essential roles in regulating immune and inflammatory responses in vivo. IL-1 signaling is associated with protection against respiratory influenza virus infection by mediation of the pulmonary (...) reduced neutrophil generation in bone marrow and neutrophil recruitment to the inflamed lung. Together, these results suggest that IL-1 signaling is associated with pulmonary anti-influenza immune response and inflammatory lung injury, particularly via the influence on neutrophil mobilization and inflammatory cytokine/chemokine production.

2017 Zoological research PubMed

91. Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 14, April 3 to 9, 2017

Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 14, April 3 to 9, 2017 Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 14, April 3 to 9, 2017 JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 14, April 3 to 9, 2017 View/ Open (...) View Statistics Altmetrics Share Citation World Health Organization. Regional Office for Africa, Health Emergencies Programme . (‎2017)‎. Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 14, April 3 to 9, 2017. Influenza Virological Surveillance, 3 (‎14)‎, 1 - 3. World Health Organization. Regional Office for Africa. Journal Influenza Virological Surveillance, 3 (‎14)‎: 1 - 3 Collections Language English Metadata Related items Showing items related by title

2017 WHO

92. Presumed acute fatty liver of pregnancy following influenza A hepatitis (Full text)

Presumed acute fatty liver of pregnancy following influenza A hepatitis Acute fatty liver of pregnancy is a rare mitochondrial hepatopathy characterised by microvesicular fatty infiltration, and is believed to be due to impaired fatty acid oxidation. Hepatitis following influenza virus infection is uncommon. Rarely influenza virus infection may be complicated by Reye's syndrome, another hepatic microvesicular fat disease. A case of influenza A hepatitis in third trimester of pregnancy, followed

2017 Obstetric medicine PubMed

93. Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 13, March 27 to April 2, 2017

Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 13, March 27 to April 2, 2017 Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 13, March 27 to April 2, 2017 JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 13, March 27 to April (...) 2, 2017 View/ Open View Statistics Altmetrics Share Citation World Health Organization. Regional Office for Africa, Health Emergencies Programme . (‎2017)‎. Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 13, March 27 to April 2, 2017. Influenza Virological Surveillance, 3 (‎13)‎, 1 - 3. World Health Organization. Regional Office for Africa. Journal Influenza Virological Surveillance, 3 (‎13)‎: 1 - 3 Collections Language English Metadata Related items Showing

2017 WHO

94. Taiwan's Public Health National Laboratory System: Success in Influenza Diagnosis and Surveillance (Full text)

Taiwan's Public Health National Laboratory System: Success in Influenza Diagnosis and Surveillance Taiwan's National Laboratory System is one of the action packages of the Global Health Security Agenda, which was launched by the World Health Organization (WHO) to promote health security as an international priority and to encourage progress toward full implementation of the WHO International Health Regulations (IHR) 2005. The mission of each national laboratory system is to conduct real-time (...) laboratory system, Taiwan CDC effectively detects and characterizes pathogens that cause communicable diseases across the entire country, including both known and novel threats, and also conducts epidemiologic analyses of infectious diseases. In this article, we describe the national laboratory system for public health in Taiwan. We provide additional information on the national influenza laboratory surveillance network to demonstrate how our national laboratory systems work in practice, including

2017 Health security PubMed

95. Analyzing the clinical profile of swine flu/influenza A H1N1 infection in central India: a retrospective study (Full text)

Analyzing the clinical profile of swine flu/influenza A H1N1 infection in central India: a retrospective study Recently, India reported an increase in swine flu (influenza A H1N1) activity. There are limited studies on epidemiology of swine flu in Indian context. This study aims to analyze clinical and epidemiological profile of suspected swine flu cases in central India. 171 cases were included in a hospital based, observational, descriptive study conducted from December 2014 to April 2015

2017 Virusdisease PubMed

96. Recommended composition of influenza virus vaccines for use in the 2017–2018 northern hemisphere influenza season – Composition recommandée des vaccins antigrippaux pour la saison grippale 2017-2018 dans l’hémisphère Nord

Recommended composition of influenza virus vaccines for use in the 2017–2018 northern hemisphere influenza season – Composition recommandée des vaccins antigrippaux pour la saison grippale 2017-2018 dans l’hémisphère Nord Recommended composition of influenza virus vaccines for use in the 2017–2018 northern hemisphere influenza season – Composition recommandée des vaccins antigrippaux pour la saison grippale 2017-2018 dans l’hémisphère Nord JavaScript is disabled for your browser. Some features (...) of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links Recommended composition of influenza virus vaccines for use in the 2017–2018 northern hemisphere influenza season – Composition recommandée des vaccins antigrippaux pour la saison grippale 2017-2018 dans l’hémisphère Nord View/ Open View Statistics Altmetrics Share Citation World Health Organization = Organisation mondiale de la Santé . (‎2017)‎. Recommended composition of influenza virus

2017 WHO

97. Influenza. (PubMed)

Influenza. Influenza is an acute respiratory illness, caused by influenza A, B, and C viruses, that occurs in local outbreaks or seasonal epidemics. Clinical illness follows a short incubation period and presentation ranges from asymptomatic to fulminant, depending on the characteristics of both the virus and the individual host. Influenza A viruses can also cause sporadic infections or spread worldwide in a pandemic when novel strains emerge in the human population from an animal host. New (...) approaches to influenza prevention and treatment for management of both seasonal influenza epidemics and pandemics are desirable. In this Seminar, we discuss the clinical presentation, transmission, diagnosis, management, and prevention of seasonal influenza infection. We also review the animal-human interface of influenza, with a focus on current pandemic threats.Copyright © 2017 Elsevier Ltd. All rights reserved.

2017 Lancet

98. Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 10, March 6 to 12, 2017

Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 10, March 6 to 12, 2017 Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 10, March 6 to 12, 2017 JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 10, March 6 to 12, 2017 View/ Open (...) View Statistics Altmetrics Share Other Titles Influenza Bulletin Citation World Health Organization. Regional Office for Africa, Health Emergencies Programme . (‎2017)‎. Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 10, March 6 to 12, 2017. Influenza Virological Surveillance, 3 (‎10)‎, 1 - 3. World Health Organization. Regional Office for Africa. Journal Influenza Virological Surveillance, 3 (‎10)‎: 1 - 3 Description 3 p. Collections Language English Metadata

2017 WHO

99. Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 11, March 13 to 19, 2017

Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 11, March 13 to 19, 2017 Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 11, March 13 to 19, 2017 JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 11, March 13 to 19, 2017 View (...) / Open View Statistics Altmetrics Share Citation World Health Organization. Regional Office for Africa, Health Emergencies Programme . (‎2017)‎. Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 11, March 13 to 19, 2017. Influenza Virological Surveillance, 3 (‎11)‎, 1 - 3. World Health Organization. Regional Office for Africa. Journal Influenza Virological Surveillance, 3 (‎11)‎: 1 - 3 Description 3 p. Collections Language English Metadata Related items Showing items

2017 WHO

100. Community-Level Differences in the Microbiome of Healthy Wild Mallards and Those Infected by Influenza A Viruses (Full text)

Community-Level Differences in the Microbiome of Healthy Wild Mallards and Those Infected by Influenza A Viruses Waterfowl, especially ducks and geese, are primary reservoirs for influenza A viruses (IAVs) that evolve and emerge as important pathogens in domestic animals and humans. In contrast to humans, where IAVs infect the respiratory tract and cause significant morbidity and mortality, IAVs infect the gastrointestinal tract of waterfowl and cause little or no pathology and are spread (...) found that IAV-infected wild mallards exhibited strong differences in microbiome composition relative to noninfected mallards and identified a concise set of putative biomarker OTUs. Using Random Forest, a supervised machine learning method, we verified that these 41 bacterial OTUs are highly predictive of infection status. IMPORTANCE Seasonal influenza causes 3 to 5 million severe illnesses and 250,000 to 500,000 human deaths each year. While pandemic influenza viruses emerge only periodically

2017 mSystems PubMed