Latest & greatest articles for ketamine

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Top results for ketamine

101. Is atropine needed as an adjunct in paediatric ketamine administration?

Is atropine needed as an adjunct in paediatric ketamine administration? BestBets: Is atropine needed as an adjunct in paediatric ketamine administration? Is atropine needed as an adjunct in paediatric ketamine administration? Report By: Simon Carley - Consultant in Emergency Medicine Search checked by Rick Body - Specialist Registrar in Emergency Medicine Institution: Manchester Royal Infirmary Date Submitted: 20th February 2007 Last Modified: 14th August 2008 Status: Green (complete) Three (...) Part Question [In children requiring procedural sedation with ketamine] does [the coadministration of atropine] alter [salivation, safety, vomiting, recovery time and/or effectiveness] Clinical Scenario A 4 year old patient presents to the ED with a lip laceration, you decide to repair it under ketamine sedation and prepare an appropriate dose of ketamine and atropine. However, before administration your colleague (who has recently returned from Australia) tells you that it is a waste of time

2008 BestBETS

102. Does the time of fasting affect complication rates during ketamine sedation

Does the time of fasting affect complication rates during ketamine sedation BestBets: Does the time of fasting affect complication rates during ketamine sedation Does the time of fasting affect complication rates during ketamine sedation Report By: Ray McGlone - Consultant in Emergency Medicine Search checked by Simon Carley - Consultant in Emergency Medicine Institution: Lancaster Royal Infirmary Original author: Ray McGlone Original institution: Lancaster Royal Infirmary Current web editor (...) : Tom Bartram - middle grade A+E Date Submitted: 4th March 2005 Last Modified: 14th August 2008 Status: Green (complete) Three Part Question [In children undergoing ketamine sedation] is [prolonged fasting (6 hours or more) better than short term fasting (3 hours)] at [reducing the incidence of vomiting and other complications of sedation] Clinical Scenario A 4 year old boy is brought to the emergency department having fallen over at home. He has sustained a 3 cm deep laceration to the forehead. He

2008 BestBETS

103. Effects of intra-articular ketamine on pain and somatosensory function in temporomandibular joint arthralgia patients (PubMed)

Effects of intra-articular ketamine on pain and somatosensory function in temporomandibular joint arthralgia patients Recent studies have hypothesized that peripheral glutamate receptors could be implicated in deep craniofacial pain conditions. In this study 18 temporomandibular joint (TMJ) arthralgia patients received intra-articular injections of the N-methyl-D-aspartate (NMDA) receptor antagonist, ketamine, or normal saline to study in a cross-over, double-blinded, placebo-controlled manner (...) the effect on TMJ pain and somatosensory function. Spontaneous pain and pain on jaw function was scored by patients on 0-10 cm visual analogue scale (VAS) for up to 24h. Quantitative sensory tests (QST): tactile, pin-prick, pressure pain threshold and pressure pain tolerance were used for assessment of somatosensory function at baseline and up to 15 min after injections. There were no significant effects of intra-articular ketamine over time on spontaneous VAS pain measures (ANOVA: P=0.532), pain on jaw

2008 EvidenceUpdates

104. Postoperative ketamine administration decreases morphine consumption in major abdominal surgery: a prospective, randomized, double-blind, controlled study (PubMed)

Postoperative ketamine administration decreases morphine consumption in major abdominal surgery: a prospective, randomized, double-blind, controlled study Ketamine decreases postoperative morphine consumption, but its optimal dosing and duration of administration remain unclear. In this study, we compared the effects of ketamine administration on morphine consumption limited to the intraoperative period, or continued for 48 h postoperatively.Eighty-one patients scheduled for abdominal surgery (...) were prospectively randomized under double-blind conditions to three groups: (1) PERI group receiving intraoperative and postoperative ketamine for the first 48 h after surgery (2 microg x kg(-1) x min(-1) after a 0.5 mg/kg bolus); (2) INTRA group receiving intraoperative ketamine administration only (2 microg x kg(-1) x min(-1) after a 0.5 mg/kg bolus); and (3) CTRL group receiving placebo. Morphine consumption, visual analog scale scores and side effects (sedation score, nausea-vomiting score

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2008 EvidenceUpdates

105. Adverse events associated with ketamine for procedural sedation in adults

Adverse events associated with ketamine for procedural sedation in adults Adverse events associated with ketamine for procedural sedation in adults Adverse events associated with ketamine for procedural sedation in adults Strayer RJ, Nelson LS CRD summary The review concluded that when ketamine was used for procedural sedation in adults, cardiorespiratory adverse events were rare but dysphoric emergence phenomena occurred in 10% to 20% patients and there was a likelihood of airway obstruction (...) . The reliability of the authors’ conclusions is uncertain due to review process limitations and uncertain quality and design of the many included studies. Authors' objectives To evaluate the safety of the use of ketamine for procedural sedation in adults. Searching PubMed, EMBASE, TOXNET (to May 2006) and The Cochrane Library were searched for publications in English, Spanish, Russian, French, Portuguese and German; search terms were reported. Australian Adverse Drug Reactions Bulletin, European Public

2008 DARE.

106. Midazolam or ketamine for procedural sedation of children in the emergency department

Midazolam or ketamine for procedural sedation of children in the emergency department BestBets: Midazolam or ketamine for procedural sedation of children in the emergency department Midazolam or ketamine for procedural sedation of children in the emergency department Report By: Andrew Munro - Specialist in Emergency Medicine FACEM Search checked by Ian Machonochie - Consultant in Paediatric Emergency Medicine Institution: Coffs Harbour Base Hospital, NSW, Australia Date Submitted: 28th May 2003 (...) Date Completed: 27th July 2007 Last Modified: 18th June 2007 Status: Green (complete) Three Part Question In [children needing painful procedures in the emergency department] is [ midazolam or ketamine] [ safer and more effective at achieving conscious sedation]? Clinical Scenario A mother brings her five year old son to the Emergency Department (ED) with a deep scalp laceration having fallen onto the corner of a coffee table. The wound requires sutures. For various reasons the option

2007 BestBETS

107. Low-dose ketamine in addition to propofol for procedural sedation and analgesia in the emergency department

Low-dose ketamine in addition to propofol for procedural sedation and analgesia in the emergency department Low-dose ketamine in addition to propofol for procedural sedation and analgesia in the emergency department Low-dose ketamine in addition to propofol for procedural sedation and analgesia in the emergency department Loh G, Dalen D CRD summary This review concluded that there is insufficient evidence to recommend the routine use of low-dose ketamine combined with propofol for procedural (...) sedation in the emergency department setting. Although the review has a number of weaknesses, this conclusion is appropriate. Authors' objectives To evaluate the safety and efficacy of low-dose intravenous ketamine with intravenous propofol for sedation and analgesia during emergency department procedures. Searching MEDLINE, EMBASE, BioMed Central, the Cochrane Library, International Pharmaceutical Abstracts and Google Scholar were searched from inception to February 2007; key search terms were

2007 DARE.

108. Perioperative ketamine for acute postoperative pain. (PubMed)

Perioperative ketamine for acute postoperative pain. Postoperative pain management is often limited by adverse effects such as nausea and vomiting. Adjuvant treatment with an inexpensive opioid-sparing drug such as ketamine may be of value in giving better analgesia with fewer adverse effects.To evaluate the effectiveness and tolerability of ketamine administered perioperatively in the treatment of acute postoperative pain in adults.Studies were identified from MEDLINE (1966-2004), EMBASE (1980 (...) -2004), the Cochrane Library (2004) and by handsearching reference lists from review articles and trials. The manufacturer of ketamine (Pfizer) provided search results from their in-house database, PARDLARS.Randomised controlled trials (RCTs) of adult patients undergoing surgery, being treated with perioperative ketamine or placebo. Studies where ketamine was administered in addition to a basic analgesic (such as morphine or NSAID) in one study group, and compared with a group receiving the same

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2006 Cochrane

109. Ketamine and postoperative pain: a quantitative systematic review of randomised trials

Ketamine and postoperative pain: a quantitative systematic review of randomised trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

110. Ketamine as an adjuvant to opioids for cancer pain. (PubMed)

Ketamine as an adjuvant to opioids for cancer pain. Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of cancer pain, particularly when opioids alone prove to be ineffective. Ketamine is known to have hallucinogenic side effects. To date no systematic review of the benefits and harms of adjuvant ketamine for cancer pain has been undertaken.To determine the effectiveness and adverse effects of ketamine (...) as an adjuvant to opioids in the treatment of cancer pain.Studies were identified from MEDLINE (1966-2001), EMBASE (1980-2001), CancerLit (1966-2001), the Cochrane Library (Issue 1, 2001); by handsearching reference lists from review articles, trials, and chapters from standard textbooks on pain and palliative care. The manufacturer of ketamine (Pfizer Parke-Davis) provided search results from their in-house database, PARDLARS.RCTs of adult patients with cancer and pain being treated with an opioid

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2003 Cochrane

111. Ketamine in chronic pain management: an evidence-based review

Ketamine in chronic pain management: an evidence-based review Ketamine in chronic pain management: an evidence-based review Ketamine in chronic pain management: an evidence-based review Hocking G, Cousins M J CRD summary This review assessed the effectiveness of ketamine for chronic pain. The authors concluded that there is moderate to weak evidence about ketamine and that further controlled trials are required. The lack of a validity assessment and the inadequate reporting of the methods used (...) to conduct the review hamper an assessment of the evidence. The studies were generally of a poor quality, so the evidence is weak. Authors' objectives To evaluate the potential effectiveness of ketamine for treating chronic pain. Searching MEDLINE and EMBASE were searched from 1966 to August 2002 without any language restrictions; the search terms were reported. In addition, the Reference lists of retrieved articles and reviews were checked. Abstracts and unpublished studies were excluded. Authors

2003 DARE.

112. Does ketamine have a role in managing severe exacerbation of asthma in adults?

Does ketamine have a role in managing severe exacerbation of asthma in adults? Does ketamine have a role in managing severe exacerbation of asthma in adults? Does ketamine have a role in managing severe exacerbation of asthma in adults? Lau T T, Zed P J Authors' objectives To evaluate the role of ketamine in the management of severe exacerbation of asthma in adults. Searching MEDLINE (from January 1966 to September 2000), EMBASE (from January 1988 to September 2000) and the Cochrane Database (...) of Systematic Reviews (Issue 2, 2000) were searched for publications in the English language, using the search terms 'ketamine', 'status asthmaticus' and 'asthma'. The references in relevant literature were also examined. Study selection Study designs of evaluations included in the review All articles of any study design were eligible for inclusion in the review. Specific interventions included in the review Ketamine therapy comprised 0.75 mg/kg intravenous (i.v.) bolus, then 0.75 mg/kg i.v. over 10 minutes

2001 DARE.

113. Does midazolam alter the clinical effects of intravenous ketamine sedation in children? A double-blind, randomized, controlled, emergency department trial

Does midazolam alter the clinical effects of intravenous ketamine sedation in children? A double-blind, randomized, controlled, emergency department trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2000 PedsCCM Evidence-Based Journal Club