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Latest & greatest articles for knee osteoarthritis
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A randomized controlled trial of a combined self-management and exercise intervention for elderly people with osteoarthritis of the knee: the PLE2NO program To assess the effectiveness of a 12-week self-management and exercise intervention (the PLE2NO program) in elderly individuals with knee osteoarthritis.Randomized controlled trial.Four different community settings.Eighty individuals aged 60 years or older with clinical and radiographic kneeosteoarthritis enrolled in the study.A combined (...) self-management and exercise intervention (treatment group) and an educational intervention (control group).The primary outcomes were pain and other kneeosteoarthritis symptoms (swelling, crackling, limitation on movement, and stiffness), self-management behaviors (communication with physician and cognitive symptom management), and functional lower limb strength. Secondary outcomes were kneeosteoarthritis-specific health-related quality of life, self-perceived health, aerobic capacity, lower
Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe kneeosteoarthritis: a randomized controlled study This study was performed to evaluate the antioxidative and anti-inflammatory effects of vitamin E on oxidative stress in the plasma, synovial fluid, and synovial tissue of patients with knee osteoarthritis.Seventy-two patients with late-stage kneeosteoarthritis scheduled for total knee arthroplasty were randomized to take oral placebo (Group (...) A) or 400 IU of vitamin E (Group B) once a day for 2 months before undergoing surgery. The blood levels of endpoints indicating oxidative stress or antioxidant capacity, Knee Society Score (KSS), Western Ontario and McMaster Universities Osteoarthritis Index score (WOMAC), and adverse effects were compared before and after the intervention between the two groups. At surgery, these redox endpoints and histological findings were compared between the synovial fluid and synovial tissue.In blood samples
Maintenance of the paraspinal muscles may protect against radiographic kneeosteoarthritisKneeosteoarthritis (OA) is an increasing health problem worldwide. So far, only obesity and quadriceps weakness are identified as modifiable risk factors for knee OA. Core muscle strengthening is becoming increasingly popular among older adults because of its ability to enhance the activities of daily living during old age. This study investigated the associations of the size and quality of the abdominal (...) trunk muscles with radiographic kneeosteoarthritis (RKOA).From 2012 to 2016, data were collected from 146 males and 135 females (age 63.9±13.4 years, BMI 23.2±3.8 kg/m2) at annual musculoskeletal examinations, including knee radiographs and body composition analyses, by dual-energy X-ray absorptiometry. Cross-sectional areas of abdominal trunk muscles were measured using a single-slice computed tomography scan image obtained at the level of the umbilicus.The prevalence of RKOA was 21.2% in males
Intra-articular Corticosteroids and KneeOsteoarthritis: Interpreting Different Meta-analyses. 28027349 2017 07 19 2018 12 02 1538-3598 316 24 2016 12 27 JAMA JAMA Intra-articular Corticosteroids and KneeOsteoarthritis: Interpreting Different Meta-analyses. 2607-2608 10.1001/jama.2016.17227 Felson David T DT Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts2Arthritis Research UK Epidemiology Unit, School of Translational Medicine (...) , University of Manchester and Central Manchester Foundation Trust, Manchester, England. eng Editorial Comment United States JAMA 7501160 0098-7484 0 Adrenal Cortex Hormones AIM IM JAMA. 2016 Dec 27;316(24):2671-2672 28027351 Adrenal Cortex Hormones Humans Osteoarthritis, Knee 2016 12 28 6 0 2016 12 28 6 0 2017 7 20 6 0 ppublish 28027349 2594698 10.1001/jama.2016.17227
Effectiveness of three modes of kinetic-chain exercises on quadriceps muscle strength and thigh girth among individuals with kneeosteoarthritis The study was designed to evaluate and compare the effectiveness of 12-week open, closed and combined kinetic-chain exercises (OKCE, CKCE and CCE) on quadriceps muscle strength and thigh girth of patients with kneeosteoarthritis (OA).The randomized clinical trial involved ninety-six consecutive patients with knee OA who were randomly assigned to one
Clinical significance of Matrilin-3 gene polymorphism in Egyptian patients with primary kneeosteoarthritisOsteoarthritis (OA) is a multifactorial, degenerative, and inflammatory disorder of joints causing damage of the articular cartilage, formation of osteophytes, and eburination of the subchondral bone. Matrilin-3 (MATN-3) is a non-collagenous oligomeric extracellular matrix protein (ECM), which is the smallest member of the matrilin family. This study was conducted to identify (...) the potential association and clinical significance of MATN-3 rs8176070 (SNP6) polymorphism in a series of Egyptian patients with primary knee OA.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine genotypes of MATN-3 SNP6 for 50 primary knee OA patients in addition to 50 healthy subjects of the same sex and age range. Full history was obtained from OA patients, followed by clinical examination, together with clinical assessment of the severity of knee OA
The Effectiveness of Manual Therapy for Relieving Pain, Stiffness, and Dysfunction in KneeOsteoarthritis: A Systematic Review and Meta-Analysis Kneeosteoarthritis (KOA) is the most common form of arthritis, leading to pain disability in seniors and increased health care utilization. Manual therapy is one widely used physical treatment for KOA.To evaluate the effectiveness and adverse events (AEs) of manual therapy compared to other treatments for relieving pain, stiffness, and physical (...) , the evidence may be limited by potential bias and poor methodological quality of included studies. High-quality RCTs with long-term follow-up are warranted to confirm our findings.Key words: Kneeosteoarthritis, manual therapy, systematic review.
Efficacy and safety of single injection of cross-linked sodium hyaluronate vs. three injections of high molecular weight sodium hyaluronate for osteoarthritis of the knee: a double-blind, randomized, multi-center, non-inferiority study This randomized, double-blind, multi-center, non-inferiority trial was conducted to assess the efficacy and safety of a cross-linked hyaluronate (XLHA, single injection form) compared with a linear high molecular hyaluronate (HMWHA, thrice injection form (...) ) in patients with symptomatic knee osteoarthritis.Two hundred eighty seven patients with osteoarthritis (Kellgren-Lawrence grade I to III) were randomized to each group. Three weekly injections were given in both groups but two times of saline injections preceded XLHA injection to maintain double-blindness. Primary endpoint was the change of weight-bearing pain (WBP) at 12 weeks after the last injection. Secondary endpoints included Western Ontario and McMaster Universities Osteoarthritis index; patient's
Periarticular dextrose prolotherapy instead of intra-articular injection for pain and functional improvement in kneeosteoarthritisOsteoarthritis (OA) is a degenerative disease that can lead to painful and dysfunctional joints. Prolotherapy involves using injections to produce functional restoration of the soft tissues of the joint. Intra-articular injections are controversial because of the introduction of needles into the articular capsule.To compare the effect of periarticular versus intra (...) -articular prolotherapy on pain and disability in patients with knee OA.Randomized double-blind controlled clinical trial.Single center, university hospital (Imam Hossein Hospital, Tehran, Iran).A total of 104 patients with chronic knee OA were enrolled. In the intra-articular group, 8 mL of 10% dextrose and 2 mL of 2% lidocaine were injected. Injections were repeated at 1 and 2 weeks after the first injection. In the periarticular group, 5 mL of 20% dextrose and 5 mL of 1% lidocaine were injected
Viscosupplementation for KneeOsteoarthritis: A Review of Clinical and Cost-Effectiveness and Guidelines Viscosupplementation for KneeOsteoarthritis: A Review of Clinical and Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Viscosupplementation for KneeOsteoarthritis: A Review of Clinical and Cost-Effectiveness and Guidelines Viscosupplementation for KneeOsteoarthritis: A Review of Clinical and Cost-Effectiveness and Guidelines Published on: June 22, 2017 Project (...) Number: RC0895-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of viscosupplementation for the treatment of adults with osteoarthritis of the knee? What is the cost-effectiveness of viscosupplementation for the treatment of adults with osteoarthritis of the knee? What are the evidence-based guidelines associated with viscosupplementation for the treatment of adults with osteoarthritis
Correlations between ultrasonographic findings, clinical scores, and depression in patients with kneeosteoarthritis This study aimed to explore correlations between the presence of depression, clinical scores, and ultrasonographic (US) grading in osteoarthritis (OA) patients and to clarify if depressive symptoms might cause a discrepancy between US findings and clinical scores.Two hundred patients with primary knee OA and 100 healthy hospital volunteers of the same age and sex not complaining (...) of knee troubles participated in this study. We evaluated depressive symptoms in all participants using the Beck Depression Inventory (BDI) scale. Thorough clinical examination was performed, including assessment using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) for disability. All patients underwent US examination of their affected knees.Depression was detected in 60 patients with knee OA (30%) and in 5 controls (5%). The mean of BDI score was 12.8±12.2 in OA patients
Treatment of osteoarthritis of the knee: an update review Treatment of osteoarthritis of the knee: an update review Treatment of osteoarthritis of the knee: an update review Newberry SJ, FitzGerald J, SooHoo NF, Booth M, Marks J, Motala A, Apaydin E, Chen C, Raaen L, Shanman R, Shekelle PG. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Newberry SJ, FitzGerald (...) J, SooHoo NF, Booth M, Marks J, Motala A, Apaydin E, Chen C, Raaen L, Shanman R, Shekelle PG.. Treatment of osteoarthritis of the knee: an update review. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 190. 2017 Authors' objectives To assess the evidence for the efficacy of the following interventions for improving clinical outcomes in adults with osteoarthritis (OA) of the knee: cell-based therapies; glucosamine, chondroitin, or glucosamine
Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic kneeosteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT) Chondroitin sulfate 800 mg/day (CS) pharmaceutical-grade in the management of symptomatic kneeosteoarthritis consistent with the European Medicines Agency guideline.A prospective, randomised, 6-month, 3-arm, double-blind, double-dummy, placebo and celecoxib (200 mg/day)-controlled trial assessing (...) changes in pain on a Visual Analogue Scale (VAS) and in the Lequesne Index (LI) as coprimary endpoints. Minimal-Clinically Important Improvement (MCII), Patient-Acceptable Symptoms State (PASS) were used as secondary endpoints.604 patients (kneeosteoarthritis) diagnosed according to American College of Rheumalogy (ACR) criteria, recruited in five European countries and followed for 182 days. CS and celecoxib showed a greater significant reduction in pain and LI than placebo. In the intention-to-treat
The Main Cause of Death Following Primary Total Hip and Knee Replacement for Osteoarthritis: A Cohort Study of 26,766 Deaths Following 332,734 Hip Replacements and 29,802 Deaths Following 384,291 Knee Replacements Patients undergoing primary total joint replacement are selected for surgery and thus (other than having a transiently increased mortality rate postoperatively) have a lower mortality rate than age and sex-matched individuals do. Understanding the causes of death following joint (...) replacement would allow targeted strategies to reduce the risk of death and optimize outcome. We aimed to determine the rates and causes of mortality for patients undergoing primary total hip or knee replacement compared with individuals in the general population who were matched for age and sex.We compared causes and rates of mortality between age and sex-matched individuals in the general population (National Joint Registry for England, Wales and Northern Ireland; Hospital Episode Statistics; and Office
Efficacy of extracorporeal shockwave therapy and low-intensity pulsed ultrasound in a rat kneeosteoarthritis model: A randomized controlled trial This study aims to assess the efficacy of extracorporeal shockwave therapy (ESWT) and low-intensity pulsed ultrasound (LIPUS) on osteoarthritic rat knees.Twenty-four rats were divided into 3 groups: group 1-control (n=8), group 2-LIPUS (n=8) and group 3-ESWT (n=8). Cartilage degeneration was provided using mono-iodo-asetate (MIA). One milligram (...) of MIA was delivered to the right knees in group 1 and both knees in group 2 and 3. A 0.09% saline solution was delivered to the left knees in group 1 for control. Twenty-four hours after the delivery, ESWT was applied once on the right knees in the group 2 rats to the medial tibia plateu with a 1 Hz frequency and 800 impulses. LIPUS was applied to the right knees in the group 2 rats to the medial tibia plateu with a 3 mHz frequency and 40 mW/cm2 intensity for 20 minutes over a period of 15 days
Genetic influence of growth and differentiation factor 5 gene polymorphism (+104T/C) on the development of kneeosteoarthritis and its association with disease severity The growth and differentiation factor 5 (GDF5) gene is recognized for its role in the development, repair, and maintenance of cartilage and bone. The present case-control study was conducted to detect the genetic association between GDF5 (+104T/C) single-nucleotide polymorphism (SNP) and primary kneeosteoarthritis (KOA (...) ), as well as the possible association of SNP with the severity of KOA.The study included 50 patients with primary KOA and 50 healthy control subjects. The severity of the disease was assessed by using the Kellgren-Laurence (K-L) grading system and aided by the Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) score, visual analog scale (VAS) score, and tenderness score. The genetic association of the SNP with primary KOA was assessed by means of the TaqMan® allelic discrimination
Decrease of serum biomarker of type II Collagen degradation (Coll2-1) by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary kneeosteoarthritis This study aimed to evaluate the effect of one dose of intra-articular injection of (PRP) in the knee joint on a specific osteoarthritis (OA) serum biomarker of cartilage degeneration, Collagen 2-1 (Coll2-1), over a short period of 3 months. The aim extended to clarify the effect of PRP on the functional (...) status of the osteoarthritic knee joint.Sixty patients with primary unilateral knee OA were enrolled in this study. They were subdivided according to Kellgren-Lawrence grading scale (KL) into (Group I): including patients with KL grade < 3 and (Group II): including patients with KL grade ≥3. Patients were asked to complete the Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score. PRP was prepared and injected immediately into the affected knee. Serum Coll2-1 (S.Coll2-1
Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With KneeOsteoarthritis: A Randomized Clinical Trial. Synovitis is common and is associated with progression of structural characteristics of kneeosteoarthritis. Intra-articular corticosteroids could reduce cartilage damage associated with synovitis but might have adverse effects on cartilage and periarticular bone.To determine the effects of intra-articular injection of 40 mg of triamcinolone (...) acetonide every 3 months on progression of cartilage loss and knee pain.Two-year, randomized, placebo-controlled, double-blind trial of intra-articular triamcinolone vs saline for symptomatic kneeosteoarthritis with ultrasonic features of synovitis in 140 patients. Mixed-effects regression models with a random intercept were used to analyze the longitudinal repeated outcome measures. Patients fulfilling the American College of Rheumatology criteria for symptomatic kneeosteoarthritis, Kellgren-Lawrence
Treatment of Osteoarthritis of the Knee: An Update Review Comparative Effectiveness Review Number 190 Treatment of Osteoarthritis of the Knee: An Update Review eComparative Effectiveness Review Number 190 Treatment of Osteoarthritis of the Knee: An Update Review Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 www.ahrq.gov Contract No. 290-2015-00010-I Prepared by: RAND Southern California Evidence-based (...) on the Effective Health Care Program Web site at www.effectivehealthcare.ahrq.gov. Search on the title of the report. Persons using assistive technology may not be able to fully access information in this report. For assistance contact EffectiveHealthCare@ahrq.hhs.gov. Suggested citation: Newberry SJ, FitzGerald J, SooHoo NF, Booth M, Marks J, Motala A, Apaydin E, Chen C, Raaen L, Shanman R, Shekelle PG. Treatment of Osteoarthritis of the Knee: An Update Review. Comparative Effectiveness Review No. 190
The Ottawa panel clinical practice guidelines for the management of kneeosteoarthritis. Part one: Introduction, and mind-body exercise programs To identify effective mind-body exercise programs and provide clinicians and patients with updated, high-quality recommendations concerning non-traditional land-based exercises for knee osteoarthritis.A systematic search and adapted selection criteria included comparative controlled trials with mind-body exercise programs for patients with knee (...) osteoarthritis. A panel of experts reached consensus on the recommendations using a Delphi survey. A hierarchical alphabetical grading system (A, B, C+, C, D, D+, D-) was used, based on statistical significance ( P < 0.5) and clinical importance (⩾15% improvement).The four high-quality studies identified demonstrated that various mind-body exercise programs are promising for improving the management of kneeosteoarthritis. Hatha Yoga demonstrated significant improvement for pain relief (Grade B) and physical