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Latest & greatest articles for knee osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on knee osteoarthritis or other clinical topics then use Trip today.
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Efficacy of a natural mineral complex in North American adults with osteoarthritis of the knee: a randomized double-blind placebo-controlled study. This study evaluated the efficacy of a hydrothermal mineral complex (HMC) supplement in participants with knee osteoarthritis.This was a double-blind, placebo-controlled, 12-week crossover study with 150 participants receiving either placebo or HMC for 4 weeks, with a 4-week washout period. The primary endpoint was WOMAC™ pain, and secondary
Unique aspects of pain reduction in osteoarthritis of the knee with LMWF-5A. Osteoarthritis of the knee (OAK) is a common form of arthritis that can lead to substantial pain and disability. This commentary highlights key aspects of the recently published phase 3 A Efficacy and Safety Study of Two Doses of Intra-Articular Injection of Ampion™ in Adults With Pain Due to Osteoarthritis of the Knee (SPRING) study. SPRING (NCT01839331) was a multicenter, randomized, vehicle-controlled, double-blind (...) trial that evaluated the safety and efficacy of the low-molecular-weight fraction of 5% human serum albumin (LMWF-5A) for treatment of pain, measured by the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain scale, in patients with symptomatic OAK (N=329). Patients in this study reflected many characteristics of "real-world" individuals with OAK, with a broad range of disease severity and disability. The most important finding from this study was that treatment with a single intra
Gait analysis of patients with kneeosteoarthritis highlights a pathological mechanical pathway and provides a basis for therapeutic interventions Kneeosteoarthritis (OA) is a painful and incapacitating disease affecting a large portion of the elderly population, for which no cure exists. There is a critical need to enhance our understanding of OA pathogenesis, as a means to improve therapeutic options.Knee OA is a complex disease influenced by many factors, including the loading environment (...) in OA development, and to design therapeutic interventions. Multidisciplinary research is necessary to relate the biomechanical alterations to the structural and biological components of OA. Cite this article: Favre J, Jolles BM. Analysis of gait, knee biomechanics and the physiopathology of kneeosteoarthritis in the development of therapeutic interventions. EFORT Open Rev 2016;1:368-374. DOI: 10.1302/2058-5241.1.000051.
Efficacy of knee braces and foot orthoses in conservative management of kneeosteoarthritis: a systematic review. A systematic analysis was conducted on the effectiveness of knee braces and foot orthoses in conservative management of kneeosteoarthritis. The methodologic quality of the randomized clinical trials, controlled clinical trials, and observational studies were systematically reviewed using the Structured Effectiveness Quality Evaluation Scale. Twenty-five studies met the inclusion (...) criteria. The orthoses used in the studies included Generation II osteoarthritisknee brace, valgus knee braces, functional off-loading knee braces, knee sleeves, lateral-wedged insoles with subtalar strapping, medial-wedged insoles, and specialized footwear. Results suggest that knee braces and foot orthoses are effective in decreasing pain, joint stiffness, and drug dosage. They also improve proprioception, balance, Kellgren/Lawrence grading, and physical function scores in subjects with varus
Simultaneous anterior cruciate ligament reconstruction and dome-shaped high tibial osteotomy for severe medial compartment osteoarthritis of the knee The optimal surgical procedure to address both anterior cruciate ligament (ACL) deficiency and medial compartment osteoarthritis (OA) has been controversial.A 49-year-old woman with a 30-year history of chronic anterior cruciate ligament (ACL) deficiency, medial compartment osteoarthritis, and varus deformity presented with medial knee pain (...) and apprehension with walking and playing soccer. Her preoperative range of motion was from 0° of extension to 135° of flexion. The anterior drawer sign (1+), Lachman test (1+), and pivot shift test (glide) were positive before surgery, as measured by the International Knee Documentation Committee knee examination form. The patient underwent simultaneous arthroscopic ACL single-socket and single-bundle reconstruction using hamstring tendons, dome-shaped high tibial osteotomy using the TomoFix fixation device
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study Kneeosteoarthritis is a disabling disease that costs billions of dollars to treat. Corticosteroid gives varying pain relief and costs $12 per injection, whereas ketorolac costs $2 per injection, per institutional costs. The aim of this study was to compare ketorolac with corticosteroid based on pain relief using patient outcome measures and cost (...) data.A total of 35 patients were randomized to ketorolac or corticosteroid intra-articular knee injection in a double-blind, prospective study. Follow-up was 24 weeks. Osteoarthritis was evaluated using Kellgren-Lawrence grading. Visual analog scale (VAS) was the primary outcome measure. A query of the institutional database was performed for International Classification of Diseases, Ninth Revision codes 715.16 and 719.46, and procedure code 20610 over a 3-year period. Two-way, repeated measures
Unloading Shoes for Self-Management of KneeOsteoarthritis: A Randomized Trial. Appropriate footwear is recommended for self-management of kneeosteoarthritis. Shoes that reduce harmful knee loads are available, but symptomatic effects are uncertain.To evaluate the efficacy of unloading shoes in alleviating kneeosteoarthritis symptoms.Participant- and assessor-blinded comparative effectiveness randomized, controlled trial. (Australian New Zealand Clinical Trials Registry: ACTRN12613000851763 (...) ).Community.164 persons with medial knee osteoarthritis.Walking shoes with triple-density, variable-stiffness midsoles and mild lateral-wedge insoles designed to unload the medial knee and worn daily (intervention) versus conventional walking shoes (comparator).Primary outcomes were pain with walking (assessed on a numerical rating scale [NRS]) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]) at 6 months. Secondary outcomes were knee pain and stiffness (WOMAC
Exploring Fatigue Trajectories in Early Symptomatic Knee and Hip Osteoarthritis: 6-year Results from the CHECK Study To examine whether different groups of fatigue trajectories can be identified among patients with early symptomatic osteoarthritis (OA) of the knee or hip, to describe the level of fatigue severity within each of these fatigue groups, and to investigate the involvement of age, sex, use of medication, comorbidity, and OA severity in relation to group membership.Six years (...) of followup data on fatigue (Medical Outcomes Study Short Form-36 Vitality scale) came from the Cohort Hip and Cohort Knee (CHECK) cohort. Growth mixture modeling was applied to identify distinct fatigue trajectories as well as to take into account the effects of the patient characteristics.Three fatigue trajectories were identified: low fatigue, low-to-high fatigue, and high fatigue. Latter trajectories showed considerable overlap from years 2 to 6, but differed in some patient characteristics
Efficacy of Elaeagnus Angustifolia extract in the treatment of kneeosteoarthritis: a randomized controlled trial. Osteoarthritis (OA) is one of the most common musculoskeletal disorders all over the world. Available anti-arthritic medications have only partial efficacy and their long-term use is associated with adverse events. Elaeagnus Angustifolia (EA) is a medicinal plant with analgesic and anti-inflammatory properties. The present study evaluated the impact of two doses of EA extract (...) compared with ibuprofen on the severity of disease in patients with knee OA. This study was designed as a randomized, double blind, active-controlled and parallel group trial. Patients with OA were randomized to receive 300 mg/day (n=33) or 600 mg/day (n=32) of EA aqueous extract, or 800 mg/day ibuprofen (n=32) for 7 weeks. EA extract contained 0.21 % (w/w) kaempferol according to HPLC. Efficacy of treatment was assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC
Physical Therapist-Delivered Pain Coping Skills Training and Exercise for KneeOsteoarthritis: Randomized Controlled Trial To investigate whether a 12-week physical therapist-delivered combined pain coping skills training (PCST) and exercise (PCST/exercise) is more efficacious and cost effective than either treatment alone for kneeosteoarthritis (OA).This was an assessor-blinded, 3-arm randomized controlled trial in 222 people (73 PCST/exercise, 75 exercise, and 74 PCST) ages ≥50 years (...) with knee OA. All participants received 10 treatments over 12 weeks plus a home program. PCST covered pain education and training in cognitive and behavioral pain coping skills, exercise comprised strengthening exercises, and PCST/exercise integrated both. Primary outcomes were self-reported average knee pain (visual analog scale, range 0-100 mm) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index, range 0-68) at week 12. Secondary outcomes included other pain measures
Comparative Effectiveness of Tai Chi Versus Physical Therapy for KneeOsteoarthritis: A Randomized Trial. Few remedies effectively treat long-term pain and disability from kneeosteoarthritis. Studies suggest that Tai Chi alleviates symptoms, but no trials have directly compared Tai Chi with standard therapies for osteoarthritis.To compare Tai Chi with standard physical therapy for patients with knee osteoarthritis.Randomized, 52-week, single-blind comparative effectiveness trial (...) . (ClinicalTrials.gov: NCT01258985).An urban tertiary care academic hospital.204 participants with symptomatic kneeosteoarthritis (mean age, 60 years; 70% women; 53% white).Tai Chi (2 times per week for 12 weeks) or standard physical therapy (2 times per week for 6 weeks, followed by 6 weeks of monitored home exercise).The primary outcome was Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score at 12 weeks. Secondary outcomes included physical function, depression, medication use
Low-dose Spironolactone: Treatment for Osteoarthritis-related Knee Effusion. A Prospective Clinical and Sonographic-based Study To evaluate the effectiveness of spironolactone as a treatment for osteoarthritis (OA)-related knee effusion in comparison to ibuprofen, cold compresses, and placebo.This study was carried out on 200 patients, aged 40 years or older, attending the outpatient clinic of the Rheumatology Department of Sohag University Hospital with unilateral knee effusion related to OA (...) , 10% partial improvement, and 84% no response.Low-dose spironolactone is a safe and effective medical treatment for OA-related knee effusion.
Efficacy of Platelet-Rich Plasma versus Hyaluronic Acid for treatment of KneeOsteoarthritis: A systematic review and meta-analysis. Kneeosteoarthritis is a very common chronic degenerative disease that could impose significant costs to the health system. Although osteoarthritis can affect all joints, kneeosteoarthritis is the most common type among adolescents. Non-surgical treatments include corticosteroids injection, hyaluronic acid, and platelet-rich plasma. The aim of this study (...) was to investigate the efficiency of platelet-rich plasma versus hyaluronic acid for the treatment of knee osteoarthritis.Pubmed, Cochran library, Scopus and Ovid databases were investigated to identify related studies from 2000 through August 2015. To study the efficiency, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) outcome using the Standard Mean Difference (SMD) index was calculated using a random model and a confidence interval of 95%. In addition, sensitivity and cumulative
Re: "Kinesio Taping Improves Pain, Range of Motion, and Proprioception in Older Patients with KneeOsteoarthritis: A Randomized Controlled Trial". 26495811 2016 04 11 2018 12 02 1537-7385 95 1 2016 Jan American journal of physical medicine & rehabilitation Am J Phys Med Rehabil Re: "Kinesio Taping Improves Pain, Range of Motion, and Proprioception in Older Patients with KneeOsteoarthritis: A Randomized Controlled Trial". e7-8 10.1097/PHM.0000000000000394 Cho Hwi-Young HY Department of Physical (...) Therapy, Gachon University College of Health Science, Incheon, South Korea Department of Physiology, Korea University College of Medicine, Seoul, South Korea. Yoon Young Wook YW eng Letter Comment United States Am J Phys Med Rehabil 8803677 0894-9115 AIM IM Am J Phys Med Rehabil. 2015 Mar;94(3):192-200 25706053 Am J Phys Med Rehabil. 2016 Jan;95(1):e7 26390398 Athletic Tape Female Humans Knee Joint physiopathology Male Osteoarthritis, Knee therapy Proprioception Range of Motion, Articular 2015 10 27 6
DMI-9523 (Ampion) for moderate to severe osteoarthritis of the knee DMI-9523 (Ampion) for moderate to severe osteoarthritis of the knee DMI-9523 (Ampion) for moderate to severe osteoarthritis of the knee NIHR HSRIC Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. DMI-9523 (Ampion) for moderate to severe osteoarthritis of the knee. Birmingham: NIHR (...) Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2016 Authors' conclusions Osteoarthritis is the most common type of arthritis in the UK and leads to painful and stiff joints. Osteoarthritis can affect any joint, but commonly affects knee joints. Daily routine activities can become difficult for patients with osteoarthritis of the knee. There is no cure for osteoarthritis of the knee but there are treatments which help to reduce the pain. In cases where treatment does not work
Feasibility of a Randomized Controlled Trial of Self-Administered Acupressure for Symptom Management in Older Adults with KneeOsteoarthritis. To assess the feasibility of a study to evaluate the efficacy of self-administered acupressure in pain and related symptom management for older people with symptomatic kneeosteoarthritis. Feasibility with regard to (1) sample recruitment and retention, (2) treatment fidelity and adherence, and (3) tolerability and adverse events was examined.The study (...) from performing the acupressure. Thirty adverse events were reported; most were related to pre-existing health conditions.It is feasible to conduct a study of self-administered acupressure for symptom management in community-living older adults with kneeosteoarthritis, although sample recruitment may be challenging.
Aquatic exercise for the treatment of knee and hip osteoarthritis. Osteoarthritis is a chronic disease characterized by joint pain, tenderness, and limitation of movement. At present, no cure is available. Thus only treatment of the person's symptoms and treatment to prevent further development of the disease are possible. Clinical trials indicate that aquatic exercise may have advantages for people with osteoarthritis. This is an update of a published Cochrane review.To evaluate the effects (...) of aquatic exercise for people with knee or hip osteoarthritis, or both, compared to no intervention.We searched the following databases up to 28 April 2015: the Cochrane Central Register of Controlled Trials (CENTRAL; the Cochrane Library Issue 1, 2014), MEDLINE (from 1949), EMBASE (from 1980), CINAHL (from 1982), PEDro (Physiotherapy Evidence Database), and Web of Science (from 1945). There was no language restriction.Randomized controlled clinical trials of aquatic exercise compared to a control group
Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic KneeOsteoarthritis: A Randomized Clinical Trial. Observational studies suggest that vitamin D supplementation is associated with benefits for kneeosteoarthritis, but current trial evidence is contradictory.To compare the effects of vitamin D supplementation vs placebo on knee pain and knee cartilage volume in patients with symptomatic kneeosteoarthritis and low vitamin D levels.A (...) multicenter randomized, double-blind, placebo-controlled clinical trial in Tasmania and Victoria, Australia. Participants with symptomatic kneeosteoarthritis and low 25-hydroxyvitamin D (12.5-60 nmol/L) were enrolled from June 2010 to December 2011. The trial was completed in December 2013.Participants were randomly assigned to receive monthly treatment with oral vitamin D3 (50,000 IU; n = 209) or an identical placebo (n = 204) for 2 years.Primary outcomes were change in tibial cartilage volume (assessed
Walking cane: kneeosteoarthritis RACGP - Walking cane for kneeosteoarthritis Search Become a student member today for free and be part of the RACGP community A career in general practice Starting the GP journey Enrolments for the 2019.1 OSCE FRACGP exams closing 29 March 2019 Fellowship FRACGP exams Research Practice Experience Program is a self-directed education program designed to support non vocationally registered doctors on their pathway to RACGP Fellowship Fellowship International (...) Media Releases 2013 Media Releases 2012 Media Releases Search Walking cane for kneeosteoarthritis Walking cane for kneeosteoarthritis Introduction Use of a cane is one of a number of non-drug treatments for kneeosteoarthritis; which include weight reduction, exercise and taping. Intervention Daily use of a walking cane or stick to decrease the load transmitted through the affected knee(s) and improve pain and function. Indication People with kneeosteoarthritis (OA) who have pain and difficulty
Exercise for kneeosteoarthritis RACGP - Handbook of Non-Drug Interventions (HANDI) Search Become a student member today for free and be part of the RACGP community A career in general practice Starting the GP journey Enrolments for the 2019.1 OSCE FRACGP exams closing 29 March 2019 Fellowship FRACGP exams Research Practice Experience Program is a self-directed education program designed to support non vocationally registered doctors on their pathway to RACGP Fellowship Fellowship International