Latest & greatest articles for knee replacement

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Top results for knee replacement

161. Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor on pain management and recovery of function after knee replacement: a randomized controlled trial. (PubMed)

Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor on pain management and recovery of function after knee replacement: a randomized controlled trial. Controlling postoperative pain after knee replacement while reducing opioid-induced adverse effects and improving outcomes remains an important challenge.To assess the effect of combined preoperative and postoperative administration of a selective inhibitor of cyclooxygenase 2 on opioid consumption and outcomes after (...) total knee arthroplasty (TKA).Randomized, placebo-controlled, double-blind trial conducted June 2001 through September 2002, enrolling 70 patients aged 40 to 77 years and undergoing TKA at a university hospital in the United States.Patients were randomly assigned to receive 50 mg of oral rofecoxib at 24 hours and at 1 to 2 hours before TKA, 50 mg daily for 5 days postoperatively, and 25 mg daily for another 8 days, or matching placebo at the same times.Postoperative outcomes including postsurgical

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2003 JAMA

162. Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement. (PubMed)

Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement. In a previous study of the prevention of venous thromboembolism after total knee replacement, the efficacy of ximelagatran, an oral direct thrombin inhibitor that does not require monitoring of coagulation or dose adjustment, was found to be similar to that of warfarin at a dose of 24 mg of ximelagatran twice daily. The purpose of the present study was to determine whether (...) percent vs. 4.1 percent; P=0.17).The efficacy of oral ximelagatran, administered starting the morning after total knee replacement, was superior to that of warfarin for prevention of venous thromboembolism. Rates of hemorrhagic complications with the two drugs were similar.Copyright 2003 Massachusetts Medical Society

2003 NEJM

163. Total knee replacement

Total knee replacement Total knee replacement Total knee replacement Kane RL, Saleh KJ, Wilt TJ, Bershadsky B, Cross WW III, MacDonald RM, Rutks I Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Kane RL, Saleh KJ, Wilt TJ, Bershadsky B, Cross WW III, MacDonald RM, Rutks I. Total knee replacement. Rockville: Agency for Healthcare Research (...) and Quality (AHRQ). Evidence Report/Technology Assessment No. 86. 2003 Authors' objectives A systematic review of the literature was undertaken to address the following questions: - What are the current indications for, and outcomes from, primary total knee replacement? - How do specific characteristics of the patient, material and design of the prosthesis, and surgical factors, affect the short-term and long-term outcomes of primary total knee replacement? - Are there important perioperative

2003 Health Technology Assessment (HTA) Database.

164. The St. Leger total knee replacement: a false economy

The St. Leger total knee replacement: a false economy The St. Leger total knee replacement: a false economy The St. Leger total knee replacement: a false economy Westwood M J, White S P, Bannister G C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions (...) drawn. Health technology The St. Leger total knee replacement (TKR) was compared with the Kinemax Plus TKR for patients with osteoarthritis. The St. Leger TKR is a posterior cruciate retaining total condylar knee replacement. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients with osteoarthritis who had undergone TKRs. Setting The setting was tertiary care (a teaching hospital). The economic study was carried out

2003 NHS Economic Evaluation Database.

165. Low-molecular-weight heparin therapy for patients undergoing total knee replacement surgery: cost and outcomes

Low-molecular-weight heparin therapy for patients undergoing total knee replacement surgery: cost and outcomes Low-molecular-weight heparin therapy for patients undergoing total knee replacement surgery: cost and outcomes Low-molecular-weight heparin therapy for patients undergoing total knee replacement surgery: cost and outcomes Allen L R, Bonck M J, Lofgren K L, Mayo K W, Mozaffari E Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion (...) on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study compared a formulary interchange of low molecular weight heparin (LMWH) products for prophylactic therapy in patients undergoing total knee replacement (TKR) surgery. The products compared were enoxaparin (Lovenox, Aventis) and dalteparin (Fragmin, Pharmacia). Type

2003 NHS Economic Evaluation Database.

166. NIH Consensus Development Conference on Total Knee Replacement

NIH Consensus Development Conference on Total Knee Replacement NIH Consensus Statement on Total Knee Replacement NIH Consensus and State-of-the-Science Statements Volume 20, Number 1 December 8–10, 2003 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of the Director About the NIH Consensus Development Program NIH Consensus Development and State-of-the-Science Conferences are convened to evaluate the available scientific evidence on a given biomedical or public (...) bibliographic reference to this consensus statement, it is recommended that the following format be used, with or without source abbreviations, but without authorship attribution: NIH Consensus Statement on Total Knee Replacement. NIH Consens State Sci Statements. 2003 Dec 8–10; 20(1) 1–32. Publications Ordering Information NIH Consensus Statements, State-of-the-Science Statements, and Technol­ ogy Assessment Statements and related materials are available by writing to the NIH Consensus Development Program

2003 NIH Consensus Statements

167. Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial. (PubMed)

Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial. Heparins substantially reduce the risk of thromboembolic complications after total hip or knee replacement. However, they can be given only by injection and have several other drawbacks. We did a multicentre, randomised, double-blind study to examine the dose-response relation of subcutaneous melagatran, a direct thrombin inhibitor (...) , followed by oral ximelagatran as thromboprophylaxis after total hip or knee replacement. We aimed to compare the efficacy and safety with that of dalteparin.Of 1900 patients, 1495 were assigned to four dose categories of subcutaneous melagatran from just before surgery (1.00 mg, 1.50 mg, 2.25 mg, or 3.00 mg twice daily) followed from the day after surgery by oral ximelagatran (8 mg, 12 mg, 18 mg, or 24 mg twice daily). 381 patients were assigned subcutaneous dalteparin 5000 IU once daily, from

2002 Lancet

168. Short-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of prospective studies investigating symptomatic outcomes

Short-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of prospective studies investigating symptomatic outcomes Short-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of prospective studies investigating symptomatic outcomes Short-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of prospective studies investigating symptomatic (...) outcomes Douketis J D, Eikelboom J W, Quinlan D J, Willan A R, Crowther M A Authors' objectives To provide reliable estimates of the risk of symptomatic venous thromboembolism (VTE), occurring within 3 months of hip or knee replacement in patients who received short-duration (7 to 10 days) anticoagulant prophylaxis. Searching MEDLINE, EMBASE and the Cochrane Controlled Trials Register were searched for studies of anticoagulant prophylaxis after hip or knee replacement that were published between

2002 DARE.

169. Cost/death averted with venous thromboembolism prophylaxis in patients undergoing total knee replacement or knee arthroplasty

Cost/death averted with venous thromboembolism prophylaxis in patients undergoing total knee replacement or knee arthroplasty Cost/death averted with venous thromboembolism prophylaxis in patients undergoing total knee replacement or knee arthroplasty Cost/death averted with venous thromboembolism prophylaxis in patients undergoing total knee replacement or knee arthroplasty Nerurkar J, Wade W E, Martin B C Record Status This is a critical abstract of an economic evaluation that meets (...) the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Two prophylaxis modalities for deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients who had undergone total knee replacement (TKR) were studied. The use of low molecular weight heparin or adjusted-dose warfarin was considered. Type of intervention Primary

2002 NHS Economic Evaluation Database.

170. Extended-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of the randomised trials. (PubMed)

Extended-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of the randomised trials. The optimum duration of prophylaxis against venous thromboembolism after total hip or knee replacement is uncertain. Our primary objective was to establish the efficacy of extended-duration prophylaxis on symptomatic venous thromboembolic events.We identified randomised trials comparing extended-duration prophylaxis using heparin or warfarin with placebo (...) or untreated control in patients undergoing elective total hip or knee replacement by searching electronic databases (MEDLINE, EMBASE), references from retrieved articles, and abstracts from conference proceedings, and by contact with pharmaceutical companies and investigators. Two reviewers independently extracted data on study design, symptomatic and symptomless venographic venous thromboembolism, death, and bleeding outcomes. Results from individual trials were combined with the Mantel-Haenszel

2001 Lancet

171. The Oxford unicompartmental knee replacement for osteoarthritis

The Oxford unicompartmental knee replacement for osteoarthritis The Oxford unicompartmental knee replacement for osteoarthritis The Oxford unicompartmental knee replacement for osteoarthritis Brown A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Brown A. The Oxford unicompartmental knee replacement for osteoarthritis. Ottawa: Canadian (...) Coordinating Office for Health Technology Assessment/Office Canadien de Coordination de l'Evaluation des Technologies de la Sante (CCOHTA) 2001: 4 Authors' objectives To summarise the available evidence on the use of the Oxford unicompartmental knee replacement for osteoarthritis. Authors' conclusions The Oxford unicompartmental knee replacement is a reliable treatment for medial knee compartment osteoarthritis, provided patients with the correct indications are chosen and the appropriate surgical

2001 Health Technology Assessment (HTA) Database.

172. Autologous blood transfusion in total knee replacement surgery

Autologous blood transfusion in total knee replacement surgery Autologous blood transfusion in total knee replacement surgery Autologous blood transfusion in total knee replacement surgery Thomas D, Wareham K, Cohen D, Hutchings H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability (...) of the study and the conclusions drawn. Health technology Autologous blood transfusion (transfusion using post-operative red cell salvage (PRCS)) was assessed. This involved the use of collected blood which was washed and re-suspended in saline before re-infusion using a centrifugal cell washing machine (Cell Saver 5 Haemonetics). Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients undergoing total knee replacement (TKR

2001 NHS Economic Evaluation Database.

173. Cost implications of low molecular weight heparins as prophylaxis following total hip and knee replacement

Cost implications of low molecular weight heparins as prophylaxis following total hip and knee replacement Cost implications of low molecular weight heparins as prophylaxis following total hip and knee replacement Cost implications of low molecular weight heparins as prophylaxis following total hip and knee replacement Bell G K, Goldhaber S Z Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief (...) summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Low molecular weight heparins (LMWHs) were compared with warfarin for prophylaxis following total hip (THR) or total knee (TKR) replacement. Type of intervention Primary prevention. Economic study type Cost-effectiveness analysis. Study population The study population comprised hospital records from patients admitted for THR and TKR

2001 NHS Economic Evaluation Database.

174. Extended-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of the randomised trials

Extended-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of the randomised trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2001 DARE.

175. [Cost-effectiveness analysis of an autotransfusion program in primary knee and hip replacement surgery]

[Cost-effectiveness analysis of an autotransfusion program in primary knee and hip replacement surgery] Analisis de la relacion coste-efectividad de un programa de autotransfusion en cirugia protesica primaria de rodilla y cadera [Cost-effectiveness analysis of an autotransfusion program in primary knee and hip replacement surgery] Analisis de la relacion coste-efectividad de un programa de autotransfusion en cirugia protesica primaria de rodilla y cadera [Cost-effectiveness analysis (...) of an autotransfusion program in primary knee and hip replacement surgery] Diaz-Espallardo C, Moral-Garcia V Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of an autotransfusion programme in patients undergoing primary prosthetic surgery

1999 NHS Economic Evaluation Database.

176. Costs and cost-effectiveness in hip and knee replacements: a prospective study

Costs and cost-effectiveness in hip and knee replacements: a prospective study Costs and cost-effectiveness in hip and knee replacements: a prospective study Costs and cost-effectiveness in hip and knee replacements: a prospective study Rissanen P, Aro S, Sintonen H, Asikainen K, Slatis P, Paavolainen P Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Total hip (THA) and knee (TKA) replacements in patients with primary arthrosis, primary operation, and total joint replacement. Type of intervention Treatment. Economic study type Cost-utility analysis. Study population Patients with primary arthrosis, primary operation, and total joint replacement. Setting Hospital. The economic study was carried out in Finland. Dates

1997 NHS Economic Evaluation Database.

177. Cost effectiveness of revision total knee replacement

Cost effectiveness of revision total knee replacement Cost effectiveness of revision total knee replacement Cost effectiveness of revision total knee replacement Rorabeck C H, Murray P Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health (...) technology A revision total knee replacement versus a primary total knee replacement in patients undergoing knee replacement surgery. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Patients undergoing either a revision or a primary total knee replacement. Setting Hospital. The economic study was carried out in Canada. Dates to which data relate The effectiveness and resource use data were collected in 1994. The fiscal year was 1994. Source

1997 NHS Economic Evaluation Database.

178. Patient outcomes following tricompartmental total knee replacement. A meta-analysis. (PubMed)

Patient outcomes following tricompartmental total knee replacement. A meta-analysis. To provide estimates of patient outcomes following tricompartmental knee replacement and to examine variation in outcomes due to patient and prosthesis characteristics.English-language articles identified through a computerized literature search and bibliography review.Studies were included if they enrolled 10 or more patients at the time of initial knee replacement and measured patient outcomes using a global (...) bilateral knee replacement. Global rating scale scores improved by 100% for the typical enrolled patient, and 89.3% of patients reported good or excellent outcomes. Anatomic classification of the prosthesis, percentage of enrolled patients with osteoarthritis, publication year, and number of enrolled patients explained 27% of the variation in reported mean postoperative global rating scale scores. The weighted mean complication rate was 18.1%, and the mean mortality rate per year of follow-up was 1.5

1994 JAMA

179. Patient outcomes following tricompartmental total knee replacement: a meta-analysis

Patient outcomes following tricompartmental total knee replacement: a meta-analysis Patient outcomes following tricompartmental total knee replacement: a meta-analysis Patient outcomes following tricompartmental total knee replacement: a meta-analysis Callahan C M, Drake B G, Heck D A, Dittus R S Authors' objectives To provide estimates of patient outcomes following tricompartmental knee replacement, and to examine variation in outcomes due to patient and prosthesis characteristics. Searching (...) interventions included in the review Tricompartmental knee replacement using 37 different prostheses of 4 differing types: posterior cruciate ligament sparing; anterior and posterior cruciate ligament sacrificing without posterior cruciate ligament substitution; anterior and posterior cruciate ligament sacrificing with posterior cruciate ligament substitution; anterior and posterior cruciate ligament sacrificing with posterior cruciate and collateral ligament substitution. Participants included

1994 DARE.

180. Cognitive and functional competence after anaesthesia in patients aged over 60: controlled trial of general and regional anaesthesia for elective hip or knee replacement. (PubMed)

Cognitive and functional competence after anaesthesia in patients aged over 60: controlled trial of general and regional anaesthesia for elective hip or knee replacement. To determine the influence of general or regional anaesthesia on long term mental function in elderly patients.Prospective study of patients randomly allocated to receive general or regional anaesthesia.The patients' homes and a large teaching hospital in Cardiff.146 Patients aged 60 and over scheduled for elective hip or knee

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1990 BMJ