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Latest & greatest articles for magnesium
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Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses. Non-steroidal anti-inflammatory drugs (NSAIDs), such as non-selective NSAIDs (nsNSAIDs) or selective cyclooxygenase-2 (COX-2) inhibitors, are commonly prescribed for arthritic pain relief in patients with osteoarthritis (OA), rheumatoid arthritis (RA), or ankylosing spondylitis (AS). Treatment guidelines for chronic NSAID therapy (...) include the consideration for gastroprotection for those at risk of gastric ulcers (GUs) associated with the chronic NSAID therapy. The United States Food and Drug Administration has approved naproxen/esomeprazole magnesium tablets for the relief of signs and symptoms of OA, RA, and AS, and to decrease the risk of developing GUs in patients at risk of developing NSAID-associated GUs. The European Medical Association has approved this therapy for the symptomatic treatment of OA, RA, and AS in patients
The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review. Women juggling multiple roles in our complex society are increasingly experiencing psychological stress. Dietary supplementation to manage stress is widespread despite limited supporting evidence. A systematic review of the available literature was undertaken to investigate the efficacy of specific dietary supplements in managing female stress (...) and anxiety.To identify the impact of essential fatty acids (EFAs), B vitamins, vitamin C, magnesium and/or zinc, consumed as dietary supplements to the daily diet, on female stress and anxiety levels.Women aged 18 years and over, who had participated in a study where stress and/or anxiety were assessed.Dietary supplementation with EFAs, B vitamins, vitamin C, magnesium and/or zinc.Supplements, either alone or combined, were compared with either no intervention or placebo.Randomized controlled and pseudo
The influence of phosphate, calcium and magnesium on matrix Gla-protein and vascular calcification: a systematic review. Vitamin K-dependent matrix Gla protein (MGP) is a key inhibitor of vascular calcification (VC). MGP is synthesized by chondrocytes and vascular smooth muscle cells (VSMC) and the absence or inactivity of MGP results in excessive calcification of both growth plate and vasculature. Apart from its vitamin K dependency little is known about other factors that influence MGP (...) metabolism. Phosphate, calcium and magnesium are involved in bone mineralization and play an important role in VC. In this review we provide a summary of the effect of phosphate, calcium, and magnesium on MGP metabolism. Elevated phosphate and calcium levels promote VC, in part by increasing the release of matrix vesicles (MV) that under the influence of calcium and phosphate become calcification competent. Phosphate and calcium simultaneously induce an upregulation of MGP protein and gene expression
Inducible expression of magnesium protoporphyrin chelatase subunit I (CHLI)-amiRNA provides insights into cucumber mosaic virus Y satellite RNA-induced chlorosis symptoms Recent studies with Y satellite RNA (Y-sat) of cucumber mosaic virus have demonstrated that Y-sat modifies the disease symptoms in specific host plants through the silencing of the magnesium protoporphyrin chelatase I subunit (CHLI), which is directed by the Y-sat derived siRNA. Along with the development of peculiar yellow
The use of therapeutic magnesium for neuroprotection during global cerebral ischemia associated with cardiac arrest and cardiac surgery in adults: a systematic review. Global cerebral ischemia occurs due to reduced blood supply to the brain. This is commonly caused by a cessation of myocardial activity associated with cardiac arrest and cardiac surgery. Survival is not the only important outcome because neurological dysfunction impacts on quality of life, reducing independent living. Magnesium (...) has been identified as a potential neuroprotective agent; however, its role in this context is not yet clear.The objective of this review was to present the best currently available evidence related to the neuroprotective effects of magnesium during a period of global cerebral ischemia in adults with cardiac arrest or cardiac surgery.The current review considered adults aged over 18 years who were at risk of global cerebral ischemia associated with cardiac arrest or cardiac surgery. Studies
Oral Magnesium Supplementation in Chronic Kidney Disease Stages 3 and 4: Efficacy, Safety, and Effect on Serum Calcification Propensityâ€”AÂ Prospective Randomized Double-Blinded Placebo-Controlled Clinical Trial Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality. Recent evidence suggests that increases in both serum and intracellular magnesium (Mg) can slow or even prevent the development of vascular calcification seen in CKD. Serum calcification
ACTH, Cortisol and IL-6 Levels in Athletes following Magnesium Supplementation Physical exercise activates the hypothalamo-pituitary-adrenal (HPA) axis and induces the body's inflammatory response. Due to contemporary dietary habits and increased energy expenditure, athletes are susceptible to depletion of magnesium ions. The aim of our study was to investigate, through assessment of plasma ACTH, serum IL-6, and salivary/serum cortisol levels, if chronic magnesium supplementation might reduce (...) damaging stress effects in amateur rugby players.Rugby players (N=23) were randomly assigned to intervention and control group. Basal samples were collected before intervention group started a 4-week-long supplementation with magnesium (500 mg Mg/d). Blood and saliva sampling were done a day before the match (Day-1), on the morning of competition (Game), and during a six-day-long recovery period (Day1, Day3 and Day6). ACTH, serum/salivary cortisol, IL-6 and total/differential leukocytes counts were
The effect of intravenous magnesium sulfate infusion on reduction of pain after abdominal hysterectomy under general anesthesia: a double-blind, randomized clinical trial. Post-surgical pain is a physiological response to tissue trauma that produces unpleasant physiological effects with manifestations on various organic systems.According to the effect of magnesium sulfate on the N-methyl-d-aspartate (NMDA) receptor, this study examined the effect of magnesium sulfate on the reduction of pain (...) of the patients received 5 mg of intravenous morphine 30 min after induction of anesthesia. Afterwards, the study group received 50 mg/kg of magnesium sulfate in 500 cm(3) of Ringer's serum during the 20 minutes, and 500 cm(3) of Ringer's serum was administered to the members of the placebo group. Visual analogue scale VAS scores were evaluated to reach the minimum difference of 0.8 in mean pain score.The results of this study indicated that the mean pain scores immediately after surgery and at 1, 2, 6
Intravenous magnesium sulfate for treating children with acute asthma in the emergency department. Acute asthma in children can be life-threatening and must be treated promptly in the emergency setting. Intravenous magnesium sulfate is recommended by various guidelines for cases of acute asthma that have not responded to first-line treatment with bronchodilators and steroids. The treatment has recently been shown to reduce the need for hospital admission for adults compared with placebo (...) , but it is unclear whether it is equally effective for children.To assess the safety and efficacy of intravenous magnesium sulfate (IV MgSO4) in children treated for acute asthma in the emergency department (ED).We identified studies by searching the Cochrane Airways Review Group Specialised Register up to 23 February 2016. We also searched ClinicalTrials.gov and reference lists of other reviews, and we contacted study authors to ask for additional information.We included randomised controlled trials of children
Magnesium Sulfate Use in Obstetrics Magnesium Sulfate Use in Obstetrics - ACOG Menu ▼ Magnesium Sulfate Use in Obstetrics Page Navigation ▼ INTERIM UPDATE Number 652, January 2016 (Replaces Committee Opinion Number 573, September 2013) (Reaffirmed 2018) The American College of Obstetricians and Gynecologists Committee on Obstetric Practice Society for Maternal-Fetal Medicine This document reflects emerging clinical and scientific advances as of the date issued and is subject to change (...) . The information should not be construed as dictating an exclusive course of treatment or procedure to be followed. INTERIM UPDATE: This Committee Opinion is updated to reflect a limited, focused change in gestational age at which to consider tocolysis. Magnesium Sulfate Use in Obstetrics ABSTRACT: The U.S. Food and Drug Administration advises against the use of magnesium sulfate injections for more than 5–7 days to stop preterm labor in pregnant women. Based on this, the drug classification was changed from
A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children Magnesium, a vasodilator, anti-inflammatory, and pain reliever, could alter the pathophysiology of sickle cell pain crises. We hypothesized that intravenous magnesium would shorten length of stay, decrease opioid use, and improve health-related quality of life (HRQL) for pediatric patients hospitalized with sickle cell pain crises. The Magnesium for Children in Crisis (MAGiC) study (...) was a randomized, double-blind, placebo-controlled trial of intravenous magnesium vs normal saline placebo conducted at 8 sites within the Pediatric Emergency Care Applied Research Network (PECARN). Children 4 to 21 years old with hemoglobin SS or Sβ(0) thalassemia requiring hospitalization for pain were eligible. Children received 40 mg/kg of magnesium or placebo every 8 hours for up to 6 doses plus standard therapy. The primary outcome was length of stay in hours from the time of first study drug infusion
Different treatment regimens of magnesium sulphate for tocolysis in women in preterm labour. Magnesium sulphate has been used to inhibit preterm labour to prevent preterm birth. There is no consensus as to the safety profile of different treatment regimens with respect to dose, duration, route and timing of administration.To assess the efficacy and safety of alternative magnesium sulphate regimens when used as single agent tocolytic therapy during pregnancy.We searched the Cochrane Pregnancy (...) and Childbirth Group's Trials Register (30 September 2015) and reference lists of retrieved studies.Randomised trials comparing different magnesium sulphate treatment regimens when used as single agent tocolytic therapy during pregnancy in women in preterm labour. Quasi-randomised trials were eligible for inclusion but none were identified. Cross-over and cluster trials were not eligible for inclusion. Health outcomes were considered at the level of the mother, the infant/child and the health
Intravenous Magnesium Sulphate for Refractory Torsades de Pointes or Ventricular fibrillation: Clinical Effectiveness and Guidelines Intravenous Magnesium Sulphate for Refractory Torsades de Pointes or Ventricular fibrillation: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Intravenous Magnesium Sulphate for Refractory Torsades de Pointes or Ventricular fibrillation: Clinical Effectiveness and Guidelines Intravenous Magnesium Sulphate for Refractory Torsades de (...) Pointes or Ventricular fibrillation: Clinical Effectiveness and Guidelines Published on: November 6, 2015 Project Number: RB0928-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of intravenous magnesium sulphate for patients with refractory torsades de pointes or ventricular fibrillation? What are the evidence-based guidelines regarding the administration of intravenous magnesium sulphate for patients
Magnesium aspartate dihydrate (Magnaspartate) Magnesium aspartate dihydrate (Magnaspartate) Magnesium aspartate dihydrate (Magnaspartate) All Wales Medicines Strategy Group (AWMSG) Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation All Wales Medicines Strategy Group (AWMSG). Magnesium aspartate dihydrate (Magnaspartate) Penarth: All Wales Therapeutics (...) and Toxicology Centre (AWTTC), secretariat of the All Wales Medicines Strategy Group (AWMSG). AWMSG Secretariat Assessment Report Advice No. 2596. 2015 Authors' conclusions Magnesium aspartate dihydrate (Magnaspartate®) is recommended as an option for use within NHS Wales for the treatment and prevention of magnesium deficiency, as diagnosed by a doctor, in adults, children and adolescents aged from two years. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Adolescent; Adult
The effectiveness of essential fatty acid, B vitamin, Vitamin C, magnesium and zinc supplementation for managing stress in women: a systematic review protocol. 26455850 2016 05 25 2018 12 02 2202-4433 13 7 2015 Aug 14 JBI database of systematic reviews and implementation reports JBI Database System Rev Implement Rep The effectiveness of essential fatty acid, B vitamin, Vitamin C, magnesium and zinc supplementation for managing stress in women: a systematic review protocol. 104-18 10.11124 (...) /jbisrir-2015-2298 McCabe Delia D The Joanna Briggs Institute, Faculty of Health Sciences, University of Adelaide, Australia. Colbeck Mark M The Joanna Briggs Institute, Faculty of Health Sciences, University of Adelaide, Australia. eng Journal Article 2015 08 14 Australia JBI Database System Rev Implement Rep 101648258 2202-4433 0 Fatty Acids, Essential 12001-76-2 Vitamin B Complex I38ZP9992A Magnesium J41CSQ7QDS Zinc PQ6CK8PD0R Ascorbic Acid IM Ascorbic Acid therapeutic use Dietary Supplements Fatty
The use of therapeutic magnesium for neuroprotection during global cerebral ischemia associated with cardiac arrest and cardiac bypass surgery in adults: a systematic review protocol. 26447069 2016 04 22 2018 12 02 2202-4433 13 4 2015 May 15 JBI database of systematic reviews and implementation reports JBI Database System Rev Implement Rep The use of therapeutic magnesium for neuroprotection during global cerebral ischemia associated with cardiac arrest and cardiac bypass surgery in adults (...) : a systematic review protocol. 3-13 10.11124/jbisrir-2015-1675 Pearce Anna A Joanna Briggs Institute, Faculty of Health Sciences, The University of Adelaide, South Australia. Lockwood Craig C Joanna Briggs Institute, Faculty of Health Sciences, The University of Adelaide, South Australia. Van Den Heuvel Corinna C School of Medical Sciences, The University of Adelaide, South Australia. eng Journal Article 2015 05 15 Australia JBI Database System Rev Implement Rep 101648258 2202-4433 I38ZP9992A Magnesium IM
Intravenous Magnesium Sulphate for Pre-Hospital Management of Refractory Asthma: Clinical Effectiveness and Guidelines Intravenous Magnesium Sulphate for Pre-Hospital Management of Refractory Asthma: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Intravenous Magnesium Sulphate for Pre-Hospital Management of Refractory Asthma: Clinical Effectiveness and Guidelines Intravenous Magnesium Sulphate for Pre-Hospital Management of Refractory Asthma: Clinical (...) Effectiveness and Guidelines Published on: September 2, 2015 Project Number: RB0906-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of intravenous administration of magnesium sulphate for the treatment of acute and unrelieved, refractory asthma-related bronchospasm in prehospital settings? What are the evidence-based guidelines regarding the intravenous administration of magnesium sulphate for the treatment of acute