Latest & greatest articles for nivolumab

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Top results for nivolumab

101. Nivolumab in Nonsquamous Non-Small-Cell Lung Cancer. (Full text)

Nivolumab in Nonsquamous Non-Small-Cell Lung Cancer. 26840145 2016 02 05 2018 12 02 1533-4406 374 5 2016 02 04 The New England journal of medicine N. Engl. J. Med. Nivolumab in Nonsquamous Non-Small-Cell Lung Cancer. 492-3 10.1056/NEJMc1514790 Hasegawa Takahiro T Uno Hajime H Wei Lee-Jen LJ eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Antibodies, Monoclonal 0 Antineoplastic Agents 0 Taxoids AIM IM N Engl J Med. 2016 Feb 4;374(5):493-4 26840144 N Engl J Med. 2015 Oct 22;373

2016 NEJM PubMed

102. Nivolumab in Nonsquamous Non-Small-Cell Lung Cancer. (PubMed)

Nivolumab in Nonsquamous Non-Small-Cell Lung Cancer. 26840144 2016 02 05 2018 12 02 1533-4406 374 5 2016 02 04 The New England journal of medicine N. Engl. J. Med. Nivolumab in Nonsquamous Non-Small-Cell Lung Cancer. 493-4 10.1056/NEJMc1514790 Borghaei Hossein H Brahmer Julie J eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Antibodies, Monoclonal 0 Antineoplastic Agents 0 Taxoids AIM IM N Engl J Med. 2016 Feb 4;374(5):493 26840146 N Engl J Med. 2015 Oct 22;373(17):1627-39

2016 NEJM

103. Nivolumab in Nonsquamous Non-Small-Cell Lung Cancer. (Full text)

Nivolumab in Nonsquamous Non-Small-Cell Lung Cancer. 26840146 2016 02 05 2018 12 02 1533-4406 374 5 2016 02 04 The New England journal of medicine N. Engl. J. Med. Nivolumab in Nonsquamous Non-Small-Cell Lung Cancer. 493 10.1056/NEJMc1514790 Gyawali Bishal B Ota Akiko A Ando Yuichi Y eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Antibodies, Monoclonal 0 Antineoplastic Agents 0 Taxoids AIM IM N Engl J Med. 2016 Feb 4;374(5):493-4 26840144 N Engl J Med. 2015 Oct 22;373(17

2016 NEJM PubMed

104. [Nivolumab: addendum to Commission A15-27]

[Nivolumab: addendum to Commission A15-27] Nivolumab (addendum zum Auftrag A15-27) [Nivolumab: addendum to Commission A15-27] Nivolumab (addendum zum Auftrag A15-27) [Nivolumab: addendum to Commission A15-27] Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG) Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Institut (...) für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). Nivolumab (addendum zum Auftrag A15-27). [Nivolumab: addendum to Commission A15-27] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 346. 2016 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Antibodies, Monoclonal; Antineoplastic Agents; Humans Language Published German Country of organisation Germany English summary There is no English language summary

2016 Health Technology Assessment (HTA) Database.

105. Nivolumab (melanoma): Addendum to Commission A16-35

Nivolumab (melanoma): Addendum to Commission A16-35 Nivolumab (Melanom): Addendum zum Auftrag A16-35; Auftrag A16-68 [Nivolumab (melanoma): Addendum to Commission A16-35] Nivolumab (Melanom): Addendum zum Auftrag A16-35; Auftrag A16-68 [Nivolumab (melanoma): Addendum to Commission A16-35] Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen. Nivolumab (Melanom): Addendum zum Auftrag A16-35; Auftrag A16-68. [Nivolumab (melanoma): Addendum to Commission A16-35] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 465. 2016 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Antibodies, Monoclonal; Humans; Melanoma Language Published German Country

2016 Health Technology Assessment (HTA) Database.

106. [Nivolumab (new therapeutic indication): benefit assessment according to §35a Social Code Book V (dossier assessment)]

[Nivolumab (new therapeutic indication): benefit assessment according to §35a Social Code Book V (dossier assessment)] Nivolumab (neues anwendungsgebiet) – nutzenbewertung gemäß § 35a SGB V [Nivolumab (new therapeutic indication): benefit assessment according to §35a Social Code Book V (dossier assessment)] Nivolumab (neues anwendungsgebiet) – nutzenbewertung gemäß § 35a SGB V [Nivolumab (new therapeutic indication): benefit assessment according to §35a Social Code Book V (dossier assessment (...) )] IQWiG Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation IQWiG. Nivolumab (neues anwendungsgebiet) – nutzenbewertung gemäß § 35a SGB V. [Nivolumab (new therapeutic indication): benefit assessment according to §35a Social Code Book V (dossier assessment)] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG

2016 Health Technology Assessment (HTA) Database.

107. [Nivolumab: benefit assessment according to §35a Social Code Book V (dossier assessment)]

[Nivolumab: benefit assessment according to §35a Social Code Book V (dossier assessment)] Nivolumab – nutzenbewertung gemäß § 35a SGB V [Nivolumab: benefit assessment according to §35a Social Code Book V (dossier assessment)] Nivolumab – nutzenbewertung gemäß § 35a SGB V [Nivolumab: benefit assessment according to §35a Social Code Book V (dossier assessment)] IQWiG Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation IQWiG. Nivolumab – nutzenbewertung gemäß § 35a SGB V. [Nivolumab: benefit assessment according to §35a Social Code Book V (dossier assessment)] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 331. 2015 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Antibodies, Monoclonal; Humans Language Published German Country of organisation Germany English summary

2016 Health Technology Assessment (HTA) Database.

108. Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. (Full text)

Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. Nivolumab, a fully human IgG4 programmed death 1 (PD-1) immune-checkpoint-inhibitor antibody, disrupts PD-1-mediated signaling and may restore antitumor immunity.In this randomized, open-label, international phase 3 study, we assigned patients with nonsquamous non-small-cell lung cancer (NSCLC) that had progressed during or after platinum-based doublet chemotherapy to receive nivolumab at a dose of 3 mg per kilogram (...) of body weight every 2 weeks or docetaxel at a dose of 75 mg per square meter of body-surface area every 3 weeks. The primary end point was overall survival.Overall survival was longer with nivolumab than with docetaxel. The median overall survival was 12.2 months (95% confidence interval [CI], 9.7 to 15.0) among 292 patients in the nivolumab group and 9.4 months (95% CI, 8.1 to 10.7) among 290 patients in the docetaxel group (hazard ratio for death, 0.73; 96% CI, 0.59 to 0.89; P=0.002). At 1 year

2015 NEJM PubMed

109. Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. (Full text)

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. Nivolumab, a programmed death 1 (PD-1) checkpoint inhibitor, was associated with encouraging overall survival in uncontrolled studies involving previously treated patients with advanced renal-cell carcinoma. This randomized, open-label, phase 3 study compared nivolumab with everolimus in patients with renal-cell carcinoma who had received previous treatment.A total of 821 patients with advanced clear-cell renal-cell carcinoma (...) for which they had received previous treatment with one or two regimens of antiangiogenic therapy were randomly assigned (in a 1:1 ratio) to receive 3 mg of nivolumab per kilogram of body weight intravenously every 2 weeks or a 10-mg everolimus tablet orally once daily. The primary end point was overall survival. The secondary end points included the objective response rate and safety.The median overall survival was 25.0 months (95% confidence interval [CI], 21.8 to not estimable) with nivolumab

2015 NEJM PubMed

110. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. (Full text)

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. 26398076 2015 09 24 2018 12 02 1533-4406 373 13 2015 09 24 The New England journal of medicine N. Engl. J. Med. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. 1270-1 10.1056/NEJMc1509660 Larkin James J Hodi F Stephen FS Wolchok Jedd D JD eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Antibodies, Monoclonal AIM IM N Engl J Med. 2015 Jul 2;373(1):23-34 26027431 N Engl J Med. 2015

2015 NEJM PubMed

111. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. (Full text)

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. 26398077 2015 09 24 2018 12 02 1533-4406 373 13 2015 09 24 The New England journal of medicine N. Engl. J. Med. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. 1270 10.1056/NEJMc1509660 Valsecchi Matias E ME eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Antibodies, Monoclonal AIM IM N Engl J Med. 2015 Jul 2;373(1):23-34 26027431 N Engl J Med. 2015 Sep 24;373(13):1270-1 26398076

2015 NEJM PubMed

112. Nivolumab (Opdivo) Metastatic Melanoma - Details

Nivolumab (Opdivo) Metastatic Melanoma - Details Opdivo for Metastatic Melanoma - Details | CADTH.ca Find the information you need Opdivo for Metastatic Melanoma - Details Opdivo for Metastatic Melanoma - Details Project Number pCODR 10063 Brand Name Opdivo Generic Name Nivolumab Strength 40mg/4mL and 100mg/10mL vials Tumour Type Skin and Melanoma Indication Metastatic Melanoma Funding Request For the treatment of both first-line and previously-treated advanced adult melanoma patients (...) has been granted for nivolumab (Opdivo). In accordance with the pCODR Procedures, the pCODR Provincial Advisory Group (PAG) requested additional information on nivolumab (Opdivo) which extends beyond the submitted scope of the review. Revision of review scope may be considered by pCODR in very limited instances, based on jurisdictional input, feasibility to conduct the revised review and clinical importance. All three criteria for scope modification were met in this case. The timeline

2015 CADTH - Pan Canadian Oncology Drug Review

113. Nivolumab (Opdivo®) as single-agent first-line therapy for unresectable or metastatic melanoma

Nivolumab (Opdivo®) as single-agent first-line therapy for unresectable or metastatic melanoma Nivolumab (Opdivo®) as single-agent first-line therapy for unresectable or metastatic melanoma Nivolumab (Opdivo®) as single-agent first-line therapy for unresectable or metastatic melanoma Ludwig Boltzmann Institute for Health Technology Assessment (LBI-HTA) Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation Ludwig Boltzmann Institute for Health Technology Assessment (LBI-HTA). Nivolumab (Opdivo®) as single-agent first-line therapy for unresectable or metastatic melanoma. Vienna: Ludwig Boltzmann Institut fuer Health Technology Assessment (LBIHTA). DSD: Horizon Scanning in Oncology No. 50. 2015 Project page URL Final publication URL PubMedID Indexing Status Subject indexing assigned by NLM MeSH Antibodies, Monoclonal /therapeutic use; Antineoplastic

2015 Health Technology Assessment (HTA) Database.

114. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. (Full text)

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. Nivolumab (a programmed death 1 [PD-1] checkpoint inhibitor) and ipilimumab (a cytotoxic T-lymphocyte-associated antigen 4 [CTLA-4] checkpoint inhibitor) have been shown to have complementary activity in metastatic melanoma. In this randomized, double-blind, phase 3 study, nivolumab alone or nivolumab plus ipilimumab was compared with ipilimumab alone in patients with metastatic melanoma.We assigned, in a 1:1:1 ratio, 945 (...) previously untreated patients with unresectable stage III or IV melanoma to nivolumab alone, nivolumab plus ipilimumab, or ipilimumab alone. Progression-free survival and overall survival were coprimary end points. Results regarding progression-free survival are presented here.The median progression-free survival was 11.5 months (95% confidence interval [CI], 8.9 to 16.7) with nivolumab plus ipilimumab, as compared with 2.9 months (95% CI, 2.8 to 3.4) with ipilimumab (hazard ratio for death or disease

2015 NEJM PubMed

115. Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. (Full text)

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. Patients with advanced squamous-cell non-small-cell lung cancer (NSCLC) who have disease progression during or after first-line chemotherapy have limited treatment options. This randomized, open-label, international, phase 3 study evaluated the efficacy and safety of nivolumab, a fully human IgG4 programmed death 1 (PD-1) immune-checkpoint-inhibitor antibody, as compared with docetaxel in this patient population.We (...) randomly assigned 272 patients to receive nivolumab, at a dose of 3 mg per kilogram of body weight every 2 weeks, or docetaxel, at a dose of 75 mg per square meter of body-surface area every 3 weeks. The primary end point was overall survival.The median overall survival was 9.2 months (95% confidence interval [CI], 7.3 to 13.3) with nivolumab versus 6.0 months (95% CI, 5.1 to 7.3) with docetaxel. The risk of death was 41% lower with nivolumab than with docetaxel (hazard ratio, 0.59; 95% CI, 0.44

2015 NEJM PubMed

116. Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma. (Full text)

Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma. In a phase 1 dose-escalation study, combined inhibition of T-cell checkpoint pathways by nivolumab and ipilimumab was associated with a high rate of objective response, including complete responses, among patients with advanced melanoma.In this double-blind study involving 142 patients with metastatic melanoma who had not previously received treatment, we randomly assigned patients in a 2:1 ratio to receive ipilimumab (3 mg per (...) kilogram of body weight) combined with either nivolumab (1 mg per kilogram) or placebo once every 3 weeks for four doses, followed by nivolumab (3 mg per kilogram) or placebo every 2 weeks until the occurrence of disease progression or unacceptable toxic effects. The primary end point was the rate of investigator-assessed, confirmed objective response among patients with BRAF V600 wild-type tumors.Among patients with BRAF wild-type tumors, the rate of confirmed objective response was 61% (44 of 72

2015 NEJM PubMed

117. Nivolumab (Nivolumab BMS©) for the second-line therapy of metastatic squamous non-small cell lung cancer

Nivolumab (Nivolumab BMS©) for the second-line therapy of metastatic squamous non-small cell lung cancer Nivolumab (Nivolumab BMS®) for the second-line therapy of metastatic squamous non-small cell lung cancer Nivolumab (Nivolumab BMS®) for the second-line therapy of metastatic squamous non-small cell lung cancer Ludwig Boltzmann Institut fuer Health Technology Assessment (LBI-HTA) Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA (...) . No evaluation of the quality of this assessment has been made for the HTA database. Citation Ludwig Boltzmann Institut fuer Health Technology Assessment (LBI-HTA). Nivolumab (Nivolumab BMS®) for the second-line therapy of metastatic squamous non-small cell lung cancer. Vienna: Ludwig Boltzmann Institut fuer Health Technology Assessment (LBIHTA). Decision Support Document: Horizon Scanning in Oncology No. 53. 2015 Authors' conclusions Nivolumab is the first immunotherapy medicine licensed in the European

2015 Health Technology Assessment (HTA) Database.

118. Nivolumab for recurrent glioblastoma - second line

Nivolumab for recurrent glioblastoma - second line Nivolumab for recurrent glioblastoma – second line Nivolumab for recurrent glioblastoma – second line NIHR HSRIC Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. Nivolumab for recurrent glioblastoma – second line. Birmingham: NIHR Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review (...) . 2015 Authors' objectives Glioblastoma is a type of brain cancer that develops from cells that support nerve tissue. Glioblastoma is the most common type of brain cancer. After surgery or chemotherapy, this cancer often returns and most patients with glioblastoma do not survive for very long after their diagnosis. Nivolumab is a new antibody drug for the treatment of glioblastoma and is delivered straight into the bloodstream via a drip. It may stimulate the immune system to attack cancer cells

2015 Health Technology Assessment (HTA) Database.

119. Nivolumab (Opdivo) for recurrent or metastatic squamous cell carcinoma of the head and neck - second line

Nivolumab (Opdivo) for recurrent or metastatic squamous cell carcinoma of the head and neck - second line Nivolumab (Opdivo) for recurrent or metastatic squamous cell carcinoma of the head and neck – second line Nivolumab (Opdivo) for recurrent or metastatic squamous cell carcinoma of the head and neck – second line NIHR HSRIC Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA (...) database. Citation NIHR HSRIC. Nivolumab (Opdivo) for recurrent or metastatic squamous cell carcinoma of the head and neck – second line. Birmingham: NIHR Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2015 Authors' objectives Head and neck cancer is a rare type of cancer. There are over 30 areas in the head and neck where the cancer can develop, for example, the mouth, nose, sinuses and throat. Tobacco smoking and alcohol are known to increase the risk of developing head

2015 Health Technology Assessment (HTA) Database.

120. Nivolumab (Opdivo) for Hodgkin lymphoma in brentuximab treated patients - second line

Nivolumab (Opdivo) for Hodgkin lymphoma in brentuximab treated patients - second line Nivolumab (Opdivo) for Hodgkin lymphoma in brentuximab treated patients – second line Nivolumab (Opdivo) for Hodgkin lymphoma in brentuximab treated patients – second line NIHR HSRIC Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. Nivolumab (Opdivo) for Hodgkin (...) lymphoma in brentuximab treated patients – second line. Birmingham: NIHR Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2015 Authors' objectives Hodgkin lymphoma is a cancer of the lymphatic system – part of the body's immune system. In Hodgkin lymphoma, blood cells called lymphocytes become abnormal, increase in number and collect in the lymph nodes (glands) and other organs. Nivolumab is a new antibody drug for the treatment of Hodgkin lymphoma, and is delivered straight

2015 Health Technology Assessment (HTA) Database.