Latest & greatest articles for nsaids

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Top results for nsaids

21. Should PPIs be routinely co-prescribed with long-term NSAIDs?

Should PPIs be routinely co-prescribed with long-term NSAIDs? Should PPIs be routinely co-prescribed with long-term NSAIDs? – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2017\/07\/mo2017-7-ee-cover.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Jul 03 2017 Should PPIs be routinely co (...) -prescribed with long-term NSAIDs? By in , , Journal reference: Rostom A, Dube C, Wells G, et al. Prevention of NSAID-induced gastroduodenal ulcers. Cochrane database of systematic reviews 2002(4):CD002296. Link: Published: June 2011 Evidence cookie says… Proton-pump inhibitors (PPIs) protect against the development of ulcers seen on endoscopy, in patients taking longer-term NSAIDs little data exists on clinical outcomes prophylaxis should be considered for patients at increased risk of gastrointestinal

2017 Morsels of Evidence

22. Should PPIs be routinely co-prescribed with long-term NSAIDs?

Should PPIs be routinely co-prescribed with long-term NSAIDs? Should PPIs be routinely co-prescribed with long-term NSAIDs? – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2017\/07\/mo2017-7-ee-cover.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Jul 03 2017 Should PPIs be routinely co (...) -prescribed with long-term NSAIDs? By in , , Journal reference: Rostom A, Dube C, Wells G, et al. Prevention of NSAID-induced gastroduodenal ulcers. Cochrane database of systematic reviews 2002(4):CD002296. Link: Published: June 2011 Evidence cookie says… Proton-pump inhibitors (PPIs) protect against the development of ulcers seen on endoscopy, in patients taking longer-term NSAIDs little data exists on clinical outcomes prophylaxis should be considered for patients at increased risk of gastrointestinal

2017 Morsels of Evidence

23. NSAIDs for Chronic Low Back Pain. (PubMed)

NSAIDs for Chronic Low Back Pain. Are nonsteroidal anti-inflammatory drugs (NSAIDs) associated with greater pain relief than placebo, other drugs, and nondrug treatments for patients with chronic low back pain?Compared with placebo, NSAIDs are associated with a small but significant improvement in pain and disability in patients with chronic low back pain, although this difference became nonsignificant when studies with high risk for bias were excluded. The associated benefits were smaller than

2017 JAMA

24. NSAIDs as treatment for uncomplicated urinary tract infections (Full text)

NSAIDs as treatment for uncomplicated urinary tract infections NSAIDs as treatment for uncomplicated urinary tract infections – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2017\/06\/mo2017-5.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Jun 09 2017 NSAIDs as treatment for uncomplicated (...) urinary tract infections By in , , Journal reference: Gagyor I, Bleidorn J, Kochen MM, Schmiemann G, Wegscheider K, Hummers-Pradier E. Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: randomised controlled trial. Bmj 2015 Dec 23;351:h6544. Link: Published: December 2015 Evidence cookie says… NSAIDs should not be recommended as a first line treatment for uncomplicated UTIs in women compared with women who received empirical antibiotics, those who received regular

2017 Morsels of Evidence PubMed

25. NSAIDs as treatment for uncomplicated urinary tract infections (Full text)

NSAIDs as treatment for uncomplicated urinary tract infections NSAIDs as treatment for uncomplicated urinary tract infections – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2017\/06\/mo2017-5.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Jun 09 2017 NSAIDs as treatment for uncomplicated (...) urinary tract infections By in , , Journal reference: Gagyor I, Bleidorn J, Kochen MM, Schmiemann G, Wegscheider K, Hummers-Pradier E. Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: randomised controlled trial. Bmj 2015 Dec 23;351:h6544. Link: Published: December 2015 Evidence cookie says… NSAIDs should not be recommended as a first line treatment for uncomplicated UTIs in women compared with women who received empirical antibiotics, those who received regular

2017 Morsels of Evidence PubMed

26. Unborn children still exposed to NSAIDs

Unborn children still exposed to NSAIDs Prescrire IN ENGLISH - Spotlight ''In the April issue of Prescrire International: unborn children still exposed to NSAIDs'', 1 April 2017 {1} {1} {1} | | > > > In the April issue of Prescrire International: unborn children still exposed to NSAIDs Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight In the April (...) issue of Prescrire International: unborn children still exposed to NSAIDs FREE DOWNLOAD In the Adverse Effects section of the April edition: results of a French study showing that around 5% of unborn children in France are exposed to prescribed NSAIDs, including about 1% from the 6th month of pregnancy. And these numbers exclude self-medication. Authorities need to send out a stronger message: "NEVER USE NSAIDs DURING PREGNANCY". Full text available for free download. Summary A study based on data

2017 Prescrire

27. NSAIDs are Caspase Inhibitors (Full text)

NSAIDs are Caspase Inhibitors Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in the world. While the role of NSAIDs as cyclooxygenase (COX) inhibitors is well established, other targets may contribute to anti-inflammation. Here we report caspases as a new pharmacological target for NSAID family drugs such as ibuprofen, naproxen, and ketorolac at physiologic concentrations both in vitro and in vivo. We characterize caspase activity in both in vitro (...) and in cell culture, and combine computational modeling and biophysical analysis to determine the mechanism of action. We observe that inhibition of caspase catalysis reduces cell death and the generation of pro-inflammatory cytokines. Further, NSAID inhibition of caspases is COX independent, representing a new anti-inflammatory mechanism. This finding expands upon existing NSAID anti-inflammatory behaviors, with implications for patient safety and next-generation drug design.Copyright © 2017 Elsevier Ltd

2017 Cell chemical biology PubMed

28. Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses. (Full text)

Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses. Non-steroidal anti-inflammatory drugs (NSAIDs), such as non-selective NSAIDs (nsNSAIDs) or selective cyclooxygenase-2 (COX-2) inhibitors, are commonly prescribed for arthritic pain relief in patients with osteoarthritis (OA), rheumatoid arthritis (RA), or ankylosing spondylitis (AS). Treatment guidelines for chronic NSAID therapy (...) include the consideration for gastroprotection for those at risk of gastric ulcers (GUs) associated with the chronic NSAID therapy. The United States Food and Drug Administration has approved naproxen/esomeprazole magnesium tablets for the relief of signs and symptoms of OA, RA, and AS, and to decrease the risk of developing GUs in patients at risk of developing NSAID-associated GUs. The European Medical Association has approved this therapy for the symptomatic treatment of OA, RA, and AS in patients

2017 Open access rheumatology : research and reviews PubMed

29. Topical NSAIDs versus Opioids for Acute Musculoskeletal Pain: A Review of the Clinical Effectiveness

Topical NSAIDs versus Opioids for Acute Musculoskeletal Pain: A Review of the Clinical Effectiveness Topical NSAIDs versus Opioids for Acute Musculoskeletal Pain: A Review of the Clinical Effectiveness | CADTH.ca Find the information you need Topical NSAIDs versus Opioids for Acute Musculoskeletal Pain: A Review of the Clinical Effectiveness Topical NSAIDs versus Opioids for Acute Musculoskeletal Pain: A Review of the Clinical Effectiveness Published on: January 30, 2017 Project Number: RC0844 (...) -000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative clinical effectiveness of topical NSAIDs versus opioids for the treatment of acute musculoskeletal pain? Key Message Compared with placebo, topical NSAIDs were effective in reducing pain from acute musculoskeletal conditions, such as sprains, strains or sport injuries. Adverse events were rare and were usually related to skin reactions. No evidence regarding

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

31. Nonsteroidal anti-inflammatory drug (NSAID) toxicity - emergency management

Nonsteroidal anti-inflammatory drug (NSAID) toxicity - emergency management

2017 DynaMed Plus

34. Musculoskeletal Strains and Sprains - Guidelines for Prescribing NSAIDs

Musculoskeletal Strains and Sprains - Guidelines for Prescribing NSAIDs Musculoskeletal Strains and Sprains - Guidelines for Prescribing NSAIDs - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Musculoskeletal Strains and Sprains - Guidelines for Prescribing NSAIDs Musculoskeletal pain arises from the muscles, bones, joints, and connective tissue. The musculoskeletal system includes the muscles, tendons, ligaments, cartilage (...) with the differential assessment. Diabetes - expect longer healing times Stroke - could cause one-sided weakness Cancer - pain with no apparent cause could be a sign of worsening cancer control in a patient with a history of cancer Bleeding disorders - avoid NSAIDs in these patients History of DVT - significant leg or calf pain may be a sign of a DVT, especially in a patient who has had a prior DVT GI disorders - may choose to avoid NSAIDs in these patients Cardiovascular disorders - may choose to avoid NSAIDs

2017 medSask

35. Safety considerations for NSAIDs

Safety considerations for NSAIDs Vol 24. DTB: Vol 24, No 2 - navarra.es Castellano | Euskara | Français | English Use the search tool! Search engine : : : : : : DTB: Vol 24, No 2 DTB: Vol 24, No 2 Content tools Share it Safety considerations for NSAIDs The gastrointestinal, cardiovascular, and renal adverse effects of NSAIDs are related to the total daily dose and may appear less than 15 days from the start of treatment. The safest NSAIDs are ibuprofen and naproxen, whether used alone (...) . Although gastrointestinal risk can be countered using gastric protectors, there is no concomitant drug therapy for cardiovascular risk. The results of this review reveal an overuse of celecoxib and etoricoxib in Navarre. NSAIDs in combination with proton pump inhibitors (PPIs) should be used with caution, since PPIs are not indicated for all patients requiring NSAIDs. Furthermore, the combination of these drugs may result in incorrect dosages. Authors: Isabel Aranguren. Pharmacist. Navarre Health

2016 Drug and Therapeutics Bulletin of Navarre (Spain)

36. Can topical NSAIDs help relieve the pain of arthritis? (Full text)

Can topical NSAIDs help relieve the pain of arthritis? Can topical NSAIDs help relieve the pain of arthritis? - Evidently Cochrane Search and hit Go By May 6, 2016 // A blog for non-medical readers by Lynda Ware, Senior Fellow in General Practice with Cochrane UK. “Just put some cream on it….” According to my three daughters, this was my stock response to any request they made for motherly intervention when pain struck. Whilst refuting this slur utterly (and the one about not even looking), I (...) might now point them in the direction of this updated review, which assesses the efficacy and safety of topical nonsteroidal anti-inflammatory drugs (NSAIDs), albeit in the context of chronic musculoskeletal pain rather than a bruised shin or finger. What’s more, I will point out that it’s likely that the carrier, to which the active drug is added, is pretty effective in its own right. Why is this important? Topical NSAIDs can act precisely where needed and without having to be absorbed via

2016 Evidently Cochrane PubMed

37. Can topical NSAIDs help relieve the pain of arthritis? (Full text)

Can topical NSAIDs help relieve the pain of arthritis? Can topical NSAIDs help relieve the pain of arthritis? - Evidently Cochrane Search and hit Go By May 6, 2016 // A blog for non-medical readers by Lynda Ware, Senior Fellow in General Practice with Cochrane UK. “Just put some cream on it….” According to my three daughters, this was my stock response to any request they made for motherly intervention when pain struck. Whilst refuting this slur utterly (and the one about not even looking), I (...) might now point them in the direction of this updated review, which assesses the efficacy and safety of topical nonsteroidal anti-inflammatory drugs (NSAIDs), albeit in the context of chronic musculoskeletal pain rather than a bruised shin or finger. What’s more, I will point out that it’s likely that the carrier, to which the active drug is added, is pretty effective in its own right. Why is this important? Topical NSAIDs can act precisely where needed and without having to be absorbed via

2016 Evidently Cochrane PubMed

38. Topical NSAIDs for chronic musculoskeletal pain in adults. (Full text)

Topical NSAIDs for chronic musculoskeletal pain in adults. Use of topical nonsteroidal anti-inflammatory drugs (NSAIDs) to treat chronic musculoskeletal conditions has become widely accepted because they can provide pain relief without associated systemic adverse events. This review is an update of 'Topical NSAIDs for chronic musculoskeletal pain in adults', originally published in Issue 9, 2012.To review the evidence from randomised, double-blind, controlled trials on the efficacy and safety (...) of topically applied NSAIDs for chronic musculoskeletal pain in adults.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and our own in-house database; the date of the last search was February 2016. We also searched the references lists of included studies and reviews, and sought unpublished studies by asking personal contacts and searching online clinical trial registers and manufacturers' web sites.We included randomised, double-blind, active or inert carrier

2016 Cochrane PubMed

39. Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy Using an NSAID for Other Pain Conditions: A Double-Blind Crossover Study (PubMed)

Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy Using an NSAID for Other Pain Conditions: A Double-Blind Crossover Study To evaluate pregabalin's efficacy and safety versus placebo to reduce pain in patients with diabetic peripheral neuropathy (DPN) using a concomitant nonsteroidal anti-inflammatory drug.In a randomized, double-masked, 14-week, 2-period, crossover study, patients with painful DPN using a nonsteroidal anti-inflammatory drug for non-DPN-related pain received

2016 EvidenceUpdates

40. Systematic review: Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries

Systematic review: Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries Article Text Therapeutics/Prevention Systematic review Topical NSAIDs significantly reduces pain in adults

2016 Evidence-Based Medicine (Requires free registration)