Latest & greatest articles for nsaids

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Top results for nsaids

61. Systematic review with meta-analysis: Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS

Systematic review with meta-analysis: Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie (...) settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Topical NSAIDS provide effective pain

2013 Evidence-Based Medicine (Requires free registration)

62. Cohort study: Use of diuretics with ACE inhibitors or angiotensin receptor blockers and NSAIDs increases the risk of acute kidney injury

Cohort study: Use of diuretics with ACE inhibitors or angiotensin receptor blockers and NSAIDs increases the risk of acute kidney injury Use of diuretics with ACE inhibitors or angiotensin receptor blockers and NSAIDs increases the risk of acute kidney injury | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our (...) . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Use of diuretics with ACE inhibitors or angiotensin receptor blockers and NSAIDs increases the risk of acute kidney injury Article

2013 Evidence-Based Medicine (Requires free registration)

63. NSAIDs - prescribing issues

NSAIDs - prescribing issues NSAIDs - prescribing issues - NICE CKS Clinical Knowledge Summaries Share NSAIDs - prescribing issues: Summary Nonsteroidal anti-inflammatory drugs (NSAIDs) have analgesic, antipyretic and, at higher doses, anti-inflammatory actions. NSAIDs inhibit prostaglandin synthesis by reversibly inhibiting cyclo-oxygenase (COX) enzymes — the two main types of COX enzyme are COX-1 and COX-2, which have different physiological functions. COX-1 produces prostaglandins that help (...) to maintain gastric mucosal integrity and platelet-initiated blood clotting. Inhibition is thought to be responsible for gastrointestinal toxicity. COX-2 produces prostaglandins that mediate pain and inflammation. Inhibition is thought to be responsible for the anti-inflammatory action of NSAIDs. NSAIDs vary in how selective they are for COX-1 and COX-2 pathways and the degree of selectivity for COX-1 relative to COX-2 can be used to classify NSAIDs: Standard NSAIDs — these are nonselective NSAIDs

2013 NICE Clinical Knowledge Summaries

64. Economic evaluation of NSAID and radiation to prevent heterotopic ossification after hip surgery

Economic evaluation of NSAID and radiation to prevent heterotopic ossification after hip surgery Economic evaluation of NSAID and radiation to prevent heterotopic ossification after hip surgery Economic evaluation of NSAID and radiation to prevent heterotopic ossification after hip surgery Vavken P, Dorotka R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study assessed the cost-effectiveness of radiation versus non-steroidal anti-inflammatory drugs (NSAIDs) for the prevention of heterotopic ossification (bony growth in soft tissue) after hip surgery. The authors concluded that the two interventions were similarly effective, but NSAIDs were more cost-effective. Studies were needed to investigate complications and quality

2012 NHS Economic Evaluation Database.

65. Cost-effectiveness evaluation of etoricoxib versus celecoxib and nonselective NSAIDs in the treatment of ankylosing spondylitis in Norway

Cost-effectiveness evaluation of etoricoxib versus celecoxib and nonselective NSAIDs in the treatment of ankylosing spondylitis in Norway Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 NHS Economic Evaluation Database.

66. NSAIDs and other complementary treatments for episodic migraine prevention in adults

NSAIDs and other complementary treatments for episodic migraine prevention in adults Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: [RETIRED] | Neurology Advertisement Search for this keyword Main menu User menu Search Search for this keyword The most widely read and highly cited peer-reviewed neurology journal Share April 24, 2012 ; 78 (17) Special Articles Evidence-based guideline update: NSAIDs and other complementary (...) Center, Dallas, TX; Mayo Clinic (D.D.), Scottsdale, AZ; New York University School of Medicine (C.A.), Albany; and Elmendorf Air Force Base (E.A.), AK. Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: [RETIRED] S. Holland , S.D. Silberstein , F. Freitag , D.W. Dodick , C. Argoff , E. Ashman Neurology Apr 2012, 78 (17) 1346-1353; DOI: 10.1212/WNL.0b013e3182535d0c Citation Manager Formats Make Comment See Comments Downloads 42567

2012 American Academy of Neurology

67. Non-steroidal anti-inflammatory drugs (NSAIDs): cardiovascular risks

Non-steroidal anti-inflammatory drugs (NSAIDs): cardiovascular risks Non-steroidal anti-inflammatory drugs (NSAIDs): cardiovascular risks - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Non-steroidal anti-inflammatory drugs (NSAIDs): cardiovascular risks Further evidence that the cardiovascular risk with diclofenac is higher than other non-selective NSAIDs and similar to the selective COX-2 inhibitors. Published 11 December 2014 From: Therapeutic area: , Article date: October (...) 2012 A new review on the cardiovascular safety of NSAIDs has highlighted further evidence that diclofenac is associated with cardiovascular risks that are higher than the other non-selective NSAIDs, and similar to the selective COX-2 inhibitors. Naproxen and low-dose ibuprofen are still considered to have the most favourable cardiovascular safety profiles of all non-selective NSAIDs. This review, by the European Medicines Agency’s (CHMP), evaluated all available data on this issue since the last

2012 MHRA Drug Safety Update

68. Case control study: Use of non-aspirin NSAIDs during pregnancy may increase the risk of spontaneous abortion

Case control study: Use of non-aspirin NSAIDs during pregnancy may increase the risk of spontaneous abortion Use of non-aspirin NSAIDs during pregnancy may increase the risk of spontaneous abortion | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Use of non-aspirin NSAIDs during pregnancy may increase the risk of spontaneous abortion Article Text Midwifery Case control study Use of non-aspirin NSAIDs during pregnancy may increase the risk

2012 Evidence-Based Nursing

69. NSAID use selectively increases the risk of non-fatal myocardial infarction: a systematic review of randomised trials and observational studies

NSAID use selectively increases the risk of non-fatal myocardial infarction: a systematic review of randomised trials and observational studies Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

70. Cardiovascular and Gastrointestinal Safety of NSAIDs: A Systematic Review of Meta-Analyses of Randomized Clinical Trials (PubMed)

Cardiovascular and Gastrointestinal Safety of NSAIDs: A Systematic Review of Meta-Analyses of Randomized Clinical Trials As part of the Safety of Non-Steroidal Anti-Inflammatory Drugs (SOS) Project, we reviewed the incidence of cardiovascular (CV) and gastrointestinal (GI) events associated with the use of this category of drugs. We collected data from published meta-analyses (MAs) of clinical trials of nonsteroidal anti-inflammatory drugs (NSAIDs). The Medline, Cochrane, ISI, and SCOPUS (...) databases were systematically searched for MAs of NSAID clinical trials that could potentially contain data on adverse incidents such as myocardial infarction (MI), cerebrovascular events (CeVs), stroke, thromboembolic events (ThEs), heart failure (HF), gastrointestinal bleeding (GIB), and perforation, ulcer, and bleeding (PUB). From 1,733 identified references, 29 MAs were selected for the review. This allowed 109 estimations of incidence rates of CV adverse events and 26 estimations of incidence rates

2011 EvidenceUpdates

71. Colchicine as an adjunct to NSAIDs for the treatment of acute pericarditis

Colchicine as an adjunct to NSAIDs for the treatment of acute pericarditis BestBets: Colchicine as an adjunct to NSAIDs for the treatment of acute pericarditis Colchicine as an adjunct to NSAIDs for the treatment of acute pericarditis Report By: Alex Eppert - Emergency Medicine Resident Search checked by Janos P Baombe - Senior Emergency Trainee Institution: Grand Rapid Medical Education and Research Center, Michigan State University, Michigan, US and Manchester Royal Infirmary, Manchester, UK (...) Date Submitted: 6th June 2006 Date Completed: 9th March 2011 Last Modified: 10th March 2011 Status: Green (complete) Three Part Question In [adult patients with a first episode of acute pericarditis] is [colchicine plus NSAIDs better than NSAIDSs alone] at [relieving pain and preventing recurrence]? Clinical Scenario A 32-year-old woman with no significant medical history presents to the emergency department with chest pain and dyspnoea. A pericardial friction rub is heard on examination. The ECG

2011 BestBETS

72. Should You Eradicate Helicobacter Pylori Prior to Chronic NSAID Treatment?

Should You Eradicate Helicobacter Pylori Prior to Chronic NSAID Treatment? Should You Eradicate Helicobacter Pylori Prior to Chronic NSAID Treatment? – Clinical Correlations Search Should You Eradicate Helicobacter Pylori Prior to Chronic NSAID Treatment? January 19, 2011 4 min read By Joshua Smith, MD Faculty Peer Reviewed CASE: A 54-year-old Asian female with no significant past medical history presents to her primary care physician with the complaint of several weeks of pain in her fingers (...) bilaterally along with pronounced, worsening morning stiffness. She is subsequently diagnosed with rheumatoid arthritis (RA), and the decision is made to start her on long-term, high-dose non-steroidal anti-inflammatory drugs (NSAIDs). Given the link between NSAIDs and peptic ulcer disease (PUD), should this patient first be tested, and if positive, treated for Helicobacter pylori (H. pylori) ? It has been widely recognized that infection with H. pylori predisposes individuals to PUD as well as gastric

2011 Clinical Correlations

73. Should Topical NSAIDs Be Used to Treat Acute Musculoskeletal Conditions?

Should Topical NSAIDs Be Used to Treat Acute Musculoskeletal Conditions? SystematicReviewSnapshot ClinicalSynopsis TAKE-HOME MESSAGE Topical nonsteroidal anti-in?ammatory drugs effectively reduce pain associated with musculoskeletal conditions compared with placebo, with fewer adverse events compared with oral nonsteroidal anti-in?ammatory drugs. METHODS DATA SOURCES The authors searched the Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library, 2009, issue 4), MEDLINE (...) the list of those included in this review. 7 This Cochrane review demonstrated that topical non- steroidal anti-in?ammatory drugs, com- pared with placebo, provide adequate Performance of topical nonsteroidal anti-in?ammatory drugs versus placebo in acute musculoskeletal injuries. Studies (Total No. of Patients) Treatment Bene?t,* RR (95% CI) Adverse Event, † RR (95% CI) I 2 ,% Topical NSAID vs placebo 31 (3,462) 1.5 (1.4–1.6) 1.1 (0.88–1.4) 74 RR, Relative risk; CI, con?dence interval; NSAID

2011 Annals of Emergency Medicine Systematic Review Snapshots

74. Systematic review of randomised controlled trials: Only a small reduction in morphine use with adding NSAIDs, paracetamol or COX-2 inhibitors to patient controlled morphine in the 24 h after major surgery

Systematic review of randomised controlled trials: Only a small reduction in morphine use with adding NSAIDs, paracetamol or COX-2 inhibitors to patient controlled morphine in the 24 h after major surgery Only a small reduction in morphine use with adding NSAIDs, paracetamol or COX-2 inhibitors to patient controlled morphine in the 24 h after major surgery | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie (...) with adding NSAIDs, paracetamol or COX-2 inhibitors to patient controlled morphine in the 24 h after major surgery Article Text Pain management Systematic review of randomised controlled trials Only a small reduction in morphine use with adding NSAIDs, paracetamol or COX-2 inhibitors to patient controlled morphine in the 24 h after major surgery Hance Clarke Statistics from Altmetric.com Commentary on: McDaid C , Maund E , Rice S , et al . Paracetamol and selective and non-selective non-steroidal anti

2011 Evidence-Based Nursing

75. Cochrane systematic review: Topical NSAIDs provide effective relief of acute musculoskeletal pain compared to placebo, with no increase in risk of adverse effects

Cochrane systematic review: Topical NSAIDs provide effective relief of acute musculoskeletal pain compared to placebo, with no increase in risk of adverse effects Topical NSAIDs provide effective relief of acute musculoskeletal pain compared to placebo, with no increase in risk of adverse effects | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about (...) how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Topical NSAIDs provide effective relief of acute musculoskeletal pain compared to placebo

2011 Evidence-Based Nursing

76. Systematic review with meta-analysis: NSAID use associated with increased cardiovascular risk and death, but naproxen appears to be the least harmful

Systematic review with meta-analysis: NSAID use associated with increased cardiovascular risk and death, but naproxen appears to be the least harmful NSAID use associated with increased cardiovascular risk and death, but naproxen appears to be the least harmful | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see (...) our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here NSAID use associated with increased cardiovascular risk and death, but naproxen appears to be the least harmful Article Text

2011 Evidence-Based Medicine (Requires free registration)

77. Stroke risk and NSAIDs: a systematic review of observational studies

Stroke risk and NSAIDs: a systematic review of observational studies Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

78. NSAIDs vs acetaminophen in knee and hip osteoarthritis: a systematic review regarding heterogeneity influencing the outcomes

NSAIDs vs acetaminophen in knee and hip osteoarthritis: a systematic review regarding heterogeneity influencing the outcomes Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

79. Evaluation of the treatment effect of NSAIDs/TNF blockers according to different domains in ankylosing spondylitis: results of a meta-analysis (PubMed)

Evaluation of the treatment effect of NSAIDs/TNF blockers according to different domains in ankylosing spondylitis: results of a meta-analysis To assess the treatment effect of NSAIDs and TNF blockers in AS according to different domains of interest.A systematic literature research was performed in electronic databases up to October 2009. All randomized controlled trials (RCTs) reporting the efficacy (on pain and/or physical function and/or acute-phase reactants) of NSAIDs/anti-TNF vs placebo (...) in AS were selected. Pooled effect sizes were calculated by meta-analysis, using fixed or random-effect models.Optimal data to calculate the effect size were available in 8 out of the 240 selected RCTs evaluating anti-TNF and 5 of the 135 evaluating NSAIDs. For the domains pain, physical function and patient's global assessment, the treatment effect was large or medium for both TNF blockers and NSAIDs. For the domain acute-phase reactants, the effect of TNF blockers was medium [standardized mean

Full Text available with Trip Pro

2010 EvidenceUpdates

80. Medications (NSAIDs, statins, proton pump inhibitors) and the risk of esophageal adenocarcinoma in patients with Barrett`s esophagus (PubMed)

Medications (NSAIDs, statins, proton pump inhibitors) and the risk of esophageal adenocarcinoma in patients with Barrett`s esophagus Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia. However, the possible effect these medications may have on the risk of esophageal adenocarcinoma (EAC) in patients with existing Barrett's esophagus (BE) is unclear.We conducted (...) a nested case-control study in a cohort of patients with BE identified in the national Department of Veterans' Affairs computerized databases. Cases with incident EAC were matched by incidence density sampling to controls with BE who remained without EAC at the date of the EAC diagnosis for the corresponding case. We identified prescriptions for PPI, NSAIDs/aspirin, and statins that were filled between BE diagnosis and EAC diagnosis. Incidence density ratios were calculated using conditional logistic

Full Text available with Trip Pro

2010 EvidenceUpdates