Latest & greatest articles for omeprazole

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Top results for omeprazole

21. Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine and placebo: evidence from randomized clinical trials

Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine and placebo: evidence from randomized clinical trials Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine and placebo: evidence from randomized clinical trials Healing (...) and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine and placebo: evidence from randomized clinical trials Caro J J, Salas M, Ward A Authors' objectives To estimate the healing and relapse rates in the acute and maintenance treatment of gastroesophageal reflux disease (GERD) with the newer proton-pump inhibitors (PPIs) lansoprazole, rabeprazole and pantoprazole, compared

2001 DARE.

22. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. (Full text)

Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. After endoscopic treatment of bleeding peptic ulcers, bleeding recurs in 15 to 20 percent of patients.We assessed whether the use of a high dose of a proton-pump inhibitor would reduce the frequency of recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. Patients with actively bleeding ulcers or ulcers with nonbleeding visible vessels were treated with an epinephrine (...) injection followed by thermocoagulation. After hemostasis had been achieved, they were randomly assigned in a double-blind fashion to receive omeprazole (given as a bolus intravenous injection of 80 mg followed by an infusion of 8 mg per hour for 72 hours) or placebo. After the infusion, all patients were given 20 mg of omeprazole orally per day for eight weeks. The primary end point was recurrent bleeding within 30 days after endoscopy.We enrolled 240 patients, 120 in each group. Bleeding recurred

2000 NEJM PubMed

23. Effectiveness and costs of omeprazole vs ranitidine for treatment of symptomatic gastroesophageal reflux disease in primary care clinics in West Virginia

Effectiveness and costs of omeprazole vs ranitidine for treatment of symptomatic gastroesophageal reflux disease in primary care clinics in West Virginia Effectiveness and costs of omeprazole vs ranitidine for treatment of symptomatic gastroesophageal reflux disease in primary care clinics in West Virginia Effectiveness and costs of omeprazole vs ranitidine for treatment of symptomatic gastroesophageal reflux disease in primary care clinics in West Virginia Kaplan-Machlis B, Spiegler G E, Zodet (...) M W, Revicki D A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology This study considered omeprazole sodium (20 mg once daily) and ranitidine hydrochloride (150 mg twice daily) for the treatment of symptomatic gastroesophageal

2000 NHS Economic Evaluation Database.

24. Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine. The European Study Group. (Full text)

Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine. The European Study Group. To assess intermittent treatment over 12 months in patients with symptomatic gastro-oesophageal reflux disease.Randomised, multicentre, double blind, controlled study. Patients with heartburn and normal endoscopy results or mild erosive changes received omeprazole 10 mg or 20 mg daily or ranitidine 150 mg twice daily for 2 weeks (...) . Patients remaining symptomatic had omeprazole 10 mg or ranitidine dose doubled for another 2 weeks while omeprazole 20 mg was continued for 2 weeks. Patients who were symptomatic or mildly symptomatic were followed up for 12 months. Recurrences of moderate or severe heartburn during follow up were treated with the dose which was successful for initial symptom control.Hospitals and primary care practices between 1994 and 1996.677 patients with gastro-oesophageal reflux disease.Total time off active

1999 BMJ PubMed

25. Management of acid-related dyspepsia in general practice: cost-effectiveness analysis comparing an omeprazole vs an antacid-alginate/ranitidine management strategy

Management of acid-related dyspepsia in general practice: cost-effectiveness analysis comparing an omeprazole vs an antacid-alginate/ranitidine management strategy Management of acid-related dyspepsia in general practice: cost-effectiveness analysis comparing an omeprazole vs an antacid-alginate/ranitidine management strategy Management of acid-related dyspepsia in general practice: cost-effectiveness analysis comparing an omeprazole vs an antacid-alginate/ranitidine management strategy Mason I (...) , Marchant N J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Management of acid-related dyspepsia in general practice using either omeprazole or antacid-alginate/ranitidine. Type of intervention Treatment. Economic study type Cost

1999 NHS Economic Evaluation Database.

26. The cost-effectiveness of the omeprazole test in patients with noncardiac chest pain

The cost-effectiveness of the omeprazole test in patients with noncardiac chest pain The cost-effectiveness of the omeprazole test in patients with noncardiac chest pain The cost-effectiveness of the omeprazole test in patients with noncardiac chest pain Ofman J J, Gralnek I M, Udani J, Fennerty M B, Fass R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The omeprazole test in patients with non-cardiac chest pain. Type of intervention Diagnosis. Economic study type Cost-effectiveness analysis. Study population Hypothetical cohort of patients with non-cardiac chest pain in whom a comprehensive evaluation had excluded a cardiac cause for chest pain. Setting Hospital. The study was carried out in the USA. Dates to which data

1999 NHS Economic Evaluation Database.

27. Cost effectiveness of omeprazole and ranitidine in intermittent treatment of symptomatic gastro-oesophageal reflux disease

Cost effectiveness of omeprazole and ranitidine in intermittent treatment of symptomatic gastro-oesophageal reflux disease Cost effectiveness of omeprazole and ranitidine in intermittent treatment of symptomatic gastro-oesophageal reflux disease Cost effectiveness of omeprazole and ranitidine in intermittent treatment of symptomatic gastro-oesophageal reflux disease Stalhammar N, Carlsson J, Peacock R, Muller-Lissner S, Bigard M, Porro G B, Ponce J, Hosie J, Scott M, Weir D G, Fulton C, Gillon (...) K, Bardhan K D Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of omeprazole (10 or 20 mg once daily) or ranitidine (150 mg twice daily) as initial therapy, and subsequent open maintenance treatment, following initial

1999 NHS Economic Evaluation Database.

28. Clinical and economic assessment of the omeprazole test in patients with symptoms suggestive of gastroesophageal reflux disease

Clinical and economic assessment of the omeprazole test in patients with symptoms suggestive of gastroesophageal reflux disease Clinical and economic assessment of the omeprazole test in patients with symptoms suggestive of gastroesophageal reflux disease Clinical and economic assessment of the omeprazole test in patients with symptoms suggestive of gastroesophageal reflux disease Fass R, Ofman J J, Gralnek I M, Johnson C, Camargo E, Sampliner R E, Fennerty M B Record Status This is a critical (...) abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of omeprazole test (40 mg AM + 20 mg PM for 7 days) as a noninvasive strategy in the diagnosis of gastroesophageal reflux disease (GERD) in patients with typical GERD symptoms. Type of intervention Diagnosis

1999 NHS Economic Evaluation Database.

29. Evaluation of omeprazole as a cost-effective diagnostic test for gastro-oesophageal reflux disease

Evaluation of omeprazole as a cost-effective diagnostic test for gastro-oesophageal reflux disease Evaluation of omeprazole as a cost-effective diagnostic test for gastro-oesophageal reflux disease Evaluation of omeprazole as a cost-effective diagnostic test for gastro-oesophageal reflux disease Bate C M, Riley S A, Chapman R W G, Durnin A T, Taylor M D Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains (...) a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Omeprazole 40mg compared to endoscopy in the initial management of patients with symptoms suggestive of the presence of gastro-oesophageal reflux disease (GERD) based on symptom assessment alone. Type of intervention Diagnosis and treatment. Economic study type Cost-effectiveness analysis. Study population Patients between

1999 NHS Economic Evaluation Database.

30. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group. (PubMed)

A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group. Suppressing acid secretion is thought o reduce the risk of ulcers associated with regular use of nonsteroidal antiinflammatory drugs (NSAIDs), but the best means of accomplishing this is uncertain.We studied 541 patients who required continuous treatment with NSAIDs and who (...) had ulcers or more than 10 erosions in either the stomach or duodenum. Patients were randomly assigned to double-blind treatment with omeprazole, 20 mg or 40 mg orally per day, or ranitidine, 150 mg orally twice a day, for four or eight weeks, depending on when treatment was successful (defined as the resolution of ulcer and the presence of fewer than five erosions in the stomach, and fewer than five erosions in the duodenum, and not more than mild dyspepsia). We randomly assigned 432 patients

1998 NEJM

31. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. (PubMed)

Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. Misoprostol is effective for ulcers associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs) but is often poorly tolerated because of diarrhea and abdominal pain. We compared the efficacy of omeprazole and misoprostol in healing and preventing ulcers associated with NSAIDs.In a double-blind (...) study, we randomly assigned 935 patients who required continuous NSAID therapy and who had ulcers or more than 10 erosions in the stomach or duodenum (or both) to receive 20 mg or 40 mg of omeprazole orally in the morning or 200 microg of misoprostol orally four times daily. Patients were treated for four weeks or, in the absence of healing, eight weeks. Treatment success was defined as the absence of ulcers and the presence of fewer than five erosions at each site and not more than mild dyspepsia

1998 NEJM

32. Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin Effect One Year after Treatment (OCAY) Study Group. (PubMed)

Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin Effect One Year after Treatment (OCAY) Study Group. It is uncertain whether treatment of Helicobacter pylori infection relieves symptoms in patients with nonulcer, or functional, dyspepsia.We conducted a double-blind, multicenter trial of patients with H. pylori infection and dyspeptic symptoms (moderate-to-very-severe pain and discomfort centered (...) in the upper abdomen). Patients were excluded if they had a history of peptic ulcer disease or gastroesophageal reflux disease and had abnormal findings on upper endoscopy. Patients were randomly assigned to seven days of treatment with 20 mg of omeprazole twice daily, 1000 mg of amoxicillin twice daily, and 500 mg of clarithromycin twice daily or with omeprazole alone and then followed up for one year. Treatment success was defined as the absence of dyspeptic symptoms or the presence of minimal symptoms

1998 NEJM

33. Omeprazole: a review of its use in Helicobacter pylori infection, gastro-oesophageal reflux disease and peptic ulcers induced by nonsteroidal anti-inflammatory drugs

Omeprazole: a review of its use in Helicobacter pylori infection, gastro-oesophageal reflux disease and peptic ulcers induced by nonsteroidal anti-inflammatory drugs Omeprazole: a review of its use in Helicobacter pylori infection, gastro-oesophageal reflux disease and peptic ulcers induced by nonsteroidal anti-inflammatory drugs Omeprazole: a review of its use in Helicobacter pylori infection, gastro-oesophageal reflux disease and peptic ulcers induced by nonsteroidal anti-inflammatory drugs (...) Langtry H D, Wilde M I Authors' objectives To review the use of omeprazole in Helicobacter pylori infections, gastro-oesophageal reflux disease (GORD) and peptic ulcers induced by non steroidal anti-inflammatory drugs. Searching Medical literature published in any language since 1966 was identified using AdisBase (proprietary database of Adis International, New Zealand), MEDLINE and EMBASE. The following terms were used to search AdisBase: omeprazole, gastro- oesophageal reflux, NSAI-induced gastric

1998 DARE.

34. Randomised controlled trial of omeprazole or endoscopy in patients with persistent dyspepsia: a cost-effectiveness analysis

Randomised controlled trial of omeprazole or endoscopy in patients with persistent dyspepsia: a cost-effectiveness analysis Randomised controlled trial of omeprazole or endoscopy in patients with persistent dyspepsia: a cost-effectiveness analysis Randomised controlled trial of omeprazole or endoscopy in patients with persistent dyspepsia: a cost-effectiveness analysis Laheij R J, Severens J L, Van de Lisdonk E H, Verbeek A L, Jansen J B Record Status This is a critical abstract of an economic (...) evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Empirical treatment with omeprazole in patients with persistent dyspeptic symptoms, and, in the case of symptom relapse, serological screening for Helicobacter pylori (H. pylori) infection followed by eradication therapy in seropositive patients

1998 NHS Economic Evaluation Database.

35. Meta-analyses of cisapride, omeprazole and ranitidine in the treatment of GORD: implications for treating patient subgroups

Meta-analyses of cisapride, omeprazole and ranitidine in the treatment of GORD: implications for treating patient subgroups Meta-analyses of cisapride, omeprazole and ranitidine in the treatment of GORD: implications for treating patient subgroups Meta-analyses of cisapride, omeprazole and ranitidine in the treatment of GORD: implications for treating patient subgroups Iskedjian M, Einarson T R Authors' objectives To examine the efficacy of the pharmocological treatment of gastro-oesophageal (...) reflux disease (GORD) with cisapride, omeprazole or ranitidine. Searching MEDLINE was searched from 1984 to 1995 using the following keywords: 'GERD' (gastroesophageal reflux disease), 'GORD', 'gastroesophageal', 'reflux', 'cisapride', 'ranitidine' and 'omeprazole'. The search was limited to studies in humans, but was not limited to articles published in the English language; articles in French, German and Italian were also included. The bibliographies of the retrieved articles and reviews located

1998 DARE.

36. A cost-utility analysis comparing omeprazole with ranitidine in the maintenance therapy of peptic esophageal stricture

A cost-utility analysis comparing omeprazole with ranitidine in the maintenance therapy of peptic esophageal stricture A cost-utility analysis comparing omeprazole with ranitidine in the maintenance therapy of peptic esophageal stricture A cost-utility analysis comparing omeprazole with ranitidine in the maintenance therapy of peptic esophageal stricture Stal J M, Gregor J C, Preiksaitis H G, Reynolds R P Record Status This is a critical abstract of an economic evaluation that meets (...) data Effectiveness data were identified from a review of previously completed studies Modelling A decision tree model was used to determine the incremental cost utility of omeprazole compared with ranitidine over a one year period. Outcomes assessed in the review The probabilities of patients requiring redilation while receiving either omeprazole or ranitidine over a one year period, the risk of esophageal perforation during dilation or peptic stricture, the probability of surgery following

1998 NHS Economic Evaluation Database.

37. The clinical and economic value of a short course of omeprazole in patients with noncardiac chest pain

The clinical and economic value of a short course of omeprazole in patients with noncardiac chest pain The clinical and economic value of a short course of omeprazole in patients with noncardiac chest pain The clinical and economic value of a short course of omeprazole in patients with noncardiac chest pain Fass R, Fennerty M B, Ofman J J, Gralnek I M, Johnson C, Camargo E, Sampliner R E Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion (...) on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of the omeprazole test, compared with placebo, as a diagnostic test for detecting gastroesophageal reflux disease (GERD) in patients with noncardiac chest pain (NCCP). The omeprazole test consisted of a short course of high-dose omeprazole. Type of intervention Diagnosis. Economic

1998 NHS Economic Evaluation Database.

38. A comparison of omeprazole and placebo for bleeding peptic ulcer. (PubMed)

A comparison of omeprazole and placebo for bleeding peptic ulcer. The role of medical treatment for patients with bleeding peptic ulcers is uncertain.We conducted a double-blind, placebo-controlled trial in 220 patients with duodenal, gastric, or stomal ulcers and signs of recent bleeding, as confirmed by endoscopy. In 26 patients the ulcers showed arterial spurting, in 34 there was active oozing, in 35 there were nonbleeding, visible vessels, and in 125 there were adherent clots. The patients (...) were randomly assigned to receive omeprazole (40 mg given orally every 12 hours for five days) or placebo. The outcome measures studied were further bleeding, surgery, and death.Twelve of the 110 patients treated with omeprazole (10.9 percent) had continued bleeding or further bleeding, as compared with 40 of the 110 patients who received placebo (36.4 percent) (P<0.001). Eight patients in the omeprazole group and 26 in the placebo group required surgery to control their bleeding (P<0.001). Two

1997 NEJM

39. Decision analysis of Helicobacter pylori eradication therapy using omeprazole with either clarithromycin or amoxicillin

Decision analysis of Helicobacter pylori eradication therapy using omeprazole with either clarithromycin or amoxicillin Decision analysis of Helicobacter pylori eradication therapy using omeprazole with either clarithromycin or amoxicillin Decision analysis of Helicobacter pylori eradication therapy using omeprazole with either clarithromycin or amoxicillin Craig A M, Davey P, Malek M, Murray F Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Helicobacter pylori eradication therapy using omeprazole with either clarithromycin or amoxicillin. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The analysis was carried out for three distinct patient groups: patients with proven

1996 NHS Economic Evaluation Database.

40. Omeprazole and H-2-receptor antagonists in the acute treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis: a meta-analysis

Omeprazole and H-2-receptor antagonists in the acute treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis: a meta-analysis Omeprazole and H-2-receptor antagonists in the acute treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis: a meta-analysis Omeprazole and H-2-receptor antagonists in the acute treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis: a meta-analysis Eriksson S, Langstrom G, Rikner L, Carlsson R, Naesdal J Authors' objectives To compare (...) , using meta-analysis, the efficacies of omeprazole, ranitidine and cimetidine for symptom resolution and healing in patients with acute duodenal ulcer, gastric ulcer and reflux oesophagitis. Searching MEDLINE and omeprazole databases were searched. Study selection Study designs of evaluations included in the review Randomised double-blind studies including at least 50 patients, with analysis of results based on intention to treat and completed by end of September 1992, were included. Specific

1995 DARE.