Latest & greatest articles for omeprazole

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Top results for omeprazole

41. [Cost-effectiveness comparison between omeprazole and ranitidine for treatment of reflux oesophagitis]

[Cost-effectiveness comparison between omeprazole and ranitidine for treatment of reflux oesophagitis] Comparaison des rapports cout-efficacite du traitement de l'oesophagite par reflux par omeprazole et ranitidine [Cost-effectiveness comparison between omeprazole and ranitidine for treatment of reflux oesophagitis] Comparaison des rapports cout-efficacite du traitement de l'oesophagite par reflux par omeprazole et ranitidine [Cost-effectiveness comparison between omeprazole and ranitidine (...) for treatment of reflux oesophagitis] Bergmann J F, Hamelin B, Barbier J P Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Omeprazole versus ranitidine for the treatment of reflux oesophagitis. Type of intervention Treatment. Economic

1995 NHS Economic Evaluation Database.

42. Long-term consequences with regard to clinical outcome and cost-effectiveness of episodic treatment with omeprazole or ranitidine for healing of duodenal ulcer

Long-term consequences with regard to clinical outcome and cost-effectiveness of episodic treatment with omeprazole or ranitidine for healing of duodenal ulcer Long-term consequences with regard to clinical outcome and cost-effectiveness of episodic treatment with omeprazole or ranitidine for healing of duodenal ulcer Long-term consequences with regard to clinical outcome and cost-effectiveness of episodic treatment with omeprazole or ranitidine for healing of duodenal ulcer Walan A, Eriksson S (...) Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Treatment of duodenal ulcer with omeprazole or ranitidine. Type of intervention Treatment Economic study type Cost-effectiveness analysis Study population Hypothetical cohort

1994 NHS Economic Evaluation Database.

43. Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomised double blind controlled trial. (PubMed)

Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomised double blind controlled trial. To investigate the possible therapeutic role of omeprazole, a powerful proton pump inhibitor, in unselected patients presenting with upper gastrointestinal bleeding.Double blind placebo controlled parallel group study. Active treatment was omeprazole 80 mg intravenously immediately, then three doses of 40 mg intravenously at eight hourly intervals, then 40 mg orally at 12 hourly (...) to treat analysis, 569 received placebo and 578 omeprazole. No significant differences were found between the placebo and omeprazole groups for rates of transfusion (302 (53%) placebo v 298 (52%) omeprazole), rebleeding (100 (18%) v 85 (15%)), operation (63 (11%) v 62 (11%)), and death (30 (5.3%) v 40 (6.9%)). However, there was an unexpected but significant reduction in endoscopic signs of upper gastrointestinal bleeding in patients treated with omeprazole compared with those treated with placebo (236

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1992 BMJ

44. Omeprazole and cimetidine in the treatment of ulcers of the body of the stomach: a double blind comparative trial. Danish Omeprazole Study Group. (PubMed)

Omeprazole and cimetidine in the treatment of ulcers of the body of the stomach: a double blind comparative trial. Danish Omeprazole Study Group. To see whether omeprazole was superior to cimetidine in healing ulcers of the body of the stomach.Double blind randomised parallel group study of omeprazole versus cimetidine for six weeks with assessment of healing at end of every second week.Outpatient referrals in 11 centres in Denmark.One hundred sixty one patients who satisfied the following (...) patients withdrawn during trial for violations of protocol. At two weeks healing rates were identical in the two treatment groups (omeprazole 41% (30/73 patients); cimetidine 41% (30/73]. At four weeks cumulative healing rates were 77% (53/69 patients) in the omeprazole treatment group and 58% (41/71) in the cimetidine treatment group (95% confidence interval of difference between groups 4% to 34%). By six weeks the cumulative healing rates in the two treatment groups differed by only 6% (60/68

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1989 BMJ

45. Double-blind multicentre comparison of omeprazole and ranitidine in the treatment of reflux oesophagitis. (PubMed)

Double-blind multicentre comparison of omeprazole and ranitidine in the treatment of reflux oesophagitis. Omeprazole 60 mg once daily was compared with ranitidine 150 mg twice daily in an endoscopically-controlled, double-blind randomised trial in 51 outpatients with erosive or ulcerative reflux oesophagitis (grade 2 or 3). Endoscopy was repeated after 4 weeks and, in the absence of healing, again after 8 weeks. Symptoms were assessed before entry and after 2, 4, and 8 weeks. Patients who were (...) unhealed after 8 weeks were blindly switched to the other drug and treatment was continued for another 4 to 8 weeks. The healing rate (change to grade 0 or 1 oesophagitis) after 4 weeks was 19 of 25 patients treated with omeprazole and 7 of 26 patients treated with ranitidine (p = 0.002). The corresponding figures after 8 weeks were 22 of 25 and 10 of 26 (p = 0.001). The higher healing rate with omeprazole was reflected in a significantly faster and stronger improvement of reflux symptoms. 13 patients

1987 Lancet

46. Effect of omeprazole and cimetidine on duodenal ulcer. A double-blind comparative trial. (PubMed)

Effect of omeprazole and cimetidine on duodenal ulcer. A double-blind comparative trial. We conducted a double-blind randomized study of 132 patients to determine whether the new, investigational proton-pump inhibitor, omeprazole (30 mg per day), would accelerate healing and pain relief, as compared with cimetidine (1 g per day), in patients with duodenal ulcer. After two weeks of treatment, which was completed by all patients, the healing rates were 73 per cent in the omeprazole group and 46 (...) per cent in the cimetidine group (P less than 0.01). After four weeks of treatment, which was completed by 118 patients, the corresponding figures were 92 and 74 per cent (P less than 0.05). In the omeprazole group 55 per cent of the patients were free of pain after the first week, as compared with 40 per cent of those treated with cimetidine (P greater than 0.05). No major clinical or biochemical side effects of omeprazole or cimetidine were noted. A six-month follow-up study revealed

1985 NEJM

47. Rapid healing of duodenal ulcers with omeprazole: double-blind dose-comparative trial. (PubMed)

Rapid healing of duodenal ulcers with omeprazole: double-blind dose-comparative trial. In a double-blind, dose-comparative trial, 32 patients with duodenal ulcer were assigned to receive either 20 mg/day or 60 mg/day omeprazole for 4 weeks. The 2-week healing frequency of 100% in the 60 mg/day group was significantly higher than that in the 20 mg/day group (63%). After 4 weeks all ulcers but one in the 20 mg/day group were healed (93% healing frequency). In both groups transient and mostly (...) slight rises in serum alanine aminotransferase levels were observed (total 10 patients). One patient in the 20 mg/day group was withdrawn because of a pronounced rise in serum alanine aminotransferase on day 8. The reason for these liver reactions is not clear, but exclusion of a causal relation with omeprazole treatment must precede further clinical evaluation of this drug.

1983 Lancet