Latest & greatest articles for otitis media

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Top results for otitis media

141. Ventilation tubes after surgery for otitis media with effusion or acute otitis media and swimming: systematic review and meta-analysis

Ventilation tubes after surgery for otitis media with effusion or acute otitis media and swimming: systematic review and meta-analysis Ventilation tubes after surgery for otitis media with effusion or acute otitis media and swimming: systematic review and meta-analysis Ventilation tubes after surgery for otitis media with effusion or acute otitis media and swimming: systematic review and meta-analysis Carbonell R, Ruiz-Garcia V Authors' objectives To determine whether swimming using ear (...) protection, swimming without ear protection and not swimming affects the risk of acute otitis media (AOM) in children with ventilation tubes. Searching MEDLINE (from 1966 to June 2001), EMBASE (from 1980 to June 2001) and the Cochrane Library (to June 2001) were searched without language restriction. In addition, the reference lists from identified studies were checked. Experts were not contacted and grey literature was not sought. A brief summary of the search strategy was reported in the review. Study

2002 DARE.

142. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. (PubMed)

Efficacy of a pneumococcal conjugate vaccine against acute otitis media. Ear infections are a common cause of illness during the first two years of life. New conjugate vaccines may be able to prevent a substantial portion of cases of acute otitis media caused by Streptococcus pneumoniae.We enrolled 1662 infants in a randomized, double-blind efficacy trial of a heptavalent pneumococcal polysaccharide conjugate vaccine in which the carrier protein is the nontoxic diphtheria-toxin analogue CRM197 (...) . The children received either the study vaccine or a hepatitis B vaccine as a control at 2, 4, 6, and 12 months of age. The clinical diagnosis of acute otitis media was based on predefined criteria, and the bacteriologic diagnosis was based on a culture of middle-ear fluid obtained by myringotomy.Of the children who were enrolled, 95.1 percent completed the trial. With the pneumococcal vaccine, there were more local reactions than with the hepatitis B vaccine but fewer than with the combined whole-cell

2001 NEJM

143. Effect of recolonisation with "interfering" alpha streptococci on recurrences of acute and secretory otitis media in children: randomised placebo controlled trial. (PubMed)

Effect of recolonisation with "interfering" alpha streptococci on recurrences of acute and secretory otitis media in children: randomised placebo controlled trial. To study the effect of recolonisation with alpha streptococci with the ability to inhibit the growth of otopathogens ("interfering" activity) on the recurrence of acute otitis media in susceptible children and the effect on the frequency of secretory otitis media.Double blind, randomised, placebo controlled study.Ear, nose (...) , and throat clinic with three doctors.130 children prone to otitis media aged between 6 months and 6 years, 108 of whom were eligible and followed for 3 months.Recurrence of otitis media during follow up and a normal tympanic membrane at the last valid visit.Children with no recurrences during the last month received phenoxymethylpenicillin (n=22), and those with a recurrence within 1 month received amoxicillin clavulanic acid (n=86), both twice daily for 10 days. These were followed by a streptococcal

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2001 BMJ

144. Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. (PubMed)

Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. To compare immediate with delayed prescribing of antibiotics for acute otitis media.Open randomised controlled trial.General practices in south west England.315 children aged between 6 months and 10 years presenting with acute otitis media.Two treatment strategies, supported by standardised advice sheets-immediate antibiotics or delayed antibiotics (antibiotic prescription to be collected (...) mainly after first 24 hours, when symptoms were already resolving. For children who are not very unwell systemically, a wait and see approach seems feasible and acceptable to parents and should substantially reduce the use of antibiotics for acute otitis media.

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2001 BMJ

145. Effect of early or delayed insertion of tympanostomy tubes for persistent otitis media on developmental outcomes at the age of three years. (PubMed)

Effect of early or delayed insertion of tympanostomy tubes for persistent otitis media on developmental outcomes at the age of three years. A main indication for the insertion of tympanostomy tubes in infants and young children is persistent otitis media with effusion, reflecting concern that this condition may cause lasting impairments of speech, language, cognitive, and psychosocial development. However, evidence of such relations is inconclusive, and evidence is lacking that the insertion (...) +/-7 vs. 86+/-7); the General Cognitive Index of McCarthy Scales of Children's Abilities (99+/-14 vs. 101+/-13); or on measures of receptive language, sentence length, grammatical complexity, parent-child stress, and behavior.In children younger than three years of age who have persistent otitis media, prompt insertion of tympanostomy tubes does not measurably improve developmental outcomes at the age of three years.

2001 NEJM

146. Evidence assessment of management of acute otitis media - I. The role of antibiotics in treatment of uncomplicated acute otitis media

Evidence assessment of management of acute otitis media - I. The role of antibiotics in treatment of uncomplicated acute otitis media Evidence assessment of management of acute otitis media - I. The role of antibiotics in treatment of uncomplicated acute otitis media Evidence assessment of management of acute otitis media - I. The role of antibiotics in treatment of uncomplicated acute otitis media Takata G S, Chan L S, Shekelle P, Morton S C, Mason W, Marcy S M Authors' objectives (...) To synthesise the literature on the natural history of acute otitis media (AOM), the effectiveness of antibiotic treatment in uncomplicated AOM, and the relative effectiveness of specific antibiotic regimens. Searching The following sources were searched: MEDLINE from 1966 to March 1999; the Cochrane Library (to March 1999); HealthSTAR from 1975 to March 1999; International Pharmaceutical Abstracts from 1970 to March 1999; CINAHL from 1982 to March 1999; BIOSIS Previews from 1970 to March 1999; and EMBASE

2001 DARE.

147. Management of acute otitis media

Management of acute otitis media Management of acute otitis media Management of acute otitis media Marcy M, Takata G, Chan L S Shekelle P, Mason W, Wachsman L, Ernst R, Hay J W, Corley P M, Morphew T, Ramicone E, Nicholson C Authors' objectives To analyse the evidence on the initial management of uncomplicated acute otitis media (AOM) in children, and to assess the following three questions. What is the natural history of AOM without antibiotic treatment? Are antibiotics effective in preventing (...) to establish differences in antibiotic efficacy. In addition, future studies should address the issue of bacterial resistance. Bibliographic details Marcy M, Takata G, Chan L S Shekelle P, Mason W, Wachsman L, Ernst R, Hay J W, Corley P M, Morphew T, Ramicone E, Nicholson C. Management of acute otitis media. Rockville, MD, USA: Agency for Healthcare Research and Quality. Evidence Report/Technology Assessment; 15. 2001 Original Paper URL Other publications of related interest Jadad AR, Moore RA, Carroll D

2001 DARE.

148. Management of acute otitis media

Management of acute otitis media Management of acute otitis media Management of acute otitis media Agency for Healthcare Research and Quality (AHRQ) Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Agency for Healthcare Research and Quality (AHRQ). Management of acute otitis media. Rockville: Agency for Healthcare Research and Quality (...) (AHRQ). Evidence Report/Technology Assessment No. 15. 2001 Authors' objectives The objective of this report is to analyze the evidence on the initial management of uncomplicated acute otitis media (AOM) in children. Authors' conclusions There is a wide range of reported clinical failure rates in the first week in children with AOM who are not treated with antibiotics. The pooled estimates indicate that a majority of these children have clinical resolution within the first week after presentation

2001 Health Technology Assessment (HTA) Database.

149. Azithromycin vs. clarithromycin and co-amoxiclav: clinical and economic comparison in the treatment of acute otitis media in children

Azithromycin vs. clarithromycin and co-amoxiclav: clinical and economic comparison in the treatment of acute otitis media in children Azithromycin vs. clarithromycin and co-amoxiclav: clinical and economic comparison in the treatment of acute otitis media in children Azithromycin vs. clarithromycin and co-amoxiclav: clinical and economic comparison in the treatment of acute otitis media in children Kawalski H, Blacha E, Kopacz M, Mos M, Cierpiol-Tracz E, Welniak M, Dudziak B, Bojda S, Kossowska (...) B, Gatniejewska E, Ligacz M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of azithromycin, clarithromycin and co-amoxiclav in the treatment of children with acute otitis media (AOM). Azithromycin was administered

2001 NHS Economic Evaluation Database.

150. Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children. (PubMed)

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children. OME is common and may cause hearing loss with associated developmental delay. Treatment remains controversial. The effect of both systemic and intra-nasal steroids on effusions has been assessed by randomised controlled trials.To examine evidence for or against treating children with hearing loss associated with OME with systemic or topical nasal steroids.Searches were conducted in February (...) 2000. We searched the Cochrane Controlled Trials Register using the terms 'otitis-media', 'otitis media with effusion', 'glue ear', or 'OME', and 'steroids', 'glucocorticoids, synthetic', 'glucocorticoids, topical', 'anti-inflammatory agents, steroidal'. EMBASE and MEDLINE were also searched for additional information.Randomised controlled trials of oral and topical nasal steroids, either alone or in combination with another agent such as an antibiotic, were included.publications in abstract form

2000 Cochrane

151. Interventions for chronic suppurative otitis media. (PubMed)

Interventions for chronic suppurative otitis media. Chronic suppurative otitis media (CSOM) is a serious bacterial infection of the middle ear that can follow untreated acute otitis media.To assess the effects of different treatments for CSOM.We searched Medline from 1966 to 1996 and a bibliographic collection of the Hearing Impairment Research Group in Liverpool, UK. We handsearched two otolaryngology journals and contacted members of an international hearing network.Randomized trials of any

2000 Cochrane

152. Antibiotics for acute otitis media in children. (PubMed)

Antibiotics for acute otitis media in children. Acute otitis media is one of the most common diseases in early infancy and childhood. Antibiotic use for acute otitis media varies from 31% in the Netherlands to 98% in the USA and Australia.The objective of this review was to assess the effects of antibiotics for children with acute otitis media.We searched the Cochrane Controlled Trials Register, MEDLINE, Index Medicus (pre 1965), Current Contents and reference lists of articles from 1958 (...) interval 15% to 38%) in pain at two to seven days. Since approximately 80% of patients will have settled spontaneously in this time, this means an absolute reduction of 5% or that about 17 children must be treated with antibiotics to prevent one child having some pain after two days. There was no effect of antibiotics on hearing problems of acute otitis media, as measured by subsequent tympanometry. However, audiometry was done in only two studies and incompletely reported. Nor did antibiotics

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2000 Cochrane

153. Primary care based randomised, double blind trial of amoxicillin versus placebo for acute otitis media in children aged under 2 years. (PubMed)

Primary care based randomised, double blind trial of amoxicillin versus placebo for acute otitis media in children aged under 2 years. To determine the effect of antibiotic treatment for acute otitis media in children between 6 months and 2 years of age.Practice based, double blind, randomised, placebo controlled trial.53 general practices in the Netherlands.240 children aged 6 months to 2 years with the diagnosis of acute otitis media.Amoxicillin 40 mg/kg/day in three doses.Persistent symptoms (...) in the placebo group during the first 10 days (4.1 v 2.3 doses, P=0.004). In addition, no otoscopic differences were observed at days four and 11, and tympanometric findings at six weeks were similar in both groups.Seven to eight children aged 6 to 24 months with acute otitis media needed to be treated with antibiotics to improve symptomatic outcome at day four in one child. This modest effect does not justify prescription of antibiotics at the first visit, provided close surveillance can be guaranteed.

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2000 BMJ

154. Treatment of acute otitis media with an antiadhesive oligosaccharide: a randomised, double-blind, placebo-controlled trial. (PubMed)

Treatment of acute otitis media with an antiadhesive oligosaccharide: a randomised, double-blind, placebo-controlled trial. Antiadhesive compounds are promising candidates for prevention or treatment of infections. We have investigated the efficacy of such an agent, 3'-sialyllacto-N-neotetraose (NE-1530), given intranasally for prophylaxis of acute otitis media and for effect on nasopharyngeal carriage of bacteria.We did a randomised, double-blind placebo-controlled study at one study site. 507 (...) of acute otitis media was diagnosed in 108 (43%) of 254 children in the NE-1530 group and in 86 (34%) of 253 children in the placebo group. The efficacy of treatment was negative, -27% (95% CI -68 to 5; p=0.10). The nasopharyngeal carriage of S pneumoniae, H. influenzae, and M. catarrhalis was not affected by treatment, and the adverse event profiles were almost identical for NE-1530 and placebo.NE-1530 did not have a beneficial effect on the occurrence of acute otitis media or on the nasopharyngeal

2000 Lancet

155. Childhood vaccination against pneumococcal otitis media and pneumonia: an analysis of benefits and costs

Childhood vaccination against pneumococcal otitis media and pneumonia: an analysis of benefits and costs Childhood vaccination against pneumococcal otitis media and pneumonia: an analysis of benefits and costs Childhood vaccination against pneumococcal otitis media and pneumonia: an analysis of benefits and costs Weycker D, Richardson E, Oster G Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief (...) summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of a heptavalent pneumococcal conjugate vaccine (PNCRM7) in children aged younger than 5 years, for the prevention of acute otitis media (AOM), community-acquired pneumonia (CAP), and tympanostomy and related procedures (TRP). Type of intervention Primary prevention (paediatric vaccination). Economic study type Cost

2000 NHS Economic Evaluation Database.

156. Adenoidectomy and adenotonsillectomy for recurrent acute otitis media: parallel randomized clinical trials in children not previously treated with tympanostomy tubes. (PubMed)

Adenoidectomy and adenotonsillectomy for recurrent acute otitis media: parallel randomized clinical trials in children not previously treated with tympanostomy tubes. Adenoidectomy and adenotonsillectomy are commonly performed in US children to reduce the occurrence of persistent or recurrent otitis media, but evidence supporting the efficacy of the operations is limited.To test the efficacy of adenoidectomy and adenotonsillectomy in children with persistent or recurrent otitis media who had (...) an adenoidectomy, adenotonsillectomy, or control group; children who had such conditions (157 enrolled; 144 followed up) were randomized to an adenotonsillectomy or control group.Occurrence rate of episodes of acute otitis media by treatment group and estimated proportion of time with otitis media.In both trials, most subjects were eligible because of recurrent acute otitis media, with or without persistent otitis media with effusion. A total of 47 children assigned to surgical treatment groups had no surgery

1999 JAMA

157. Treatment of acute otitis media with a shortened course of antibiotics: a meta-analysis. (PubMed)

Treatment of acute otitis media with a shortened course of antibiotics: a meta-analysis. To conduct a meta-analysis of randomized controlled trials of antibiotic treatment of acute otitis media in children to determine whether outcomes were comparable in children treated with antibiotics for less than 7 days or at least 7 days or more.MEDLINE (1966-1997), EMBASE (1974-1997), Current Contents, and Science Citation Index searches were conducted to identify randomized controlled trials (...) of the treatment of acute otitis media in children with antibiotics of different durations.Studies were included if they met the following criteria: subjects aged 4 weeks to 18 years, clinical diagnosis of acute otitis media, no antimicrobial therapy at time of diagnosis, and randomization to less than 7 days of antibiotic treatment vs 7 days or more of antibiotic treatment.Trial methodological quality was assessed independently by 7 reviewers; outcomes were extracted as the number of treatment failures

1998 JAMA

158. Screening programmes for the detection of otitis media with effusion and conductive hearing loss in pre-school and new entrant school children: a critical appraisal of the literature

Screening programmes for the detection of otitis media with effusion and conductive hearing loss in pre-school and new entrant school children: a critical appraisal of the literature Screening programmes for the detection of otitis media with effusion and conductive hearing loss in pre-school and new entrant school children: a critical appraisal of the literature Screening programmes for the detection of otitis media with effusion and conductive hearing loss in pre-school and new entrant school (...) children: a critical appraisal of the literature New Zealand Health Technology Assessment Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation New Zealand Health Technology Assessment. Screening programmes for the detection of otitis media with effusion and conductive hearing loss in pre-school and new entrant school children: a critical appraisal

1998 Health Technology Assessment (HTA) Database.

159. Antibiotic treatment of acute otitis media in children under two years of age: evidence based?

Antibiotic treatment of acute otitis media in children under two years of age: evidence based? Antibiotic treatment of acute otitis media in children under two years of age: evidence based? Antibiotic treatment of acute otitis media in children under two years of age: evidence based? Damoiseaux R A, van Balen F A, Hoes A W, De Melker R A Authors' objectives To assess whether the current high prescription rates of antibiotics for acute otitis media (AOM) in children under two years of age (being (...) a risk group for poor outcome) are based on an established increased efficacy. Searching MEDLINE (1966 to January 1997) and EMBASE (1974 to January 1997) were searched using the following keywords; otitis media, child, clinical trial, and placebo. The reference sections of these articles and of several major review articles were checked for further articles. An extensive handsearch for clinical trials of therapy for AOM in patients of all ages was performed by the authors' group in 1991 (see Other

1998 DARE.

160. Screening programmes for the detection of otitis media with effusion and conductive hearing loss in pre-school and new entrant school children: a critical appraisal of the literature

Screening programmes for the detection of otitis media with effusion and conductive hearing loss in pre-school and new entrant school children: a critical appraisal of the literature Screening programmes for the detection of otitis media with effusion and conductive hearing loss in pre-school and new entrant school children: a critical appraisal of the literature Screening programmes for the detection of otitis media with effusion and conductive hearing loss in pre-school and new entrant school (...) children: a critical appraisal of the literature New Zealand Health Technology Assessment Authors' objectives To review the effectiveness of pre-school and school entrant screening programmes for otitis media with effusion (OME) and conductive hearing loss. The effectiveness of treatments for OME is also reviewed. Searching The following electronic databases were searched: MEDLINE (1966-Jan 1998); Health STAR (1975-Jan 1998); CINAHL (1982-Jan 1998); Current Contents (start-Mar 1998); Cochrane Library

1998 DARE.