Latest & greatest articles for otitis media

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on otitis media or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on otitis media and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for otitis media

161. Treatment of acute otitis media with a shortened course of antibiotics: a meta-analysis

Treatment of acute otitis media with a shortened course of antibiotics: a meta-analysis Treatment of acute otitis media with a shortened course of antibiotics: a meta-analysis Treatment of acute otitis media with a shortened course of antibiotics: a meta-analysis Kozyrskyj A L, Hildes-Ripstein G E, Longstaffe S E, Wincott J L, Sitar D S, Klassen T P, Moffatt M E Authors' objectives To conduct a meta-analysis of randomised controlled trials of antibiotic treatment of acute otitis media (AOM (...) ) in children to determine whether outcomes are comparable in children treated with antibiotics for less than 7 days or at least 7 days or more. Searching MEDLINE (JANUARY 1966 TO July 1997), EMBASE (January 1974 to July 1997), Current Contents (January to July 1997), and Science Citation Index were searched. There were no language restrictions. In MEDLINE, search terms employed were "otitis media" in medical subject headings, modified by "acute" in the title or abstract. These terms were combined

1998 DARE.

162. A comparison of the effectiveness of pharmacologic treatment of otitis media with effusion in children: integrative and meta-analysis

A comparison of the effectiveness of pharmacologic treatment of otitis media with effusion in children: integrative and meta-analysis A comparison of the effectiveness of pharmacologic treatment of otitis media with effusion in children: integrative and meta-analysis A comparison of the effectiveness of pharmacologic treatment of otitis media with effusion in children: integrative and meta-analysis Witmer A, Wells A M, Seymour R J Authors' objectives To compare the effectiveness (...) of pharmacological treatment versus placebo in otitis media with effusion in children. Searching Searches were conducted of the following using the keywords 'otitis media with effusion': MEDLINE ( including Avicenna) and CINAHL (1980 to 1997); and the Internet using the search engines Yahoo (first 60 out of 8,050 hits were reviewed) and Infoseek (first 50 out of over 12,000,000 hits were reviewed). Reference lists of 12 articles obtained from 32 abstracts were examined. Reviews were excluded for the meta

1998 DARE.

163. Are antibiotics indicated as initial treatment for children with acute otitis media? A meta-analysis. (PubMed)

Are antibiotics indicated as initial treatment for children with acute otitis media? A meta-analysis. To determine the effect of antibiotic treatment for acute otitis media in children.Systematic search of the medical literature to identify studies that used antibiotics in randomised controlled trials to treat acute otitis media. Studies were examined blind, and the results of those of satisfactory quality of methodology were pooled.Six studies of children aged 7 months to 15 years.Pain (...) , deafness, and other symptoms related to acute otitis media or antibiotic treatment.60% of placebo treated children were pain free within 24 hours of presentation, and antibiotics did not influence this. However, at 2-7 days after presentation, by which time only 14% of children in control groups still had pain, early use of antibiotics reduced the risk of pain by 41% (95% confidence interval 14% to 60%). Antibiotics reduced contralateral acute otitis media by 43% (9% to 64%). They seemed to have

Full Text available with Trip Pro

1997 BMJ

164. Macrolides in community-acquired pneumonia and otitis media - summary

Macrolides in community-acquired pneumonia and otitis media - summary Macrolides in community-acquired pneumonia and otitis media Macrolides in community-acquired pneumonia and otitis media Perras C Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Perras C. Macrolides in community-acquired pneumonia and otitis media. Ottawa: Canadian (...) /therapeutic use; Otitis Media; Pneumonia Language Published English, French Country of organisation Canada Address for correspondence 600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553, Fax: +1 613 226 5392; Email: jills@ccohta.ca AccessionNumber 31998008137 Date bibliographic record published 28/02/1998 Date abstract record published 28/02/1998 Health Technology Assessment (HTA) database Copyright © 2019 Canadian Coordinating Office for Health Technology Assessment Homepage Options

1997 Health Technology Assessment (HTA) Database.

165. Pharmacoeconomic impact of factors affecting compliance with antibiotic regimens in the treatment of acute otitis media

Pharmacoeconomic impact of factors affecting compliance with antibiotic regimens in the treatment of acute otitis media Pharmacoeconomic impact of factors affecting compliance with antibiotic regimens in the treatment of acute otitis media Pharmacoeconomic impact of factors affecting compliance with antibiotic regimens in the treatment of acute otitis media Wandstrat T L, Kaplan B Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS (...) EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Treatment of otitis media with antibiotics. Type of intervention Treatment. Economic study type Cost-effectiveness study. Study population Children of both sexes aged between 2 months and 7 years old with acute otitis media. Setting Primary care. The economic study was conducted in West

1997 NHS Economic Evaluation Database.

166. Macrolides in community-acquired pneumonia and otitis media

Macrolides in community-acquired pneumonia and otitis media Macrolides in community-acquired pneumonia and otitis media Macrolides in community-acquired pneumonia and otitis media Canadian Coordinating Office for Health Technology Assessment Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment (...) on the reliability of the study and the conclusions drawn. Health technology The use of three macrolides; erythromycin compared toazithromycin or clarithromycin for the treatment of community acquired pneumonia (CAP) and otitis media. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Patients who had received a macrolide, specifically erythromycin, azithromycin or clarithromycin for the treatment of CAP and otitis media. Setting Primary care. The economic study

1997 NHS Economic Evaluation Database.

167. Randomised controlled trial of treatment of chronic suppurative otitis media in Kenyan schoolchildren. (PubMed)

Randomised controlled trial of treatment of chronic suppurative otitis media in Kenyan schoolchildren. The outcomes of treatment of chronic suppurative otitis media (CSOM) are disappointing and uncertain, especially in developing countries. Because CSOM is the commonest cause of hearing impairment in children in these countries, an effective method of management that can be implemented on a wide scale is needed. We report a randomised, controlled trial of treatment of CSOM among children

1996 Lancet

168. Xylitol chewing gum in prevention of acute otitis media: double blind randomised trial. (PubMed)

Xylitol chewing gum in prevention of acute otitis media: double blind randomised trial. To examine whether xylitol, which reduces the growth of Streptococcus pneumoniae, might have clinical importance in the prevention of acute otitis media.A double blind randomised trial with xylitol administered in chewing gum.Eleven day care nurseries in the city of Oulu. Most of the children had had problems with recurrent acute otitis media.306 day care children: 149 children in the sucrose group (76 boys (...) ; mean (SD) age 4.9 (1.5) years) and 157 in the xylitol group (80 boys; 5.0 (1.4) years).Either xylitol (8.4 g a day) or sucrose (control) chewing gum for two months.The occurrence of acute otitis media and antimicrobial treatment received during the intervention and nasopharyngeal carriage of S pneumoniae.During the two month monitoring period at least one event of acute otitis media was experienced by 31/149 (20.8%) children who received sucrose compared with 19/157 (12.1%) of those receiving

Full Text available with Trip Pro

1996 BMJ

169. Double-blind randomised trial of co-amoxiclav versus placebo for persistent otitis media with effusion in general practice. (PubMed)

Double-blind randomised trial of co-amoxiclav versus placebo for persistent otitis media with effusion in general practice. The treatment of persistent otitis media with effusion (OME) remains controversial, but this condition is the commonest reason for children to require ear, nose, and throat (ENT) surgery. Trials of antibiotics are inconclusive, are often weak methodologically, and have not been done in general practice. Our aim was a trial of an antibiotic for OME in such a population.433

1996 Lancet

170. Brodimoprim in upper respiratory tract infections: two meta-analyses of randomised, controlled clinical trials in acute sinusitis and otitis media

Brodimoprim in upper respiratory tract infections: two meta-analyses of randomised, controlled clinical trials in acute sinusitis and otitis media Brodimoprim in upper respiratory tract infections: two meta-analyses of randomised, controlled clinical trials in acute sinusitis and otitis media Brodimoprim in upper respiratory tract infections: two meta-analyses of randomised, controlled clinical trials in acute sinusitis and otitis media Rahlfs V W, Macciocchi A, Monti T Authors' objectives (...) The authors aimed to assess the clinical efficacy of brodimoprim and standard comparator agents in adults with acute bacterial sinusitis, and in children with acute otitis media. Searching All clinical studies performed during the development of brodimoprim up to 1994 were reviewed for inclusion. MEDLINE and Excerpta Medica were also searched for relevant literature. Study selection Study designs of evaluations included in the review Individual patient data (IPD) from randomised controlled trials (RCTs

1996 DARE.

171. Otitis media with effusion and s-carboxymethylcysteine and/or its lysine salt: a critical overview

Otitis media with effusion and s-carboxymethylcysteine and/or its lysine salt: a critical overview Otitis media with effusion and s-carboxymethylcysteine and/or its lysine salt: a critical overview Otitis media with effusion and s-carboxymethylcysteine and/or its lysine salt: a critical overview Pignataro O, Pignataro L D, Gallus G, Calori G, Cordaro C I Authors' objectives To evaluate the therapeutic relevance of the medical treatment with S-carboxymethylcysteine (SCMC) and its monohydrate (...) lysine salt (SCMC-LYS) in patients with otitis media with effusion (OME). Searching EMBASE, BIOSIS Previews and MEDLINE were searched from 1972 to 1993 using the keywords 'carbocysteine', 'S-carboxymethylcysteine', 'double blind controlled' and 'otitis media'. No other restrictions or sources are discussed. Study selection Study designs of evaluations included in the review Only randomised placebo-controlled trials with double-blinded outcome assessment and complete follow-up were included. Studies

1996 DARE.

172. A cost-utility analysis of second-line antibiotics in the treatment of acute otitis media in children

A cost-utility analysis of second-line antibiotics in the treatment of acute otitis media in children A cost-utility analysis of second-line antibiotics in the treatment of acute otitis media in children A cost-utility analysis of second-line antibiotics in the treatment of acute otitis media in children Oh P, Maerov P, Pritchard D, Knowles S, Einarson T, Shear N Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Second-line antibiotic treatment used to treat acute otitis media in children. Type of intervention Treatment. Economic study type Cost-utility analysis. Study population Male and female children with acute otitis media. Ages ranged from 2 months to 18 years, but the majority of patients were between 6 months and 12

1996 NHS Economic Evaluation Database.

173. A pharmacoeconomic comparison of amoxicillin/clavulanate and cefpodoxime proxetil in the treatment of acute otitis media

A pharmacoeconomic comparison of amoxicillin/clavulanate and cefpodoxime proxetil in the treatment of acute otitis media A pharmacoeconomic comparison of amoxicillin/clavulanate and cefpodoxime proxetil in the treatment of acute otitis media A pharmacoeconomic comparison of amoxicillin/clavulanate and cefpodoxime proxetil in the treatment of acute otitis media Landholt T F, Kotschwar T R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion (...) on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Treatment of acute otitis media in children with amoxicillin/ clavulanate potassium or cefpodoxime proxetil. Type of intervention Treatment Economic study type Cost-effectiveness analysis. Study population Children (males and females) were divided equally into two groups with an average

1994 NHS Economic Evaluation Database.

174. Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials

Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials Rosenfeld R M, Vertrees J E, Carr J, Cipolle R J, Uden D L, Giebink G S, Canafax D M Authors' objectives (...) To review the clinical effectiveness of antimicrobial drugs for acute otitis media (glue ear) in children. Searching MEDLINE was searched from 1966 to June 1992 using the MeSH (explode) 'otitis media' or (explode) 'drug therapy', and limiting the search by: (1) use of MeSH 'prospective studies', 'placebos', 'random allocation', 'double-blind method' or (explode) 'clinical trials'; (2) check tag comparative study; or (3) publication-type clinical trial. Current Contents (1992;35(13-26)), and references

1994 DARE.

175. Use of antibiotics in preventing recurrent acute otitis media and in treating otitis media with effusion. A meta-analytic attempt to resolve the brouhaha. (PubMed)

Use of antibiotics in preventing recurrent acute otitis media and in treating otitis media with effusion. A meta-analytic attempt to resolve the brouhaha. To determine the efficacy of antibiotics for prophylaxis of recurrent otitis media and treatment of otitis media with effusion (OME) in children.MEDLINE from 1966 through April 1993, textbooks, Current Contents, and bibliographies of selected articles.Thirty-three studies initially identified were reviewed by three blinded reviewers assessing (...) study quality and suitability for inclusion. Twenty-seven met inclusion criteria for the meta-analyses.We abstracted quantitative data and calculated rate differences (RDs) using tympanometry as the preferred outcome measure.Nine studies of antibiotic prophylaxis of recurrent otitis media with 958 subjects had an RD of 0.11 (95% confidence interval [Cl], 0.03 to 0.19) favoring antibiotic treatment. Twelve studies of short-term patient outcomes of OME with 1697 subjects had an RD favoring antibiotics

1993 JAMA

176. Antimicrobial therapy for otitis media with effusion ('secretory' otitis media). (PubMed)

Antimicrobial therapy for otitis media with effusion ('secretory' otitis media). To determine the effectiveness of antimicrobial treatment for otitis media with effusion ("secretory" otitis media) in children.We report the reexamination of a previously published study by Mandel et al that evaluated the efficacy of a 2-week course of antimicrobials (amoxicillin trihydrate) with and without a 4-week course of an oral decongestant-antihistamine combination in a double-blind, placebo-controlled (...) , randomized trial involving 518 infants and children with otitis media with effusion.At 4 weeks, amoxicillin efficacy as determined by a tympanometric criterion (P = .121) or by a measure of improvement in hearing (P = .311) was insignificant. Only by otoscopic judgment, which is shown to contain a systematic bias as used in this clinical trial, could an argument be made for a marginal efficacy of amoxicillin at the 4-week end point. Logistic regression analyses of the combined effects of treatment

1991 JAMA

177. Co-amoxiclav in recurrent acute otitis media: placebo controlled study. (PubMed)

Co-amoxiclav in recurrent acute otitis media: placebo controlled study. To determine the efficacy of coamoxiclav in children aged 6 months to 12 years with recurrent acute otitis media.A randomised double blind placebo controlled clinical trial.General practice in the Netherlands.121 children with recurrent acute otitis media, defined by onset of otalgia and otoscopic signs of middle ear infection within four to 52 weeks after the previous attack. Confirmation of diagnosis and randomisation (...) for irregular course of the disease (odds ratio 5.9; 1.8 to 19.1). Among children aged below 2 years, 28% (4/14) in the co-amoxiclav group and 58% (7/12) in the placebo group had irregular courses. For children 2 years and older these percentages were 13% (7/52) and 7% (3/41).Children with recurrent acute otitis media are at greater risk of an irregular clinical course of the disease than children with a first episode of acute otitis media. Co-amoxiclav has no significant benefit over placebo in treating

Full Text available with Trip Pro

1991 BMJ

178. Efficacy of adenoidectomy for recurrent otitis media in children previously treated with tympanostomy-tube placement. Results of parallel randomized and nonrandomized trials. (PubMed)

Efficacy of adenoidectomy for recurrent otitis media in children previously treated with tympanostomy-tube placement. Results of parallel randomized and nonrandomized trials. We studied the efficacy of adenoidectomy in 213 children who had received tympanostomy-tube placement because of persistent and/or recurrent otitis media and had again developed otitis media after tubal extrusion. Ninety-nine of the children were assigned randomly to either an adenoidectomy group or a control group (...) in the randomized trial, where during the first and second years, respectively, adenoidectomy subjects had 47% and 37% less time with otitis media than control subjects and 28% and 35% fewer suppurative (acute) episodes than control subjects. We conclude that adenoidectomy is warranted on an individualized basis for children who develop recurrent otitis media after extrusion of tympanostomy tubes.

1990 JAMA

179. Screening for otitis media with effusion in preschool children. (PubMed)

Screening for otitis media with effusion in preschool children. 1439 Dutch children were included in a randomised trial to evaluate the efficacy of preschool screening for otitis media with effusion (OME) by 3-monthly tympanometry. Children with bilateral OME on two consecutive occasions were referred for further investigation and then, if parents gave their consent, allocated at random to treatment or non-treatment groups. The effect of childhood screening for OME and subsequent treatment

1989 Lancet

180. Randomised study of myringotomy, amoxycillin/clavulanate, or both for acute otitis media in infants. (PubMed)

Randomised study of myringotomy, amoxycillin/clavulanate, or both for acute otitis media in infants. In a prospective study, 105 infants aged 3-12 months with acute otitis media were randomly assigned to one of three treatment groups: amoxycillin/clavulanate ('Augmentin') alone (36 patients), myringotomy plus placebo (35 patients), or augmentin plus myringotomy (34 patients). The last two groups were double-blinded. Bacterial pathogens, mainly Haemophilus influenzae (of which 20% were beta

1989 Lancet