Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for pain
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on pain or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on pain and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via firstname.lastname@example.org
Low-level laser therapy for pain relief after episiotomy: a double-blind randomised clinical trial To evaluate the effectiveness of a low-level laser therapy for pain relief in the perineum following episiotomy during childbirth.Laser irradiation is a painless and non-invasive therapy for perineal pain treatment and its effects have been investigated in several studies, with no clear conclusion on its effectiveness.A double-blind randomised controlled clinical trial.One hundred and fourteen (...) women who underwent right mediolateral episiotomies during vaginal birth in an in-hospital birthing centre in São Paulo, Brazil and reported pain ≥ 3 on a numeric scale (0-10) were randomised into three groups of 38 women each: two experimental groups (treated with red and infrared laser) and a control group. The experimental groups were treated with laser applied at three points directly on the episiotomy after suturing in a single session between 6-56 hours postpartum. We used a diode laser
CT for acute chest pain CT for acute chest pain CT for acute chest pain Mitchell MD, Han Y, Hollander JE, Jha S, Williams K Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mitchell MD, Han Y, Hollander JE, Jha S, Williams K. CT for acute chest pain. Philadelphia: Center for Evidence-based Practice (CEP). 2012 Final publication URL Indexing Status Subject (...) indexing assigned by CRD MeSH Chest Pain; Humans; Predictive Value of Tests; Tomography, X-Ray Computed Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence Center for Evidence-based Practice, University of Pennsylvania Health System, 3535 Market St. Suite 50, Philadelphia PA 19104 Email: Cep2@uphs.upenn.edu AccessionNumber 32012000266 Date abstract record published 06/07/2012 Health Technology Assessment
A meta-analysis of the use of nonsteroidal antiinflammatory drugs for pediatric postoperative pain A meta-analysis of the use of nonsteroidal antiinflammatory drugs for pediatric postoperative pain A meta-analysis of the use of nonsteroidal antiinflammatory drugs for pediatric postoperative pain Michelet D, Andreu-Gallien J, Bensalah T, Hilly J, Wood C, Nivoche Y, Mantz J, Dahmani S CRD summary The authors concluded that coadministration of NSAIDs and opioids reduced both postoperative opioid (...) use and pain in children, but further research was needed to establish this finding due to potential publication bias. Uncertainties about the comparisons of interest and limitations in the conduct of the meta-analyses mean that the authors' conclusions should be treated with caution. Authors' objectives To evaluate the efficacy of using nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids in the management of postoperative pain in children. Searching PubMed and EMBASE were searched up
Perioperative single dose ketorolac to prevent postoperative pain: a meta-analysis of randomized trials Perioperative single dose ketorolac to prevent postoperative pain: a meta-analysis of randomized trials Perioperative single dose ketorolac to prevent postoperative pain: a meta-analysis of randomized trials De Oliveira GS Jr, Agarwal D, Benzon HT CRD summary The review concluded that single-dose ketorolac was effective to reduce post-operative pain as well as post-operative nausea (...) and vomiting. However, interpretation of the data may have been limited by variation amongst studies and unclear study quality. The authors' conclusions reflect the presented evidence but in light of the mentioned limitations their conclusions should be interpreted carefully. Authors' objectives To evaluate the efficacy of single dose ketorolac to prevent post-operative pain. Searching PubMed, EMBASE and the Cochrane Database of Systematic Reviews were searched to 1st March 2011. Search terms were reported
Transcranial direct current stimulation for the reduction of clinical and experimentally induced pain: a systematic review and meta-analysis To evaluate the effectiveness of transcranial direct current stimulation on clinical and experimental pain, and to identify the most beneficial stimulation parameters.Predefined search using key terms of information sources including: MEDLINE, EMBASE, CAB Abstracts, and PsychINFO, Cochrane Register of Controlled Trials, CINAHL, and PeDRO databases (...) ; reference lists of retrieved articles, journal contents, and conference proceedings. Two reviewers independently searched and evaluated publications. English and non-English controlled trials that applied direct current stimulation to the brain published before September 30, 2010 were included. Studies using magnetic stimulation or pulsed currents were excluded.Trials investigating experimental pain in healthy participants (n=6) used a wide variety of stimulation and outcome parameters that did
Do educational interventions improve cancer patients` quality of life and reduce pain intensity? Quantitative systematic review This paper reports a quantitative systematic review of the effects of educational interventions on quality of life, pain intensity and pain interference in cancer patients.Cancer pain has a marked negative impact on quality of life, and this has become an important issue in discussions of treatment options. Patient education seems to be effective in pain management (...) , but no review has been published with quality of life as an outcome measure.Relevant publications from 2000 to 2010 were identified in six databases (Medline, CIHAHL, PubMed, EMBASE, PsycINFO and DARE) and by means of hand-searches. All randomized controlled trial studies of pain-education programmes for cancer patients were considered, and a quantitative review of effectiveness carried out.Studies were critically appraised by three independent reviewers, and the Jadad score was used to assess the quality
Low-Level Laser Therapy: An Efficient Method for Controlling Pain in Orthodontic Patients UTCAT2321, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Low-Level Laser Therapy: An Efficient Method for Controlling Pain in Orthodontic Patients Clinical Question In orthodontic patients, is low-level laser therapy effective in controlling pain after placement of the first orthodontic archwire, compared to placebo? Clinical (...) Bottom Line Low-level laser therapy efficiently controls pain caused by placement of the first orthodontic arch wire. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Tortamano/2009 60 orthodontic patients (ages, 12-18 years; mean, 15.9 years) Randomized Controlled Trial Key results Orthodontic patients who received low-level laser therapy (LLLT) after placement of the first archwire experienced less pain
Protrusive Splint Therapy (PST) Reduces Pain For Patients With Temporalmandibular Disorder (TMD) UTCAT2308, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Protrusive Splint Therapy (PST) Reduces Pain For Patients With Temporalmandibular Disorder (TMD) Clinical Question Is Protrusive Splint Therapy (PST) more effective at reducing pain for patients suffering from Temporalmandibular Disorder compared to no treatment (...) or compared to flat (Michigan) occlusal splints? Clinical Bottom Line Two PST studies (one for 6 months & one for 3 years) show that PST is effective at reducing TMD pain. However, another study was done with non-PST, flat occlusal Michigan splints and it was also effective at reducing TMD pain. More studies comparing PST to flat occlusal splints are needed to justify PST's more aggressive mandibular positioning compared to the flat Michigan occlusal splint. These studies suggest that occlusal splint
Changes in Temporomandibular Disorders (pain and clicking) after Orthognathic Surgery: A Meta-Analysis UTCAT2311, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Changes in Temporomandibular Disorders (pain and clicking) after Orthognathic Surgery: A Meta-Analysis Clinical Question For an adult patient with skeletal Class II malocclusion undergoing orthognathic surgery, is this patient at higher risk of developing TMD (...) compared to not undergoing orthognathic surgery? Clinical Bottom Line Though not evidence supported, patients undergoing orthognathic surgery to correct dentofacial deformities in general are more likely to show improvement in TMD pain and clicking than deterioration. An exception is for TMJ crepitus which may not show improvement. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Al-Riyami/2009 A Meta
Intravenous Ketorolac versus Intravenous Opiates for the Management of Acute Pain in the Emergency Department: Safety Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within (...) versus Intravenous Opiates for the Management of Acute Pain in the Emergency Department: Safety DATE: 17 July 2012 RESEARCH QUESTION What is the clinical evidence regarding the comparative safety of intravenous ketorolac versus intravenous opiate analgesics for the management of acute pain in adult patients in the emergency department? KEY MESSAGE One randomized controlled trial was identified regarding regarding the comparative safety of intravenous ketorolac versus intravenous opiate analgesics
Urgent C-Reactive Protein or Erythrocyte Sedimentation Rate Testing for the Identification of Pediatric Pain: Clinical Evidence and Guidelines Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all (...) and conditions. TITLE: Urgent C-Reactive Protein or Erythrocyte Sedimentation Rate Testing for the Identification of Pediatric Pain: Clinical Evidence and Guidelines DATE: 17 July 2012 RESEARCH QUESTIONS 1. What is the evidence supporting the use of urgent c-reactive protein testing for the identification of pain and subsequent pain management in pediatric patients with suspected pain? 2. What is the evidence supporting the use of urgent erythrocyte sedimentation rate testing for the identification of pain
Combination pharmacotherapy for the treatment of neuropathic pain in adults. Pharmacotherapy remains an important modality for the treatment of neuropathic pain. However, as monotherapy current drugs are associated with limited efficacy and dose-related side effects. Combining two or more different drugs may improve analgesic efficacy and, in some situations, reduce overall side effects (e.g. if synergistic interactions allow for dose reductions of combined drugs).This review evaluated (...) the efficacy, tolerability and safety of various drug combinations for the treatment of neuropathic pain.We identified randomised controlled trials (RCTs) of various drug combinations for neuropathic pain from CENTRAL, MEDLINE, EMBASE and handsearches of other reviews and trial registries. The most recent search was performed on 9 April 2012.Double-blind, randomised studies comparing combinations of two or more drugs (systemic or topical) to placebo and/or at least one other comparator for the treatment
Sublingual buprenorphine in acute pain management: a double-blind randomized clinical trial We compare the efficacy and safety of sublingual buprenorphine versus intravenous morphine sulfate in emergency department adults with acute bone fracture.Enrolled patients received buprenorphine 0.4 mg sublingually or morphine 5 mg intravenously in this double-blind, double-dummy, randomized controlled trial. Patients graded their pain with a standard 11-point numeric rating scale before medication (...) administration and 30 and 60 minutes after, and we recorded adverse reactions.We analyzed 44 and 45 patients in the buprenorphine and morphine groups, respectively. Mean pain scores were similar at 30 minutes (5.0 versus 5.0; difference 0; 95% confidence interval -0.6 to 0.8) and at 60 minutes (2.2 versus 2.2; difference 0; 95% confidence interval -0.3 to 0.3). Adverse effects observed within 30 minutes were nausea (14% versus 12%), dizziness (14% versus 22%), and hypotension (4% versus 18%).For adults
Duloxetine for the management of pain in older adults with knee osteoarthritis: randomised placebo-controlled trial pain is the leading symptom of osteoarthritis (OA) and is often chronic in nature, leading to significant morbidity and decreased quality of life. Duloxetine, a selective serotonin norepinephrine reuptake inhibitor has been demonstrated to have a centrally acting analgesic effect.the aim of the present study was to investigate the efficacy of duloxetine in reducing pain in older (...) adults with knee OA.totally, 288 patients aged 65 years and above with primary knee OA were enrolled in this study. Patients were randomised 1:1. Totally, 144 received 60 mg/day of duloxetine HCL and 144 received placebo for 16 weeks. Outcome measures included pain reduction and improvement in physical functioning scores. Pain was assessed using the visual analogue pain scale (VAS; 0-100 mm). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were used to assess
The effects of music intervention in the management of chronic pain: a single-blind, randomized, controlled trial A music intervention method in the management of pain was recently developed while taking account of recommendations in the scientific literature. The objective of this study was to assess the usefulness of this music intervention to the management of patients with chronic pain.A controlled, single-blind, randomized trial was used. Eighty-seven patients presenting with lumbar pain (...) , and D90 were: pain (VAS), anxiety-depression (HAD) and the consumption of medication.At D60 in the music intervention arm, this technique enabled a more significant reduction (P<0.001) in pain (6.3 ± 1.7 at D0 vs. 3 ± 1.7 at D60) when compared with the arm without music intervention (6.2 ± 1.5 at D0 vs. 4.6 ± 1.7 at D60). In addition, music intervention contributed to significantly reducing both anxiety/depression and the consumption of anxiolytic agents.These results confirm the value of music
Spinal cord stimulation for relief of neuropathic pain Spinal cord stimulation for relief of neuropathic pain Spinal cord stimulation for relief of neuropathic pain Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Spinal cord stimulation for relief of neuropathic pain. Lansdale: HAYES, Inc.. Directory Publication. 2012 Authors' conclusions Spinal cord stimulation (...) (SCS) involves the electrical stimulation of spinal nerves using electrodes implanted in the epidural space of the spinal column. The goal of SCS is to suppress pain in specific areas for patients with a variety of chronic pain disorders, including chronic, refractory, neuropathic pain. Timeliness warning This report has been archived and may contain outdated information. To request a copy of the report please contact the organisation directly. Final publication URL Indexing Status Subject indexing
Validation of DN4 as a screening tool for neuropathic pain in painful diabetic polyneuropathy DN4 (Douleur Neuropathique en 4 Questions) is a screening tool for neuropathic pain consisting of interview questions (DN4-interview) and physical tests. It has not formally been validated in diabetes. We evaluated the validity and diagnostic accuracy of DN4 and DN4-interview in identifying neuropathic pain of painful diabetic polyneuropathy.In 158 patients with diabetes, the presence of diabetic (...) polyneuropathy and neuropathic pain was assessed using scoring system for symptoms and signs, quantitative sensory testing, nerve conduction studies, pain history, numerical rating scale, and Short-Form McGill Pain Questionnaire. Painful diabetic polyneuropathy was defined as the presence of diabetic polyneuropathy plus chronic neuropathic pain in the same area as neuropathic deficits. A blinded investigator performed DN4.The DN4 score was significantly related to all the neurological
Perioperative Administration of Selective Cyclooxygenase-2 Inhibitors for Postoperative Pain Management in Patients After Total Knee Arthroplasty Total knee arthroplasty (TKA) is associated with considerable postoperative pain. The relative analgesic efficacy and adverse effect profile of perioperative use of selective cyclooxygenase-2 (COX-2) inhibitors for patients undergoing TKA are unclear. This is a systematic review and meta-analysis of all randomized controlled trials evaluating (...) perioperative administration of COX-2 inhibitors for TKA. Eight studies that had enrolled a total of 571 patients were identified. There was a statistical significance in postoperative pain scores (0-24 hours: P = .0007, 24-48 hours: P = .01, 48-72 hours: P < .0001), opioid consumption (P = .006), active range of motion (P = .002), itching (P = .005), and postoperative nausea/vomiting (P = .003) between groups. There was no difference in blood loss during the first 24 hours after operation between groups