Latest & greatest articles for pain

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Top results for pain

4161. Controlled trial of the antigonadotropin danazol in painful nodular benign breast disease. (PubMed)

Controlled trial of the antigonadotropin danazol in painful nodular benign breast disease. In a double-blind crossover study of the effects of the antigonadotropin danazol on pain and nodularity in 28 women with cyclical mastalgia danazol was given at doses of 200 mg/day and 400 mg/day, and the responses were assessed both subjectively and objectively. Danazol caused a significant and progressive decrease in breast pain and nodularity when compared with placebo. Symptoms responded more quickly

1982 Lancet

4162. Analgesic efficacy of parenteral metkephamid acetate in treatment of postoperative pain. (PubMed)

Analgesic efficacy of parenteral metkephamid acetate in treatment of postoperative pain. The analgesic efficacy and side-effects of a single parenteral dose of metkephamid acetate 70 mg were compared with those of pethidine (meperidine) hydrochloride 100 mg and placebo in a double-blind, randomised, controlled clinical trial. 30 out of 32 postoperative patients completed the study--10 in the metkephamid group, 11 in the pethidine group, and 9 in the placebo group. The time-effect curves (...) of summated pain measures and analyses of derived measures all indicated that the analgesic activity of metkephamid 70 mg was significantly greater than that of placebo and not less than that of pethidine 100 mg. The metkephamid group had a greater incidence of side-effects than the other two treatment groups. Some side-effects, such as sensations of heaviness of the extremities and nasal congestion, were peculiar to metkephamid but not distressing.

1982 Lancet

4163. Administration of levodopa for relief of herpes zoster pain. (PubMed)

Administration of levodopa for relief of herpes zoster pain. Forty-seven outpatients with herpes zoster, seen within five days of onset of the eruption, received ten days' administration of oral levodopa and benserazide or placebo in a double-blind controlled study. Both the total patient group and high-risk group, eg, those with either ophthalmic zoster or those older than 65 years, were analyzed. Both groups were comparable in terms of demographic and pathological criteria. Vomiting (...) was the only side effect observed in both groups. A significant decrease in intensity of pain was seen in the group receiving levodopa from the third day, and complete cessation of both pain and sleep disturbances was more frequent in the patients. Two months later, postherpetic neuralgia was also less frequent in the group that received levodopa.

1981 JAMA

4164. Spinal manipulation for low back pain. (PubMed)

Spinal manipulation for low back pain. A randomized clinical trial of rotational manipulation was conducted on 95 patients with low back pain selected for (1) the absence of any contraindications for vertebral manipulation, (2) the absence of any psychosocial problems that might affect the outcome of treatment, (3) the absence of any previous experience with manipulative therapy, and (4) the presence of palpatory cues indicating that manipulation might be successful. Patients were randomly

1981 JAMA

4165. Cryoanalgesia for post-thoracotomy pain. (PubMed)

Cryoanalgesia for post-thoracotomy pain. Intercostal block by a freezing technique was compared with blockade by local anaesthetics or no blockade as a method of treating post-thoracotomy pain. The 15 patients who received cryotherapy had significantly less postoperative pain than the 9 patients whose nerves were blocked by local anaesthetics or who did not receive any nerve block. The interruption of nerve function produced by cryotherapy was temporary (not more than 30 days), and there were

1980 Lancet

4166. Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain. (PubMed)

Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain. A double-blind study comparing the analgesic efficacy of orally administered zomepirac sodium with intramuscularly (IM) administered morphine sulfate was conducted in 109 patients with acute postoperative pain. Single treatments were administered within 48 hours of surgery, and subjective responses were obtained from patients by specially employed trained nurses. Pain relief

1980 JAMA

4167. Cyclobenzaprine in intractable pain syndromes with muscle spasm. (PubMed)

Cyclobenzaprine in intractable pain syndromes with muscle spasm. The effectiveness of cyclobenzaprine hydrochloride, a new tricyclic skeletal muscle relaxant, was shown in patients with long-term intractable pain of cervical and lumbar origin aggravated by skeletal muscle spasm and tenderness. The investigation was double-blind and randomized, comparing cyclobenzaprine hydrochloride (10 mg three times a day) with diazepam (5 mg three times a day) and with placebo. After two weeks of treatment (...) , the 16 patients in the cyclobenzaprine group showed an overall improvement in pain variables as did the 16 patients in the diazepam group. No serious adverse reactions to cyclobenzaprine were observed in the study. However, dry mouth due to cyclobenzaprine's anticholinergic action and mild degrees of drowsiness were encountered more often than with diazepam or placebo.

1978 JAMA

4168. Codeine and propoxyphene in postepisiotomy pain. A two-dose evaluation. (PubMed)

Codeine and propoxyphene in postepisiotomy pain. A two-dose evaluation. In a double-blind control study, oral doses of placebo, propoxyphene napsylate (50 or 100 mg), or codeine sulfate (30 or 60 mg) were administered to 46 postepisiotomy patients, grouped by severity of pain reported at first-dose drug administration. Eight hourly observations by a trained observer provided estimates of analgesia. The analgesia scores for placebo treatments were significantly lower than for the lesser doses

1977 JAMA

4169. Dextroamphetamine with morphine for the treatment of postoperative pain. (PubMed)

Dextroamphetamine with morphine for the treatment of postoperative pain. In a double-blind, single-dose study, dextroamphetamine combined with morphine was compared with morphine alone to determine the relative efficacy of the combination given intramuscularly for postoperative pain. Each of 450 patients received one treatment of morphine sulfate (3, 6 or 12 mg) with dextroamphetamine (0, 5 or 10 mg). Analgesia, as measured by the patients' subjective responses to questions about relief of pain

1977 NEJM

4170. [Tilidine in the treatment of postoperative pain]. (PubMed)

[Tilidine in the treatment of postoperative pain]. 4617663 1975 07 24 2013 11 21 0012-7183 90 23 1974 Duodecim; laaketieteellinen aikakauskirja Duodecim [Tilidine in the treatment of postoperative pain]. 1663-9 Janhunen L L Aromaa U U Tammisto T T fin Clinical Trial Comparative Study English Abstract Journal Article Randomized Controlled Trial Tilidiini leikkauksen jälkeisenä kipulää-keenä Finland Duodecim 0373207 0012-7183 0 Analgesics 0 Cyclohexanecarboxylic Acids 9E338QE28F Meperidine (...) GY33N31E9Y Tilidine IM Adult Aged Analgesics therapeutic use Clinical Trials as Topic Cyclohexanecarboxylic Acids therapeutic use Female Humans Male Meperidine therapeutic use Middle Aged Pain, Postoperative drug therapy Tilidine administration & dosage adverse effects therapeutic use Time Factors 1974 1 1 1974 1 1 0 1 1974 1 1 0 0 ppublish 4617663

1975 Duodecim; laaketieteellinen aikakauskirja

4171. Efficacy of acupuncture on osteoarthritic pain. A controlled, double-blind study. (PubMed)

Efficacy of acupuncture on osteoarthritic pain. A controlled, double-blind study. Forty patients, randomly assigned to an experimental and a control group, participated in a double-blind study to assess the effectiveness of acupuncture in reducing chronic pain associated with osteoarthritis. The experimental group received treatment at standard acupuncture points, and the control group at placebo points. Analysis before and after treatment showed a significant (P less than 0.05) improvement (...) in tenderness and subjective report of pain in both groups as evaluated by two independent observers and in activity by one observer. Comparison of responses to treatment between the two groups showed no significant (P greater than 0.05) difference. Thus, both experimental and control groups showed a reduction in pain after the treatments. These results may reflect the natural course of illness, and various attitudinal and social factors.

1975 NEJM

4172. Relief of pain by oral medications. A controlled evaluation of analgesic combinations. (PubMed)

Relief of pain by oral medications. A controlled evaluation of analgesic combinations. 4599149 1974 08 23 2016 10 17 0098-7484 229 1 1974 Jul 01 JAMA JAMA Relief of pain by oral medications. A controlled evaluation of analgesic combinations. 55-9 Moertel C G CG Ahmann D L DL Taylor W F WF Schwartau N N eng Clinical Trial Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Analgesics 0 Azepines 0 Ethers, Cyclic 0 Morphinans 3G6A5W338E Caffeine I4744080IR (...) administration & dosage therapeutic use Humans Morphinans administration & dosage therapeutic use Pain drug therapy Pentazocine administration & dosage therapeutic use Pentobarbital administration & dosage therapeutic use Promazine administration & dosage therapeutic use 1974 7 1 1974 7 1 0 1 1974 7 1 0 0 ppublish 4599149

1974 JAMA

4173. The effects of early corticosteroid therapy on the skin eruption and pain of herpes zoster. (PubMed)

The effects of early corticosteroid therapy on the skin eruption and pain of herpes zoster. 4905733 1970 03 31 2016 10 17 0098-7484 211 10 1970 Mar 09 JAMA JAMA The effects of early corticosteroid therapy on the skin eruption and pain of herpes zoster. 1681-3 Eaglstein W H WH Katz R R Brown J A JA eng Clinical Trial Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Placebos 1ZK20VI6TY Triamcinolone AIM IM Adult Age Factors Aged Clinical Trials as Topic Herpes (...) Zoster complications drug therapy Humans Middle Aged Neuralgia drug therapy etiology Pain Placebos Triamcinolone administration & dosage adverse effects therapeutic use 1970 3 9 1970 3 9 0 1 1970 3 9 0 0 ppublish 4905733

1970 JAMA

4174. [The effects of Doleron in postoperative pain]. (PubMed)

[The effects of Doleron in postoperative pain]. 4875091 1968 09 28 2007 11 15 0012-7183 83 24 1967 Duodecim; laaketieteellinen aikakauskirja Duodecim [The effects of Doleron in postoperative pain]. 1427-34 Rejman F F Mattsson T T fin Clinical Trial Controlled Clinical Trial Journal Article Randomized Controlled Trial Doleron postoperatiivisissa kivuissa. Finland Duodecim 0373207 0012-7183 0 Analgesics 0 Placebos IM Analgesics Clinical Trials as Topic Humans Placebos Postoperative Care 1967 1 1

1968 Duodecim; laaketieteellinen aikakauskirja