Latest & greatest articles for pain

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Top results for pain

4181. Intravenous lidocaine for the treatment of background or procedural burn pain. Full Text available with Trip Pro

Intravenous lidocaine for the treatment of background or procedural burn pain. This is an update of the review on 'Lidocaine for pain relief in burn injured patients' first published in Issue 3, 2007. Pain is a major issue for patients suffering from many different types of wounds, in particular those with burn injuries. Prompt, aggressive use of opioid analgesics such as morphine has been suggested as critical to avert the cycle of pain and anxiety, but side effects are encountered (...) . It is proposed that newer agents such as lidocaine could be effective in reducing pain and alleviating the escalating opioid dosage requirements in patients with burn injury.To assess the safety and effectiveness of intravenous lidocaine as a means of pain relief versus no therapy, placebo, other drugs or two or more of the above therapies in combination in patients exposed to burn injury.We searched the Cochrane Central Register of Controlled Trials (The Cochrane Library 2011, Issue 2), MEDLINE (1966

2012 Cochrane

4182. Fluid replacement therapy for acute episodes of pain in people with sickle cell disease. (Abstract)

Fluid replacement therapy for acute episodes of pain in people with sickle cell disease. Treating vaso-occlusive painful crises in people with sickle cell disease is complex and requires multiple interventions. Extra fluids are routinely given as adjunct treatment, regardless of the individual's state of hydration with the aim of slowing or stopping the sickling process and thereby alleviating pain.To determine the optimal route, quantity and type of fluid replacement for people with sickle (...) cell disease with acute painful crises.We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.We also conducted searches of EMBASE (November 2007), LILACS and www.ClinicalTrials.gov (05 January 2010).Date of most recent search of the Group's Haemoglobinopathies Trials Register: 09 February 2012

2012 Cochrane

4183. Is abdominal pain when asked to hop suggestive of appendicitis in children?

Is abdominal pain when asked to hop suggestive of appendicitis in children? BestBets: Is abdominal pain when asked to hop suggestive of appendicitis in children? Is abdominal pain when asked to hop suggestive of appendicitis in children? Report By: Craig McRoberts - CT3 Emergency Medicine Search checked by Dr Vincent Choudhery - Consultant Paediatric Emergency Medicine Institution: Royal Hospital for Sick Children, Glasgow Date Submitted: 12th January 2012 Date Completed: 13th June 2012 Last (...) Modified: 13th June 2012 Status: Green (complete) Three Part Question In [children with suspected appendicitis] how [useful is abdominal pain when asked to hop] at [confirming or refuting the diagnosis] Clinical Scenario A 9 year old presents to the ED with acute abdominal pain; is pain on hopping/jumping indicative of appendicitis? Search Strategy Medline 1946-February week 3 2012 using the OVID interface {(appendicitis/ OR acute appendicitis/ OR appendicitis.mp) AND (hop.mp OR hopping.mp OR jump$.mp

2012 BestBETS

4184. Ultrasound-Guided Ilioinguinal/Iliohypogastric Nerve Blocks for Persistent Inguinal Postherniorrhaphy Pain: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial (Abstract)

Ultrasound-Guided Ilioinguinal/Iliohypogastric Nerve Blocks for Persistent Inguinal Postherniorrhaphy Pain: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial Ilioinguinal and iliohypogastric nerve blocks are used in the clinical management of persistent inguinal postherniorrhaphy pain, but no controlled studies have been published on the subject. In this controlled study, we investigated the analgesic and sensory effects of ultrasound-guided blocks of the ilioinguinal (...) and iliohypogastric nerves with lidocaine.A randomized, double-blind, placebo-controlled, crossover trial in 12 patients with severe persistent inguinal postherniorrhaphy pain, including a control group of 12 healthy controls, was performed. Assessments included pain ratings under standardized conditions with numerical rating scale (0-10), sensory mapping to a cool roller, and quantitative sensory testing (QST), in the groin regions, before and after each ultrasound-guided block. A needle approach of 1 to 2 cm

2012 EvidenceUpdates Controlled trial quality: predicted high

4185. NGX-4010, a capsaicin 8% dermal patch, administered alone or in combination with systemic neuropathic pain medications, reduces pain in patients with postherpetic neuralgia (Abstract)

NGX-4010, a capsaicin 8% dermal patch, administered alone or in combination with systemic neuropathic pain medications, reduces pain in patients with postherpetic neuralgia Analyses of integrated data from 4 controlled postherpetic neuralgia studies evaluated the effect of NGX-4010, a capsaicin 8% patch, administered alone or together with systemic neuropathic pain medications.Patients recorded their “average pain for the past 24 hours” daily for 12 weeks using an 11-point Numeric Pain Rating (...) Scale (NPRS). Efficacy assessment included the percentage NPRS score reduction from baseline during weeks 2 to 8 and 2 to 12, the proportion of patients responding during weeks 2 to 8 and 2 to 12 and the Patient Global Impression of Change (PGIC) at weeks 8 and 12.During the studies, 302 NGX-4010 and 250 control (capsaicin, 0.04% wt/wt) patients were using at least 1 systemic neuropathic pain medication; 295 NGX-4010 and 280 control patients were not. During weeks 2 to 8, NGX-4010 patients reported

2012 EvidenceUpdates Controlled trial quality: uncertain

4186. Kinesio Taping reduces disability and pain slightly in chronic non-specific low back pain: a randomised trial Full Text available with Trip Pro

Kinesio Taping reduces disability and pain slightly in chronic non-specific low back pain: a randomised trial Does Kinesio Taping reduce disability, pain, and kinesiophobia in people with chronic non-specific low back pain?Randomised trial, with concealed allocation, assessor blinding, and intention-to-treat analysis.Sixty adults with chronic non-specific low back pain.The experimental intervention was Kinesio Taping over the lumbar spine for one week; the control intervention was sham (...) taping.The following outcomes were measured at baseline, immediately after the week with the tape in situ, and four weeks later: Oswestry Disability Index, Roland- Morris Low Back Pain and Disability Questionnaire, pain on a 10-cm visual analogue scale, Tampa kinesiophobia scale, trunk flexion range of motion, and the McQuade test of trunk muscle endurance.At one week, the experimental group had significantly greater improvement in disability, by 4 points (95% CI 2 to 6) on the Oswestry score and by 1.2

2012 EvidenceUpdates Controlled trial quality: predicted high

4187. Evaluation of Opioid Use for Patients with Chronic Non-Cancer Pain: Clinical Evidence

Evaluation of Opioid Use for Patients with Chronic Non-Cancer Pain: Clinical Evidence Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses (...) for Patients with Chronic Non-Cancer Pain: Clinical Evidence DATE: 04 June 2012 RESEARCH QUESTION What is the clinical evidence evaluating inappropriate use of opioids by patients with chronic non-cancer pain, using administrative databases? KEY MESSAGE Seven non-randomized studies using administrative databases to evaluate inappropriate use of opioids by patients with chronic non-cancer pain were identified. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4188. Phenytoin for neuropathic pain and fibromyalgia in adults. Full Text available with Trip Pro

Phenytoin for neuropathic pain and fibromyalgia in adults. Antiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. Phenytoin is an established antiepileptic drug that has been used occasionally to treat intractable trigeminal neuralgia.To assess the analgesic efficacy and adverse effects of the antiepileptic drug phenytoin in neuropathic pain and fibromyalgia.We searched the Cochrane Central Register (...) of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 2), MEDLINE, and EMBASE to 28 February 2012, together with reference lists of retrieved papers and reviews, and ClinicalTrials.gov.We planned to include randomised, double-blind studies of eight weeks duration or longer, comparing phenytoin with placebo or another active treatment in chronic neuropathic pain or fibromyalgia.Two review authors would independently extract data for efficacy and adverse events, and examine issues of study

2012 Cochrane

4189. Clonazepam for neuropathic pain and fibromyalgia in adults. Full Text available with Trip Pro

Clonazepam for neuropathic pain and fibromyalgia in adults. Antiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. Clonazepam, a benzodiazepine, is an established antiepileptic drug, but its place in the treatment of neuropathic pain is unclear.To assess the analgesic efficacy and adverse effects of the antiepileptic drug clonazepam in neuropathic pain and fibromyalgia.We searched the Cochrane Central (...) Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 2). MEDLINE, and EMBASE to 28 February 2012, together with reference lists of retrieved papers and reviews, and ClinicalTrials.gov.We planned to include randomised, double-blind studies of eight weeks duration or longer, comparing clonazepam with placebo or another active treatment in chronic neuropathic pain or fibromyalgia.Two review authors would independently extract data for efficacy and adverse events, and examine issues

2012 Cochrane

4190. Meta-analysis of psychosocial interventions to reduce pain in patients with cancer Full Text available with Trip Pro

Meta-analysis of psychosocial interventions to reduce pain in patients with cancer Pain is one of the most common, burdensome, and feared symptoms experienced by patients with cancer. American Pain Society standards for pain management in cancer recommend both pharmacologic and psychosocial approaches. To obtain a current, stable, and comprehensive estimate of the effect of psychosocial interventions on pain-an important clinical topic-we conducted a meta-analysis of randomized controlled (...) studies among adult patients with cancer published between 1966 and 2010.Three pairs of raters independently reviewed 1,681 abstracts, with a systematic process for reconciling disagreement, yielding 42 papers, of which 37 had sufficient data for meta-analysis. Studies were assessed for quality using a modified seven-item Physiotherapy Evidence Database (PEDro) coding scheme. Pain severity and interference were primary outcome measures.Study participants (N = 4,199) were primarily women (66

2012 EvidenceUpdates

4191. A meta-analysis of the use of nonsteroidal antiinflammatory drugs for pediatric postoperative pain Full Text available with Trip Pro

A meta-analysis of the use of nonsteroidal antiinflammatory drugs for pediatric postoperative pain Opioid side effects are a great concern during the postoperative period in children. Nonsteroidal antiinflammatory drugs (NSAIDs) have been shown to effectively decrease postoperative pain, but their opioid-sparing effect is still controversial. In this present meta-analysis, we investigated the postoperative opioid-sparing effect of NSAIDs in children.A comprehensive literature search (...) was conducted to identify clinical trials using NSAIDs and opioids as perioperative analgesic compounds in children and infants. Outcomes measured were opioid consumption, pain intensity, postoperative nausea and vomiting (PONV), and urinary retention. All outcomes were studied during postanesthesia care unit (PACU) stay and the first 24 postoperative hours. Data from each trial were combined to calculate the pooled odds ratios (ORs) or standardized mean difference (SMD) and their 95% confidence

2012 EvidenceUpdates

4192. Relief of TMD pain in patients diagnosed with PTSD: modifications of traditional occlusal appliances

Relief of TMD pain in patients diagnosed with PTSD: modifications of traditional occlusal appliances UTCAT2212, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Relief Of TMD Pain In Patients Diagnosed With PTSD: Modifications Of Traditional Occlusal Appliances Clinical Question In a patient diagnosed with post-traumatic stress disorder who reports of night time clenching activity during during PTSD nightmares, and has (...) of an opposing mandibular soft appliance may provide additional benefit. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Wright/2004 1 patient diagnosed with PTSD reporting of tooth pain Case Study Key results A maxillary acrylic appliance provided some relief, while addition of a subsequent soft occlusal appliance opposing on the mandibular provided additional relief. Evidence Search "Stress Disorders, Post

2012 UTHSCSA Dental School CAT Library

4193. Occlusal Splint Is More Effective Than Transcutaneous Electric Nerve Stimulation In Reducing Pain Due To Acute TMJ Disc Displacement Without Reduction

Occlusal Splint Is More Effective Than Transcutaneous Electric Nerve Stimulation In Reducing Pain Due To Acute TMJ Disc Displacement Without Reduction UTCAT2281, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Occlusal Splint Is More Effective Than Transcutaneous Electric Nerve Stimulation In Reducing Pain Due To Acute TMJ Disc Displacement Without Reduction Clinical Question In adults with a TMJ acute disc (...) displacement without reduction, will an occlusal splint or transcutaneous electric nerve stimulation be more effective in reducing TMD pain. Clinical Bottom Line Using a VAS, occlusal splints were found to be more effective in reducing pain in adult patients with a TMJ acute disc displacement without reduction. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Linde /1995 31 Patients Randomized Controlled Trial

2012 UTHSCSA Dental School CAT Library

4194. Fentanyl Pectin Nasal Spray Reduced Oral-Cancer Related Pain

Fentanyl Pectin Nasal Spray Reduced Oral-Cancer Related Pain UTCAT2270, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Fentanyl Pectin Nasal Spray Reduced Oral-Cancer Related Pain Clinical Question In a patient with oral cancer, is fentanyl pectin nasal spray (FPNS) compared to immediate-release morphine sulfate (IRMS) more effective in reducing oral cancer related pain? Clinical Bottom Line Fentanyl pectin nasal (...) spray is more effective in reducing oral cancer related pain than immediate-release morphine sulfate. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Fallon/ 2011 Oral cancer patients (n=110) experiencing cancer pain 1-4 episodes/ day Randomized Controlled Trial Key results There was statistically significant improvement in pain intensity difference (PID) at 15 minutes after dosing of fentanyl pectin

2012 UTHSCSA Dental School CAT Library

4195. SpineForce Neuromuscular Trainer for Back Pain: Clinical Effectiveness

SpineForce Neuromuscular Trainer for Back Pain: Clinical Effectiveness Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should (...) study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions. TITLE: SpineForce Neuromuscular Trainer for Back Pain

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4196. Codeine and Acetaminophen for Pain Relief: A Review of the Clinical Efficacy and Safety

Codeine and Acetaminophen for Pain Relief: A Review of the Clinical Efficacy and Safety Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources and a summary of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed (...) to CADTH. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions. TITLE: Codeine and Acetaminophen for Pain Relief: A Review of the Clinical Efficacy and Safety DATE: 12 April 2012 CONTEXT AND POLICY ISSUES Pain has been defined as “an unpleasant sensory and emotional experience arising from actual

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4197. Dienogest - Pain (pelvic) associated with endometriosis

Dienogest - Pain (pelvic) associated with endometriosis Common Drug Review CDEC Meeting – March 21, 2012 Notice of CDEC Final Recommendation – April 19, 2012 Page 1 of 4 © 2012 CADTH CDEC FINAL RECOMMENDATION DIENOGEST (Visanne – Bayer Inc.) Indication: Management of Pelvic Pain Associated With Endometriosis Recommendation: The Canadian Drug Expert Committee (CDEC) recommends that dienogest be listed for the management of pelvic pain associated with endometriosis in patients for whom one (...) or more less costly hormonal options are either ineffective or cannot be used. Reasons for the Recommendation: 1. In two randomized controlled trials (RCTs) included in the systematic review, dienogest was superior to placebo (study A32473), and non-inferior to leuprolide (study AU19), in reducing pelvic pain in patients with endometriosis. 2. At the submitted price, the daily drug cost of dienogest ($1.96) is less than all alternatives with a Health Canada indication for the treatment or hormonal

2012 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

4198. Prevention of Pegfilgrastim-Induced Bone Pain: A Phase III Double-Blind Placebo-Controlled Randomized Clinical Trial of the University of Rochester Cancer Center Clinical Community Oncology Program Research Base. Full Text available with Trip Pro

Prevention of Pegfilgrastim-Induced Bone Pain: A Phase III Double-Blind Placebo-Controlled Randomized Clinical Trial of the University of Rochester Cancer Center Clinical Community Oncology Program Research Base. Pegfilgrastim-induced bone pain is a significant clinical problem that may result in discontinuation of pegfilgrastim and lead to less effective chemotherapy dosing. Interventions for pegfilgrastim-induced bone pain are needed.The University of Rochester Cancer Center Clinical (...) Community Oncology Program Research Base randomly assigned 510 patients at 17 sites to receive either naproxen (500 mg two times per day) or placebo on the day of pegfilgrastim administration, continuing for 5 to 8 days after pegfilgrastim. Patients recorded pain severity (using a scale of 0 to 10) and duration in daily diaries. The primary outcome measure was the area under the curve (AUC) for pain for days 1 through 5. Secondary outcome measures included the identification of risk factors

2012 EvidenceUpdates Controlled trial quality: predicted high

4199. Postoperative levonorgestrel-releasing intrauterine system for pelvic endometriosis-related pain: a randomized controlled trial Full Text available with Trip Pro

Postoperative levonorgestrel-releasing intrauterine system for pelvic endometriosis-related pain: a randomized controlled trial To estimate the effectiveness of a postoperative levonorgestrel-releasing intrauterine system for relieving pelvic pain in patients with endometriosis.A double-blind randomized controlled trial was conducted in 55 patients with endometriosis and moderate-to-severe dysmenorrhea (visual analog scale, greater than 50 mm) undergoing laparoscopic conservative surgery. After (...) surgery, patients were randomized to a levonorgestrel-releasing intrauterine system (n=28) or expectant management (n=27) group. Primary outcome was the change of dysmenorrhea visual analog scale. Secondary outcomes included changes of pelvic pain and dyspareunia visual analog scale, Short Form-36 score, and adverse effects.The two groups were comparable in age, body mass index, parity, and baseline pain scores. At 12 months, the levonorgestrel-releasing intrauterine system group had a significantly

2012 EvidenceUpdates Controlled trial quality: predicted high

4200. Botulinum toxin for myofascial pain syndromes in adults. (Abstract)

Botulinum toxin for myofascial pain syndromes in adults. Myofascial pain syndrome (MPS) is a regional muscular pain syndrome characterised by the presence of trigger points, which are painful points in one or more muscles. The pain can be felt at the site where the trigger point is located or it can be felt away from that place when the muscle is pressed (referred pain). Botulinum toxin is a protein produced by the bacterium Clostridium botulinum and is a potent neurotoxin that eventually (...) inhibits muscle contractions. It is capable of selectively weakening painful muscles and interrupting the pain cycle.To assess the effectiveness and safety of botulinum toxin in treating MPS, excluding MPS in neck and head muscles.The search strategy was composed of terms for myofascial pain and botulinum toxin. We searched the Cochrane Pain, Palliative and Supportive Care (PaPaS) Review Group's Specialised Register until December 2011, CENTRAL (Cochrane Database of Systematic Reviews 2011, Issue 4

2012 Cochrane