Latest & greatest articles for pneumonia

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Top results for pneumonia

121. Predictive value of copeptin as a severity marker of community-acquired pneumonia (PubMed)

Predictive value of copeptin as a severity marker of community-acquired pneumonia Pneumonia is the leading cause of death in children. Few studies have explored the predictive value of copeptin in pediatric pneumonia.This study aimed to assess the role of copeptin as a marker of severity of community-acquired pneumonia (CAP).This prospective case-control study was carried out at Minia University Children's Hospital in Minia (Egypt) from January to December 2016. Eighty children aged from 2 (...) months to 42 months were enrolled in this study and were classified into group 1 (40 children with clinical, laboratory and radiological evidence of pneumonia) and group 2 (40 apparently healthy control). Serum copeptin level was assayed for all enrolled children.Mean serum copeptin level was significantly higher in pneumonic patients (985.7±619) pg/ml compared to controls (519±308.2) pg/ml (p<0.001). Serum copeptin was significantly elevated in survivors of pneumonia more than non-survivors (p=0.001

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2017 Electronic physician

122. Advances in the causes and management of community acquired pneumonia in adults. (PubMed)

Advances in the causes and management of community acquired pneumonia in adults. Community acquired pneumonia remains a common cause of morbidity and mortality. Usually, the causal organism is not identified and treatment remains empiric. Recent computed tomography and magnetic resonance imaging studies have challenged the accuracy of the clinical diagnosis of pneumonia, and epidemiologic studies are changing our perspective of what causes community acquired pneumonia, especially the role (...) of viral pathogens and the frequent finding of multiple pathogens. The past decade has seen increasing overuse of empiric coverage of meticillin resistant Staphylococcus aureus and antibiotic resistant Gram negative pathogens owing to inappropriate application of guidelines for healthcare associated pneumonia. Optimal treatment remains a matter for debate, especially in very sick patients, including the role of combination antibiotic therapy and corticosteroids. Pneumonia care bundles are being defined

2017 BMJ

123. Tropical pyomyositis caused by Klebsiella pneumoniae with rheumatoid arthritis (PubMed)

Tropical pyomyositis caused by Klebsiella pneumoniae with rheumatoid arthritis 29657883 2018 11 30 2147-9720 5 1 2018 Mar European journal of rheumatology Eur J Rheumatol Tropical pyomyositis caused by Klebsiella pneumoniae with rheumatoid arthritis. 83-84 10.5152/eurjrheum.2017.160126 Carneiro Juliana Brandão Pinto JBP http://orcid.org/0000-0001-7184-0582 Department of Rheumatology, Getúlio Vargas University Hospital (HUGV), Federal University of Amazon School of Medicine (UFAM), Manaus

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2017 European journal of rheumatology

124. Evaluation of the Yale New Haven Readmission Risk Score for Pneumonia in a General Hospital Population

Evaluation of the Yale New Haven Readmission Risk Score for Pneumonia in a General Hospital Population The Yale New Haven Readmission Risk Score (YNHRRS) for pneumonia is a clinical prediction tool developed to assess risk for 30-day readmission. This tool was validated in a cohort of Medicare patients; generalizability to a broader patient population has not been evaluated. In addition, it lacks indicators of functional status or social support, which have been shown in other studies (...) to be predictors of readmission. The objective of this study was to evaluate the generalizability of the YNHRRS for pneumonia in a general population of hospitalized patients, and assess the impact of incorporating measures of functional status and social support on its predictive value.This retrospective chart review comprised all patients admitted to a 563-bed academic medical center with a primary diagnosis of pneumonia between March 2014 and March 2015. Abstraction of clinical variables allowed calculation

2017 EvidenceUpdates

125. Efficacy of a respiratory physiotherapy intervention for intubated and mechanically ventilated adults with community acquired pneumonia: a systematic review protocol. (PubMed)

Efficacy of a respiratory physiotherapy intervention for intubated and mechanically ventilated adults with community acquired pneumonia: a systematic review protocol. The objective of the review is to map evidence on the efficacy of a respiratory physiotherapy intervention for intubated and mechanically ventilated adults with community acquired pneumonia (CAP). Specifically, the review seeks to investigate if respiratory physiotherapy interventions can achieve the following for intubated

2017 JBI database of systematic reviews and implementation reports

126. The impact of blood glucose on community-acquired pneumonia: a retrospective cohort study (PubMed)

The impact of blood glucose on community-acquired pneumonia: a retrospective cohort study Hyperglycaemia is common in patients with community-acquired pneumonia (CAP) and is a predictor of severe outcomes. Data are scarce regarding whether this association is affected by diabetes mellitus (DM) and also regarding its importance for severe outcomes in hospital. We determined the impact of blood glucose on severe outcomes of CAP in hospital. We studied 1318 adult CAP patients hospitalised at three

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2017 ERJ open research

127. The Protein Interactome of Streptococcus pneumoniae and Bacterial Meta-interactomes Improve Function Predictions (PubMed)

The Protein Interactome of Streptococcus pneumoniae and Bacterial Meta-interactomes Improve Function Predictions The functions of roughly a third of all proteins in Streptococcus pneumoniae, a significant human-pathogenic bacterium, are unknown. Using a yeast two-hybrid approach, we have determined more than 2,000 novel protein interactions in this organism. We augmented this network with meta-interactome data that we defined as the pool of all interactions between evolutionarily conserved (...) proteins in other bacteria. We found that such interactions significantly improved our ability to predict a protein's function, allowing us to provide functional predictions for 299 S. pneumoniae proteins with previously unknown functions. IMPORTANCE Identification of protein interactions in bacterial species can help define the individual roles that proteins play in cellular pathways and pathogenesis. Very few protein interactions have been identified for the important human pathogen S. pneumoniae. We

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2017 mSystems

128. Solithromycin Triskel - community-acquired pneumonia, anthrax and tularaemia

Solithromycin Triskel - community-acquired pneumonia, anthrax and tularaemia 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Un on Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2017. Reproduction is authorised provided the source is acknowledged. 15 December 2016 EMA/CHMP/226929/2017 Committee for Medicinal Products for Human Use (CHMP) Assessment (...) -acquired bacterial pneumonia CE clinically evaluable CFU colony-forming unit CI confidence interval CL/F clearance CLd1, CLd2 distributional clearances Cmax maximum plasma concentration CrCL creatinine clearance CSR clinical study report CV% percent coefficient of variation CYP human cytochrome P450 ECG electrocardiogram ECR Early Clinical Response eGFR estimated glomerular filtration rate ELF epithelial lining fluid EOT end of therapy F absolute bioavailability GI gastrointestinal GMR geometric mean

2017 European Medicines Agency - EPARs

129. CRACKCast E076 – Pneumonia

CRACKCast E076 – Pneumonia CRACKCast E076 - Pneumonia - CanadiEM CRACKCast E076 – Pneumonia In , by Adam Thomas May 8, 2017 This episode of CRACKCast covers Rosen’s Chapter 76, Pneumonia. This episode tackles high yield information on diagnosis and management of pneumonia, one of the most common emergency department presenting illnesses. Shownotes – Rosen’s in Perspective This is a common disease – thankfully most cases can be managed as an outpatient, however, this is expected to change (...) 10,000 L of air each day!! Pneumonia develops when: Host defences are overwhelmed A Virulent organism shows up A large amount of oropharyngeal organisms is aspirated Typical vs Atypical infections Typical ones: Streptococcus pneumoniae (very virulent) Haemophilus influenzae Staphylococcus aureus CA MRSA can commonly be associated with influenzae IVDU’s Look for the cavitation, and necrosis on the CXR Atypicals Legionella Mycoplasma Chlamydophila Virals: Influenzae Parainfluenza Usually named

2017 CandiEM

130. Study on Perioperative Administration of a Neutrophil Elastase Inhibitor for Interstitial Pneumonias

Study on Perioperative Administration of a Neutrophil Elastase Inhibitor for Interstitial Pneumonias Although acute exacerbation of idiopathic interstitial pneumonias (IIPs) is a lethal complication after pulmonary resection for lung cancer with IIPs, there are no established methods to prevent its occurrence. This prospective randomized study was conducted to evaluate whether perioperative administration of the neutrophil elastase inhibitor sivelestat prevents acute exacerbation after

2017 EvidenceUpdates

131. Risk of pneumonia associated with incident benzodiazepine use among community-dwelling adults with Alzheimer disease (PubMed)

Risk of pneumonia associated with incident benzodiazepine use among community-dwelling adults with Alzheimer disease Knowledge regarding whether benzodiazepines and similarly acting non-benzodiazepines (Z-drugs) are associated with an increased risk of pneumonia among older adults is lacking. We sought to investigate this association among community-dwelling adults with Alzheimer disease, a condition in which both sedative/hypnotic use and pneumonia are common.We obtained data on all community (...) -dwelling adults with a recent diagnosis of Alzheimer disease in Finland (2005-2011) from the Medication use and Alzheimer disease (MEDALZ) cohort, which incorporates national registry data on prescriptions, reimbursement, hospital discharges and causes of death. Incident users of benzodiazepines and Z-drugs were identified using a 1-year washout period and matched with nonusers using propensity scores. The association with hospital admission or death due to pneumonia was analyzed with the Cox

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2017 EvidenceUpdates

132. Procalcitonin and CRP as Biomarkers in Discrimination of Community-acquired Pneumonia and Exacerbation of COPD (PubMed)

Procalcitonin and CRP as Biomarkers in Discrimination of Community-acquired Pneumonia and Exacerbation of COPD Serum procalcitonin (PCT) and C-reactive protein (CRP) are markers of systemic inflammation and bacterial infection. We aimed to compare the usefulness of procalcitonin and CRP in patients with community-acquired pneumonia and exacerbations of chronic obstructive pulmonary disease (COPD).A total of 116 consecutive patients were included in the study: 76 with chronic obstructive (...) pulmonary disease in group 1, and 40 with pneumonia in group 2.Median serum CRP level was 44 mg/L in the COPD group and 132 mg/L in the pneumonia group. Median value of serum PCT was found to be 0.07 in the COPD group and 0.14 ng/mL in the pneumonia group. Serum PCT and CRP levels were significantly higher in the pneumonia group compared to the COPD group (p<0.001). The area under the ROC curve was 0.788 (CI: 0.704-0.872) for CRP and 0.699 (CI: 0.599-0.800) for procalcitonin to identify

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2017 Journal of medical biochemistry

133. The mask of acute bacterial pneumonia may disguise the face of tuberculosis (PubMed)

The mask of acute bacterial pneumonia may disguise the face of tuberculosis Pulmonary tuberculosis (TB) can present as acute pneumonia. Differentiation of tuberculous from non-tuberculous community-acquired pneumonia (CAP) is an important challenge in endemic areas. The purpose of this study was the comparison between characteristics of tuberculous and non-tuberculous CAP patients.In this prospective and observational study, all adult patients (aged ≥16 years) who were admitted to Imam Reza (...) Hospital in Mashhad (Iran) with the diagnosis of CAP, between February 2013 and January 2014, were enrolled. Clinical, radiological, and microbiological data of the patients were collected and reviewed. Statistical analyses were performed using SPSS 14 software and R programming language.We studied 120 patients with diagnosis of acute CAP including 21 (17.5%) tuberculous and 99 (82.5%) non-tuberculous CAP. The etiologies of CAP in the latter group were as follow: S. pneumoniae 29 (29.3%), followed by S

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2017 Electronic physician

134. Increased incidence of adult pneumococcal pneumonia during school holiday periods (PubMed)

Increased incidence of adult pneumococcal pneumonia during school holiday periods Child contact is a recognised risk factor for adult pneumococcal disease. Peaks in invasive pneumococcal disease incidence observed during winter holidays may be related to changes in social dynamics. This analysis was conducted to examine adult pneumococcal community-acquired pneumonia (CAP) incidence during school holiday periods. Between September 2008 and 2013, consecutive adults admitted to hospitals covering (...) the Greater Nottingham area with a diagnosis of CAP were studied. Pneumococcal pneumonia was detected using culture and antigen detection methods. Of 2221 adults studied, 575 (25.9%) were admitted during school holidays and 643 (29.0%) had pneumococcal CAP. CAP of pneumococcal aetiology was significantly more likely in adults admitted during school holidays compared to term time (35.3% versus 26.7%; adjusted OR 1.38, 95% CI 1.11-1.72, p=0.004). Over the 5-year period, the age-adjusted incidence

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2017 ERJ open research

135. Risk of heart failure after community acquired pneumonia: prospective controlled study with 10 years of follow-up. (PubMed)

Risk of heart failure after community acquired pneumonia: prospective controlled study with 10 years of follow-up. Objective To determine the attributable risk of community acquired pneumonia on incidence of heart failure throughout the age range of affected patients and severity of the infection.Design Cohort study.Setting Six hospitals and seven emergency departments in Edmonton, Alberta, Canada, 2000-02.Participants 4988 adults with community acquired pneumonia and no history of heart (...) failure were prospectively recruited and matched on age, sex, and setting of treatment (inpatient or outpatient) with up to five adults without pneumonia (controls) or prevalent heart failure (n=23 060).Main outcome measures Risk of hospital admission for incident heart failure or a combined endpoint of heart failure or death up to 2012, evaluated using multivariable Cox proportional hazards analyses.Results The average age of participants was 55 years, 2649 (53.1%) were men, and 63.4% were managed

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2017 BMJ

136. Bedside lung ultrasound for the diagnosis of pneumonia in children

Bedside lung ultrasound for the diagnosis of pneumonia in children BestBets: Bedside lung ultrasound for the diagnosis of pneumonia in children Bedside lung ultrasound for the diagnosis of pneumonia in children Report By: Louis-David Audette - PGY-4, emergency medicine Search checked by Marc-Charles Parent - MD, FRCPC Institution: Emergency Medicine Residency Program, Laval University Date Submitted: 20th January 2016 Date Completed: 10th February 2017 Last Modified: 10th February 2017 Status (...) : Green (complete) Three Part Question In [children] presenting with suspected pneumonia), can [bedside lung ultrasound] be used to diagnose [pneumonia]? Clinical Scenario A 4 year-old child presents to your local ED with respiratory symptoms and fever. In order to confirm your suspicion of pneumonia, you plan to order a chest radiograph, but a quick look into the child's medical record shows he has already undergone several X-rays in the last few years for the evaluation of upper respiratory tract

2017 BestBETS

137. Pneumococcal vaccines for preventing pneumonia in chronic obstructive pulmonary disease. (PubMed)

Pneumococcal vaccines for preventing pneumonia in chronic obstructive pulmonary disease. People with chronic obstructive pulmonary disease (COPD) are at increased risk of pneumococcal disease, especially pneumonia, as well as acute exacerbations with associated morbidity and healthcare costs.To determine the efficacy of injectable pneumococcal vaccination for preventing pneumonia in persons with COPD.We searched the Cochrane Airways COPD Trials Register and the databases CENTRAL, MEDLINE (...) of 12 RCTs involving 2171 participants with COPD. Average age of participants was 66 years, male participants accounted for 67% and mean forced expiratory volume in one second (FEV1) was 1.2 L (five studies), 54% predicted (four studies). We assessed risks of selection, attrition and reporting bias as low, and risks of performance and detection bias as moderate.Compared with control, the vaccine group had a lower likelihood of developing community-acquired pneumonia (CAP) (odds ratio (OR) 0.62, 95

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2017 Cochrane

138. Household expenditures on pneumonia and diarrhoea treatment in Ethiopia: a facility-based study (PubMed)

Household expenditures on pneumonia and diarrhoea treatment in Ethiopia: a facility-based study Out-of-pocket (OOP) medical payments can lead to catastrophic health expenditure and impoverishment. We quantified household OOP expenditure for treatment of childhood pneumonia and diarrhoea and its impact on poverty for different socioeconomic groups in Ethiopia.This study employs a mix of retrospective and prospective primary household data collection for direct medical and non-medical costs (2013 (...) US$). Data from 345 pneumonia and 341 diarrhoea cases (0-59 months of age) were collected retrospectively through exit interviews from 35 purposively sampled health facilities in Ethiopia. Prospective 2-week follow-up interviews were conducted at the household level using a structured questionnaire.The mean total medical expenditures per outpatient visit were US$8 for pneumonia and US$6 for diarrhoea, while the mean for inpatient visits was US$64 for severe pneumonia and US$79 for severe

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2017 BMJ global health

139. Cohort study: Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia in children

Cohort study: Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia in children Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia in children | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please (...) see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia

2017 Evidence-Based Medicine (Requires free registration)